Diagnostics
·
2022
·Vol. 12
·期 2
·239
·
IF 3.992
Yingying Xie,Wenwen Chen,Mengqian Zhao,Yuhai Xu,Hao Yu,Jianhua Qin,Hongjing Li
Arthritis is caused by inflammation, infection, degeneration, trauma, or other factors that affect approximately 250 million people all over the world. Early diagnosis and prediction are essential for treatment. Exosomes are nanoscale vesicles that participate in the process of joint disease. Serum is the mainly used sources in the study of arthritis-related exosomes, while whether serum exosomes can reflect the contents of synovial fluid exosomes is still unknown. In this work, we separated exosomes from serum and the synovial fluid of osteoarthritis patients and compared their miRNA expression utilizing miRNA sequencing. The results revealed that 31 upregulated and 33 downregulated miRNAs were found in synovial fluid compared to serum. Transcriptome analysis showed that these differentially expressed miRNAs were mainly associated with intercellular processes and metabolic pathways. Our results show that serum-derived exosomes cannot fully represent the exosomes of synovial fluid, which may be helpful for the study of joint diseases and the discovery of early diagnostic biomarkers of arthritis.Keywords:exosomes;miRNA;synovial fluid;arthritis
研究领域:
生物标志物发现
·
分子生物学
·
风湿病学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Bingfeng Li,Kefan Huang,Shuaiya Xue,Weimin Liu,Jian Li
Slippery liquid-infused porous surfaces (SLIPSs), a class of functional bioinspired surface, have earned a position at the forefront of many areas such as anticorrosion, anti-icing, antifogging, antibacterial, anticontaminant, microflow control, and drag reduction. However, the fast self-replenishing ability of SLIPS remains extremely challenging due to limited lubricant storage capacity or microstructure impeding fluid flow. Herein, a superhydrophobic surface was prepared by spraying the sepiolite/zeolitic imidazolate framework-8 hybrid material with a layered three-dimensional (3D) fibrous porous network structure on the magnesium (Mg) alloy surface. Subsequently, SLIPS with fast self-replenishing properties was obtained by injecting silicone oil on the superhydrophobic surface. The unique internal structure of SLIPS not only served as a container for storing the lubricant but also provided a channel for the flow of lubricants. In addition, the SLIPS possessed favorable self-replenishment, anticontaminant, and anti-icing properties. Moreover, compared with the superhydrophobic surface, SLIPS exhibited better corrosion resistance, which was attributed to the stable continuous lubricating oil replacing the air trapped in the rough structure and effectively blocking the invasion of corrosive ions. Significantly, the as-prepared SLIPS still maintained excellent corrosion stability on the Mg alloy after soaking in 3.5 wt % NaCl solution for 30 days. The research provides an avenue for designing green environmental protection, sustainable anticorrosion, and rapidly self-replenishing SLIPSs with great application potential.
研究领域:
材料科学
·
表面工程
·
生物仿生学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Mingtian Xu,Zhengjie Xu,Zhijun Jiang,Wenwen Shao,Lihao Zhang,Yufei Chen,Zhixia Dong,Cihui Liu,Weixing Zhang,Xinjian Wan
Biliary stents (BS) play an important role in the field of modern interventional therapy. However, the surface of BS is easy to cause microbial attachment, which causes serious postoperative infections and threatens the life safety of patients. Here, inspired by the microstructures of Nepenthes alata ’s peristome surface and Morpho menelaus , we presented an excellent slippery surface for BS tips by employing inverse opal colloidal crystals hydrogels. The inverse opal structure not only imparts a tunable structural color to the slippery surface but provides sufficient room for liquid absorption, such as lubricants and drugs. The slippery liquid-infused porous surfaces (SLIPS) endow the slippery surface with anti-adhesion and antibacterial properties. Due to the good temperature sensitivity of hydrogels, we can control the drug release by changing the temperature. In particular, the drug release process can be monitored through visually structural color variations. Furthermore, we also proposed a mechanism of droplet infiltration on SLIPS under the heating which is expected to be used for the smart transport of droplets. The multifunctional SLIPS BS tips also exhibit good generalization, we believe it will bring more possibilities for biliary stents.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Lubricants
·
2022
·Vol. 10
·期 8
·189
·
IF 3.584
Jiju Guan,Chao Gao,Zhengya Xu,Lanyu Yang,Shuiquan Huang
Developing high-efficiency lubricant additives and high-performance green cutting fluids has universal significance for maximizing processing efficiency, lowering manufacturing cost, and more importantly reducing environmental concerns caused by the use of conventional mineral oil-based cutting fluids. In this study, a nanocomposite is synthesized by filling sulfurized isobutylene (T321) into acid-treated carbon nanotubes (CNTs) with a liquid-phase wet chemical method. The milling performance of a nanocutting fluid containing CNTs@T321 composites is assessed using a micro-lubrication technology in terms of cutting temperature, cutting force, tool wear, and surface roughness. The composite nanofluid performs better than an individual CNT nanofluid regarding milling performance, with 12%, 20%, and 15% reductions in the cutting force, machining temperature, and surface roughness, respectively. The addition of CNTs@T321 nanocomposites improves the thermal conductivity and wetting performance of the nanofluid, as well as produces a complex lubricating film by releasing T321 during machining. The synergistic effect improves the cutting state at the tool–chip interface, thereby resulting in improved machining performance.
研究领域:
材料科学
·
机械工程
·
绿色制造
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Nan Wang,Dangsheng Xiong,Sai Pan,Yaling Deng,Yan Shi
Superhydrophobic/oleophilic coating was prepared on steel via wet chemical etching, and followed by surface modification. Surface grafting was manifested to be realized mainly on the oxidized area. Slippery liquid infused porous surface(s) (SLIPS) was prepared by infusing perfluorinated lubricant into the prepared superhydrophobic coating, to repel water, coffee, kerosene, and even hexane, suggesting a transition from superoleophilicity to lyophobicity. Furthermore, the lyohobicity was accessible only when the substrate is fluorinated. Moreover, the kinematic viscosity was demonstrated to be negatively correlated to the traveling speed of the liquids on the SLIPS.
研究领域:
材料科学
·
表面工程
✓ 已验证
DOI
高影响因子
Advanced Materials Technologies
·
2024
·
IF 6.4
Jiru Huai,Jiaxuan Zhang,Peng Wang,Wenjie An,Xiang Zhao,Zhen Zhang,Wenliang Wang,Wei Duan,Ying Yue
Recently, slippery liquid-infused porous surface (SLIPS) is widely utilized for anti-icing. Nevertheless, a major challenge hindering the practical applications of SLIPS is the depletion of lubricating oil, significantly deteriorating its deicing performance. Given that super-slippery effects are not required during most non-icing periods, this research introduces a novel dynamic wettability-adjustable SLIPS anti-icing coating inspired by the nepenthes. This coating-comprising modified diatomaceous earth and soft silicone rubber-releases lubricating oil only when temperatures fall below −2 °C, thus exhibiting super-slippery characteristics and effectively preventing icing. The porous modified diatomaceous earth retains lubricating oil for prolonged periods and facilitates its controlled release under external forces. The high elasticity and strength of the soft silicone rubber endow the coating with thermal expansion and contraction capabilities, enabling the active absorption and release of lubricating fluid in response to temperature variations. This coating, prepared using a straightforward strategy, demonstrates an ice adhesion strength and an oil loss rate of less than 23 kPa and 13%, respectively, after 50 icing/de-icing cycles. These findings highlight the remarkable performance of the coating, providing valuable insights for achieving long-term anti-icing on the external surfaces of equipment in extreme working conditions.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2023
·Vol. 38
·期 9
·2339-2348
·
IF 2.7
Zhou Jiajie,Li Longyang,Zhu Lijing,Zeng Zhixiang,Zhang Jinwei,Lin Cunguo
When the impact force of the droplets is low (the Weber number is low), the influence of the solid surface and the lubricating liquid cannot be ignored. Here, slippery liquid-infused surfaces were prepared by hydrochloric acid etching and low surface energy triethoxy-1H,1H,2H,2H-tridecafluoro-n-octylsilane modification on Al sheets, then infiltrated with different lubricating liquids. The bounce behavior of droplets is studied under the condition of controlling the Weber number is 19. The results show that the lubricating liquids can be locked when the roughness is sufficient. The adhesion of a slippery liquid-infused surface is related to the surface tension and viscosity, which is lower, and it is more beneficial to droplet bounce. But lubricating fluids with too low viscosity are more likely to be lost from the microstructure after being struck by droplets. It is significant for the application of slippery liquid-infused surfaces in low impact. Graphical Abstract
研究领域:
材料科学
·
流体力学
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产品关联
DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Qianqian Cai,Jinkai Xu,Zhongxu Lian,Zhanjiang Yu,Huadong Yu,Shen Yang,Jian Li
Slippery liquid-infused surfaces (SLISs) are developed as a potential alternative to superhydrophobic surfaces (SHSs) to resolve the issues of poor durability in corrosion protection and wear resistance. In this work, we used a simple laser processing technology to prepare a SLIS on the aluminum alloy (7075) surface. The superhydrophobicities of the modified surface and the oil film formed by liquid injection make the corrosive medium difficult to directly contact the surface and thus have a significant effect on corrosion resistance. The water and oil repellent SLIS exhibits durable corrosion resistance and excellent tribological properties compared with the SHS. The anticorrosion and wear resistance performances provided by the composite film have been assessed by multiple methods including the electrochemical test, immersion test, and friction wear test. The results indicate that compared to the bare surface, laser-ablated surface (LAS), and fluoroalkyl silane-modified SHS, the SLIS composite coating has better corrosion resistance and wear resistance, which is of great significance to expand the potential applications of 7075 aluminum alloys. The work provides a research basis for expanding the practical application of SLISs in complex environments.
研究领域:
材料科学
·
表面工程
·
腐蚀与防护
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Zhen Shi,Chenxi Fang,Jiaqian Li,Sateesh Bandaru,Muwen Liu,Lizhong Zhao,Xuefeng Zhang
In spite of superior magnetic properties, neodymium–iron–boron (Nd-Fe-B) applications in harsh environments have been greatly hindered by their susceptibility to corrosion, humidity, mechanical, and temperature attacks. Herein, a construction strategy of robust slippery liquid-infused porous surfaces (SLIPS) coatings is proposed via the multi-dimensional design of surface, bulk coating, and interface. The manipulation of colloidal states of silica particles by chemical hydrophobization allows for building a dense polymer network, enhancing interfacial adhesion and locking lubricant film effectively. The resulting coating is demonstrated to be extremely stable, endowing the magnet with excellent liquid repellency, anti-corrosion, and anti-icing properties. Strikingly, no trace of corrosion is detected after 136-day immersion in 3.5 wt.% NaCl solution and the impedance modulus at 0.1 Hz can be maintained as the initial of 3.31 × 10 8 Ω·cm 2 even after 132-day immersion, which is far superior to that of commercial Ni-Cu-Ni, Zn, and EP coatings. Additionally, anti-icing performance at low temperatures is evidenced by the delayed icing time and decreased ice adhesion strength. Importantly, the self-healing property offers the surface intensified durability even after mechanical damage. This work demonstrates a construction strategy of robust SLIPS coatings with a multi-dimensional design, enabling the practical applications of Nd-Fe-B magnets in extreme environments like offshore wind turbines.
研究领域:
材料科学
·
表面工程
·
腐蚀防护
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2012
·Vol. 434
·期 1
·73-77
·
IF 2.996
Zhirui Song,Yue Xu,Zuanguang Chen,Jianping Yang,Xinchun Li,Zhiguang Zhang
This article describes the determination of lactate in synovia by microchip capillary electrophoresis (MCE) integrated with contactless conductivity detection (CCD). The optimal running buffer consists of 10 mM tris(hydroxymethyl)aminomethane, 1 mM HCl , and 0.1 mM hexadecyltrimethylammonium bromide (pH 9.1). The quantitative measurement of lactate in dilute synovia samples can be finished in less than 40 s. The results indicated that the peak area had a good linear relationship with lactate concentration in the range of 20 to 1000 μM, and the correlation coefficient was 0.9984. The average recovery was from 96.6% to 106.1%, and the interday relative standard deviation was less than 4.0% ( n = 6). The limit of detection (signal/noise = 3) reached 6.5 μM. To validate the assay results, we compared the current method with the high-performance liquid chromatography method by measuring lactate in synovia samples. The data analysis verified that there was no significant difference between the two methods. Due to significant features such as low cost, integration, and miniaturization, the MCE–CCD method may have great potential in clinical diagnosis.
研究领域:
分析化学
·
临床检验
·
分子诊断
·
转化医学
✓ 已验证
DOI
高影响因子
Coatings
·
2023
·Vol. 13
·期 4
·732
·
IF 3.4
Bo Li,Jie Bai,Lei Fan,Xianyin Mao,Zhimin Ding,Hao Mu,Guoyong Liu,Yuan Yuan
Slippery liquid-infused porous surfaces (SLIPS) have received growing attention as promising icephobic materials. In this study, SLIPS were prepared on aluminum alloys by combining anodization and infusion of common silicone oil. An SLIPS with low ice-adhesion strength (6 kPa) was obtained by optimizing the anodizing time parameters (10 min). In addition, the frosting process and freezing of water droplets on the as-prepared SLIPS at −10 °C were delayed for 2000 s and 4800 s, respectively. Simultaneously, the as-prepared SLIPS also exhibited excellent anti-icing performance in glaze ice, since the supercooled water drips/ice slipped from the surface. The ice weight of the as-prepared SLIPS was significantly lower than that of the bare aluminum surface and the anti-icing-fluid-coated aluminum surface, which was reduced by 38.2%–63.6% compared with the bare aluminum surface. The ice weight increased with decreased temperature and inclination angle. This work proposes a method suitable for large-area preparation of SLIPS that achieves excellent anti-icing performance and significantly reduces the weight of glaze ice.Keywords:slippery liquid-infused porous surfaces;anti-icing;glaze ice;ice-adhesion strength
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
TRIBOLOGY INTERNATIONAL
·
2024
·
IF 6.1
Jiajia Cen,Qin Chen,Kai Chen,Xinyue Zhang,Haiyan Feng,Cunao Feng,Xiaowei Li,Dekun Zhang,Shirong Ge
Environmental factors greatly affect the tribological behavior of hip joint materials in synovial fluid. In this paper, four groups of the synovial fluid with different concentrations of albumin (Alb), γ-globulin (γ-Glo), hyaluronic acid (HA), and phospholipids (PLs) were prepared based on the concentration of each component of the synovial fluid after artificial joint replacement. Then, taking cobalt-chrome-molybdenum (CoCrMo) and high crosslinked polyethylene (XLPE) as research objects of the hip joint materials, the tribological behaviors in the synovial fluid with different pH values and temperature were systematically explored, elucidating the influence mechanisms of external conditions and synovial fluid components on friction and wear behaviors. Results indicated that the tribological behaviors of hip joint materials were significantly affected by the pH value and temperature of the synovial fluid. The coefficient of friction (COF) of the hip joint materials in the synovial fluid initially decreased and then increased with the pH value, reaching a minimum at pH= 8.0, and sample 4 was the most sensitive to pH change. The COF of the hip joint materials in the synovial fluid ascended with temperature, showing an opposite trend to calf serum (protein concentration of 30 mg/mL) in the standard experiment. In addition, the wear of the hip joint materials was more severe in the synovial fluid with lower pH (pH=7.5 and pH=8.0) and mild in the synovial fluid with higher pH (pH=8.5). Additionally, the wear of the hip joint materials in the synovial fluid and calf serum in the standard experiment increased with the ascend of temperature, and the wear in calf serum in the standard experiment was the most affected by temperature. In conclusion, this study sheds light on the tribological behaviors and mechanisms of artificial hip joints under simulated working conditions, providing a crucial foundation for accurately evaluating the bio-tribological characteristics of artificial joint materials.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）