ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Yemian Zhou,Yun Liu,Tong Wang,Han Li,Jing He,An Xu
Disinfection by-products (DBPs) generated from water treatment have serious adverse effects on human health and natural ecosystems. However, research on the mutagenicity of DBPs with different chemical structures is still limited. In the present study, we compared the mutagenicity of 8 typical DBPs in human-hamster hybrid (A L ) cells and clarified the mechanisms involved. Our data displayed that the rank order for mutagenicity was as follows: iodoacetamide (IAcAm) > iodoacetonitrile (IAN) > iodoacetic acid (IAA) > bromoacetamide (BAcAm) ≈ bromoacetonitrile (BAN) > bromoacetic acid (BAA), which was confirmed by DNA double strand breaks and oxidative DNA damage. In contrast, bromoform (TBM) and iodoform (TIM) had minimal mutagenicity. The mutation spectrum analysis further revealed that IAN, IAcAm, and IAA could induce multilocus deletions in mammalian cells. Interestingly, nitrogenous DBPs (N-DBPs) and IAA were found to cause varying degrees of iron overload and lipid peroxidation, which was mediated by the activation of the Nrf2/HO-1 signaling pathway. Moreover, the presence of deferoxamine (DFO), an iron ion inhibitor, effectively reduced γ-H2AX and 8-OHdG induced by N-DBPs and IAA. These results indicated that the variations in genotoxicity among DBPs with different structures were associated with their ability to disrupt iron homeostasis. This study provided new insights into the mechanisms underlying the structure-dependent toxicity of DBPs and established a foundation for a more comprehensive understanding and intervention of the health risks associated with DBPs.
研究领域:
环境科学
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毒理学
·
分子生物学
·
细胞生物学
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Han Chen,Tao Lin,Xiaoshu Yan,Hang Xu
The formation of haloacetonitriles (HANs) during chlorination after sulfite/ultraviolet (UV) treatment of bromate (BrO 3 − ) in the presence of amino acids (AAs) was investigated. During sulfite/UV treatment, the primary species hydrated electrons (e aq − ) and hydrogen atom radicals (H ) dominated the reduction of BrO 3 − to bromide (Br − ), whereas the sulfite anion radicals (SO 3 − ) and H degraded AAs to produce the intermediates HN=C(CH 3 )–COOH, CH 3 –CH=NH, and CH 3 –C≡N via α‑hydrogen abstraction and NH 2 –hydrogen abstraction mechanisms. During post-chlorination, Br − was converted to HBrO/BrO-, and the HN=C(CH 3 )–COOH, CH 3 –CH=NH, and CH 3 –C≡N groups featured higher bromine utilization factor (BUF) and chlorine utilization factor (CUF) values than AAs, enhancing the formation of dibromoacetonitrile (DBAN) and dichloroacetonitrile (DCAN). The energetic feasibility of the transformation pathway, that is, HN=C(CH 3 )–COOH, CH 3 –CH=NH, and CH 3 –C ≡ N formation via hydrogen abstraction by SO 3 − and H and their further conversion to HANs, was proved by density functional theory calculations, which showed stepwise negative Gibbs free energy changes (ΔG < 0). The effects of pH and water matrices (e.g., HCO 3 − , Cl − , Fe 3+ , and natural organic matter) were comprehensively evaluated. Although 72% of BrO 3 − was removed by sulfite/UV treatment in the presence of AAs, the cytotoxicity index (CTI) and genotoxicity index (GTI) during post-chlorination increased by 213% and 125%, respectively, due to the formation of 24 CX 3 R-type disinfection by-products (DBPs), especially brominated DBPs. Accordingly, more attention should be given to the formation of brominated DBPs during post-chlorination when using sulfite/UV processes to remove BrO 3 − in the presence of AAs. As a solution, using monochloramine instead of chlorine as a disinfectant after the sulfite/UV process could significantly lower the CTI and GTI values by alleviating the formation of brominated DBPs.
研究领域:
环境科学
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水处理
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化学工程
·
毒理学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Ziying Wang,Yisheng Shao,Naiyun Gao,Bin Xu,Na An,Xian Lu
Applying the highly oxidative sulfate radical ( SO 4 - · ) to pollutant degradation may cause it to react with the coexisting bromide (Br − ) to form undesired byproducts. This study investigated the transformation of Br − during the degradation process of a contaminant (diethyl phthalate (DEP)) via heat-activated persulfate (PS). Dibromoacetonitrile and bromoform formed with Br − and natural organic matter (NOM) in the solution, while only bromoform was detected without NOM. The formation of these brominated disinfection byproducts (Br-DBPs) can be ascribed to the reactions between the phenolic groups of DEP degradation intermediates or NOM and reactive bromine species (free bromine and radical bromine) generated through the oxidation of Br − by SO 4 - · . Br-DBPs were degraded by excessive SO 4 - · , which indicates that organic bromine is a temporary phase during the turnover of Br − . The time-dependent formation of organic and inorganic bromines suggests that Br − may have cycled several times between organic and inorganic forms before eventually turning into bromate. The bromate formation showed a lag phase before continuously increasing. Generally, increasing the temperature, PS dosage, and Br − and organic matter (DEP and NOM) concentrations increased the maximum concentration of Br-DBPs. Additionally, these reaction parameters facilitated bromate formation except for organic matter, whose inhibitory effect is probably due to the consumption of reactive species by organic matter and the generated superoxide anion. The total organic carbon concentration of the solution exhibited a relatively quick reduction followed by a slow decrease. These results highlight the potential risks of PS activation technologies and can help prevent such risks in actual practice.
研究领域:
环境科学
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水处理
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化学工程
·
污染物降解
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Saleem Raza,Ata Ur Rehman,Zhiyu Zhao,Hua Li,Cheng Chen,Wei Yu,Ying Liu,Yanchao Xu,Liguo Shen,Hongjun Lin
This study reports the development of a novel, recoverable photocatalyst, Ti 3 C 2 T x @TACs-SA, for the efficient degradation of carcinogenic disinfection byproducts (DBPs) in drinking water. The composite was fabricated via a simple, eco-friendly strategy involving the growth of transition metal atom clusters (TACs: Co, Fe, Ni) on MXene (Ti 3 C 2 T x ) nanosheets, followed by incorporation into a crosslinked sodium alginate (SA) biopolymer matrix. Comprehensive characterization via SEM-EDX, XPS, XRD, HAADF-STEM, XANES, TGA, BET, and DFT confirmed the composite's structure and properties. The photocatalytic performance of the composite was systematically investigated for the degradation of DBPs in drinking water. Key experimental conditions, including pH, initial pollutant concentration, irradiation time, and thermodynamic study, were carefully optimized to determine their effect on the overall degradation performance. Five common DBPs, trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), halonitromethanes (HNMs), and dichloroacetaldehyde (DCAL), were chosen as target contaminants. The composite exhibited excellent photocatalytic activity across a wide pH range. At neutral pH (7.0) and an initial DBP concentration of 100 μg/L, the photocatalyst achieved degradation efficiencies of 83.8% for THMs, 84.4% for HAAs, 85.3% for HANs, 83.8% for HNMs, and 83.4% for DCAL after 60 min of UV irradiation. At acidic pH 3.0, removal efficiencies were slightly reduced to 80.1%, 78.3%, 79.3%, 77.6%, and 75.8%, respectively. In contrast, alkaline conditions significantly enhanced DBPs removal, achieving 90.0%, 92.0%, 93.6%, 95.4%, and 96.0% for the respective contaminants. These findings demonstrate the strong potential of the Ti 3 C 2 T x @TACs-SA composite as a practical and efficient photocatalyst for eliminating carcinogenic DBPs from water.
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高影响因子
DESALINATION
·
2025
·
IF 9.8
Xiaoyan He,Runze Cao,Jing Li,Zhilan Wang,Yanling Liang,Penggai Ma,Shuo Ma,Xin Tian,Yuanyuan Lu,Zhiqiang Wang,Xiaoquan Lu
The traditional hydrogel evaporators used for interfacial solar vapor generation (SVG) are considered one of the most appealing desalination technologies to global freshwater crisis. In this paper, a simple method like dough making is designed to prepare a self-polymerizing porous hydrogel (PDIH) evaporator. Not only can its morphology be changed arbitrarily, but also the pore size of the hydrogel evaporator can be controlled only by changing the concentration of saline water. The hydrogel evaporator was used in high concentration saltwater, an excellent evaporation rate of 3.1 kg m −2 h −1 and >90 % energy efficiency were obtained under simulated solar irradiation (1.0 kW m −2 ) at 10 % brine, and similar evaporation rates were obtained in seawater and 7 % brine. Additionally, the hydrogel exhibited excellent antibacterial properties and had a high capacity of sewage disposal (organic dyes and heavy metal solutions). It is expected that the preparation of this hydrogel evaporator will promote the development of SVG technology in high concentration saline.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Sihan Tang,Zhiyue Dong,Xiangwei Zhu,Qiang Zhao
Advanced membranes for pervaporation dehydration of acidic mixtures are demanded since the membrane swelling and stability in acidic feed differ from that in neutral feed. Herein we exploited poly(ionic liquid) complex (PILC) membranes featuring high dehydration performance in acidic conditions versus feed temperature and operation time. A poly(ionic liquid), i.e., poly[1-cyanomethyl-3-vinylimidazolium bromide] (PCMVImBr), was synthesized and complexed with sodium carboxymethyl cellulose (CMCNa) to prepare membranes. Chemical structures , compositions, microstructures and surface properties of PCMVIm-CMCNa PILC membranes were characterized by Fourier-transform infrared spectroscopy, element analysis , scanning electron microscopy, atomic force microscopy and water contact angle. The PILC membranes were efficient in dehydrating 10 wt% acidic water-isopropanol mixtures. Water in permeate for PILC membranes was maintained 99.5 ± 0.3 wt% (feed pH: 7–1, feed temperature: 70 °C), in stark contrast to the pristine CMCNa membrane whose separation factor declined significantly from 1791 to 91.
研究领域:
化学工程
·
材料科学
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产品关联
DOI
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Lijie Gao,Jiawei Liu,Rui Zhang,Xi Chen,Mo Wang,Yujia Dong,Mykhaylo S. Frasinyuk,Wen Zhang,David Watt,Wenxiang Meng,Jun Xue,Chunming Liu,Yu Cheng,Xifu Liu
Colorectal cancer (CRC), one of the diseases posing a threat to global health, according to the latest data, is the third most common cancer globally and the second leading cause of cancer-related deaths. The development and refinement of novel structures of small molecular compounds play a crucial role in tumor treatment and overcoming drug resistance. In this study, our objective was to screen and characterize novel compounds for overcoming drug resistance via the B Lymphoma Mo-MLV insertion region 1 (Bmi-1) reporter screen assay. The stable cell line harboring the Bmi-1 reporter gene was utilized to screen 300 compounds, leading to the identification of an amino-pyrimidine compound, APD-94 . In vitro , APD-94 markedly inhibited cancer cell proliferation and decreased Bmi-1 expression at both the RNA and protein levels. In vivo , APD-94 repressed the growth of HT29 cell xenografts in NOD/SCID mice without notable side effects. Flow cytometry results demonstrated that APD-94 induced G2/M phase arrest and apoptosis in cells. APD-94 was identified as a novel inhibitor of microtubule polymerization by directly targeting the tubulin. Furthermore, APD-94 was more effective in overcoming the resistance to paclitaxel in paclitaxel-resistant A549/Tax cells. This bifunctional inhibitor is a promising candidate drug for CRC treatment.
研究领域:
肿瘤学
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分子生物学
·
药理学
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2016
·Vol. 35
·期 1
·54-65
·
IF 1.811
Chen Qi-jing,An Ze-sheng
A series of well-defined core cross-linked star (CCS) polymeric ionic liquids (PILs) were synthesized via a three-step approach. First, the styrenic imidazole-based CCS polymer (S-PVBnIm) was prepared by the RAFT-mediated heterogeneous polymerization in a water/ethanol solution, followed by the quaternization of S-PVBnIm with bromoalkanes and anion exchange. The CCS polymers were characterized by gel permeation chromatography (GPC), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). The obtained CCS polymers were used as the effective emulsifiers for oil-in-water high internal phase emulsions (HIPEs). Multiple oils with different polarity including n -dodecane, undecanol, toluene and octanol were emulsified using 0.5 wt% S-PVBnIm aqueous solution under the acidic condition to form HIPEs with long-term stabilities. The excellent emulsification properties of CCS PILs were demonstrated by HIPE formation for a variety of oils. The properties of HIPEs in terms of emulsion type and oil droplet size were characterized by the confocal laser scanning microscopy (CLSM). The intriguing capability of CCS PILs to stabilize HIPEs of various oils holds great potentials for the practical applications.
研究领域:
聚合物化学
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材料科学
·
胶体与表面化学
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DOI
高影响因子
ENVIRONMENT INTERNATIONAL
·
2019
·
IF 7.943
Feilong Dong,Jiaqi Liu,Cong Li,Qiufeng Lin,Tuqiao Zhang,Kejia Zhang,Virender K. Sharma
Algal organic matter (AOM) from seasonal algal blooms may be an important precursor of disinfection byproducts (DBPs) in drinking water. This paper presents the effect of ferrate(VI) treatment on two blue-green algae, Chlorella sp. and Pseudanabaena limnetica , in eutrophic water. The results demonstrated that Fe(VI) removed the algal cells by causing cell death, apoptosis, and lost integrity, and decreased AOM (in terms of total organic carbon) in water via oxidation and coagulation. Chlorination of the Fe(VI) pre-oxidized algal water samples generated halogenated DBPs (including trihalomethanes, haloacetic acids, haloketones, chloral hydrate, haloacetonitriles, and trichloronitromethane), but the concentrations of DBPs were lower than those formed in the chlorinated samples without pre-treatment by Fe(VI). Higher Fe(VI) dose, longer oxidation time, and alkaline pH were beneficial in controlling DBPs. In bromide-containing algal solutions, negligible amount of bromo-DBPs were generated in the Fe(VI) pre-oxidation, and halogenated DBPs were mainly formed in the subsequent chlorination.
研究领域:
环境科学
·
水处理工程
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DOI
PubMed
高影响因子
Nature Photonics
·
2023
·Vol. 17
·期 4
·346-353
·
IF 35
Liang Wenfei,Nie Chengming,Du Jun,Han Yaoyao,Zhao Guohui,Yang Fan,Liang Guijie,Wu Kaifeng
Near-infrared-to-visible photon upconversion holds great promise for a diverse range of applications. Current photosensitizers for triplet-fusion upconversion across this spectral window often contain either precious or toxic elements and have relatively low efficiencies. Although colloidal nanocrystals have emerged as versatile photosensitizers, the only family of nanocrystals discovered for near-infrared upconversion is the highly toxic lead chalcogenides. Here we report zinc-doped CuInSe 2 nanocrystals as a low-cost and lead-free alternate, enabling near-infrared-to-yellow upconversion with an external quantum efficiency reaching 16.7%. When directly merged with photoredox catalysis, this system enables efficient near-infrared-driven organic synthesis and polymerization, which in turn solves the issue of reabsorption loss for nanocrystal-sensitized upconversion. Moreover, the broadband light capture of these nanocrystals enables very rapid reactions under indoor sunlight. Extending the reach of ‘solar synthesis’ into the near-infrared may realize the century-long dream of conducting high-added-value chemical transformations using sunlight.
研究领域:
光子学
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纳米技术
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材料科学
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化学
·
太阳能
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DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 5
·3567-3573
·
IF 3.708
Yanqin Yang,Qifeng Zhang,Shenghai Li,Suobo Zhang
Polyelectrolyte complex membranes were prepared from poly(acrylic acid-co-acrylonitrile)s and imidazolium-based polycations via a combination of blend film casting and ammonia solution immersion procedures. The membranes were free-standing and tough, showing excellent mechanical properties (with tensile strength of 6.71–23.7 MPa and elongation at break of 15–59%). Hierarchically structured nanopores were formed in the membranes during the ammonia soaking step, due to NH3-triggered –COOH deprotonation and in situ ionic crosslinking with polycations. Zeta potential measurements indicated that the membranes were negatively charged under neutral conditions. The membranes exhibited moderate rejection to salts in the order of Na2SO4 > NaCl > MgCl2, but high rejection to methyl orange (>99.9%).
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Chongrui Zhang,Qiang Zhao
Paper sheets are economic and sustainable materials alleviating the world’s reliance on petroleum plastics, yet the facile preparation of water-proof paper combing high strength with tunable surface properties is difficult. This work exploited a self-crosslinkable polyelectrolyte (poly[1-cyanomethyl-3-vinylimidazolium], PCMVIm) to circumvent this problem. The PCMVIm solution was filled into paper sheets, dried, and treated by mild ammonia (NH 3 ) vapor at 25 °C. Paper sheets incorporated with 0.6 wt% PCMVIm were rendered water-proof (80 °C, 1 week) and acid-resistant (6 M HCl), exhibiting a wet strength that is 6 times higher than pristine paper without PCMVIm. In addition, the hydrophilicity and oleophilicity of NH 3 -treated paper were easily tuned by modulating the counter anions of PCMVIm. The modified paper sheets show high permeability, selectivity and stability in separating water/oil emulsions containing toluene, petroleum ether, hexane and chloroform, respectively. The facile method of NH 3 vapor treatment confers wet-resistance, high strength, and tunable surface properties to paper valorization, leading to sustainable paper sheets for efficient oil/water separation.
研究领域:
材料科学
·
环境工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）