JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·
IF 3
Ao Nan Lai,Shu Chun Li,Pei Zhi Zheng,Shu Feng Zhou,Shi Jie Wu
A well-designed architecture is presented here to construct high-performance anion exchange membranes (AEMs). A series of quaternized fluorene-containing block poly(arylene ether sulfone ketone)s (QFPESK-m-n) is synthesized as the main chains, and grafted with comb-shaped C8 long alkyl chains for the AEMs. By varying the hydrophilic segment’ length, there has been a significant change in the microstructure as well as phase separation morphology of the membranes, as confirmed by atomic force microscopy. Hence the as-prepared AEMs with moderate ion exchange capacities (IECs) show enhanced hydroxide conductivities in the range of 28.8―94.7 mS⋅cm −1 from 30 to 80°C. Furthermore, based on the block backbones and hydrophobic comb-shaped alkyl chains, the AEMs show low-level swelling ratios of 4.3% to 9.2% at 30°C and from 6.2% to 13.2% at 80°C, and superior ratios of conductivity to swelling. In addition, the QFPESK-m-n AEMs also depict acceptable mechanical properties, good thermal stability and an optimizable alkaline stability.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2023
·Vol. 224
·期 22
·2300266
·
IF 2.5
Jie Ren,Ningrui Zhan,Jing Yang,Xu Xiang
Hydrogels can swell without dissolving in water and are widely used in water treatment and biomedicine. The swelling rate of hydrogels is closely related to the network structure and charge density of hydrogels, but there are few detailed studies in this area. In this work, poly(acrylamide- co -acrylic acid) anionic hydrogel with acrylic acid (AA) as anionic monomer is prepared. By changing the monomer ratio, or changing the pH value of hydrogels, the internal charge density can be adjusted, and then the swelling rate can be controlled. With the increase of AA monomer content, the content of carboxylate in hydrogel increases, resulting in higher charge density. A high charge density corresponds to a high swelling rate. On the other hand, the swelling rate is closely related to the pH value, which is because the concentration of proton affects the ionization of carboxylic acid, which leads to the change of charge density. It is worth noting when pH increases to 10, the charge shielding effect of the counter-ion (Na + ) gradually increases, thus limiting the swelling of the hydrogel and reducing the swelling rate. This work has reference value for the practical application of hydrogels.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2022
·Vol. 33
·期 9
·2656-2666
·
IF 3.348
Qian Liu,Zhe Wang,Zhiyin Sui,Tianen Shui,Song Wang
To achieve good stability of anion-exchange membranes. We report an organic–inorganic composite anion exchange membrane based on polyphenylene oxide (PPO) and 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane to improve dimensional stability and mechanical stability without affecting ionic conductivity. The successful synthesis of the membranes was confirmed by FT-IR, 1 H NMR, and EDX. The Si O Si three-dimensional network cross-linked structure was formed inside the anion-exchange membranes by added inorganic fillers. It suppressed the swelling behavior of the membrane after water uptake, with water uptake rate of 48.2%–55.6% and swelling rate of 3.1%–14.2%. It improved the mechanical strength of the membranes with tensile strength of 33.5–37.8 MPa as the ratio of the membrane structure varied. Meanwhile, the flexible chain segments in the polymer structure contributed to the formation of microscopic phase separation structures, and the constructed ion-conducting channels enabled QPPO-Si-5 to reach the highest hydroxide ion conductivity of 78.7 mS/cm at 80°C (ion exchange capacity [IEC] value of 1.2 mmol/g). QPPO-Si-1 exhibited better long-term chemical stability, retaining 48.3% of the initial conductivity (30.8 mS/cm) after 600 h of alkali stability testing at 80°C in 1 M KOH solution. In conclusion, the results of this study provide a facile synthetic strategy with improved membrane's comprehensive performance.
研究领域:
材料科学
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燃料电池技术
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产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Lan Guanhua,Zhu Suping,Chen Dong,Zhang Hua,Zou Lijin,Zeng Yuanlin
Polyzwitterionic hydrogels as skin wound dressings have been extensively studied owing to their superior antibacterial properties and skin adhesiveness, but their practical applications still suffer from a low adhesion strength and a high swelling ratio, which hinder the application of hydrogel for cutaneous healing. Here, we developed a novel biocompatible poly[2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (PolySBMA) composite hydrogel with high stretchability, low swelling, strong skin adhesiveness, and antibacterial effect for enhancing wound healing. Naturally rigid polymers including quaternized chitosan methacrylate (QCSMA) and gelatin methacrylate (GelMA) are used as bioactive cross-linkers to endow PolySBMA/QCSMA/GelMA (SQG) hydrogel with a low swelling ratio and high bioactivity. The optimized hydrogel has excellent mechanical flexibility, with the ultimate tensile strength, tensile strain, modulus, and toughness of up to 344.5 kPa, 364%, 14.7 kPa, and 33.4 kJ m−3, respectively. The adhesiveness of the hydrogel to the skin tissue is as high as 38.2 kPa, which is critical for stopping the bleeding from the wound. The synergistic contributions from the PolySBMA and QCSMA endow hydrogel with good antibacterial properties against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Moreover, the natural polymer cross-linked polyzwitterionic hydrogel shows good cell activity, hemocompatibility, and histocompatibility. The in vivo full-thickness skin defect model demonstrates that the SQG hydrogel efficiently improves the granulation tissue formation and collagen deposition. In summary, such superiorly skin-adhesive antibacterial biocompatible hydrogel with controllable flexibility and swelling holds great promise as wound dressings for acute wounds.
研究领域:
材料科学
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生物医学工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 15
·1999
·
IF 4.9
Wenzhe Li,Pingya Luo,Xudong Wang
Lost circulation is a major challenge in oil and gas drilling operations, severely restricting drilling efficiency and compromising operational safety. Conventional bridging and plugging materials rely on precise particle-to-fracture size matching, resulting in low success rates. Self-healing gels penetrate loss zones as discrete particles that progressively swell, accumulate, and self-repair in integrated gel masses to effectively seal fracture networks. Self-healing gels effectively overcome the shortcomings of traditional bridging agents including poor adaptability to fractures, uncontrollable gel formation of conventional downhole crosslinking gels, and the low strength of conventional pre-crosslinked gels. This work employs stearyl methacrylate (SMA) as a hydrophobic monomer, acrylamide (AM) and acrylic acid (AA) as hydrophilic monomers, and graphene oxide (GO) as an inorganic dopant to develop a GO-based self-healing organic–inorganic hybrid plugging material (SG gel). The results demonstrate that the incorporation of GO significantly enhances the material’s mechanical and rheological properties, with the SG-1.5 gel exhibiting a rheological strength of 3750 Pa and a tensile fracture stress of 27.1 kPa. GO enhances the crosslinking density of the gel network through physical crosslinking interactions, thereby improving thermal stability and reducing the swelling ratio of the gel. Under conditions of 120 °C and 6 MPa, SG-1.5 gel demonstrated a fluid loss volume of only 34.6 mL in 60–80-mesh sand bed tests. This gel achieves self-healing within fractures through dynamic hydrophobic associations and GO-enabled physical crosslinking interactions, forming a compact plugging layer. It provides an efficient solution for lost circulation control in drilling fluids.
研究领域:
石油工程
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材料科学
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化学工程
·
地质学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Jilong Cao,Guanghua He,Xiaoqing Ning,Xiuhao Chen,Lihong Fan,Ming Yang,Yihua Yin,Weiquan Cai
A simple method had been developed through O -chitosan quaternary ammonium salt ( O -HACC), polyvinyl alcohol (PVA) and graphene oxide (GO) to prepare O -HACC/PVA/GO dual self-healing bacteriostatic hydrogels. Then the hydrogels and materials were characterized by FT-IR, X-RD, 1 H NMR, SEM and TG. The hydrogel's compressive strength , equilibrium swelling and bacteriostatic efficiency were systematically studied. The research results showed that the maximum equilibrium swelling rate of hydrogel was 720%, the maximum compressive strength was 1500 Pa, and could self-heal within 12 h. In addition, the hydrogel could effectively inhibit E. coli and S. aureus , and also showed a good release behavior for bovine serum albumin (BSA). The CCK-8 method proved that the hydrogel was non-toxic to murine fibroblasts and could promote cell proliferation and growth to a certain extent. This research has potential significance for the application of self-healing hydrogel materials in the field of biomedicine .
研究领域:
生物材料学
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生物医药
✓ 已验证
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2014
·
IF 3.107
Xuefei Cao,Xinwen Peng,Linxin Zhong,Runcang Sun
Stimulus-responsive hydrogels, which can undergo significant physicochemical changes in response to various physical or chemical stimuli, have drawn wide attention in many fields. In this study, novel photoresponsive hydrogels prepared by free radical copolymerization of xylan-type hemicellulose methacrylate with 4-[(4-acryloyloxyphenyl)azo]benzoic acid (AOPAB) were investigated, which showed multiresponsive behaviors to pH, water/ethanol alternating solutions, and light. The swelling ratios of the prepared hydrogels in distilled water decreased from 9.8 to 2.2 g/g with AOPAB content increase from 2% to 16%. The hydrogel displayed rapid swelling and deswelling performance in water and ethanol alternating solutions. Additionally, under UV irradiation the trans-conformation of azobenzene in the hydrogel would generally convert into the cis-conformation and resulted in the hydrophilic/hydrophobic balance variation of the hydrogel. Therefore, the hydrogel loaded with vitamin B12 (VB12) showed a higher drug cumulative release rate under UV irradiation than that without UV irradiation.
研究领域:
材料科学
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药学
·
聚合物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2018
·
IF 1.911
Ruirui Feng,Rongzhan Fu,Zhiguang Duan,Chenhui Zhu,Xiaoxuan Ma,Daidi Fan,Xian Li
Polyvinyl alcohol (PVA) hydrogels have been widely studied for biomedical applications due to their water solubility, non-toxicity, non-carcinogenicity, and biocompatibility. However, PVA hydrogels prepared by the physical crosslinking method usually do not exhibit a macroporous structure, which limits their application when PVA hydrogels are used alone as a wound dressing. Here, we reported a sponge-like macroporous PVA hydrogel (SPH) prepared by employing polyethylene glycol and nano-hydroxyapatite (n-HA) to enhance phase separation. After being fabricated through cyclic freezing/thawing, the resulting PVA hydrogels possessed macroporous structures. The swelling ratio could reach nearly 1500%, resulting from the excellent water absorption capacity, and the sample could rapidly restore to the original state after being pressed, suggesting a sponge-like characteristic. Furthermore, cell experiments showed that macroporous PVA hydrogels exhibited good biocompatibility and the results of wound closure and H&E analysis consistently indicated that SPHs could significantly promote the wound healing process.
研究领域:
材料科学
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生物医学工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Wei Wei,Xiaoliang Qi,Junjian Li,Yin Zhong,Gancheng Zuo,Xihao Pan,Ting Su,Jianfa Zhang,Wei Dong
Salecan is a biological macromolecular and biocompatible polysaccharide that has been investigated for recent years. Herein, we report a novel cationic hydrogel fabricated by graft-polymerizing 3-(methacryloylamino)propyl-trimethylammonium chloride (MAPTAC) onto salecan chains. The obtained hydrogels were transparent, solid-elastic, macro-porous, ion-sensitive, and non-cytotoxic. The swelling ratios increased with salecan content, while mechanical strength does the opposite. Moreover, drug delivery test was studied as a potential application. Diclofenac sodium (DS) and insulin were selected as model drugs. Interestingly, in drug loading process, DS molecules exhibited highly affinity to these cationic hydrogels. Almost all the DS molecules in loading solution were absorbed and spread into the hydrogel. For drug release profiles, insulin-loaded hydrogel showed an initial rapid release and a sustained release. As a comparison, DS-loaded hydrogel exhibited a more sustained release profile. Results suggested salecan-g-PMAPTAC hydrogel could be a good candidate for anionic drug loading and delivery.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Jiafeng Qian,Chenyi Wang,Xiaojing Zhang,Jianxiong Hu,Xiaoyan Zhao,Jian Li,Qiang Ren
Quaternary ammonium-functionalized anion exchange membranes (AEMs) have important potential application value in water electrolysis. In order to further improve the ionic conductivity and stability of AEMs, a series of crosslinked AEMs based on poly (aryl ether sulfone)s (Co-PAES-QA-x-m, “x” represents the functionalized polymer segment, “m” represents the crosslinking ratio) are prepared by introducing dense quaternary ammonium cations on the side chains via Menshutkin reaction. Their polymer structures are characterized by hydrogen nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy FT-IR, and the microscopic phase separation structure of the obtained membranes is observed by atomic force microscope AFM. The ion exchange capacity (IEC) of Co-PAES-QA-x-m (x = 25%, m = 40%–100%) is between 2.03–2.48 mmol g −1 , and their water uptake (WU), swelling ratio (SR) and ionic conductivity are in the range of 26.9–56.7%, 6.3–12.9% and 53.43–119.43 mS cm −1 at 80 °C, respectively. The test of chemical stability show that the ionic conductivity retention ratio of these AEMs reaches 84.7% after soaking in 2 mol L −1 NaOH solution for 480 h at 80 °C. The water electrolyzer assembled with representative Co-PAES-QA-25-60 reaches 1646.7 mA cm −2 in 2 mol L −1 NaOH solution at 2.0 V and 80 °C, and the durability test shows that its voltage only rises by 5% after 480 h at the current density of 500 mA cm −2 . This work is expected to provide an effective modification method for high-performance AEMs which are used in water electrolyzer.
研究领域:
材料科学
·
化学工程
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yichun Yang,Zemin Ou,Zhimin Wang,Tianxiao Yang,Jingjing Zhu,Xiaoqian Liu
It is the expectation of wound management to develop high-efficiency wound dressing which can control bleeding and prevent infection in clinics. In this study, a new wound dressing was synthesized by cross-linking oligomeric gum from Eucommia ulmoides (OGE) and carboxymethyl chitosan (CC) with genipin. The chemical structure, micromorphology and wettability of the synthetic OGE-CC were characterized. The physical properties and biocompatibility evaluation of OGE-CC showed that the material displayed excellent swelling ratio, high porosity and no cytotoxicity. It also demonstrated strong antimicrobial activity, achieving 99.99% antibacterial efficacy against Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ) and Pseudomonas aeruginosa ( P.aeruginosa ). Compared with the maximum average compressive stress (MACS) of the commercial gelatin-based dressing (GBD, 95 ± 7 kPa), the OGE-CC (2:1) displayed a higher MACS of 166 ± 4 kPa, which indicated its superior compressive properties. OGE-CC displayed stable states under varying temperatures and humidity levels. In addition, OGE-CC showed faster hemostatic effects than GBD and silicone-based dressing (SBD) in mice models of tail amputation and hepatic hemorrhage. OGE-CC can degrade in PBS solution with the highest degradation rate of 63.24 ± 2.01 % after 20 days. These results suggested that OGE-CC had the potential to be developed as an antibacterial and hemostasis wound dressing.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Xin Jin,Chengxiong Wei,Chengwei Wu,Wei Zhang
Hydrogels have been widely investigated as gastric retention systems for drug delivery and bariatric intervention due to their good biocompatibility , degradability, and similarity with human tissues or organs. To realize long-term retention, hydrogels need to swell considerably on contact with gastric fluid to prevent passing through the pylorus and simultaneously maintain their mechanical stability after swelling to resist the damage of gastric pressure. However, high swelling ratio often results in the reduction of mechanical strength . Here, a swelling hydrogel with long-term mechanical stability for gastric retention is proposed. The hydrogel is designed as double networks, namely, the polyacrylamide as the first network and chitosan/sodium alginate as the second network. The hydrogel can reside in the stomach by the swelling of first network and maintain mechanical stability through the gradual formation of second network under the action of gastric fluid. The animal model test proves that the hydrogel can reside in the stomach with intact shape for 16 days, and then is biologically degraded in the gastric environment.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）