CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2018
·Vol. 97
·期 4
·955-966
·
IF 1.265
Chuang Wang,Guocheng Zhu,Bozhi Ren,Peng Zhang,Andrew Hursthouse
Dissolved organic carbon (DOC) and dissolved organic nitrogen (DON) are important components of the aquatic environment and may produce harmful disinfection by-products through chlorination associated with water treatment processes. Therefore, it is necessary to remove them from the water. Coagulation is a cost-effective water treatment technique as the key unit in the pretreatment of drinking water but deals with DON poorly. We present a study to investigate the enhancement of poly aluminum chloride (PAC) using a cationic polymer for the removal of both DON and DOC. The cationic dimethyl diallyl ammonium chloride (PDMDAAC) polymer was hybridized with PAC to remove DON and DOC. The results showed that the PDMDAAC increased the charge neutralization capacity of PAC and floc aggregation, thereby increasing the settling efficiency of the flocs. The PDMDAAC increased the amount of colloidal species in PAC, which was beneficial to the formation of adsorption-bridging. With the increase of pH, a greater proportion of colloidal adsorption sites were used in the removal of DON. The DOC, DON, and turbidity removal were dependent on multiple interactions through charge neutralization, adsorption-bridging, and floc sweeping. However, DOC and DON removal were primarily determined by adsorption-bridging and floc sweeping, while turbidity removal was mainly dependent on charge neutralization.
研究领域:
环境科学
·
水处理工程
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产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2020
·
IF 4.089
Xin Chen,Duanxiu Li,Zongwu Deng,Hailu Zhang
Ketoconazole (KTZ) is an imidazole derivative that is used to treat a wide variety of fungal infections and other human diseases. As a class II compound in the biopharmaceutics classification system, KTZ has low aqueous solubility. To improve this disadvantage, five phenolic acids were employed to form cocrystals with KTZ. The antifungal and anti-inflammatory activity of the phenolic acids may bring an enhanced therapeutic effect and reduce the risk of hepatotoxicity at the same time. The structural information on these five crystalline samples and KTZ were fully disclosed by single-crystal X-ray diffraction. In addition to a previously reported carboxylic acid···imidazole N interaction, hydroxyl···imidazole N hydrogen bonding also appears in the KTZ cocrystals as a main supramolecular heterosynthon. The short strong hydrogen bonds were observed in two cocrystal structures, which contain slightly longer carboxylic O–H length. 15N solid-state NMR also provided valuable clues for the confirmation of the molecular/ionization states. The dissolution tests revealed that all the newly obtained cocrystals exhibit significantly improved solubility compared to KTZ.
研究领域:
药学
·
化学
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2012
·
IF 4.72
Qian Tao,Jia-Mei Chen,Lei Ma,Tong-Bu Lu
One phenazopyridine monohydrate (1·H2O), one cocrystal of phenazopyridine with phthalimide (2), and three salts of phenazopyridine with benzoic acid (3), 4-hydroxyphenylacetic acid (4), and scaaharin (5) were synthesized, and their structures were determined by single crystal X-ray diffraction. The results of dissolution experiments indicate that the solubility of phenazopyridine can be enhanced after the formations of cocrystal and salts, in which the apparent solubility value of 5is approximately 9 times as large as that of phenazopyridine in water, and the apparent solubility value of 4 is approximately 10 times as large as that of phenazopyridine hydrochloride (1·HCl) in 0.1 M HCl aqueous solution. The results of the stability study demonstrate that 2–5 are less hygroscopic than 1·H2O and 1·HCl at both 85% and 98% RH.
研究领域:
药学
·
化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 42
·19704-19713
·
IF 3.591
Yunan Zhang,Yu Duan,Jin Su,Lixin Liu,Yanru Feng,Lili Wu,Lei Zhang,Yunjie Zhang,Dongyu Zou,Yingli Liu
In order to improve the solubility of pipemidic acid (PPA) which belongs to quinolones and becomes an “old drug” due to its low aqueous solubility that restricts its application, two unreported pharmaceutical salts of PPA with catecholcarboxylic acid (CCA) (HPPA·C7H5O4·2(H2O)) and m-hydroxybenzoic acid (MHA) (HPPA·C7H5O3·C7H6O3·2(H2O)) have been designed, synthesized and characterized. A comprehensive analysis of the structure and Hirshfeld surface reveals that the CAHBs formed from the N atoms in the piperazine ring from PPA molecules with the carboxylic acid group in the coformers could have a stable crystal structure. As expected, the solubility experiments showed that the solubilities of the PPA–CCA and PPA–MHA were significantly improved compared with that of the PPA, which may be due to the increased hydration enthalpy resulting from the formation of CAHBs between PPA and coformers, which leads to increased solubility. Moreover, the antibacterial activities of PPA–CCA and PPA–MHA are also improved. At the same time, surprisingly, the permeability of PPA–CCA and PPA–MHA was also better than that of PPA. In addition, the hygroscopic stabilities of PPA–CCA and PPA–MHA were significantly improved compared with that of PPA. The reason may be due to that the hydrogen bonds between PPA and CCA weaken their attraction to external water molecules. Thus, the present work implies that CAHBs play a key role in adjusting the molecular packing via a cocrystallization strategy to improve the physicochemical properties of quinolones, which could offer a tremendous opportunity to recycle these “old” drugs and give them a new life.
研究领域:
药学
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化学
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产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2024
·Vol. 18
·期 12
·9856-9866
·
IF 2.9
Zhang Maoying,Quan Fan,Zhang Jing,Feng Wanli,Zou Xianfeng
This study aims to covalently couple black soybean 7S globulin with polysaccharides via the Maillard reaction to enhance the solubility and emulsifying properties of black soybean 7S globulin. After glycosylation modification, the solubility of the modified product is significantly higher than that of natural black soybean 7S globulin (7S). When the pH is above 4, the solubility of the 7S globulin coupled with 20 kDa molecular weight glucan is notably higher compared to other polysaccharides. Among the glycosylation products, the 7S globulin coupled with 100 kDa molecular weight glucan exhibits the best emulsification properties, reaching 72.22 m²/g. Its emulsifying properties and stability are improved by 446.98% and 223.30%, respectively, compared to the native black soybean 7S globulin. The contact angle of the black soybean 7S globulin is 69.93 ± 1.4°, while the glycosylated product with gum arabic shows the most significant change, decreasing to 51.65 ± 1.43°, indicating an increase in hydrophilicity.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Lijuan Zhong,Xiang Li,Mengwen Duan,Yibo Song,Ning He,Liming Che
To understand the impacts of high hydrostatic pressure (HHP) processing on the microstructure and properties of pectin, an aqueous solution of apple pectin (50 g/L) was treated at 200, 400, and 600 MPa for 30 min. The chemical structure and properties of resultant pectin were characterized and compared with those of native pectin (0.1 MPa). The contents of α -1,4-linked d -galacturonic acid and reducing sugar in pectin did not change after HHP, whereas the degree of esterification of pectin increased slightly. Fourier transform infrared spectroscopy showed that no chemical conversion of pectin occurred during HHP process. For the first time, molecular dynamics simulation revealed that the hydrophobic hydration of the methyl group dramatically improved under HHP, thereby enhancing pectin dissolution in water. In turn, this result increased the aqueous pectin solution's apparent viscosity and stability, which are very important for fruit- and vegetable-based products containing pectin.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Yanxia Wei,Linli Hu,Jinrong Yao,Zhengzhong Shao,Xin Chen
The conformation and stability of zein in solution are closely associated with its solvation process and influence the mechanical properties of the related zein-based materials. In this work, a common solvent dimethyl sulfoxide (DMSO) was used to dissolve zein, rather than solvents frequently used such as aqueous ethanol and acetic acid. It was found that DMSO could dissolve zein readily and the solution was stable for at least 2 weeks. Rheological analysis and small-angle X-ray scattering (SAXS) were employed to characterize the zein DMSO solution. Results of rheological analysis suggested a Huggins coefficient of 0.24, indicating DMSO to be a good solvent for zein. SAXS results revealed that zein adopted an elongated conformation and had dimensions of 2.8 nm × 2.8 nm × 14.8 nm in DMSO solution. Moreover, robust zein films were fabricated from zein DMSO solutions. The content of residual DMSO in the films was determined to be approximately 15 wt % by thermogravimetric analysis, in consistence with the value obtained by other two methods. The film showed a large breaking strain of 320.6% with a considerable breaking stress of 1.9 MPa, yielding a breaking energy of 376.2 MJ/m3. Therefore, the ease of dissolution and good mechanical performance of the final zein-based material make DMSO a potential solvent for fabrication of zein materials, thereby improving the scope of practical applications of zein.
研究领域:
材料科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2017
·
IF 3.756
Jun-Hui Deng,Tong-Bu Lu,Changquan Calvin Sun,Jia-Mei Chen
Dapagliflozin (DAP) is a potent and selective sodium-glucose contransporter-2 inhibitor, for treating type 2 diabetes . DAP propanediol monohydrate (DAP-PDO-H 2 O, 1:1:1) is the solid form used in the current tablet product to address the severe hygroscopicity problem of DAP free form. DAP-PDO-H 2 O, however, suffers the problem of instability when exposed to high temperature, which renders it amorphous. In this work, we report on the preparation and evaluation of a new 1:1 cocrystal between DAP and citric acid (DAP-CA). The DAP-CA cocrystal exhibits superior stability against high temperature and high relative humidity without compromising dissolution and tableting performance. Thus, DAP-CA is a promising solid form for developing the next generation DAP tablet products with improved performance.
研究领域:
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Xuan Chang,Tingting Duan,Jiashen Feng,Ying-Xia Li
The common use of peroxides in the remediation of malodorous black water may lead to the activation of heavy metals in sediment when eliminating black and odorous substances. The mechanisms of heavy metal interactions with dissolved organic matter (DOM) in response to in situ capping have not been elucidated, but this information could guide the optimization of capping materials. We developed a capping material consisting of hydrothermally carbonized sediment (HCS), hydrated magnesium carbonate (HMC) and sodium percarbonate (SPC) and used microcosm experiments to investigate the dynamics of Mn and Cu at the sediment–water interface in malodorous black water. The results showed that HCS, HMC and SPC contributed multiple functions of mechanical protection, chemical isolation and oxygen provision to the new caps. HMC promoted the conversion of Mn/Cu into carbonate minerals. The optimal mass proportions were 25 % HCS, 60 % HMC and 15 % SPC based on the mixture design. In situ capping altered the fate and transformation of metals in the sediment-overlying water profile in the short term through Mn immobilization and Cu activation. The complexation of Cu(II) ions was significantly stronger than that of Mn(II) ions. In situ capping had a significant effect on the order of complexation of different fluorescent DOM molecules with Mn(II)/Cu(II) ions: microbial byproducts and fulvic acid-like components were preferentially complexed with Cu(II) ions after capping, while phenolic and humic acid-like components preferentially interacted with Mn(II) ions. Humic-like components bound to Cu were affected the most by capping treatment, whereas protein-like components were relatively weakly affected. Our study provides valuable knowledge on the impact of in situ capping on DOM–metal complexes.
研究领域:
环境科学
·
化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL SCIENCES
·
2022
·
IF 3.784
Lihai Zhai,Zhaohua Zhang,Lihong Guo,Huaimin Dong,Junhou Yu,Guimin Zhang
Gefitinib (GEF) is an anti-tumor oral solid formulation with a superior advantage for lung tumors. However, it has poor aqueous solubility which limits its utility in vivo . Herein, a novel cocrystal (GEF-RES) assembled by GEF and RES (Resveratrol) has been successfully prepared and comprehensively characterized by differential scanning calorimetry , thermogravimetric analysis, Raman spectroscopy and powder X-ray diffraction. A single-crystal structure of the GEF-RES cocrystal was solved and illustrated in detail. In aqueous hydrochloric acid , the GEF-RES cocrystal showed that the maximum concentration of GEF was slightly higher than that of raw GEF. Furthermore, the thermal and physical stability of the GEF-RES cocrystal were also evaluated in this paper. The enhanced solubility and excellent solid-state stability results may provide new potential to the application of key GEF in clinical.
研究领域:
药学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Food Engineering
·
2025
·
IF 1.4
Yonghui Wang,Jingwen Wu,Weiyun Guo,Xueli Gao,Guanghui Li,Shenghua He,Jihong Huang,Zirui Du,Sa Wen
In this study, ammonium glycyrrhizate (AG) based curcumin (Cur) nanocomplexes (AG/Cur NCs) were prepared. Water solubility of Cur and the physical stability of AG/Cur NCs under varying conditions were investigated, and the stability and bioaccessibility of Cur during in vitro digestion were also studied. The results showed that Cur solubility and physical stability of the NCs increased significantly ( p < 0.05) with the increase of AG concentration. The solubility of encapsulated Cur and the physical stability of AG/Cur NCs were affected by the changes in pH, salt concentration, and temperature, but the NCs showed good stability against various environmental conditions. After in vitro simulated digestion, the stability and bioaccessibility of the embedded Cur in the NCs were 6.54 % and 21.70 % respectively, higher than that of free Cur. The formulation of AG/Cur NCs significantly enhanced the solubility and stability of Cur, indicating substantial promising for Cur-based functional foods.
研究领域:
食品科学
·
药理学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Qiuyu Chen,Yongyi Zhang,Haiwang Liu,Peng Liu,Xinxin Ye,Xing Xia,Xiangwei Wu
Straw-derived dissolved organic matter (DOM) is widespread in farmland soils, but the relationship between straw-derived DOM and As in their co-sorption on minerals and the underlying mechanisms remain unclear. Here, batch experiments and spectroscopic analyses were employed to investigate the co-sorption of straw-derived DOM and As(III/V) on γ-Al 2 O 3 . Results showed a trade-off between the As(III/V) and DOM immobilization on γ-Al 2 O 3 under different pH levels, which was caused by competitive sorption. The rape straw-derived DOM (DOM_Ra) exhibited a stronger inhibition on As(III/V) sorption than rice straw-derived DOM (DOM_Ri). This could be due to more aromatic fractions in the DOM_Ra and DOM_Ri, which were preferentially sorbed by γ-Al 2 O 3 . In turn, the preferential sorption of aromatic DOM components was weakened by As(V) sorption, which, however, was not found in As(III) and DOM co-sorption. Furthermore, spectral results indicated that carboxylic groups on the sorbed DOM could provide additional binding sites for As(III/V) to form ternary complexes, but its role was overwhelmed by the DOM competitive sorption, which ultimately exhibited the inhibitory effect of DOM on As(III/V) sorption. These findings enhance the fundamental understanding of the co-sorption of As(III/V) and DOM on soil minerals and contribute to predicting As mobility and OM stability in As-contaminated farmlands with straw return.
研究领域:
环境科学
·
土壤化学
·
农业生态学
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产品关联
DOI
PubMed
高影响因子
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