DYES AND PIGMENTS
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2025
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IF 4.2
Tingye Gu,Qing Guo,Dongming Qi,Pu Gao,Weiguo Chen,Zhihua Cui,Sateesh Bandaru
N -hydroxysuccinimide esters (NHS esters) are widely recognized as amine-reactive compounds due to their mild reaction conditions and high efficiency. In this study, NHS ester group was introduced into the dye chromophores to design and synthesize carboxylic acid succinimidyl ester dyes ( CSED s) in red, yellow and blue colors. The CSED s were characterized using high-resolution mass spectrometry, proton nuclear magnetic resonance, and infrared spectroscopy. When the NHS ester group was introduced, UV–vis absorption spectroscopy only slightly affected the molar extinction coefficient and maximal absorption wavelength. Hydrolysis studies demonstrated that CSED s hydrolyzed slowly in acidic environments but quickly in weakly alkaline ones, with near-complete hydrolysis taking place at pH 8.5 after half an hour. It was discovered that CSED s could successfully dye silk fibroin at room temperature in weakly alkaline conditions, producing a high color depth and more than 95 % color fixing. The binding of CSED s to silk fibroin was confirmed through covalent bonds using DMF stripping method and dialysis method. Furthermore, the color fastness of dyed silk fibroin to washing and rubbing was rated above grade 4–5. Compared to commercial dyes, the milder dyeing conditions of CSED s can save energy and did not require a significant amount of salt to promote the dyeing process.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2025
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IF 2.6
Cao Bo-Qun,Bao Hao-Tian,Zhang Ji-Wei,Shao Gang-Qin
The lithium-phosphorus-thiohalides (LPS X ) with superionic conduction are strong candidates for the new-generation solid electrolytes (SEs) in all-solid-state lithium-ion batteries (ASSLIBs). In this work, Li 6− x PS 5− x Cl 1+ x − y Br y (LPSCB; 0 ≤ x ≤ 0.7; 0 ≤ y ≤ 1.7) was synthesized by a solid-state method in which the key raw material of Li 2 S was prepared by an improved carbothermal reduction method without late decarbonization. The lattice flexibility and the degree of structural order are opposite effect and would lead to an optimum of the ionic conductivity at a composition of LPSCB. Li 6 PS 5 Br- and Li 5.5 PS 4.5 Br 1.5 -based ASSLIBs had the best rate capacity and cycle performance in Li 6 PS 5 Cl 1− y Br y - (0 ≤ y ≤ 1) and Li 5.5 PS 4.5 Cl 1.5− y Br y -based ones (0 ≤ y ≤ 1.5), respectively. To increase the ionic conductivity of LPSCB-type SEs and capacity/cycle performance of the related ASSLIBs, Br-introduction, mutual substitution and excess- X substitution were extremely effective strategies. Graphical
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EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Pan Gu,Ying Mao,Wangyang Lu,Wenxing Chen
Poly (lactide-co-glycolide) (PLGA) has been extensively utilized to fabricate electrospun fibers for tissue engineering scaffolds due to its good biocompatibility and biodegradability. However, such scaffolds in biological media shrink and distort severely, which is undesired for practical application. In this study, a silk fibroin incorporated electrospun aliphatic polyester nanofiber scaffold (PLGA/PCL/SF) was developed via facile one-step electrospinning, with PLGA as the substrate and incorporating polycaprolactone (PCL) and silk fibroin (SF). The resulting scaffold exhibited fine fibers and water absorbency. Particularly, the addition of SF into scaffolds improved the water adsorption ability, and that of PCL effectively prevented scaffold shrinkage behaviors. In vitro degradation analyses showed that it was accelerating for the obtained scaffolds with SF added, without any undesirable acidic environment induced. Additionally, the PLGA/PCL/SF scaffold exhibited the most promising result in cell proliferation, presenting a valuable insight into the design of tissue engineering scaffolds.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Yajing Xu,Tao Yang,Yao Miao,Qinglei Zhang,Mingying Yang,Chuanbin Mao
The increasing prevalence of bacterial multidrug antibiotic resistance has led to a serious threat to public health, emphasizing the urgent need for alternative antibacterial therapeutics. Lytic phages, a class of viruses that selectively infect and kill bacteria, offer promising potential as alternatives to antibiotics. However, injectable carriers with a desired release profile remain to be developed to deliver them to infection sites. To address this challenge, phage-loaded microparticles (Phage-MPs) have been developed to deliver phages to the infection site and release phages for an optimal therapeutic effect. The Phage-MPs are synthesized by allowing phages to be electrostatically attached onto the porous polyethylenimine-modified silk fibroin microparticles (SF-MPs). The high specific surface area of SF-MPs allows them to efficiently load phages, reaching about 1.25 × 1010 pfu per mg of microparticles. The Phage-MPs could release phages in a controlled manner to achieve potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Unlike the diffuse biodistribution of free phages post-intraperitoneal injection, Phage-MPs could continuously release phages to effectively boost the local phage concentration at the bacterial infection site after they are intraperitoneally injected into an abdominal MRSA-infected mouse model. In a mouse abdominal MRSA infection model, Phage-MPs significantly reduce the bacterial load in major organs, achieving an efficient therapeutic effect. Furthermore, Phage-MPs demonstrate outstanding biocompatibility both in vitro and in vivo. Overall, our research lays the foundation for a new generation of phage-based therapies to combat antibiotic-resistant bacterial infections.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Min Long,Guomin Wu,Fenghua Tao,Shuai Ma,Xiangyang Dong,Hongbing Deng
Bone tissue engineering scaffolds are an important means of repairing bone defects, but current solutions do not adequately simulate complex extracellular microenvironment fibrous structures and adjustable mechanical properties. We use template-assisted fiber freeze-shaping technology to construct silk fibroin nanofiber aerogels (SNFAs) with nanofibrous textures and adjustable mechanical properties. The parallel arranged channels, the pores, electrospun nanofibers, and silk protein conformation together constitute the hierarchical structure of SNFAs. Especially, the introduced electrospun nanofibers formed a biomimetic nanofibrous texture similar to the extracellular matrix, providing favorable conditions for cell migration and tissue regeneration. In addition, Young's modulus of SNFAs can be adjusted freely between 7 and 88 kPa. The rationally designed 3D architecture makes SNFAs perfectly mimic the fiber structure of the extracellular matrix and can adjust its mechanical properties to match the bone tissue perfectly. Finally, fiber-containing SNFAs observably promoted cell adhesion, proliferation, and differentiation, accelerating the bone repair process. The bone density in the defect area reached 0.53 g/cm 3 and the bone volume/total volume (BV/TV) ratio reached 57 % at 12 weeks, respectively. It can be expected that this kind of tissue engineering scaffold with highly simulating extracellular matrix microenvironment and adjustable mechanical properties will possess broad prospects in the field of bone repair.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
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IF 19.9
Yue An,Na Tian,Wenying Yu,Xiaolei Zhang,Yiwei He,Haitao Liu,Yihe Zhang,Hongwei Huang
The efficient synthesis of hydrogen peroxide (H 2 O 2 ) through piezo-photocatalysis is a promising yet challenging sustainable route, primarily limited by inefficient charge separation and sluggish surface reaction kinetics. This study introduces an innovative bi-ionic (K + /Ca 2+ ) co-doping strategy to engineer graphitic carbon nitride, creating a high-performance catalyst for H 2 O 2 production. The bi-ionic doping structure, combined with introduced cyano groups, constructs multi-charge transfer channels and significantly enhances the piezoelectric polarization field, which dramatically promotes the directional separation and migration of photogenerated charge carriers. More importantly, the Ca 2+ sites and adjacent N-cyano groups form synergistic Frustrated Lewis pairs, which simultaneously facilitate spontaneous ethanol dissociation to supply protons and strongly adsorb and activate O 2 molecules. Consequently, the optimized catalyst shows an exceptional piezo-photocatalytic H 2 O 2 production rate of 24.95 mmol g −1 h −1 under visible light and ultrasound, significantly outperforming most reported analogues. Furthermore, we fabricated shape-tunable hydrogels by integrating the catalyst with Sil-MA, which not only facilitates catalyst recovery but also creates a beneficial gas-solid interface when coated on floating substrates. The floating hydrogel system maintains stable H 2 O 2 production, demonstrating great potential for practical applications. This work provides valuable insights into designing efficient piezo-photocatalytic systems for sustainable chemical synthesis.
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Gels
·
2026
·Vol. 12
·期 7
·630
·
IF 6.4
Yuan Li,Ziyu Chen,Shiyu Zhu,Yan Wei,Zhen Geng,Jianping Huang,Mengmeng Li
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage and an associated decline in its intrinsic mechanoelectrical signaling. Current osteoarthritis treatments relieve symptoms but fail to prevent cartilage degeneration or restore its native biophysical microenvironment. Here, we present an ultrasound-activated, mussel-inspired bio-adhesive hydrogel that addresses these challenges by recreating the cartilage’s piezoelectric cues in situ while achieving stable intra-articular retention under synovial conditions. The hydrogel, denoted SFHD-BT@PDA, consists of a silk fibroin (SF) matrix integrated with dopamine-functionalized hyaluronic acid (HADA) and embedded barium titanate nanoparticles coated with polydopamine (BT@PDA). This multi-level design imparts strong interfacial adhesion to wet cartilage (via catechol-mediated bonding to collagen) and piezoelectric sensitivity to external ultrasound. Under ultrasound stimulation, SFHD-BT@PDA generates localized electrical microcurrents that recruit endogenous MSCs via electrotaxis and subsequently promote their chondrogenic differentiation. In vitro, ultrasound-triggered electrical cues upregulated chondrogenic markers (SOX9, collagen II, aggrecan) in MSCs and activated TGF-β signaling, demonstrating restoration of the pro-anabolic bioelectric microenvironment. In a murine DMM model, the adhesive hydrogel exhibited prolonged retention on cartilage surfaces and, with ultrasound, induced robust cartilage regeneration and OA reversal. Treated joints showed preserved proteoglycan and Type II collagen content, inhibited osteophyte formation, and protection of subchondral bone microarchitecture. In summary, this mussel-inspired piezoelectric hydrogel provides an electromechanical stimulation platform that effectively couples physical cues with bio-adhesion to regenerate cartilage.
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Journal of Energy Storage
·
2026
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IF 10.7
Wenxuan Fan,Yan Zhou,Xinglin Zhou,Lei Huang,Xiaohui Ning
The intrinsic three-layer liquid architecture of liquid metal batteries (LMBs) enables a simple cell configuration, high safety, low projected cost, and exceptional theoretical cycle life, making them a promising technology for grid-scale energy storage. However, under high-temperature and multi-physics operating conditions, the corrosion of the stainless steel positive current collector (PCC) by molten cathode metal and halide electrolyte limits long-term durability. A systematic evaluation of commercially available stainless steels under realistic electrochemical, thermal, and chemical conditions is therefore essential. Herein, we investigate the corrosion behaviors of four representative stainless steels (SS201, SS304, SS316, SS430) used as PCCs in Li|LiCl-LiF-LiBr|Bi liquid metal batteries through a two-stage approach combining high-temperature hanging-coupon screening and service-condition cell testing. The results reveal pronounced synergistic corrosion during battery operation, where the combined effects of molten Bi , molten salt electrolyte, and electrochemical polarization substantially accelerate PCC degradation compared to static exposure. Among the investigated materials, SS316 exhibits the highest corrosion resistance, enabling stable cycling without observable capacity decay over 100 cycles. By integrating corrosion resistance, electrochemical performance, and techno-economic considerations, this work establishes an engineering-oriented PCC selection framework and identifies SS316 as the optimal candidate for 200 Ah-scale LMBs, allowing thinner, lighter, and more cost-effective collector architectures. The elucidated corrosion mechanisms under coupled electrochemical, thermal, and flow conditions provide critical insights for the rational design of durable and commercially viable liquid metal batteries.
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BIORESOURCE TECHNOLOGY
·
2026
·
IF 8.2
Yuejie Dou,Shihao Song,Xuchen Wang,Fanlei Yang,Yan Du,Xiaoyu Zhang,Zibo Chen,Jia Yu,Gang Li
Fishbone-structured SF lifting threads were prototyped. • Glycerol/Ca 2+ regulation improved the mechanical properties of SF threads. • Tannic acid and gentamicin endowed the threads with antioxidant and antibacterial functions. • TA/GEN@SFs showed in vitro antibacterial activity against E. coli and S. aureus. • TA/GEN@SFs attenuated inflammatory infiltration and fibrous capsule formation in vivo . Facial thread lifting is widely employed in minimally invasive rejuvenation for its rapid recovery. However, its clinical acceptance is heavily limited by common complications, particularly local infections and severe inflammatory responses. Herein, a multifunctional silk fibroin (SF) lifting thread incorporating tannic acid (TA) and gentamicin (GEN) was fabricated using a custom-designed mold with a biomimetic fishbone architecture and was denoted as TA/GEN@SFs. TA/GEN@SFs exhibited excellent mechanical properties, with a breaking force of up to 40.00 ± 2.30 N and an elongation at break of 13.20 ± 0.98%. Moreover, TA/GEN@SFs showed significant antibacterial activity against Escherichia coli and Staphylococcus aureus , with inhibition zone diameters of 4.21 ± 0.33 mm and 5.71 ± 0.44 mm, respectively. In addition, TA/GEN@SFs achieved a free radical scavenging rate of 56.12 ± 3.31%, indicating notable antioxidant capability. Results from in vivo subcutaneous implantation further demonstrated that TA/GEN@SFs effectively modulated the wound microenvironment by suppressing excessive fibrosis and shortening the inflammatory phase. Overall, this study offers a promising strategy for creating functional implants in medical aesthetics. Download: Download high-res image (115KB) Download: Download full-size image
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
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IF 4.6
Long Yu-Si,Lu Mei-Yi,Qi Jia-Wei,Chen Geng,Sun Yu,He Xiu-Xia,Zhang Tian-Hui,Cui Li-Guo,Hu Jun-Li,Liu Yi-Chun
Silk fibroin hydrogels frequently exhibit insufficient mechanical strength for biomedical applications. Conventional enhancement strategies often rely on toxic crosslinkers or nondegradable components, thereby compromising biocompatibility and biodegradability. Recently emerged organic solvent-based methods represent an advance, but their associated environmental toxicity remains a concern. In this work, we present a novel thermal oscillation strategy for fabricating high-strength silk fibroin hydrogels exclusively from all-aqueous silk fibroin solutions, eliminating the need for toxic chemicals or non-degradable materials. The resulting hydrogels exhibit outstanding mechanical properties, tensile strength of 2.6 MPa, elongation rate of 152.6%, and toughness of 3.0 MJ/m 3 , which not only surpass the organic solvent-derived silk fibroin hydrogels but also rival the dual-crosslinked, double-networked or composite systems. The silk fibroin hydrogels also exhibit a minimal swelling ratio, outstanding long-term integrity, and excellent biocompatibility. The robust, biocompatible, and biodegradable silk fibroin hydrogels are promising for biomedical applications such as load-bearing tissue scaffolds, long-term implantable drug delivery systems, and durable wound dressings.
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ACS Biomaterials Science & Engineering
·
2026
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IF 6
Yanpei Zou,Yining Huang,Chenyu Wang,Tianlong Zhang,Haocheng Xu,Hailong Li,Yitong Xue,Xiaosheng Ma,Linli Li,Fan Zhang,Feizhou Lyu
Bone regeneration is a multifaceted process that requires the coordinated interactions among osteoblasts, endothelial cells, and even osteoclasts. Current biomaterials, however, rarely combine the capacity for multicellular modulation with ease of fabrication and high biocompatibility. Herein, a simple strategy of introducing tannic acid (TA) and MgFe layered double hydroxide (MgFe-LDH), as metal-organic frameworks (MOFs), into silk fibroin (SF) hydrogel is developed to construct a highly biocompatible, multi-functional hydrogel (SF/TA/MgFeLDH) system. The MOFs structure not only enhances the mechanical properties but also avoids rapid degradation of conventional SF/TA hydrogel, providing a good match to bone regeneration. More importantly, the SF/TA/MgFeLDH hydrogel system exhibits good promotion of osteogenic differentiation and angiogenesis while simultaneously suppressing the osteoclastic differentiation in vitro, due to the sustained release of bioactive Mg2+ and Fe3+ ions. Mechanistically, bulk RNA sequencing (RNA-seq) revealed that the hydrogel promotes osteogenesis by upregulating endogenous bone morphogenetic protein-2 (BMP2), which subsequently activates the downstream BMP2/SMAD/RUNX2 signaling pathway. Finally, in multiple bone defect animal models, the system exhibits superior vascularized bone regeneration ability compared to SF/TA controls. This study provides a promising biomaterial with potential clinical application for targeting bone regeneration.
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ChemSusChem
·
2026
·Vol. 19
·期 13
·e70855
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IF 5.9
Long Li,Yuntong Li,Fei Jing,Qianqian Shang,Zheng Pan,Meng Zhang,Caiying Bo,Yonghong Zhou,Xiaohui Yang,Xuejun Pan
Lignin is an abundant, renewable biopolymer, but its structural complexity and low reactivity have hindered its effective valorization. Herein, we report an integrated strategy combining depolymerization, demethylation, and phenolation of lignin in an acidic lithium bromide molten salt hydrate system. Spectroscopic analyses (FTIR, 1 H NMR, and 2D-HSQC NMR) confirmed efficient cleavage of major ether linkages, yielding structurally simplified lignin derivatives with enhanced functionalities. Demethylation increased phenolic hydroxyl (Ar–OH) content by 1.36–2.49 mmol/g, while subsequent phenolation further elevated Ar–OH levels to 6.77–7.71 mmol/g, more than doubling those of native lignin. These structural changes translated into enhanced bioactivity: The modified lignins exhibited strong antioxidant activity (>90% DPPH⋅ scavenging), high antimicrobial efficacy (>87% bacterial inhibition), and favorable safety profiles (IC 50 > 80 mg/L). In vivo feeding trials demonstrated that the modified lignins significantly improved growth performance and provided robust antiviral protection in mice. Overall, this integrated strategy enables efficient conversion of technical lignin into high-value bioactive polyphenols with performance comparable to or exceeding commercial tannins, while retaining clear economic advantages, highlighting their potential for sustainable applications in feed additives, cosmeceuticals, and nutraceuticals. Graphical Low-cost lignin was upgraded in an acidic lithium bromide (LiBr) solution via integrated depolymerization, demethylation, and phenolation to yield bioactive polyphenols with enhanced phenolic hydroxyl content. The resulting polyphenols exhibited strong antioxidant and antibacterial activities, along with low cytotoxicity and promising in vivo performance, including improved growth and anti-influenza efficacy in mice.
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