CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Linze Jin,Xu Han,Junxiu Piao,Yuhui Meng,Xiaoran Yang,Lifu Zhang,Zitian Zhang,Chengming Jiang,Sheng Bi
In recent years, smart shape memory materials have garnered significant attention for their potential applications in flexible electronics. However, the exploration of wood, a natural polymer with shape memory capabilities, has been limited, particularly concerning its editable and controllable memory shapes and moveable functions. This study presents a shape memory wood actuator (SMWA) with dual activation capabilities through water and heat. The SMWA is developed by connecting the treated wood with PDMS and LCE for consecutive gesture programming. The controlled contraction of LCE upon thermal activation, combined with strength changes due to reversible hydrogen bonding in the cellulose amorphous region during water activation, enables the SMWA to exhibit continuous shape memory capabilities and programmability. Additionally, the SMWA demonstrates satisfactory mechanical performance (tensile strength of 17.3 MPa when dry and 4.4 MPa when wet) and shape recovery capabilities (over 80 % shape recovery). Notably, the rigidity/flexibility change of SMWA under water-activated conditions, coupled with heat-activated posture control and memory through built-in circuits, allows for practical applications such as object grasping. Such efficient strategy offers a guideline for developing high- performance smart wooden shape memory materials, with promising prospects for applications in soft robotics, flexible sensors and oil–water separation.
研究领域:
材料科学
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智能材料
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生物材料
✓ 已验证
产品关联
DOI
高影响因子
NATURE STRUCTURAL & MOLECULAR BIOLOGY
·
2025
·
IF 10.1
Chen Xiaoying,Yuan Licheng,Wen Han,Ma Qingxia,Deng Zhenfeng,Xu Yongan,Yao Zhihao,Wang Yunfei,Yang Shilong,Su Nannan,Yang Fan
Broad-range thermal receptor 1 (BRTNaC1), activated by heat at low extracellular pH, was recently identified in myriapods. Although the overexpression of BRTNaC1 leads to robust heat-activated current with a cation selectivity profile, the structure of this receptor and how it is gated by proton and heat remain to be investigated. Here we determine cryogenic electron microscopy structures of BRTNaC1 in the apo, proton-induced and heated states. Based on these structures, patch-clamp recordings and molecular dynamic simulations, we found that a ‘twist the wrist’ mechanism is used for proton activation of BRTNaC1, while heat induces broad conformational changes in BRTNaC1, including rotation and shift in the transmembrane helices to open this channel. Moreover, as testosterone inhibited BRTNaC1 activation, we identified four clustered residues important for such inhibition. Therefore, our study has established the structural basis for ligand and temperature gating in the BRTNaC1 ion channel.
研究领域:
神经科学
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结构生物学
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离子通道研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Xiaodong Zhu,Zhen Tian,Hui Wang,Xiaonan Wang,Yifu Zhang,Yang Wang,Hui Li,Xin Bao,Xi Yuan
Carbon dot (CD)-based long-afterglow luminescent materials have attracted widespread attention owing to their unique luminescent properties, eco-friendliness, and extensive application prospects. However, the development of visible light-activated long-lived afterglow based on CD materials remains considerably challenging. Herein, a CD-based composite (Cl-CD@BA) with visible light-activated afterglow was synthesized via thermal treatment of Cl-CD and boric acid (BA). The Cl-CD@BA composite demonstrated room-temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) dual-mode afterglow emission. Notably, a green TADF emission peak at 525 nm (with 193 ms) could be observed by the naked eye for over 6 s after the composite was excited by white light from a mobile phone flashlight. Furthermore, a concept of information encryption using the Cl-CD@BA composite was proposed through inkjet printing technology, indicating the considerable potential of CD-based afterglow materials in advanced information encryption applications.
研究领域:
材料科学
·
光学
·
信息加密技术
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Xian Sun,Yanqing Xie,Xiyang Zhang,Jiebing Song,Yuping Wu
The potential risks of per- and polyfluoroalkyl substance (PFAS) accumulation in nearshore dolphins are not well understood. Here, transcriptional activities of 12 PFAS on peroxisome proliferator-activated receptors (PPAR-α, -β/δ, and -γ) in Indo-Pacific humpback dolphins (Sousa chinensis) were evaluated. All PFAS activated scPPAR-α in a dose-dependent manner. PFHpA exhibited the highest induction equivalency factors (IEFs). The order of IEFs for other PFAS was as follows: PFOA > PFNA > PFHxA > PFPeA > PFHxS > PFBA > PFOS > PFBuS ≈ PFDA ≫ PFUnDA and PFDoDA (not activated). The total induction equivalents (∑IEQs, 5537 ng/g wet weight) indicated that more attention should be paid to investigating contamination levels in dolphins, especially in PFOS (82.8% contribution to the ∑IEQs). The scPPAR-β/δ and -γ were not affected by any PFAS, except for PFOS, PFNA, and PFDA. Furthermore, PFNA and PFDA could induce higher PPAR-β/δ and PPAR-γ-mediated transcriptional activities than PFOA. Compared to human beings, PFAS might be more potent PPAR-α activators in humpback dolphins, suggesting that the dolphins may be more susceptible to the adverse effects of PFAS. Our results may be instructive for understanding the impacts of PFAS on marine mammal health due to the identical PPAR ligand-binding domain.
研究领域:
环境科学
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毒理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2016
·
IF 5.583
Xuelian Huang,Rui Wang,Ting Lu,Dongxu Zhou,Weifeng Zhao,Shudong Sun,Changsheng Zhao
The aim of this study was to create heparin-like chitosan hydrogels (HLCHs) for blood purification. Herein, we prepared two heparin-like chitosans (HLCSs) with various carboxymethyl and sulfate groups, followed by a cross-linking reaction with glutaraldehyde. The synthetic chitosan derivatives were characterized by X-ray photoelectron spectroscopy, gel permeation chromatography, FTIR and NMR. The average sulfonation degrees of two HLCSs were 0.69 and 0.94 per sugar unit, respectively. The swelling ratio of the HLCH could reach up to 4800%, and the HLCHs remained a well-defined shape and stable below 170 °C. Moreover, the activated partial thromboplastin time and thrombin time results indicated that both of the HLCSs and their hydrogels exhibited excellent thrombus inhibition property. Furthermore, the contact activation and complement activation results also proved that the hydrogels possessed good blood compatibility and had the potential to be used as blood-contacting materials.
研究领域:
生物材料
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生物医学工程
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血液学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Xingyu Gao,Zixia Hu,Yang Wang,Guode Zhao,Yan Shen,Hao Zhou,Yufen Liao,Weiwei Li,Ying Peng,Jiang Zheng
Gramine (GRM), which occurs in Gramineae plants, has been developed to be a biological insecticide. Exposure to GRM was reported to induce elevations of serum ALT and AST in rats, but the mechanisms of the observed hepatotoxicity have not been elucidated. The present study aimed to identify reactive metabolites that potentially participate in the toxicity. In rat liver microsomal incubations fortified with glutathione or N-acetylcysteine, one oxidative metabolite (M1), one glutathione conjugate (M2), and one N-acetylcysteine conjugate (M3) were detected after exposure to GRM. The corresponding conjugates were detected in the bile and urine of rats after GRM administration. CYP3A was the main enzyme mediating the metabolic activation of GRM. The detected GSH and NAC conjugates suggest that GRM was metabolized to a quinone imine intermediate. Both GRM and M1 showed significant toxicity to rat primary hepatocytes.
研究领域:
毒理学
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药理学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Optical Materials Express
·
2018
·Vol. 8
·期 6
·1425-1434
·
IF 2.566
Cong Pan,Jun-Cheng Zhang,Min Zhang,Xu Yan,Hong-Di Zhang,Yun-Ze Long,Xin-Yuan Sun,Hai-Tao Jiang
Isomorphic materials tend to exhibit differentiated performance due to the small differences between the constituent atoms and the crystal structures. Inspired by the isomorphic strategy, herein we developed a novel trap-controlled mechanoluminescent (TC-ML) material, Pr3+-activated Sr2Nb2O7, that shows mechanoluminescence (ML) under the mechanical actions of compression and friction. Compared to the isomorphic Ca2Nb2O7:Pr3+ which requires a long-time delay to achieve high-contrast ML due to the strong long-lasting afterglow, Sr2Nb2O7:Pr3+ enables the obtaining of high-contrast ML in a short-time delay because of the weak short-lasting afterglow, which greatly simplifies the imaging process to facilitate the further application of ML. The investigations of structural and optical characteristics between Sr2Nb2O7:Pr3+ and Ca2Nb2O7:Pr3+ reveal that the unique ML of Sr2Nb2O7:Pr3+ should result from its lower trap concentration and shallower trap depth relative to Ca2Nb2O7:Pr3+. Our results are expected to deepen our understanding on the behavioral diversity of isomorphic phosphors and thereby broaden the horizon of designing and regulating TC-ML materials.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
CHEMICAL RESEARCH IN TOXICOLOGY
·
2022
·
IF 3.973
Jiaru Li,Junzu Shi,Chenyang Jia,Wei Li,Ying Peng,Jiang Zheng
Propafenone (PPF) is a class IC antidysrhythmic drug, which is commonly used for the treatment of atrial fibrillation and other supraventricular arrhythmias. It is also a β-adrenoceptor antagonist that can cause bradycardia and bronchospasm. Hepatotoxicity is one of the adverse reactions reported, with clinical manifestations including acute cholestasis and hepatocyte necrosis. However, the mechanism of PPF-induced hepatotoxicity remains unclear. The present study was conducted to identify reactive metabolite(s) to determine related metabolic pathways and define the possible association of the bioactivation with PPF cytotoxicity. An O-demethylation phase I metabolite (M1), a further position C5 hydroxylation (para-position of the benzene ring) metabolite (M2), glutathione (GSH) conjugates (M3 and M4), and N-acetylcysteine (NAC) conjugates (M5 and M6) were detected in rat liver microsomal incubations containing PPF and GSH or NAC as trapping agents. The corresponding GSH conjugates and NAC conjugates were found in the bile and urine of rats after PPF administration, respectively. The observed GSH and NAC conjugates indicate that a quinone metabolite was generated in vitro and in vivo. Recombinant P450 enzyme incubations showed that CYP2D6 was the principal enzyme catalyzing this metabolic activation. Quinidine, a selective inhibitor of CYP2D6, attenuated the susceptibility of hepatocytes to the cytotoxicity of PPF. The results suggest that PPF was metabolized to a p-quinone intermediate which may be involved in PPF-induced hepatotoxicity.
研究领域:
药理学
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毒理学
·
临床医学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 13
·5176
·
IF 4.6
Dongrong Cheng,Xiaofeng Wei,Yanting Zhang,Qian Zhang,Jianwei Xu,Jiaxin Yang,Junjie Yu,Antony Stalin,Huan Liu,Jintao Wang,Dian Zhong,Lanying Pan,Wei Zhao,Yuan Chen
Erythromycin is one of the few compounds that remarkably increase ether-a-go-go-related gene (hERG) inhibition from room temperature (RT) to physiological temperature (PT). Understanding how erythromycin inhibits the hERG could help us to decide which compounds are needed for further studies. The whole-cell patch clamp technique was used to investigate the effects of erythromycin on hERG channels at different temperatures. While erythromycin caused a concentration-dependent inhibition of cardiac hERG channels, it also shifted the steady-state activation and steady-state inactivation of the channel to the left and significantly accelerated the onset of inactivation at both temperatures, although temperature itself caused a profound change in the dynamics of hERG channels. Our data also suggest that the binding pattern to S6 of the channels changes at PT. In contrast, cisapride, a well-known hERG blocker whose inhibition is not affected by temperature, does not change its critical binding sites after the temperature is raised to PT. Our data suggest that erythromycin is unique and that the shift in hERG inhibition may not apply to other compounds.Keywords:erythromycin;temperature;hERG;steady-state activation;steady-state inactivation
研究领域:
药理学
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心脏病学
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生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Water
·
2023
·Vol. 15
·期 15
·2856
·
IF 3.4
Jing Wang,Huanyu Zhou,Li Ma,Quanfeng Wang,Da Sun,Libo Jin,Guoming Zeng,Jujiao Zhao
Peroxymonosulfate (PMS) activation has gained increasing attention for its water remediation. In this work, carbon nanotube-supported FeCo2O4nanoparticles (FeCo2O4/CNT) were prepared and showed tremendous potential as a catalyst for PMS activation. The synergistic effect between FeCo2O4and CNT in FeCo2O4/CNT promotes its better catalytic performance than individual CNT or FeCo2O4. The synthesized FeCo2O4/CNT could reach 100% phenol removal with akvalue of 0.30 min−1within 15 min ([PMS] = 0.3 g L−1, [FeCo2O4/CNT] = 0.3 g L−1). FeCo2O4/CNT can adapt well to a wide pH range (4–9) and a complex water component (with inorganic ions or organic matter). Moreover, the catalytic mechanism investigation suggested that both radical and non-radical pathways are accountable for the efficient removal of phenol.Keywords:peroxymonosulfate;FeCo2O4/CNT;phenol removal
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2017
·Vol. 29
·期 2
·835-842
·
IF 1.907
Shengqiang Nie,Hui Qin,Lulu Li,Chunmei Zhang,Wei Yan,Yuan Liu,Jun Luo,Ping Chen
In this study, the influence of variations in chain length of polyvinylpyrrolidone (PVP) brushes on the blood compatibility of silicon wafer surfaces to which they were chemically attached was studied. Si surfaces were functionalized with various lengths of PVP brush using atom transfer radical polymerization technology and confirmed by elliptical polarized light, atom force microscopy, and X-ray photoelectron spectroscopy. The blood compatibility of these biointerfaces were systematically investigated by measuring protein adsorption, clotting time, platelet adhesion, contact activation, and complement activation. The results indicate that the hemocompatibility of the surfaces was highly related to PVP brush chain length and hydrophilicity of the surfaces. Our results contribute to rational biointerface design for specific biomedical applications. The results reveal that the PVP brushes with a long chain length have great potential for blood contacting applications due to their reduced protein absorption and cell activation following its contact with blood.
研究领域:
生物医学工程
·
材料科学
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
Sustainable Chemistry and Pharmacy
·
2025
·
IF 5.8
Mingzhu Guo,Yuewen Shao,Shu Zhang,Xun Hu
Fungi are an important category of biomass resource, which is carbonaceous and could be potential precursors for production of activated carbon (AC). Nonetheless, distinct composition of fungi from woody biomasses might produce AC of different pore characteristics. Herein, two common fungal species, white jade fungus (WJF) and mushrooms, were activated with K 2 C 2 O 4 , ZnCl 2 or H 3 PO 4 . The resulting ACs were analyzed by using a range of characterization techniques and their performances for adsorption of Cr (VI) were measured. The results indicated that K 2 C 2 O 4 facilitated cracking of aliphatic structures in WJF, diminishing AC production (25.9%) but enhancing formation of micropores (97.9% and 1108.6 m 2 g −1 ). Higher content of unstable organics in mushrooms further lowered AC yield (18.7%) but led to higher specific surface area (1417.2 m 2 g −1 ) with K 2 C 2 O 4 as an activator. ZnCl 2 promoted condensation to generate more AC (44.9%) with abundant mesopores (56.1%) from WJF. Except condensation, Maillard reactions catalyzed by ZnCl 2 retained nitrogen species in AC while cracking with K 2 C 2 O 4 transferred them into bio-oil. Although H 3 PO 4 catalyzed condensation, it could not facilitate pore development. In-situ IR characterization of activation showed that K 2 C 2 O 4 hindered aromatization while ZnCl 2 facilitated elimination of –OH and C O on nascent AC. This activated outer/inner surface of nascent AC, inducing structural re-construction and forming bulky particles of very densified structures.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）