Foods
·
2023
·Vol. 12
·期 7
·1415
·
IF 5.2
Shenglan Lu,Xueying Li,Xunran Wei,Caihuan Huang,Jie Zheng,Shiyi Ou,Tao Yang,Fu Liu
In contrast to their well-known physiological properties, phytochemicals, such as flavonoids, have been less frequently examined for their physiochemical properties (e.g., surface activity). A natural quercetin self-stabilizing Pickering emulsion was fabricated and characterized in the present study. The antisolvent precipitation method was used to modify quercetin (in dihydrate form), and the obtained particles were characterized by light microscope, atom force microscope, XRD, and contact angle. The antisolvent treatment was found to reduce the particle size, crystallinity, and surface hydrophobicity of quercetin. We then examined the effects of the antisolvent ratio, particle concentration, and oil fraction on the properties of the quercetin particle-stabilized emulsions. In addition, increasing the antisolvent ratio (1:1~1:10) effectively improved the emulsification performance of the quercetin particles. The emulsion showed good storage stability, and the particle size of the emulsion decreased with the rising particle concentration and increased with the rising oil phase ratio. The findings indicate that natural quercetin treated with antisolvent method has a good ability to stabilize Pickering emulsion, and this emulsion may have good prospective application potential for the development of novel and functional emulsion foods.Keywords:quercetin;Pickering;antisolvent precipitation;crystalline
研究领域:
食品科学
·
胶体化学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Zhongshan Wang,Changgeng Li,Xiaodi Liu,Wenchao Jia,Lingzhi Huang,Lu Wu,Haiqiang Shi
Processing lignin into nanoparticles (LNPs) offers a promising utilization strategy; however, its structural and molecular weight heterogeneity poses challenges in the formation of uniform LNPs. In this study, industrial kraft lignin was fractionated in stepwise molecular weight (Mw) from low to high and from which LNPs were fabricated via antisolvent precipitation. The results showed that lignin with high Mw benefits the formation of uniform and smaller-sized LNPs. Particularly, the lignin fraction with Mw of 2016 g·mol–1 fails to form LNPs. The main mechanism is that the higher content of hydrophilic groups (mainly phenolic hydroxyl groups) on the lower molecular weight lignin hinders the formation of LNPs. This hypothesis is supported by the successful formation of homogeneous LNPs after low molecular weight lignin acetylation. Fractionation effectively reduces lignin heterogeneity and promotes the formation of LNPs, which would favor the chemical reactivity and properties, enhancing the utilization of industrial lignin.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2013
·Vol. 56
·期 7
·863-873
·
IF 1.327
Wang LiTao,He Chen,Liu Yang,Zhao SuoQi,Zhang YaHe,Xu ChunMing,Chung Keng H.,Shi Quan
A vacuum topped Canadian oilsands bitumen (VTB) was subjected to solvent precipitation and subsequently characterized by elemental analysis, gel permeation chromatograph (GPC), 1 H-NMR spectroscopy and negative-ion electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Effects of experimental conditions such as solvent types ( n -C 5 , n -C 6 , and n -C 7 ), solvent purity, and solvent washing time on asphaltenes yields, bulk composition, and molecular composition of detectable heteroatom compounds in ESI source were determined. Elemental nitrogen and sulfur were enriched in asphaltenes while elemental oxygen had comparable content in maltenes and asphaltenes. Molecular composition of asphaltenes varies with separation conditions. The N 1 and O 1 species identified by ESI FT-ICR MS were enriched in maltenes. The O 2 species exhibited two different double bond equivalents (DBE) distributions and solubility in normal paraffin solvents, indicating two types of molecular structures. Multi oxygen atom containing compounds mainly detected in asphaltenes. Compound class distributions are similar for maltenes derived from n -C 5 , n -C 6 , and n -C 7 , as well as for asphaltenes. The cyclic paraffin impurities in normal paraffin solvents had a significant influence on asphaltenes yields and heteroatom molecular composition. A portion of neutral N 1 species and acidic O 2 species adsorbed on asphaltenes could be dissolved by increasing washing time. Cautions should be exercised when interpreting the properties and composition of asphaltenes obtained with different experimental conditions.
研究领域:
石油化学
·
分析化学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Junwei Yang,Jingzhou Guo,Jiwen Fu,Yuan Pu,Dan Wang
9-Phenylcarbazole (PCz) is widely used for synthesizing functional molecules in display material industry and synthetic crystal industry. This study aimed to gain reliable experimental data for PCz solubility in common organic solvents under atmospheric pressure in the temperature range of 278.15 to 313.15 K. The selected solvents are methanol, ethanol, n-propanol, isopropanol, n-butanol, n-hexane, cyclohexane, acetonitrile, 1,4-dioxane, tetrahydrofuran, dichloromethane, and trichloromethane. Evaluating the existing models for solid–liquid equilibrium showed that the Apelblat equation was reliable and that the maximum value of mean square deviation between experimental and calculated data was 0.016. This knowledge was referenced for designing the solvent antisolvent (SAS) precipitation processing. Purified products of PCz with a mass fraction purity of over 98.11% was obtained via SAS precipitation in a rotating packed bed with intensified micromixing. Bulk crystals of PCz with high quality were grown from acetonitrile via the deposited crystallization processing.
研究领域:
化学工程
·
材料科学
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产品关联
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2018
·
IF 6.012
Zaizhi Liu,Lei Yang
An improved method of ultrasonic antisolvent precipitation was used to prepare micronized high polymeric procyanidins (HPC). Response surface methodology (Plackett–Burman and Box–Behnken design) was employed to predict the optimal preparation conditions and satisfactory mean particle size. Among seven parameters, three parameters (i.e., ultrasonic irradiation power, ultrasonic-stirring time, and stirring speed) were identified as the most significant variables using Plackett–Burman design; thus, these three parameters were further optimized using Box–Behnken design. The optimal preparation conditions for micronized HPC were obtained as follows: dropping speed of 4 mL/min, HPC solution concentration of 0.3 mg/mL, ratio of antisolvent and solvent of 5 mL/mL, precipitation temperature of 10 °C, ultrasonic-stirring time of 14 min, ultrasonic irradiation power of 620 W, and stirring speed of 760 r/min. A minimum mean particle size of 96 ± 2 nm was achieved under the aforementioned conditions. The obtained micronized HPC was analysed by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric and X-ray powder diffraction patterns. Micronized HPC enjoyed the higher quantity dissolved and exhibited stronger antioxidant activity in compared to the unprocessed HPC. These results demonstrated that the improved method has great potential for the production of micronized particles.
研究领域:
食品科学
·
化学工程
·
药理学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Jinglei Zhi,Shuyao Huang,Xiaoning Zhu,Hazzel Joy Adra,Ke Luo,Young-Rok Kim
Resistant starch particles (RSP) formed by antisolvent precipitation method has attracted much attention as a functional food ingredient having beneficial effects on obesity and diabetes. However, the effect of solvent polarity on the physicochemical properties and digestibility of RSP remains unclear. Here, n -propanol, isopropanol, acetone, and ethanol were employed as antisolvents to prepare RSP. The width and length of the resulting RSP decreased from 0.87 μm to 0.59 μm and from 2.56 μm to 1.31 μm, respectively, upon increasing the solvent polarity, while dramatically decreasing their crystallinity and the gelatinization enthalpy from 80.5% to 62.3% and from 67.9 ± 14.4 J/g to 41.5 ± 8.3 J/g, respectively, suggesting that solvent polarity is critical factor determining morphology, crystallinity, and thermostability of RSP. Furthermore, the level of resistant starch in RSP was found to be inversely proportional to the degree of solvent polarity, which would provide a useful means for modulating the digestibility of RSP.
研究领域:
食品科学
·
营养学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Zhikai Liu,Mei Yang,Qiankun Zhao,Chaoqun Yao,Guangwen Chen
In this study, a seamless scale-up strategy for the antisolvent precipitation process was developed using a series of ultrasonic microreactors (USMRs). The key principle of this scale-up strategy was to maintain a constant mixing time, ensuring consistent nanoparticle (NP) production across different scales. First, lab- and production-scale USMRs were developed, enabling the customization of reactors to varying ultrasound frequencies, channel diameters, and power outputs. Then, the distinct cavitation patterns, including array, slug cluster and cluster, along with their corresponding mixing performances were studied in nine USMRs. By establishing a comprehensive map of cavitation patterns, primary factors affecting the formation of cavitation patterns were identified. Among the three cavitation patterns, the slug cluster pattern demonstrated the best mixing performance, wherein cavitation bubbles effectively occupied the channel and traversed rapidly across the cross-section. To guide the operation of USMRs under the slug cluster pattern, a tailored mixing model was developed. This model, in combination with the relationship between NP size and mixing time, enabled the successful seamless scale-up production of 55 nm PLGA-PEG NPs, with a required mixing time of 27 ms. This USMR-based scale-up strategy facilitated efficient process screening with low sample consumption (2 mL/min, 200 μL/sample) as well as high-throughput production (100 mL/min, 30 g/h).
研究领域:
化学工程
·
纳米技术
·
制药工程
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产品关联
DOI
高影响因子
Sustainable Chemistry and Pharmacy
·
2024
·
IF 5.5
Jiao Xie,Huiqun Wang,Tingyuan Ren,Qijian Zheng,Mengxue Chen
Due to the low purity of natural ellagic acid, its clinical application has been less reported. Currently, blueberry pomace is discarded as processing waste. However, it is rich in ellagic acid and a good raw material for producing high-purity ellagic acid. Therefore, this study aimed to investigate an optimal horizontal combination scheme for producing of high-purity ellagic acid by antisolvent precipitation using crude ellagic acid extracted from blueberry pomace. Solvent screening results indicated that n-methylpyrrolidone had the highest ellagic acid solubility. Single-factor analysis showed that the oscillation speed, reaction time, crystallization temperature and antisolvent-to-solvent ratio had significantly affected ellagic acid purity, but solid-liquid ratio had little effect. A Box-Behnken-Centre combined design was used to determine the optimal combined scheme. The results showed that at a solvent concentration of 20 mg/mL, the optimal parameters were crystallization temperature 21.1 °C, reaction time 11.2 min, volume ratio of 15.6:1 antisolvent to solvent and oscillation speed of 144 r/min. Under these conditions, ellagic acid purity was 96.63%, relative standard deviation (RSD) was 1.20%, and recovery rate was 69.60%. Fourier transform infrared analysis showed that the spectral peak of purified ellagic acid matched that of the standard. In summary, the antisolvent precipitation method greatly improved the purity of ellagic acid extracted from blueberry pomace, which is not only conducive to the resource recycling, but also provides a theoretical basis for the production of high-purity ellagic acid and the possibility of expanding the application scope of ellagic acid in pharmaceuticals and nutraceuticals.
研究领域:
化学工程
·
药学
·
食品科学
·
环境科学
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产品关联
DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2019
·
IF 3.25
Xiaonan Zhang,Hongwei Zhang,Xinghao Xia,Nan Pu,Zhuping Yu,Mourtada Nabih,Ying Zhu,Shuang Zhang,Lianzhou Jiang
Soy isoflavone (SIF) nanoparticles were prepared using dimethyl sulfoxide as a solvent and water as an antisolvent. Response surface methodology was used to analyse the influences of several process parameters on the mass median diameter (D50). The SIF concentration (20–40 mg/mL), volume ratio of antisolvent to solvent (5–7 mL/mL), stirring speed (800–1600 r/min), and reaction time (2–4 min) were optimized. The optimal conditions were determined to be a SIF concentration, volume ratio of antisolvent to solvent, stirring speed and reaction time of 29 mg/mL, 7 mL/mL, 1533 r/min and 3 min, respectively. Satisfactory D50 of SIF (101.24 ± 12.21 nm) were achieved. The processed and unprocessed SIFs were tested and characterized. By comparing the parameters, the chemical properties of the processed and unprocessed SIFs did not change, but the water dissolution rate of the prepared SIF nanoparticles was greatly enhanced.
研究领域:
食品科学
·
药物化学
·
纳米技术
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产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Yu Chen,Yong Zhang,Fengju Wang,Weiwei Meng,Xinlin Yang,Peng Li,Jianxin Jiang,Huimin Tan,Yongfa Zheng
The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic wound dressing was investigated. The results indicate that the modified superabsorbent polymer is non-cytotoxic. It showed a high swelling capacity and better hemostatic performance in the treatments of hemorrhage model of ear artery, arteria cruralis and spleen of the New Zealand white rabbit than the unmodified polymer and other commonly used clinic wound dressings. The hemostatic mechanism of the porous CMCTS-g-PAA polymer was also discussed.
研究领域:
生物材料学
·
医学工程
·
高分子化学
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产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2025
·
IF 2.9
Yu Chen,Yaxue Shen,Zhuojia Shi,Zhenghui Liu,Yanlong Wang,Qi Liu,Zheng Li
Conventional methods for recycling metals from the leachate of spent sodium-ion batteries (SIBs) cathodes encounter several challenges, such as high energy consumption, complicated process and environmental pollution. Herein, a capric acid-driven three-phase antisolvent precipitation (CTAP) strategy is used for the low-energy and sustainable recovery of metal and lixiviant from the leachate associated with SIBs cathode vanadium phosphate sodium (NVP) and low-melting mixture solvents (LoMMSs). The CTAP strategy results in a three-phase precipitation, with the upper layer representing the capric acid phase, the middle layer consisting of the lixiviant phase, and the bottom layer comprising the solid phase. Through the CTAP strategy, capric acid achieves the antisolvent precipitation efficiencies of 86.8% for Na and 50.5% for V when applied to leachate from NVP and LoMMS polyethylene glycol 200:phytic acid; nevertheless, capric acid is ineffective in precipitating metals from leachate derived from LoMMSs that combine polyethylene glycol 200 with citric acid, benzoic acid, urea, or acetamide. Additionally, the LoMMSs using polyethylene glycol 200:phytic acid as the lixiviant achieve maximum leaching efficiencies of 99.1% for Na and 94.4% for V from NVP at a mild temperature of 80 °C over 24 hours, with a liquid-to-solid ratio of 200 after optimizing factors, such as hydrogen bond donors, molar ratios, temperature, time, liquid-to-solid ratio and scalability. This work provides an energy-saving, process-simplified and eco-friendly strategy for the separation of metals from SIBs leachate.
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产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Xiaonan Zhang,Yan Huang,Siyi Huang,Wenyi Xie,Wenxuan Huang,Yi Chen,Qiyuan Li,Fajian Zeng,Xiongjun Liu
To further enhance the application of nobiletin (an important active ingredient in Citrus fruits), we used ultrasonic homogenization-assisted antisolvent precipitation to create ultrafine particles of nobiletin (UPN). DMSO was used as the solvent, and deionized water was used as the antisolvent. When ultrasonication (670 W) and homogenization (16000 r/min) were synergistic, the solution concentration was 57 mg/mL, and the minimum particle size of UPN was 521.02 nm. The UPN samples outperformed the RN samples in terms of the inhibition of porcine pancreatic lipase, which was inhibited (by 500 mg/mL) by 68.41 % in the raw sample, 90.34 % in the ultrafine sample, and 83.59 % in the positive control, according to the data. Fourier transform infrared spectroscopy analysis revealed no chemical changes in the samples before or after preparation. However, the crystallinity of the processed ultrafine nobiletin particles decreased. Thus, this work offers significant relevance for applications in the realm of food chemistry and indirectly illustrates the expanded application potential of nobiletin.
研究领域:
食品化学
·
药学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）