Reproductive Biology
·
2024
·
IF 2.5
Romualdo Sciorio,Pier Francesco Greco,Mohammed Adel,Lucia Maresca,Ermanno Greco,Steven Fleming
In the last decades, to enhance success rates in assisted reproductive technology (ART) cycles, scientists have continually tried to optimize embryo culture and selection to increase clinical outcomes. In this scenario, the application of laser technology has increased considerably worldwide and is currently applied across ART in several ways: for assisted hatching (AH) or thinning of the zona pellucida (ZP), embryo biopsy, to immobilize and select the sperm during intracytoplasmic sperm injection, as well as to induce artificial blastocyst shrinkage before cryopreservation. Laser-AH has been suggested as a procedure to improve embryo implantation: the concept is that drilling holes through or thinning of the ZP could improve the hatching process and implantation. The artificial disruption of the ZP can be performed by different approaches: mechanically, chemically and with the laser, which is one of the most favourable and easy methods to remove part of the ZP and to augment the possibilities of implantation in patients defined as having a poor prognosis of success, or when the ZP is too thick. However, in the current literature, there is not sufficient evidence about the potential risk or impairment that laser utilization might induce on embryo development; therefore, the main aim of the current review is to provide an overview of the existing knowledge on the ZP and the mechanisms of manipulating it to improve the effectiveness of ART. Also, it emphasizes the positive aspect of laser application as a powerful tool that might increase the chance of pregnancy for infertile couples undergoing ART cycles.
研究领域:
生殖生物学
·
辅助生殖技术
·
胚胎学
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2019
·
IF 4.916
Rui Duan,Yanzeng Li,Bojian Shi,Hanyang Li,Jun Yang
In this study, we demonstrate a novel nematic liquid crystal (LC) 4-cyano-4′-pentylbiphenyl (5CB) microdroplet-based biosensor for real-time, quantitative and sensitive detection of urea by whispering gallery mode (WGM) lasing technology. The single stearic acid-doped 5CB microdroplet is taken as both optical resonator and sensing reactor. To the best of our knowledge, this work is the first report of urea detection with WGM lasing. The enzymatic reaction between urea and urease produces hydroxide ions. Deprotonation and self-assembly of stearic acid occur at the aqueous/LC interface with increased pH value, promoting the reorientation of LC molecules. The detectable shift of WGM lasing spectra related to the configuration transition of LC microdroplets can be used as an indicator of enzymatic reaction, and this allows detection of urea molecules by the sensor at a concentration of only 0.1 mM. The proposed sensor also demonstrated the ability to detect urea in real urine samples. Compared with conventional POM observations, monitoring and identification of lasing spectra from LC microdroplets as a versatile method allow for more quantitative and sensitive detection of analyte reactions and can be expected to replace POM imaging technology for current LC-based biosensor systems.
研究领域:
生物传感
·
光学检测
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Bionic Engineering
·
2023
·Vol. 20
·期 5
·1891-1904
·
IF 4
Wang Peng,Zhao Hui,Zheng Boyuan,Guan Ximei,Sun Bin,Liao Yongli,Yue Ying,Duan Wei,Ding Haimin
It has been proved that the construction of interconnected armour on superhydrophobic surface could significantly enhance the mechanical robustness. Here, a new kind of armour with frame/protrusion hybrid structure was achieved by nanosecond laser technology. Then, this armoured superhydrophobic surface demonstrated excellent durability, which could withstand linear abrasion (~ 3 N press) 800 cycles, water jet test (1.0 MPa pressure) 40 times and 100 °C treatment 18 days. Particularly, the armoured superhydrophobic sample shows outstanding anti-icing ability, which can speed up the supercooled water dropping (no adhesion within 2 h), increase the freezing delay time by ~ 3 times and maintain low adhesion force (less than 35 kPa) after 30 icing/de-icing cycles. Further finite element analysis and theoretical modeling proved that the developed frame/protuberance hybrid structure could effectively enhance the durability. The relatively low surface accuracy in this study can significantly reduce processing cost, which provides a bright future for the practical application of armour superhydrophobic materials.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Quansheng Li,Xiaofei Sun,Xuesong Mei,Lingzhi Wang,Jianlei Cui,Wenjun Wang
High-performance metal-ion batteries are crucial to electronic devices, electric vehicles and large-scale energy storage applications. High mass-loading of electrode materials is essential to achieve high volumetric capacity and thus high energy density of batteries. However, the loading density is severely constrained by the instable electrode structure, sluggish ion diffusion, low e − transportation and inferior electrochemical performance of high-loading electrodes. Here, an integrated strategy of designing and processing laminated 3D network by femtosecond laser technology is proposed and carried out to construct high-loading Li 4 Ti 5 O 12 (LTO) anodes with high capacity, high rate and long lifetime performances for lithium-ion batteries. The laminated 3D electrode is constituted of a 3D porous current collector with an array of microporous networks and a 3D LTO layer with an interdigitated array of microgroove networks. With such a laminated 3D structure, not only are the current collectors and the electrode materials tightly interlocked, but also a series of interconnected fast charge (Li + /e − ) transfer channels are formed. Therefore, the structure stability, electrochemical kinetics, specific capacity, rate capability and cycling stability of high-loading electrodes are significantly improved as demonstrated by both computation study and experimental verification. The optimized LTO electrode could deliver a high volumetric capacity of 136 mA h cm −3 at 60 C and a fast Li + diffusivity of 4.28 × 10 −12 cm 2 /s, which is 2.82 and 107.54 times higher than that of the untreated electrode, respectively. This work provides a novel route of designing and preparing high-performance, high-loading electrodes for metal-ion batteries.
研究领域:
材料科学
·
能源存储
·
激光加工
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yi Shen,Mengmeng Fan,Chuanwei Lu,Qianqian Jia,Shijian Xu,Juan Yu,Chunpeng Wang,Qiang Yong,Jifu Wang,Fuxiang Chu
Fabrication of sustainable bio-based malleable thermosets (BMTs) with excellent mechanical properties and reprocessing ability for applications in electronic devices has attracted more and more attention but remains significant challenges. Herein, the BMTs with excellent mechanical robustness and reprocessing ability were fabricated via integrating with radical polymerization and Schiff-base chemistry, and employed as the flexible substrate to prepare the capacitive sensor. To prepare the BMTs, an elastic bio-copolymer derived from plant oil and 5-hydroxymethylfurfural was first synthesized, and then used to fabricate the dynamic crosslinked BMTs through Schiff-base chemistry with the amino-modified cellulose and polyether amine. The synergistic effect of rigid cellulose backbone and the construction of dynamic covalent crosslinking network not only achieved high tensile strength (8.61 MPa) and toughness (3.77 MJ/m 3 ) but also endowed the BMTs with excellent reprocessing ability with high mechanical toughness recovery efficiency of 104.8 %. More importantly, the BMTs were used as substrates to fabricate the capacitive sensor through the CO 2 -laser irradiation technique. The resultant capacitive sensor displayed excellent and sensitive humidity sensing performance, which allowed it to be successfully applied in human health monitoring. This work paved a promising way for the preparation of mechanical robustness malleable bio-thermosets for electronic devices.
研究领域:
材料科学
·
生物工程
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Laser & Photonics Reviews
·
2024
·
IF 9.8
Zhi Chen,Hao Huang,Jiefeng Deng,Changle Meng,Yule Zhang,Taojian Fan,Lude Wang,Shuo Sun,Yi Liu,Huiling Lin,Shuang Li,Yunpeng Bai,Lingfeng Gao,Junle Qu,Dianyuan Fan,Xueji Zhang,Han Zhang
Genetic engineering faces persistent challenges in achieving precise Deoxyribonucleic acid (DNA) cleavage, especially with the limitations associated with current enzyme-based methods, exemplified by issues in CRISPR technologies. This study introduces a groundbreaking approach: utilizing reactive oxygen species (ROS) generated by Multiphoton Absorption (MPA)-excited Black Phosphorus Quantum Dots (BPQDs) under femto-second laser irradiation. This innovative method not only allows excitation with lower energy but also enhances overall efficiency. The integration of complementary RNA sequences facilitates high-efficiency, site-selective DNA cleavage in the system, named “TADPOLE” (Targeted DNA Precision Oriented Laser Excision). Beyond its precision in targeting arbitrary DNA sequences using quantum dots, TADPOLE harnesses the unique multiphoton absorption property of BPQDs, enabling excitation with lower-energy light sources suitable for in vivo applications in the future. Moreover, the approach integrates guiding RNA and ultrafast laser technology to provide precise control over local ROS generation and minimal heat production. This guarantees site-specific DNA cleavage while mitigating the risk of damage to non-targeted sequences. In summary, this study catalyzes advancements in enzyme-free DNA cleavage technologies, with transformative implications for genetic engineering, biotechnology, and medicine. The holistic precision, versatility, and endurance presented by TADPOLE open new avenues for targeted gene therapies and transformative applications in related fields.
研究领域:
遗传学
·
生物技术
·
医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·
IF 5.1
Yi Lin,Gaoming Dong,Hang Lin,Bo Wang,Pengfei Wang,Ju Xu,Yao Cheng,Yan Xiong,Yuansheng Wang
The rise of laser diode (LD)-driven phosphor-converted near-infrared (NIR) lighting sources, offering unparalleled advantages in terms of brightness and imaging resolution, is hindered by a scarcity of color converters possessing desired properties. Herein, we synthesized a new Ca2YScAl2Si2O12:Cr3+ (CYSAS:Cr3+) broadband NIR-emissive garnet phosphor with a full width at half maximum (FWHM) of 165 nm, attributed to the presence of Cr3+ ions at two distinct crystallographic sites in CYSAS as verified through spectroscopic analyses. With the aid of a rapid infrared firing technique pioneered in our lab, a phosphor-in-glass film (PiGF) composite was then successfully sintered onto a sapphire plate (SP), showing minimal interfacial reactions during co-sintering and thus retention of luminescent properties. The saturation behavior of luminescence under intense blue laser irradiation was meticulously examined across different excitation modes. By incorporating a “phosphor wheel”, we achieved a peak NIR output power of 2626 mW (@17 W or 21.7 W mm−2), surpassing the majority of previously reported phosphor-converted lighting sources. The demonstration experiments highlighted the potential applications of the engineered laser-driven NIR light source in non-destructive detection, quantitative analysis of organic components, night vision and biological imaging.
研究领域:
材料科学
·
光学工程
·
激光技术
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zimo Cai,Chuyang Miao,Chonghao Zhang,Huayu Luo,Jiangen Wu,Tianzhen Zhao,Huan Yang,Lisha Fan,Geng Yang,Xiaoping Ouyang,Huayong Yang,Jianhua Yao,Kaichen Xu
Enhancing interfacial adhesion between functional coatings and target surfaces facilitates long-term stable service by mitigating interferences of mechanical mismatches. Design of mechanical interlocks affords an effective strategy to strengthen the interfacial bonding with durability and compatibility, but the in-depth investigations are still lacked. Herein, a gecko-inspired hierarchical strategy realized by hybrid laser direct writing is proposed, which incorporates an armored frame scale for surface protection and a riveted anchor scale for interlocks. Such dual-scale configurations endow the functional coatings with the stronger adhesion to the targets than the pristine and mono-scale cases, resulting in 2 orders of magnitude enhancement resistant to tape peeling tests. Utilizing this scheme, a laser-induced integrated deicing system is in situ manufactured on thermoplastics, primarily comprising superhydrophobic structures, carbon-based sensors as well as adhesive copper (Cu) interconnects and heaters, where Cu-based devices exhibit superior resistance to water impacts and stress fatigue. Interfacing with signal processing modules, such an all-in-one system demonstrates real-time temperature monitoring and high efficiency in deicing (4.24 folds faster than the control group). The facile route for intensified adhesion holds promise in the interfaces within advanced equipment and under harsh scenarios.
研究领域:
材料科学
·
表面工程
·
激光技术
·
粘附科学
·
涂层与薄膜
·
功能材料
·
先进制造
·
热管理
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Chao Xiao,Ming Yin,Xindan Li,Zhong Kuang,Bin Wang,Hongjiang He,Shengquan Yu,Zhuoying Jia,Xiaoqiang Li
In this study, Fe 2+ :ZnSe x S 1-x (0.6 ≤ x ≤ 1) solid solution laser ceramics with cubic crystal structures were prepared for the first time via hot pressing sintering, using FeSe, ZnSe, and ZnS powders. The resulting ceramics exhibit a unique combination of the optical and physical properties of Fe 2+ :ZnSe and Fe 2+ :ZnS. An increase in the ZnS content led to a blueshift in the maximum absorption spectra of Fe 2+ ions and an enhancement in Vickers hardness. These findings suggest that Fe 2+ :ZnSe x S 1-x solid solution ceramics could serve as promising gain media for mid-infrared solid-state lasers, offering a novel approach for the development of directly pumped mid-infrared laser systems.
研究领域:
材料科学
·
光学
·
激光技术
·
陶瓷
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·
IF 13
Yunfan Li,Ziran Zeng,Shizhuo Zhang,Dingyi Guo,Peilong Li,Xiao Chen,Longju Yi,Huai Zheng,Sheng Liu,Feng Liu
Graphene has tremendous potential in future electronics due to its superior force, electrical, and thermal properties. However, the development of graphene devices is limited by its complex, high-cost, and low-efficiency preparation process. This study proposes a novel laser bidirectional graphene printing (LBGP) process for the large-scale preparation of patterned graphene films. In LBGP, a sandwich sample composed of a thermoplastic elastomer (TPE) substrate, carbon precursor powder, and a glass cover is irradiated by a nanosecond pulsed laser. The laser photothermal effect converts the carbon precursor into graphene, with partial graphene sheets deposited directly on the TPE substrate and the remaining transferred to the glass cover via a laser-induced plasma plume. This method simultaneously prepares two face-to-face graphene films in a single laser irradiation, integrating synthesis, transfer, and patterning. The resulting graphene patterns demonstrate good performance in flexible pressure sensing and Joule heating, showcasing high sensitivity (7.7 kPa −1 ), fast response (37 ms), and good cycling stability (2000 cycles) for sensors, and high heating rate (1 °C s −1 ) and long-term stability (3000 s) for heaters. It is believed that the simple, low-cost, and efficient LBGP process can promote the development of graphene electronics and laser manufacturing processes.
研究领域:
材料科学
·
电子工程
·
激光技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICS LETTERS
·
2016
·Vol. 41
·期 6
·1221-1224
·
IF 3.04
Yan Zhou,Min Zhao,Shiwei Wang,Chen-xia Hu,Yao Wang,Shuo Yan,Yue Li,Jianqiu Xu,Yulong Tang,Lin-Feng Gao,Qiang Wang,Hao-li Zhang
Graphitic carbon nitrides (CNs) have appeared as a new type of photocatalyst for water splitting, but their optical properties (e.g., nonlinear absorption), to the best of our knowledge, have been seldom explored. Here, we report the saturable absorption effects of novel 2D carbon-nitride-type nanosheets and use them as saturable absorbers to passively mode-lock Yb-doped fiber lasers. The CN-based saturable absorber is manufactured by solution coating of 2D CN nanosheets on a gold mirror and has a modulation depth and saturation intensity of 12.5% and 7.5 MW/cm2, respectively. Two different output couplers are employed to construct ring laser cavities. With the 10% coupler, the mode-locked fiber laser produces pulses with duration of ∼310 ps, average power of 1.24 mW, and repetition rate of 7.65 MHz. The laser spectrum is centered at 1066 nm with a bandwidth of 2.4 nm. Increasing the coupling ratio to 50% improves the output power to 2.58 mW but at the same time broadens the pulse width to 420 ps. As a new kind of 2D material with strong saturable absorption, CN nanosheets will open a new way for novel photonic and optoelectronic devices.
研究领域:
光学
·
材料科学
·
激光技术
✓ 已验证
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·Vol. 51
·期 26
·47599-47610
·
IF 5.6
Weijie Zhu,Weichao Wang
The rapid expansion of data-intensive technologies such as 5G, AI, and cloud computing is pushing optical communication systems to their limits, necessitating the development of advanced materials to extend bandwidth into the L- and U-bands. Fluoro-sulfo-phosphate (FSP) glasses, owing to their multi-anionic compositions and tunable network structures, offer a promising platform for next-generation broadband fiber amplifiers. In this work, a mixed-cation approach employing K + and Ba 2+ is employed to manipulate the local structural environment and enhance glass-forming ability, lifetime (8.7–9.22 ms for Er-doped, ∼10 ms for Er 3 + /Yb 3+ co-doped), emission cross-section (0.59-0.70 × 10 − 20 cm 2 ), energy transfer efficiency (∼85 %), and thermal quenching resistance. Despite their similar sizes and electronegativities, K + and Ba 2+ exhibit contrasting field strengths and polarizabilities, enabling a controlled balance between network connectivity and local disorder. Thermodynamic modeling and experimental results confirm that the introduction of mixed cations significantly broadens the glass-forming region. The addition of AlF 3 further strengthens the network, allowing for the preparation of stable K/Ba-FSP glasses with improved mechanical, thermal, and chemical properties. Spectroscopic analysis reveals a substantial enhancement in L-band emission efficiency and gain characteristics, with performance improvements ranging from 30 % to 150 % over conventional glass hosts. These findings position K/Ba-FSP glasses as a robust and high-performance candidate material system for broadband rare-earth-doped fiber amplifiers and lasers.
研究领域:
材料科学
·
光学工程
·
无机非金属材料
·
光通信
·
激光技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）