FLUID PHASE EQUILIBRIA
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2013
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IF 2.379
Yumei Kai,Yonghong Hu,Zheng Cao,Xiang Liu,Yan Liu,Wenge Yang
The solubilities of l -malic acid in pure and mixture organic solvents were measured from 278.15 to 323.15 K using the laser monitoring observation system. The modified Apelblat equation, the semi-empirical Buchowski–Ksiazczak λh equation and the Combined Nearly Ideal Binary Solvent/Redlich (CNIBS/R-K) equation were proposed to correlate the experimental data. In pure and mixed solvents, the 100RD (relative deviation) <3.61 and 7.58, respectively, the 10 4 RMSD (root-mean-square deviations) <3.07 and 2.28, respectively, so the equations selected in this work fit the data very well. Van’t Hoff equation was used to predict the dissolution enthalpy and entropy of l -malic acid in the corresponding solvents.
研究领域:
药物化学
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物理化学
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溶液热力学
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药物结晶
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分子药剂学
✓ 已验证
DOI
高影响因子
FLUID PHASE EQUILIBRIA
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2015
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IF 2.2
Qi Zhang,Yonghong Hu,Fei Shen,Wenge Yang,Gang Wu,Pengfei Gu,Yemin Yu
In this paper, we focused on solubility and solution thermodynamics of oxytocin. By gravimetric method, the solubility of oxytocin was measured in (acetonitrile + acetone) binary solvent mixtures from 278.15 K to 328.15 K under atmosphere pressure. The solubility data were fitted using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich–Kister (CNIBS/R–K) model and Jouyban–Acree model. Computational results showed that the modified Apelblat equation was superior to the other two equations. In addition, the thermodynamic properties of the solution process, including the Gibbs energy , enthalpy, and entropy were calculated by the van’t Hoff analysis. The experimental results showed that acetonitrile could be used as an effective anti-solvent in the crystallization process.
研究领域:
热力学
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药物化学
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溶液热力学
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结晶过程
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2012
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IF 3.07
Xiaoqing Wang,Jie Liu,Li Yu,Jingjing Jiao,Rui Wang,Limei Sun
A novel class of zwitterionic surface active ionic liquids (SAILs), N-alkyl-N′-carboxymethyl imidazolium inner salts ([N C n , N′ CO 2 Im], n = 10, 12, 14), was synthesized. Their aggregation behavior in aqueous solution was investigated by surface tension, isothermal titration calorimetry, and steady-state fluorescence. Compared with the reported imidazolium-based cationic SAILs, 1-alkyl-3-methylimidazolium bromide ([C n mim]Br) and zwitterionic betaine surfactants, (C n H 2 n +1 N(CH 3 ) 2 CH 2 COO − ), [N C n , N′ CO 2 Im] exhibits significantly lower critical micelle concentration (cmc) and surface tension at cmc ( γ cmc ) values. It is attributed to the incorporation of a deprotonated carboxylic group into the head group, which weakens the electrostatic repulsion between head groups and favors micellization. The micellar aggregation number of [N C n , N′ CO 2 Im] is larger than that of [C n mim]Br, while less than that of C n H 2 n +1 N(CH 3 ) 2 CH 2 COO − . Similar to the traditional zwitterionic surfactants, the surface activity and adsorption properties of [N C 12 , N′ CO 2 Im] at air/water interface have a slight variation with temperature, pH, and ionic strength . This indicates that the present zwitterionic SAILs display the aggregation behavior much similar to zwitterionic surfactants, distinctly different from imidazolium-based cationic SAILs. Sets in low sensitivity to the environmental conditions, superior surface activity and unique physicochemical properties of ionic liquids, [N C n , N′ CO 2 Im] can be exploited for utilizing as a potential substitute for conventional surfactants in certain fields.
研究领域:
胶体与界面科学
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表面活性剂物理化学
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离子液体
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溶液热力学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
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IF 2.369
Lijiang Guo,Hongxia Li
The solubility of the RbCl–CsCl–H2O ternary system has been investigated at the temperature range from 298.15 to 348.15 K by two different methods, namely, the Flow-Cloud-Point (FCP) method and the Isothermal Dissolve Equilibrium (IDE) method. The measured solubility for this ternary system at 298.15 K by FCP method is consistent with the reported result in literature. The measured solubility results for this ternary system at 323.15 K by the FCP and IDE, two different methods that are consistent with each other, which indicated the results are more reliable. Meanwhile, the measured liquid–wet solid–solid lines proved that the equilibrium solid phases are two types of solid solutions (Rb,Cs)Cl(ss) and (Cs,Rb)Cl(ss) rather than pure salts (RbCl and CsCl) reported in literature. For the first time, the solubility of the RbCl–CsCl–H2O ternary system at 308.15 and 348.15 K has been measured by IDE method. The measured results shown that the equilibrated solid phases in this ternary system at 308.15 and 348.15 K are two types of solid solution (Rb,Cs)Cl(ss) and (Cs,Rb)Cl(ss), at RbCl rich side and CsCl rich side, respectively.
研究领域:
无机化学
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溶液热力学
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物理化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）