The photo-/thermo-chromism of spiropyran in alkanes as a temperature abuse indicator in the cold chain of vaccines
The optimal storage temperature for vaccines ranges from 2 °C to 8 °C. Electronic thermometers can provide real-time and remote temperature monitoring but are not applicable for individual packages. However, it is known that few alkanes have melting points in this range. The photo-induced conversion of colorless spiropyran to blue merocyanine can be thermally reversed, resulting in decoloration. By dispersing spiropyran in a mixture of n-tetradecane and n-pentadecane with the melting point of 8 °C, an accurate and low-cost thermochromism indicator to record temperature abuse has been designed. The results showed that the thin label based on this system has taken a permanent decoloration within 10 min of the temperature exceeding 8 °C.
研究领域:
生物化学
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制药工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）