JOURNAL OF CHEMICAL THERMODYNAMICS
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2014
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IF 2.423
Rongrong Li,Anguo Ying,Guobo Huang,Chenghong Li,Dan Chen,Jia Zhao
The solubility of sodium 3-sulfobenzoate in binary (sodium chloride + water), (sodium sulfate + water), and (ethanol + water) solvent mixtures was measured at elevated temperatures from (278.15 to 323.15) K by a steady-state method. The results of these experiments were correlated by a modified Apelblat equation. The dissolution enthalpy and entropy of sodium 3-sulfobenzoate in aqueous solutions of different mole fraction were obtained.
研究领域:
物理化学
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热力学
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产品关联
DOI
高影响因子
FLUID PHASE EQUILIBRIA
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2015
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IF 2.2
Chunlin Li,Qinbo Wang,Binwei Shen,Zhenhua Xiong,Chuxiong Chen
The solubilities of 5,10,15,20-tetrakis(4-chlorophenyl) porphyrin (abbreviated in p -ClTPP) in ethanol + water solvent mixtures at (293.2–333.2) K and 5,10,15,20-tetrakis(4-chlorophenyl) porphyrin manganese(III) chloride (abbreviated in p -ClTPPMnCl) in ethanol + water solvent mixtures at (303.2–333.2) K were measured. The concentration of ethanol in term of mole fraction on the solubility was studied. It was found that the solubility of p -ClTPP in ethanol + water solvent mixtures increases with the increasing of temperature at constant solvent composition , and decreases with the decreasing mole fraction of ethanol at constant temperature. However, for p -ClTPPMnCl, the solubility increases with the increasing of temperature at the mole fraction of ethanol from (0.6102–0.8597), and decreases with the increasing of temperature at the mole fraction of ethanol from (0.9038–1.0000). The experimental data were correlated with the modified Apelblat equation, and the solubilities correlated by the model were in good agreement with experimental data. Thermodynamic parameters including dissolution enthalpy, dissolution entropy and dissolution Gibbs free energy were calculated with van’t Hoff equation.
研究领域:
化学
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热力学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2019
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IF 4.561
Shanghong Zong,Bochen Pan,Leping Dang,Hongyuan Wei
In this work, pure form I and form II of furosemide-4,4′-bipyridine (FS-4BPY) 2:1 cocrystals were prepared. Both polymorphs were characterized by optical microscopy , powder X-ray diffraction, differential scanning calorimetry , thermogravimetric analysis , and Fourier transform infrared spectroscopy . The relative stability of the two forms was estimated from their solubility data in 2-propanol by the gravimetric method. Moreover, the thermodynamically stable form with lower solubility, form II, was further investigated in different pure and binary solvents from 293.15 K to 333.15 K under atmospheric pressure. In pure solvent system, the solubilities of forms II cocrystals increase with rising temperature and follow the order of acetone > ethanol > 1-propanol ≈ 1-butanol > 2-propanol > acetonitrile . In 2-propanol–water binary solvent system, the co-solvency phenomenon was observed and the maximum solubility of form II is higher than that in pure solvents. The experimental solubility data were correlated by the modified Apelblat model, the CNIBS/R–K model, the Jouyban–Acree model and the NRTL model, and all models give satisfactory correlations. Finally, the apparent dissolution thermodynamic properties, including the dissolution Gibbs energy , the dissolution enthalpy and the dissolution entropy, were calculated based on the NRTL model. The results indicate that the dissolution processes of form I and form II of FS-4BPY cocrystals in selected solvents are all spontaneous, endothermic, and entropy-driven.
研究领域:
药学
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物理化学
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热力学
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晶体学
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2020
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IF 2.888
Renren Sun,Haixia He,Yameng Wan,Yueru Wang,Liyuan Li,Jiao Sha,Gaoliang Jiang,Yu Li,Tao Li,Baozeng Ren
For further study on solubility behaviors of melatonin (MT), the solubility of MT in the three mono-solvents {N, N-dimethylformamide (DMF), 2-methoxyethanol, 2-ethoxyethanol} and four binary solvents {(DMF, 2-methoxyethanol, 2-ethoxyethanol and methanol) + ethyl acetate} was measured in a range of 278.15 K–323.15 K by laser monitoring method. The measurement results showed that MT solubility in all tested solvents increased with rising temperature. In binary solvents except methanol + ethyl acetate, the solubility values of MT had a positive relationship with the mass fraction of co-solvents. In methanol + ethyl acetate, the solubility of MT initially increased, followed by a decrease (with the rising mass fraction of methanol) and arrived the highest solubility value at a mass fraction of methanol being 0.4000. The Hansen solubility parameters (HSPs) were applied to study the solubility behaviors of MT in tested solvents. Moreover, in three pure solvents, the measured solubility data of MT was correlated by (NRTL-SAC, NRTL, two-Suffix Margules, UNIQUAC models and modified Apelblat equation). In binary solvents, the solubility data was fitted by (three-Suffix Margules, λh equation, Yaws model equation and modified Apelblat equation). Furthermore, the apparent thermodynamic properties were calculated based on the van’t Hoff equation. The positive values of apparent standard dissolution enthalpy and entropy suggest that the dissolution process of MT in all of chosen solvents is entropy-driven and endothermic. The larger values of ζ H than ζ TS represent that the main contributor of Δ dis G o in all investigated solvents is enthalpy.
研究领域:
化学工程
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物理化学
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药学
✓ 已验证
产品关联
DOI
高影响因子
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