CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiaqi Xing,Yuan Ding,Xiaoran Zheng,Peng Yu,Meng Qin,Rongmin Qiu,Yanyan Li,Siyuan Shang,Jing Xie,Jianshu Li
Oral ulcers (OUs) are the most common lesions of the oral mucosa and severely reduce patients' quality of life. Several types of patches for the self-treatment of OU have been developed, which have partially alleviated the problems caused by OUs. However, their wide application is limited by a few factors, including the suboptimal adhesion to the wound in the complex oral environment and the discoloration of the degraded products. Herein, an ideal Janus patch for the accelerated treatment and cure of OUs, comprising bifunctional sides, was designed. Inspired by the composition and hybrid adhesive mechanism of barnacles, glycine was modified and combined with hydroxyapatite nanoparticles (HAp) to create an adhesive layer that would form abundant covalent bonds with tissues; the HAp act as a bridge to bond polymer chains mimicking the organic–inorganic hybrid mechanism of barnacles, achieving analogous instant wet adhesion. Additionally, double bond-modified gellan gum served as a slippery layer to avoid undifferentiated adhesion and secondary damage. When applied to rat OUs, the Janus patch exhibited instant wet adhesion, with the longest residue time, overcoming the limitations of commercial products, and withstood chewing and biting and other mouth movements, thus achieving an excellent therapeutic efficacy.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 9
·3214-3226
·
IF 6.6
Haijun Fu,Jiayu Yang,Zongshan Shen,Yong Zhang,Shuhong Kuang,Lifeng Li,Zhengmei Lin,Xuetao Shi
The severe pain caused by oral ulcers seriously affects food intake and speech, bringing great inconvenience in daily life. Drug-loaded patches are mostly used to treat oral mucosal diseases such as oral ulcers and oral lichen planus, but their effects are limited because of the influences of saliva and muscle movement. To enhance the adhesion of drug-loaded patches used in the oral cavity, we designed antimicrobial peptides (AMPs)-modified polycaprolactone (PCL)–collagen nanosheets (APCNs). The internal layer is a bioactive and antibacterial collagen layer modified with antimicrobial peptides. The backing layer is a hydrophobic PCL layer with good mechanical strength that can reduce external influences. We have characterized and tested the APCNs. First, the APCNs exhibited continuous and strong adhesion to irregular buccal mucosa surfaces under wet conditions and external force action. Antibacterial experiments showed that the APCNs had high antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria. Moreover, the APCNs showed good biocompatibility and promoted the adhesion of fibroblasts in vitro. Furthermore, APCNs treatment accelerated ulcer healing in a Sprague Dawley rat oral ulcer model. Our study developed antibacterial, wet-adhesive, and healing-promoting PCL-collagen nanosheets and demonstrated that these nanosheets could be promising adhesive therapeutic agents for the treatment of oral mucosal ulcers.
研究领域:
药学
·
材料科学
·
生物医学工程
·
牙科
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Peng Ni,Yiming Chen,Kaixuan Wan,Yishi Cheng,Yan Fang,Yunxiang Weng,Haiqing Liu
Instant and strong adhesion to underwater adherends is a big challenge due to the continuous interference of water. Mussel foot protein-bioinspired catechol-based adhesives have garnered great interest in addressing this issue. Herein, a novel self-made catecholic compound with a long aliphatic chain was utilized to prepare thin (∼0.07 mm) and optically transparent (>80%) wet/underwater adhesive tapes by UV-initiated polymerization. Its adhesion activity was water-triggered, fast (<1 min), and strong (adhesion strength to porcine skin: ∼1.99 MPa; interfacial toughness: ∼610 J/m2, burst pressure: ∼1950 mmHg). The effect of the catechol/phenol group and positively charged moiety on the wet/underwater adhesion to abiotic/biotic substrates was investigated. On the wet/underwater adherends, the tape with catechol groups presented much higher interfacial toughness, adhesion strength, and burst pressure than the analogous tape with phenol groups. The tape with both the catechol group and cationic polyelectrolyte chitosan had a more impressive improvement in its adhesion to wet/underwater biological tissues than to abiotic substrates. Therefore, catechol and a positive moiety in the tape would synergistically enhance its wet/underwater adhesion to various substrates, especially to biological tissues. The instant, strong, and noncytotoxic tape may provide applications in underwater adhesion for sealing and wound closure.
研究领域:
材料科学
·
生物医学工程
·
化学工程
·
高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 32
·期 15
·2111278
·
IF 18.808
Haiyan Feng,Yanfei Ma,Zhizhi Zhang,Song Yang,Zhengfeng Ma,Yunlei Zhang,Shuanhong Ma,Bo Yu,Meirong Cai,Xiaowei Pei,Feng Zhou
Hydrogels, exhibiting wide application prospects in soft robotics, tissue engineering, implantable electronics, etc., upon functioning often require to adhere to substrates especially in wet environments despite that most hydrogels are nonsticky because of their high water content and hydrophilicity. Herein, a strategy to rapidly reverse the adhesion properties of hydrogels via surface anchoring very thin adhesive coatings is reported. Inspired by mussel adhesion, poly(vinyl alcohol) hydrogel is first coated with polymerized tannic acid that chelates with Fe 3+ , which serves as the interface bonding layer. Subsequently, a wet adhesive poly(dopamine methacrylamide- co -methoxyethyl acrylate) is firmly anchored to form the very thin adhesive coating (<10 µm) that can generate high adhesion strength both in the air and underwater. The adhesive coating also endows hydrogels with high water retention capacity under warm condition (50 °C) and is able to get on-demand functionalization on the designated area to achieve asymmetric adhesion, static and dynamic control over wettability. The strategy demonstrates potentials for broad applications from biomedicine to wearable electronics.
研究领域:
材料科学
·
生物医学工程
·
软体机器人
·
组织工程
·
可穿戴电子设备
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Luyao Gao,Shuanhong Ma,Luyao Bao,Xiaoduo Zhao,Yangyang Xiang,Zhizhi Zhang,Yanfei Ma,Zhengfeng Ma,Yong-min Liang,Feng Zhou
Despite the fact that synthetic adhesives have achieved great progress, achieving robust dry/wet adhesion under harsh operating environments is still challenging. Herein, inspired from the extraordinary adhesion mechanism of nature mussel protein adhesive, the balanced design concept of co-adhesion and interfacial adhesion is proposed to prepare one kind of novel copolymer adhesive of [poly(dopamine methacrylamide-co-methoxethyl acrylate-co-adamantane-1-carboxylic acid 2-(2-methyl-acryloyloxy)-ethyl ester)] [p(DMA-co-MEA-co-AD)], named as super-robust adhesive (SRAD). The SRAD exhibits ultra-high interface bonding strengths in air (∼7.66 MPa) and underwater (∼2.78 MPa) against an iron substrate. Especially, a greatly tough and stable adhesion strength (∼2.11 MPa) can be achieved after immersing the bonded sample in water for half a year. Furthermore, the SRAD demonstrates surprising wet bonding robustness/tolerance even encountering harsh conditions such as fluid shearing, dynamic loading, and cyclic mechanical fretting. The great advantages of SRAD, such as strong interface bonding, stable wet adhesion underwater, and good mechanical tolerance, makes it demonstrate huge application potential in engineering sealants and underwater adhesion.
研究领域:
材料科学
·
化学工程
·
高分子科学
·
粘合技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）