SENSORS AND ACTUATORS B-CHEMICAL
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2017
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IF 5.401
Fanyong Yan,Qianghua Ye,Jinxia Xu,Juanjuan He,Li Chen,Xuguang Zhou
A novel fluorescent sensor based on carbon dots (CDs) was synthesized for direct determination of glutathione (GSH), which bromoacetyl bromide was functionalized CDs (CDs-Br) sensing system for the first time. The bromoacetyl bromide functional groups (halogen moiety) can quench the fluorescence of CDs, which were substituted by the -SH group, could lead to a significant fluorescence increase of CDs-Br via the halogen substitution cyclization. This method could effectively immediately detect amino acids with thiols and it needn’t to be combined with metal ions. Under optimum conditions, the probe has a good selectivity for GSH over other various biologically relevant species and even two other similar biothiols (Cys/Hcy) and could image GSH in living cells.
研究领域:
分析化学
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生物化学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2014
·
IF 3.107
Zhihai Hao,Dongju Wang,Hou Chen,Jinming Sun,Yuanyuan Xu
Sweet potato starch residue (SPSR) was used as starting material to prepare an eco-friendly adsorbent. SPSR was modified by bromoacetyl bromide to obtain a macroinitiator for surface-initiated single electron transfer-living radical polymerization (SI-SET-LRP) of acrylonitrile (AN) catalyzed by La(0)/hexamethylenetetramine (HMTA) in N,N-dimethylformamide (DMF) in the presence of ascorbic acid (VC). The amidoxime (AO) adsorbent was prepared by the reaction of the graft copolymer bromoactylated sweet potato starch (BSPS)/polyacrylonitrile (BSPS-g-PAN) with hydroxylamine. The maximum adsorption capacity for Hg(II) was 4.03 mmol·g–1. This simple method provided a novel approach to recycle and reuse agricultural residues for controlling heavy metal pollution.
研究领域:
环境科学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
iScience
·
2025
·Vol. 28
·期 12
·
IF 4.1
Dan Chen,Qingqing Ma,Xin Li,Tao Yang,Shang Wu,Yanju Wang,Deyu Hu
Intercellular movement plays an important role in plant virus infection and transmission, which provides an opportunity for antiviral agents that interfere with the intercellular motion. However, there are still few compounds that directly interfere with the movement of viruses between cells. Herein, a series of aurone derivatives containing sulfonamide active groups were designed and synthesized. Among them, compound D13 effectively inhibits virus infection by forming a stable hydrogen bond with Pro154 (P154) of potato virus Y (PVY) coat protein (CP). Further studies have shown that D13 can effectively interfere with the process of P154-mediated viral intercellular trafficking in plasmodesmata (PD). This study emphasizes the core position of virus intercellular movement in plant virus diseases and its inhibition strategy and confirms that the aurone derivative D13 is a candidate molecule for antiviral pesticides or intercellular movement inhibitors, providing a new direction for plant virus prevention and control.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hongbo Wang,Jinhong Xue,Junming Liang,Xianpei Xu,Limin You,Yaxin An,Fu Li,Pengfei Fei,Shuqiang Liu,Mei Liu,Fulai Zhao
Composite membranes with excellent antibacterial properties, hydrophilic/hydrophobic differentiation, and selective permeability are preferred materials for wound dressings. In this work, antibacterial bromoacetyl and quaternary ammonium groups were chemically introduced into a regenerated cellulose nanofiber membrane. This hydrophilic membrane was then compounded with a polylactic acid (PLA) liquid film through a non-solvent-induced phase separation process to prepare a composite membrane. FTIR, XPS, and EDS results confirmed the successful chemical modification and presence of antibacterial groups. SEM analysis revealed a stable composite with an asymmetric structure. Modification time, particularly the bromoacetylation duration, had a certain impact on the structure and properties of the composite membrane. The optimized composite membrane exhibited excellent gas permeability (air and water vapor) and differentiated hydrophilic/hydrophobic properties. Membrane modified via bromoacetylation for over 3 h demonstrated >95 % antibacterial efficiency against Escherichia coli and Staphylococcus aureus , indicating broad-spectrum efficacy. The biomass-derived polymer matrix, scalable production process, and multifunctionality highlight its potential for healthcare applications, particularly in wound dressings.
研究领域:
材料科学
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生物医学工程
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DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
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2015
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IF 2.101
Xiu-Rong Zhang,Nian-Qiu Shi,Yang Zhao,He-Yun Zhu,Jiao Guan,Ying Jin
Mitomycin C (MTC) was incorporated to a micelle system preparing from a polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA was synthesized and characterized by 1H nuclear magnetic resonance (1H-NMR) and Fourier transform infrared spectroscopy. mPEG-CS-DA formed a core-shell micellar structure with a critical micelle concentration of 6.57 µg/mL. The mPEG-CS-DA micelles were spherical with a hydrodynamic diameter of about 231 nm. After poly(ethylene glycol)ylation of deoxycholic acid chitosan (CS-DA), the encapsulation efficiency and drug loading efficiency increased from 50.62% to 56.42% and from 20.51% to 24.13%, respectively. The mPEG-CS-DA micelles possessed a higher drug release rate than the CS-DA micelles. For pharmacokinetics, the area under the curve (AUC) of the mPEG-CS-DA micelles was 1.5 times higher than that of MTC injection, and these micelles can enhance the bioavailability of MTC. mPEG-CS-DA micelles reduced the distribution of MTC in almost all normal tissues and had the potential to improve the kidney toxicity caused by MTC injection.
研究领域:
药剂学
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生物医学工程
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DOI
PubMed
高影响因子
Coatings
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2024
·Vol. 14
·期 4
·381
·
IF 2.9
Zixu Xie,Zhiran Zheng,Chen Chen,Guofeng Li,Xing Wang
Chitosan exhibits remarkable broad-spectrum antibacterial activity, especially in acidic environments. However, its poor solubility in water and significantly decreased antibacterial performance after membrane formation greatly limit its extensive application. To address this issue, glycol chitosan-4-pyridylcarboxaldehydeborneol (GCBP) was synthesized by conjugating glycol chitosan (GC) with 4-pyridylcarboxaldehydeborneol ester (BP) through dynamic Schiff base bonds utilizing a layer-by-layer self-assembly strategy. When bacteria come into contact with the surface, the local acidic microenvironment triggers the cleavage of the Schiff base, resulting in the release of bactericidal BP and GC for combined sterilization. In vitro results demonstrated that the antibacterial properties of GCBP were positively related to the modification layers. The excellent antibacterial performance of the GCBP modification demonstrates not only great potential for clinical urinary catheters but also for broad antibacterial applications in the medical field.
研究领域:
生物材料学
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医学工程
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微生物学
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高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Hao Tian,Hongpei Deng,Xinlong Liu,Chang Liu,Chuan Zhang,Kam W. Leong,Jing Ruan,Xianqun Fan
Uveal melanoma (UM) is the most prevalent primary ocular malignancy in adults, with high lethality and limited effective treatment options. Despite identified driver mutations in GNAQ , GNA11 , and BAP1 , therapeutic advancements have been minimal. This study highlights the pivotal role of N6-methyladenosine (m 6 A) modifications in UM pathogenesis and progression, focusing on the demethylase FTO as a therapeutic target. Elevated FTO expression in UM tissues correlates with decreased m 6 A levels, increased aggressiveness, and poor prognosis. The FTO inhibitor meclofenamic acid (MA) restored m 6 A levels, upregulated SLC7A11, and induced disulfidptosis, a unique form of cell death triggered by GSH depletion and NADPH consumption. To address MA's limitations in bioavailability and tumor targeting, we developed an MA-loaded nucleic acid nanodrug (SNAMA). SNAMA demonstrated effective tumor growth inhibition in orthotopic and metastatic UM models through GSH-responsive release and m 6 A-mediated disulfidptosis activation. Incorporating a PD-L1 aptamer into SNAMA further improved tumor targeting and immune modulation, enhancing therapeutic efficacy. This study identifies FTO as a critical target for UM therapy and introduces SNAMA-apt as a promising nanodrug. The findings offer a foundation for m 6 A-targeted approaches in UM and other malignancies, addressing bioavailability, targeting, and immune evasion challenges.
研究领域:
肿瘤学
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分子生物学
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药理学
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免疫学
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Wensheng Zou,Wei Ma,Shufen Zhang
In this paper, we present the modification of cotton with glycidyltrimethylammonium chloride (GTA), demonstrating its capability not only for salt-free dye adsorption but also for achieving fixation reactions with monochlorotriazine-type reactive dyes under neutral conditions. The results of adsorption kinetics and isotherm experiments indicate that the adsorption of reactive dyes by modified cotton is chemisorption. Color-stripping experiments conducted on modified cotton dyed with different dyes revealed that GTA-modified cotton underwent fixation reactions with monochlorotriazine-type reactive dyes under neutral conditions. The reaction sites of modified cotton with reactive dyes were determined by measuring the 1 H NMR of the model reaction products. Mechanism investigation using Density Functional Theory (DFT) on the fixation reaction revealed that the hydroxyl groups on the modification agent chain exhibit a lower pKa value and carry more negative charge, resulting in a lower reaction barrier with monochlorotriazine-type reactive dyes. Our research findings demonstrate that GTA-modified cotton fiber enhance the reactivity of cotton, providing significant guidance for the development of novel modifiers.
研究领域:
纺织科学
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材料化学
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PubMed
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Zhihao Wang,Qiuli Cheng,Xingda Jiang,Xinyang Chu,Bingcan Li,Leitao Zhang,Wenlan Wu,Junbo Li,Ravin Narain
Nanoparticles-based drug delivery systems show great promise for cancer therapy due to the advantages of crossing physiological barrier, high drug availability and good stability. However, deep tumor penetration, long blood circulation, and rapid drug release remain intractable problems for nanocarriers. In this work, we report a tumor microenvironment-sensitive nanodrug delivery system containing both acidic pH and hypoxia response sites to achieve enhanced drug permeability and on-demand release for precise cancer therapy. The covalent organic frameworks (COFs) with introduced azobenzene (azo) groups were used as employed as nanocarrier, and modified by pH-sensitive sulfamide-based zwitterionic polymers (PBA), followed by loading with the chemotherapeutic drug doxorubicin (DOX) to obtain COF-PBA@DOX. Copolymer PBA achieved charge conversions in tumor acidic environment, resulting in a positive charge on the nanocarrier surfaces, thus facilitating the augmented tumor accumulation. Meanwhile, azo which was formed the COF carrier, could be reduced to amines by the highly expressed azoreductase under tumor hypoxia conditions, resulting in nanoparticle dissociation and the drug-controlled release at the solid tumor sites. The fabricated dual-responsive nanomedicine, based on the surface charge-reversal of zwitterion in the acidic environment of tumor, can realize the accumulation and targeted drug release at the tumor site, which has great potential as a nanocarrier in tumor therapy.
研究领域:
纳米技术
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癌症研究
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药物递送系统
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材料科学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Xinyu Zhou,Limin Wang,Jianwei Han
The multifunctional chemicals with structural diversity are particularly attractive for various applications. In this study, we present a series of surfactants featuring the chemical structure of quaternary pyridinium salts (QPSs), wherein two types of alcohol fragrance molecules are linked to QPSs via ester bonds and acetal moieties. These profragrances exhibit multifunctional properties, including exceptional surface activity, antibacterial capability, and effective fragrance release performance. A notable feature of this system is their dual-controlled release of the perfume mixture of two different alcohols. In this context, the surface tension of the QPS was determined with the critical micelle concentration (CMC) ranging from 0.0313–0.4349 mmol L–1 and a γ-CMC value of 19.4–26.1 mN m–1. The minimum inhibitory concentration (MIC) tests demonstrated significant antibacterial properties, particularly against Gram-positive bacteria. Gas chromatography with headspace solid-phase microextraction was employed to test the release performance of profragrances in both the solution and the surface of cotton. The controlled release of individual fragrance alcohols under alkaline conditions resulted in a long-lasting scent, while the simultaneous release of two flavors was achieved under acidic conditions. Moreover, the QPSs were shown to be an effective fragrance delivery system for textiles.
研究领域:
化学
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材料科学
·
日用化工
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Ahmed H. Tantawy,Kamal A. Soliman,Hany M. Abd El-Lateef
Three novel quaternary bisammonium fluorosurfactants (FGS-4, FGS-6, and FGS-8) were designed and synthesized using furan-2,5-diylbis(methylene) bis(2-bromoacetate) with N-(3-(dimethylamino)propyl)-1,1,2,2,3,3,4,4,4-nonafluoroalkan-1-sulfonamide through a heterocyclic spacer of 3,3′-((furan-2,5-diylbis(methylene))bis(oxy))bis(3-oxopropan-1-ylium) to connect two fluorocarbon tails. Their corrosion protection characteristics of mild steel/1.0 M H 2 SO 4 solution interface at different temperatures were inspected by electrochemical (PDP and EIS) and weight loss measurements. The PDP plots established that the three-quaternary bisammonium fluorosurfactants are mixed-type inhibitors; EIS experiments exhibited that the as-prepared surfactants possess the superior protection capacities of 93.5 % (FGS-4), 95.5 % (FGS-6), and 96.6 % (FGS-8) at the optimum dose of 2.00 mmol L −1 . The Adsorption considerations showed that the three additives demonstrated both the physisorption and chemisorption mechanisms and followed the Langmuir model. Surface morphology investigations indicated that the synthesized fluorocarbon surfactants impeded mild steel corrosion. The relationships between the protection performance of the fluorocarbon surfactants, their molecular configurations, and the adsorption mode were checked by DFT calculations and MD simulations, which confirmed that FGS-8 has a higher protection power than FGS-4 and FGS-6. The current investigation exhibited that quaternary bisammonium fluorosurfactants could be used as eco-friendly, economic, and efficient inhibitors for mild steel corrosion with the probable for extensive applications.
研究领域:
材料化学
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电化学
·
计算化学
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高影响因子
ENVIRONMENTAL POLLUTION
·
2019
·
IF 5.714
Jie Ding,Zijun Yan,Lanqi Feng,Fuwan Zhai,Xiao Chen,Yuwei Xu,Siqun Tang,Chao Huang,Laicai Li,Ning Pan,Yi He,Yongdong Jin,Chuanqin Xia
There is a need to develop highly efficient materials for capturing uranium from nuclear wastewater. Here, 5-methylbenzotriazole modified graphene oxide (MBTA-GO) was used to adsorb U(VI) from aqueous solution. By the trials of different conditions, we found that the removal of U(VI) from acidic solution was strongly dependent on pH but independent of ionic strength. The U(VI) adsorption was perfectly conformed to the pseudo-second-order kinetics and the adsorption isotherms were simulated by the Langmuir model well. A high removal capacity ( q max = 264 mg/g) for U(VI) at pH 3.5 was obtained. XPS, EXAFS analyses and DFT calculations revealed that the mechanism of uranium capture was ascribed to (i) the surface complexation by benzotriazole and carboxyl groups (providing lone pair electrons) on MBTA-GO and (ii) enhanced synergistic coordination ability of delocalized π-bond of triazole group toward U due to the transfer of electrons from graphene sheet to benzotriazole. DFT calculations further demonstrated that benzotriazole displayed stronger binding with U(VI) compared to carboxyl group due to higher binding energy of [Side/Surface-U-MBTA-GO] (79.745, 54.986 kcal/mol) than [MBTA-GO–COOH–U] (27.131 kcal/mol). This work will provide valuable insight into designing novel nitrogen-containing adsorbents for practical application in wastewater treatment .
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）