ENERGY AND BUILDINGS
·
2024
·
IF 6.6
Xuemei Zhang,Jianjuan Yuan,Yue Han,Xiangfei Kong
The huge heat loss/gain through windows is the reason for a large amount of energy consumption in buildings. Although using the heat storage capacity of phase change material (PCM) to improve the thermal inertia of windows is an important way to reduce energy consumption, leakage and overheating at noon limit the development of windows containing solid–liquid PCM. Smart windows based on temperature-sensitive hydrogel have aroused great interest due to their excellent ability to dynamically control solar energy. However, current temperature-sensitive hydrogels with single transition temperature and uncontrollable transition speed affect indoor light comfort. Meanwhile, the low heat storage performance of hydrogels limited their energy-saving effect. Therefore, a novel smart window (P3H6) integrating temperature sensitivity and energy storage was constructed by the prepared hydrogel and form-stable PCM. The double-network hydrogel with adjustable temperature band and mechanical enhancement was constructed by acrylamide and N-isopropylacrylamide, which realized the dynamic adjustment of solar energy. The prepared form-stable PCM avoided the leakage problem and improved the heat storage capacity of the window. The comprehensive transmittance of P3H6 can be changed between 3.3 %-62.7 %-2.6 % in a day, which blocked the sunlight from transmitting heat at noon and protected privacy at night. The outdoor experiments showed that P3H6 delayed the inner surface temperature of the window to 32 °C by 1.05 h compared with traditional windows, which reduced the thermal radiation of windows to the room and improved the thermal comfort of indoor personnel. More importantly, the application of P3H6 can reduce the daytime cooling load of buildings by 28.84 %. To sum up, the proposed smart window shows great potential in energy-saving buildings.
研究领域:
材料科学
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能源工程
·
建筑技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2019
·
IF 2.606
Yan-hong Wang,Ming Zhong,Lu Wang,Yu-liang Liu,Bin Wang,Yong Li
Chelerythrine (CHE) is an alkaloid with significant anticancer activity. However, CHE is required repeat administration to achieve the treatment effect due to its short half-life. To address this issue, a novel CHE controlled release drug delivery system consisted of composite magnetic-thermosensitive hydrogels (CMHs) with magnetocaloric properties was designed. The CMHs consisting of magnetic vinyl-Fe 3 O 4 @SiO 2 with good water dispersibility and crosslinking ability, and N-isopropylacrylamide-co-acrylamide copolymers , were synthesized by in situ polymerization. Vibrating sample magnetometer characterization verified that integration of vinly-Fe 3 O 4 @SiO 2 nanoparticles in the hydrogel network provided the sensitivity to magnetic fields. The CHE release experiment showed that the CMHs have temperature/magnetic field-triggered and sustained release properties, and the higher cumulative release amount could be achieved under higher temperature conditions or in the presence of an intermittent alternative magnetic field. It can be concluded that composite magnetic-thermosensitive hydrogels could be a potential anticancer drug delivery system with excellent thermotriggered release capabilities for CHE in magnetic hyperthermia.
研究领域:
药学
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生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
·
2023
·
IF 1.6
Su Jiangtao,Zhang Yuxuan,Ye Lu,Chen Xue,Hu Yuchen
Psoriasis is a chronic papulosquamous skin disease whose current treatments have severe side effects, which limits their long-term application. Developing effective treatments for psoriasis is an important and challenging task. Coptis chinensis Franch., Ranunculaceae, and Phellodendron amurense Rupr., Rutaceae, are widely used in traditional Chinese medicine to treat psoriasis. Therefore, this article aims to construct a thermo-sensitive local administration system based on multiple alkaloids from C. chinensis and P. amurense . The methods of extracting the effective components of C. chinensis and P. amurense were screened by single-factor experiment and orthogonal experiment. Furthermore, the optimal gel formulation was determined, and the obtained CPG-S hydrogel ( C. chinensis and P. amurense gel with S -nitrosated acetylpenicillamine as a penetration promoter) exhibited thermo-sensitivity and excellent transdermal ability. Then, the therapeutic effect of the CPG-S hydrogel was examined in a psoriasis mouse model. The effectiveness of the CPG-S hydrogel in reducing the symptoms of redness, swelling, and squamous epidermis, as well as downregulating the related inflammatory factors IL-17A and IL-23, was confirmed. The CPG-S hydrogel was found to be more effective than the commercially available psoriasis treatment drug mometasone furoate cream, indicating its potential application as an effective psoriasis treatment drug. Graphical abstract
研究领域:
药剂学
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中医药学
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皮肤病学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 7
·6364
·
IF 5.6
Chang Wang,Chang Liu,Chen Liang,Xingyuan Qu,Xinying Zou,Siyu Du,Qian Zhang,Lei Wang
Periodontitis is a long-term inflammatory illness and a leading contributor to tooth loss in humans. Due to the influence of the anatomic parameters of teeth, such as root bifurcation lesions and the depth of the periodontal pocket, basic periodontal treatment on its own often does not completely obliterate flora microorganisms. As a consequence, topical medication has become a significant supplement in the treatment of chronic periodontitis. Berberine (BBR) has various pharmacological effects, such as hypoglycemic, antitumor, antiarrhythmic, anti-inflammatory, etc. The target of our project is to develop a safe and non-toxic carrier that can effectively release berberine, which can significantly reduce periodontal tissue inflammation, and to investigate whether berberine thermosensitive hydrogel can exert anti-inflammatory and osteogenic effects by modulating phosphatifylinositol-3-kinase/Protein Kinase B (PI3K/AKT) signaling pathway. Consequently, firstly berberine temperature-sensitive hydrogel was prepared, and its characterizations showed that the mixed solution gelated within 3 min under 37 °C with a hole diameter of 10–130 µm, and the accumulation of berberine release amounted to 89.99% at 21 days. CCK-8 and live-dead cell staining results indicated that this hydrogel was not biotoxic, and it is also presumed that the optimum concentration of berberine is 5 µM, which was selected for subsequent experiments. Real-time polymerase chain reaction (qRT-PCR) and Western blotting (WB)results demonstrated that inflammatory factors, as well as protein levels, were significantly reduced in the berberine-loaded hydrogel group, and LY294002 (PI3K inhibitor) could enhance this effect (p< 0.05). In the berberine-loaded hydrogel group, osteogenesis-related factor levels and protein profiles were visibly increased, along with an increase in alkaline phosphatase expression, which was inhibited by LY294002 (p< 0.05). Therefore, berberine thermosensitive hydrogel may be an effective treatment for periodontitis, and it may exert anti-inflammatory and osteogenic effects through the PI3K/AKT signaling pathway.Keywords:periodontitis;berberine;thermosensitive hydrogel;anti-inflammatory;osteogenesis
研究领域:
牙科学
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药理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yu Chen,Boqi Gu,Xiaodi Hao,Zhentan Lu,Dong Wang
As a novel treatment, photothermal therapy (PTT) has been widely employed to deal with bacterial infection. Nevertheless, the high temperature in conventional PTT unavoidably results in damages to normal tissues. Herein, a nanofibrous membrane/thermoresponsive hydrogel composites (PB NCs@PLA/P(NIPAM-AM) hydrogels) with the ability to regulate heat generation are developed for the treatment of infected wound. Under NIR light laser irradiation, a large amount of heat generated by PB NCs@PLA nanofibrous membrane can be transferred to thermoresponsive P(NIPAM-AM) hydrogel. After reaching a lower critical solution temperature, P(NIPAM-AM) hydrogel rapidly undergoes phase transformation and generate considerable light-scattering centers to prevent NIR penetration. Through this dynamic and reversible process, temperature of PB NCs@PLA/P(NIPAM-AM) hydrogels can maintain at the predefined level to avoid overheating at the wound site. The PB NCs@PLA/P(NIPAM-AM) hydrogels not only exhibit excellent antibacterial effect, but also effectively protect normal tissues from damage, which improve the rate of wound closure. Therefore, the PB NCs@PLA/P(NIPAM-AM) hydrogels provide a promising alternative for infected wound healing.
研究领域:
生物医学工程
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材料科学
·
感染与免疫
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2018
·
IF 8.806
Ge Gao,Yao-Wen Jiang,Hao-Ran Jia,Fu-Gen Wu
A near-infrared (NIR) light-triggerable thermo-sensitive hydrogel-based drug reservoir that can realize on-demand antibiotics release and hyperthermia-assisted bacterial inactivation was prepared to combat bacterial infection and promote wound healing. The drug reservoir was fabricated by mixing ciprofloxacin (Cip, a potent antibiotic)-loaded polydopamine (PDA) nanoparticles (NPs) and glycol chitosan (GC) to form an injectable hydrogel (PDA NP-Cip/GC hydrogel, abbreviated as Gel-Cip). On the one hand, the positive charge of GC and the adsorbability of PDA NPs made bacteria be readily trapped on the surface of Gel-Cip. On the other hand, the Gel-Cip exhibited minimal leakage under physiological conditions , but could boost Cip release upon NIR light irradiation. Meanwhile, NIR light irradiation could activate the photothermal PDA NPs, and the generated local hyperthermia induced the destruction of the bacterial integrity, leading to bacterial inactivation in a synergistic way. Moreover, the exceptional bacterial killing activity and outstanding wound healing ability of the system were also verified by the S. aureus -infected mouse skin defect model. Taken together, the light-activatable hydrogel-based platform allows us to release antibiotics more precisely, eliminate bacteria more effectively, and inhibit bacteria-induced infections more persistently, which will advance the development of novel antibacterial agents and strategies.
研究领域:
生物医学工程
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材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yingying Li,Yanqiu Wang,Jing Lu,Wenwen Wang,Dong Wang
Smart windows are highly desired as emerging optical devices based on appealing sunlight modulation, however, some prevailing limitations remain with low photothermal conversion and narrow spectral adjusting ranges, which drastically restrict energy-saving performance. Herein, a strategically designed smart window achieves significant breakthroughs, containing photothermal fillers of Au nanoprisms (AuNPRs) hybrid MXene nanosheets, and copolymerized thermochromic poly( N -isopropyl acrylamide)-doped hyaluronic acid (HA) hydrogels. By harness of AuNPR@MXene nanocomposites as photo-trapped nanoheaters, stimulating thermo-responsive behaviors of hydrogels boosts solar transmittance switching. The compelling photothermal features depend on the amalgamation: thermoplasmonic effect of AuNPRs, broad-band-absorbed AuNPRs endowed by MXene, and thermal conductivity from AuNPRs to MXene, generating synergistic effects. We maximize the advancing transmittance regulation by controlling the proportion gain of HA to increase hydrogen-bonded interaction. The resulting device with low-loadings AuNPR@MXene composites (0.9 wt% and 0.98 vol%) is capable of allowing 78 % of the maximum visible light through before thermochromism and blocking 98.04 % of sunlight penetration when photothermal stimulation. Besides, outdoor measurements show an achievable great indoor temperature drop of about 7 °C only 30 min irradiation, and a skin-cooling performance in the wearable, illustrating the potential of adaptive solar modulation application.
研究领域:
材料科学
·
能源技术
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Biomimetics
·
2023
·Vol. 8
·期 4
·379
·
IF 4.5
Wenlong Pan,Chongyi Gao,Chen Zhu,Yabing Yang,Lin Xu
Fruit fly larvae, which exist widely in nature, achieve peristaltic motion via the contraction and elongation of their bodies and the asymmetric friction generated by the front and rear parts of their bodies when they are in contact with the ground. Herein, we report the development of an untethered, magnetic, temperature-sensitive hydrogel-based soft robot that mimics the asymmetric micro-patterns of fruit-fly-larvae gastropods and utilizes cyclic deformation to achieve directional peristaltic locomotion. Due to Néel relaxation losses of nanomagnetic Fe3O4particles, the hydrogel-based soft robot is capable of converting changes in external alternating magnetic stimuli into contracting and expanding deformation responses which can be remotely controlled via a high-frequency alternating magnetic field (AMF) to realize periodic actuation. Furthermore, the Fe3O4particles included in the hydrogel-based soft robot cause it to follow a gradient magnetic field in confined liquid environments and can be coupled with AMFs for the targeted release of water-soluble drugs or targeted magnetic hyperthermia therapy (MHT). We believe that such a controlled motion can enable highly targeted drug delivery, as well as vascular disease detection and thrombus removal tasks, without the use of invasive procedures.Keywords:magnetic;temperature-sensitive hydrogel;untethered soft robot;bionic gastropod;gradient magnetic field
研究领域:
生物医学工程
·
材料科学
·
仿生学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2015
·Vol. 22
·期 5
·1-14
·
IF 1.92
Li Yinwen,Guo Huilong,Gan Jianqun,Zheng Jian,Zhang Yan,Wu Kun,Lu Mangeng
Thermal-responsive hydrogels poly[(N-isopropylacrylamide)-co-(aminoethyl methacrylate β-cyclodextrin)] (PNiCD) were synthesized, and the morphology, thermal behavior and swelling/deswelling kinetic of the PNiCD hydrogels were studied. The results indicate that PNiCD hydrogels not only had considerable swelling ratios and rapid swelling/deswelling kinetics, but also behaved with fast thermal response sensitivities. In addition, by adjusting the weight ratio of GCD/NIPAAm ratio PNiCD hydrogels with different macroporous and thermal-responsive performances can be prepared for potential application in the biological medicine field. Levofloxacin lactate (LL) and rhodamine B (Rh) were elected as model drugs to explore controlled drug release for PNiCD hydrogels. The results showed that about 30 % of the LL and Rh were released within the first 30 min, and 80 % drugs were released at around 300 min, and this release process was faster than that of PNIPAAm hydrogel. The fast release performance indicated that these new CD modified PNIPAAm-based PNiCD hydrogels are promising for use in rapid drug delivery in the biological medicine field.
研究领域:
生物医学工程
·
药物递送
·
高分子材料
·
智能响应材料
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2021
·
IF 3.517
Lingying Wu,Yuling Wu,Xun Che,Dandan Luo,Jiaju Lu,Ruibo Zhao,Muhammed Zubair Iqbal,Quan Zhang,Xiumei Wang,Xiangdong Kong
In this study, we recruited chitosan (CS) both for selenium nanoparticles (SeNPs) synthesis and for the development of a thermoresponsive nanocomposite hydrogel with the addition of glycerol phosphate (GP). Considering that SeNPs are toxic at high concentrations, five different ingredients of the nanocomposite hydrogel system with low concentrations of SeNPs (1.25–20 μg/mL) were prepared. The gelation conditions, structural characteristics, and mechanical properties of SeNPs-loaded thermosensitive CS/GP hydrogels were investigated. We also evaluated their antioxidizing activities and biocompatibility of the CS/GP/SeNPs hydrogels. Our study demonstrated that the incorporation of SeNPs in the hydrogel improved its mechanical properties, antioxidant activity, and degree of swelling. According to the properties of SeNPs and CS/GP thermosensitive hydrogels, the combination of these two technologies in an appropriate manner would be a promising antioxidant system for drug delivery and tissue engineering.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2022
·
IF 8.431
Yun Huang,Beiyu Zhang,Keming Chen,Ao Xia,Xianqing Zhu,Xun Zhu,Qiang Liao
Microalgae biofilm-based culture provides an efficient CO 2 reduction and wastewater treatment method for its high photosynthetic efficiency and density. As supporting substrates for microalgae biofilm, porous materials have a big available adsorption area, but mutual shading makes it difficult to transmit external light to the internal surface for attached cells' photosynthesis. Thus, light-guided particles (SiO 2 ) were introduced into photosensitive resin to fabricate a light-guided ordered porous photobioreactor (PBR) by 3D printing technology in this study. The space utilization of the PBR was significantly enhanced and the effective microalgae adsorption area was increased by 13.6 times. Further, a thermo-responsive hydrogel was grafted onto the surface of the substrate to form a smart temperature-controllable interface that could enhance microalgae adsorption and desorption in both directions. When the thermo-responsive layer received light, it would generate heat due to the hydrogel's photo-thermal effect. And the surface temperature would then raise to 33 °C, higher than the hydrogel phase transition point of 32 °C, making the surface shrinking and more hydrophobicity for microalgae cells attachment. The microalgae cells' adsorption capacity increased by 103%, resulting in a high microalgae growth rate of 3.572 g m −2 d −1 . When turning off the light, the surface temperature would cool down to below 20 °C, the surface would shrink. And the biofilm shows a 564.7% increase in desorption ability, realizing temperature-controlled microalgae harvesting.
研究领域:
环境科学
·
生物技术
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Shuai Qiang Jiang,Su Ping Dai,Wei Ming Liu,Yin Wang,Zhao Yuan Li,Ya Wei Chen,Hyun Jin Park,Hui Yun Zhou
In this paper, three kinds of cyclodextrin-grafted-chitosan (CD-g-CS) were synthesized from chitosan (CS) and β-cyclodextrin (β-CD) with different ratios. And a series of hydrogel with good temperature sensitivity and injectability were prepared by using sodium glycerophosphate (GP) and ammonium hydrogen phosphate (AHP) as dual gelling agents. The gelation formation time of hydrogel was short, and the shortest time was 0.75 min. The FTIR spectrum and 1 H-NMR spectrum showed the structure of the compounds and intermolecular interactions. The molecular docking technique probed the encapsulation mechanism of the drug with β-CD. The SEM results showed that the hydrogel had a highly interconnected three-dimensional spatial structure. The swelling ratio of hydrogel was not less than 150 % within 1 h and the degradation rate of hydrogel was not less than 75 % within 14 days. The in vitro drug release results showed that the hydrogel had optimal sustained release effect, and the cumulative release ratio was 58.3 % in 34 h. The release kinetics analysis exhibited that the hydrogel conformed to the Riter-Peppas model. The hemocompatibility test and cytotoxicity test proved that the hydrogel had good biocompatibility and biosafety. The antibacterial experiments showed that the hydrogel could inhibit the biological activity of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Therefore, the CD-g-CS/GP-AHP hydrogel has a broad application prospect in the biological fields of drug delivery and antibacterial materials.
研究领域:
生物材料学
·
药物递送系统
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）