Gels
·
2023
·Vol. 9
·期 9
·712
·
IF 4.6
Kairui Duan,Nabila Mehwish,Mengdie Xu,Hu Zhu,Jiajun Hu,Mian Lin,Lu Yu,Bae Hoon Lee
The development of autoclavable hydrogels has been driven by the need for materials that can withstand the rigors of sterilization without compromising their properties or functionality. Many conventional hydrogels cannot withstand autoclave treatment owing to the breakdown of their composition or structure under the high-temperature and high-pressure environment of autoclaving. Here, the effect of autoclaving on the physical, mechanical, and biological properties of bovine serum albumin methacryloyl (BSAMA) cryogels at three protein concentrations (3, 5, and 10%) was extensively studied. We found that BSAMA cryogels at three concentrations remained little changed after autoclaving in terms of gross shape, pore structure, and protein secondary structure. Young’s modulus of autoclaved BSAMA cryogels (BSAMAA) at low concentrations (3 and 5%) was similar to that of BSAMA cryogels, whereas 10% BSAMAAexhibited a higher Young’s modulus value, compared with 10% BSAMA. Interestingly, BSAMAAcryogels prolonged degradation. Importantly, cell viability, drug release, and hemolytic behaviors were found to be similar among the pre- and post-autoclaved cryogels. Above all, autoclaving proved to be more effective in sterilizing BSAMA cryogels from bacteria contamination than UV and ethanol treatments. Thus, autoclavable BSAMA cryogels with uncompromising properties would be useful for biomedical applications.Keywords:autoclavable;hydrogel;cryogel;BSAMA;sterilization
研究领域:
生物材料学
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医学工程
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DOI
PubMed
高影响因子
Nano Energy
·
2023
·
IF 17.6
Haotian Li,Ning Li,Yiyan Yang,Linjun Zhang,Wanjie Bai,Xueqian Zhang,Yuanting Xu,Yiwen Li
Surgical masks are crucial personal protective equipment to prevent and suppress the transmission of highly infectious viruses, especially suffered from some pandemic outbreaks. However, due to the lack of sterilization functions, the long-term reused masks become the hotbed of microorganisms and further cause additional damages to human health. Furthermore, it is desirable to endow multifunctionalities to the masks, such as self-powered real-time respiratory monitoring to forecast breath-related diseases. Although many efforts have been made towards those requirements, the complicated surface engineering process and involved extra weight of these mask still brought adverse effects in high respiratory resistance and poor wearing comfortability. In this work, we reported a facile fabrication strategy towards multifunctional masks based on the surface modification of melt-blown cloth by two kinds of bioinspired coatings. After sequentially performed mussel-inspired polydopamine coating and metal-phenolic network (Fe 3+ and gallic acid) coatings, the obtained masks not only maintained the features of light, flexibility, breathability and filterability , but also realized the self-sterilization under the sunlight irradiation, thus allowing the facile reutilization for many times. Moreover, benefiting from the wet electricity generated by carboxyl group of gallic acid, the modified mask could effectively monitor the different respiratory status in real time. It was anticipated that this work can provide a new strategy towards the multifunctional integration of next-generation masks.
研究领域:
材料科学
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医学工程
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生物学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2017
·
IF 3.671
Chen Bao,Hongliang Zeng,Yi Zhang,Longtao Zhang,Xu Lu,Zebin Guo,Song Miao,Baodong Zheng
In order to investigate the effects of different preparation methods on Semen coicis resistant starch, the structural properties and prebiotic effects of autoclaving treatment–purified S. coicis resistant starch (GP-SRS3), ultrasonic-autoclaving treatment–purified S. coicis resistant starch (UP-SRS3), enzyme-autoclaving treatment–purified S. coicis resistant starch (EP-SRS3) and microwave-moisture treatment–purified S. coicis resistant starch (MP-SRS3) were studied compared to high-amylose maize starch (HAMS). Fourier transform infrared spectroscopy and Solid-state 13 C NMR spectroscopy showed all of SRS3 displayed B-type crystallite structure, furthermore, MP-SRS3 and UP-SRS3 showed higher degree of ordered structure and degree of double helical structure compared to other samples. Field emission scanning electron microscopy showed MP-SRS3 displayed deeply layered strips and UP-SRS3 exhibited some cavities. Moreover, S. coicis resistant starch could promote the growth of Bifidobacteria adolescentis better compared to high-amylose maize starch, among these samples. MP-SRS3 exhibited best prebiotic effect, which was possible attributed to its rough surface and double helix structure. B. adolescentis displayed a higher survival rate to the simulated gastrointestinal tract environment in SRS3 medium than that in high-amylose maize starch medium, especially MP-SRS3 and UP-SRS3, which partly contributed to its strips and cavities. Overall, MP-SRS3 could be regarded as a potential prebiotic to promote the growth of B. adolescentis for its structural trait.
研究领域:
食品科学
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营养学
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微生物学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Peng Zhu,Dongze Niu,Sainan Zhang,Chunyu Li,Dongmin Yin,Junqiang Zhi,Lili Zhang,Xingmei Jiang,Jianjun Ren
This study aimed to examine the effects of sterilization methods on the degradation ability and bioactive compound production of Irpex lacteus in wheat straw. Following 28 days of fermentation, the lignin content of samples autoclaved and pasteurized at pH 4.5 was reduced by 16.0 % − 21.7 % compared to pasteurized samples without pH adjustment, accompanied by a significant increase in sugar yield ranging from 83.30 % − 96.35 %. Autoclaved samples exhibited the lowest total phenol content and antioxidant activity ( P < 0.05). Bacillus occupied an absolute advantage (89.1 %) in samples pasteurized at pH 4.5, whereas 10 bacterial genera exhibited abundances above 1 % in pasteurized samples without pH adjustment. Furthermore, 45.1 % − 47.2 % of the metabolites comprised lipids and lipid-like molecules, and some of them were improved by pasteurization at pH 4.5. Overall, pasteurization at acidic conditions is an effective sterilization method for the fungal conversion of wheat straw.
研究领域:
生物技术
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微生物学
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生物化学
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农业科学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Bingquan Chen,Xiao-Wen Gu,Liyun Zhong,Enyu Wu,Bin Li
The development of efficient and long-duration antimicrobial agents remains an important and challenging goal for public health safety. Current silver-containing antimicrobials commonly suffer from the limited silver (Ag) content or uncontrolled release of Ag + ions, leading to restricted bactericidal activity and duration. Herein, we report an example of chelating Ag(I) into a highly stable and scalable aluminum-based MOF (Ag + @MOF-303) for achieving highly efficient sterilization. Due to the edge-to-edge arrangement of pyrazole rings with a short N − N distance of 3.4 Å, Ag + ions can be precisely chelated into the MOF-303 framework with a controlled amount of 0.28 g Ag g MOF −1 . The resulting material Ag + @MOF-303 was thoroughly characterized by powder X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy. Bactericidal activity experiments revealed that Ag + @MOF-303 can efficiently inhibit a wide range of bacteria, with a minimal inhibitory concentration of 31.25 μg mL −1 and a minimum bactericidal concentration of 62.5 μg mL −1 against the Gram-negative strain Escherichia coli , corresponding to silver content of 8.75 and 17.5 μg mL −1 , respectively. The controlled Ag + release from Ag + @MOF-303 was monitored to show a gradual release of 26.1 % of its total silver content over 7 days. Benefiting from its highly stable framework, this material after sterilization could be easily regenerated by the re-metalation of Ag + ions into MOF-303, indicating its unique reutilization and sustainability for sterilization applications.
研究领域:
材料科学
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纳米技术
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无机化学
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生物医学工程
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环境卫生
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产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Yi Zhao,Xiufang Bi,Chunlei Ni,Ruifeng Ying,Khizar Hayat,Meigui Huang
This research utilized a laser particle size distribution analyzer, stability analyzer, atomic force microscope, fluorescence spectrophotometer, and ultra – performance liquid chromatography - mass spectrometry instrument to compare the impacts of pasteurization (PAST), ultra - high temperature instantaneous (UHT) sterilization, and ultra - high pressure (UHP) sterilization on the structure and stability of yak milk fat globules (MFGs). The findings indicated that all three sterilization methods led to a reduction in the diameter of fat globules and damaged the edge structure of the milk fat globule membrane (MFGM). Nevertheless, the stability was enhanced through the reduction of Young's modulus and micropolarity of the MFGM, with UHT milk fat globules exhibiting the highest stability. Lipidomic analysis revealed a decrease in the phospholipid content in UHT milk and UHP milk, whereas the phospholipid content in PAST milk increased. Therefore, the yak milk system after UHT sterilization is the most stable. These data can contribute to the improvement of the quality of yak milk products and facilitate the further development and utilization of yak milk resources.
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DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2016
·Vol. 97
·期 5
·1459-1466
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IF 2.076
Qixing Nie,Lei Feng,Jielun Hu,Sunan Wang,Haihong Chen,Xiaojun Huang,Shaoping Nie,Tao Xiong,Mingyong Xie
BACKGROUND Blueberry products have various health benefits due to their high content of dietary anthocyanins. The aim of this study was to investigate the impact of fermentation and sterilization on total anthocyanin content, composition and some quality attributes of blueberry puree. The blueberry puree used here was fermented for 40 h at 37 °C by Lactobacillus after sterilization. The method of ultra-performance liquid chromatography–mass spectrometry was optimized for the rapid analysis of anthocyanins. Quality attributes including pH, color, total soluble solids and viscosity were measured. RESULTS A total of 21 anthocyanins and five anthocyanidins were quantified by ultra-performance liquid chromatography. Fermented blueberry had reduced total anthocyanin content (29%) and levels of individual anthocyanins compared with fresh blueberry. Total anthocyanin content was decreased 46% by sterilization, and different degradation behavior of individual anthocyanin was appeared between fermented and sterilized–fermented blueberry puree. Fermentation and sterilization decreased the total soluble solids and pH and changed color parameters, while minimally influencing viscosity. CONCLUSIONS The loss of total anthocyanin content by fermentation was related to the unstable structure of blueberry anthocyanins. Anthocyanins are sensitive to temperature (>80 °C), and degradation of anthocyanins by sterilization in blueberry should be considered in the fermentation procedure. © 2016 Society of Chemical Industry
研究领域:
食品科学
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植物化学
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PubMed
高影响因子
Nano Materials Science
·
2024
·
IF 12.6
Hua-Jie Wang,Hao Peng,Wen-Hao Ji,Jia-Xin Wang,Xiao-Yan Du,Wen Song,Wen Zhang,Fazli Wahid,Ali Raza
Face masks play a pivotal role in preventing infection transmission. However, the capture of infection-sourced particles in face masks poses challenges related to reuse, necessitating proper disposal. We developed a self-sterilizable polypropylene-based membrane for face masks to address challenges associated with infection transmission prevention. The membrane, created using 3D printing, underwent functionalization with zinc oxide (ZnO) and polydopamine (PDA)-TEMPO to achieve broad-spectrum light absorption and facilitate self-sterilization through photocatalytic and photothermal effects upon light exposure. The hydrophobic surface (water contact angle: 133 ± 2°) minimized moisture accumulation, and the membrane exhibited robust mechanical properties, including shear strength (1.25 ± 0.5 kPa) and peel resistance strength (112.8 ± 11.2 kPa). The evaluation demonstrated stability in airflow (0–500 cm 3 /s) and excellent aerosol filtration efficiency (94.8 ± 0.6 %) for particles (PM 0.3, PM 2.5, PM 10), comparable to commercial masks. The membrane showed antibacterial efficacy over five uses in a simulated respiratory environment. Safety assessments confirmed biocompatibility through cytocompatibility and skin irritation assays. In conclusion, this membrane offers efficient filtration and photo-triggered sterilization, presenting a promising solution for next-generation face masks to address concerns related to reuse, disposal, and infection control.
研究领域:
材料科学
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纳米技术
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生物医学工程
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环境科学
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产品关联
DOI
高影响因子
Small
·
2021
·Vol. 18
·期 2
·2105570
·
IF 13.281
Jian Xiong,Ailin Li,Ye Liu,Liming Wang,Xiaohong Qin,Jianyong Yu
Airborne particulate matter (PM) pollutants, especially with nanoscale size, have caused serious public health issues. The global demand for high-performance and recyclable face masks is increasing dramatically, especially during the COVID-19 pandemic. However, present masks suffer from low-efficiency interception of PM 0.3 /pathogen, limited air permeability, and incapacity to reuse and recycle. Here, multi-scale nanoarchitectured nanofiber/carbon nanotube (NF/CNT) networks are constructed by a needleless-electrospinning/spraying-netting strategy, enabling well-dispersed CNT networks (diameter ≈ 25 nm) welded on charged nanofibrous scaffolds (diameter > 100 nm) layer by layer. The optimized NF/CNT networks possess a fluffy structure with narrow-distribution small pores (size ≈ 400 nm), “free molecular flow” behavior, and electrostatic adsorption property, thereby exhibiting high filtration efficiency ( > 99.994% PM 0.3 removal) and low resistance ( < 0.05% atmosphere pressure). Furthermore, they demonstrate reliable and ultra-fast photothermal-driven self-sterilization ( > 99.986% in 5 min) under 1 sun and electrothermal-driven self-sterilization ( > 99.9999% in 2 min) in sunless scenes owing to their unique nanoarchitecture. Most importantly, the abandoned NF/CNT filters can be fully recycled as high-performance solar vapor generators to desalinate seawater (3.56 L m −2 d −1 ). This work offers a fascinating solution to reduce disease transmission, resource consumption, and environmental burdens.
研究领域:
材料科学
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纳米技术
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环境工程
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生物医学工程
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可持续技术
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DOI
PubMed
高影响因子
JOURNAL OF FOOD SCIENCE
·
2021
·Vol. 86
·期 8
·3550-3562
·
IF 3.167
Ying Cai,Jingwei Guan,Wen Wang,Li Wang,Jianyu Su,Liming Fang
Food packaging materials, especially biodegradable polymer composites incorporated with natural antimicrobial agents with excellent antibacterial activities, are in high demand and attracted immense attention. Herein, a polycaprolactone/curcumin@zeolitic imidazolate framework-8 (PCL/Cur@ZIF-8) composite film with enhanced antibacterial activity was developed. Curcumin, a natural photosensitizer, was loaded in the highly porous nanocrystals ZIF-8 to improve its poor water solubility and stability. The integral structure of Cur@ZIF-8 was maintained well in the PCL matrix even at the highest loading of 35% (w/w), and all composite films had good light transmittance at 420–430 nm. The PCL/Cur@ZIF-8 composite films responded to the acidic growth environment of bacteria by releasing zinc ions and curcumin molecules. Furthermore, upon blue light irradiation (420–430 nm, 2.2 mW/cm 2 ), curcumin molecules generated singlet oxygen. With the synergistic effects of zinc ions and singlet oxygen, the composite films exhibited a 99.9% reduction of Escherichia coli and Staphylococcus aureus strains when the amount of Cur@ZIF-8 loading was more than 15% (w/w), as well as a strong anti-adhesion effect on bacteria. Moreover, bacterial resuscitation tests indicated that the composite films exhibited 99.9% reduction in the adhered bacteria population through treatment with photodynamic sterilization. This is the first study presenting that the incorporated curcumin ZIF-8 nanoparticles in the matrix of polymer are pH and light responsive for anti-adhesion of bacteria, which is of great potential application as antibacterial packaging material for the food industry. Practical Application A novel, biodegradable, pH, and light-responsive composite film was developed for antibacterial activity. Natural photosensitizer curcumin was encapsulated in ZIF-8 nanocrystals (Cur@ZIF-8) as the antimicrobial agent. With the synergistic effects of Zn 2+ and singlet oxygen, the composite film exhibited a 99.9% reduction of Escherichia coli and Staphylococcus aureus strains, and a strong anti-adhesion property toward bacteria. This composite film is of great potential application as an antibacterial packaging material that enhances the shelf life of fruits, meat, and so on.
研究领域:
食品科学
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材料科学
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生物医学工程
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Liang Jiang,Xuanjin Zhu,Jiaqi Li,Jiang Shao,Yu Zhang,Jintuo Zhu,Shihang Li,Lina Zheng,Xiao-Peng Li,Shenghui Zhang,Heguo Li,Gan-Ji Zhong,Huan Xu
Biodegradable poly (lactic acid) (PLA) nanofibrous membranes (NFMs) are appealing to address the increasing air pollution and outbreak of epidemic diseases, as well as the drastic accumulation of plastic and microplastic pollutions. Central to the development of high-performance PLA membrane filters are the promotion of electroactivity, polarization and electret properties, which has been a roadblock toward efficient capturing of airborne particulate matters (PMs) and bacterial pathogens. Herein, we proposed a microwave-assisted synthetic approach to enable direct growth of ZIF-8 nanocrystals at carbon nanotubes (CNT@ZIF-8 nanohybrids), which were spontaneously embedded into PLA nanofibers by a combined electrospinning–electrospray technology. With uniform and affinitive anchoring of CNT@ZIF-8 (8, 10 and 12 wt%), the PLA NFMs were characterized by largely increased surface potential (up to 1.78 kV), nearly doubled dielectric constant, and excellent triboelectric properties (output voltage of 12.7 V at 10 N, 0.5 Hz). The highly electroactive PLA/CNT@ZIF-8 NFMs exhibited excellent air filtration properties (98.7 % and 99.8 % removal of PM 0.3 and PM 2.5 , 206.9 Pa) even at the highest airflow capacity of 85 L/min, in clear contrast to the pure PLA counterpart (81.2 % and 84.1 %, 465.2 Pa). This was accompanied by 100 % perfect inhibition of both E. coli and S. aureus regardless of the CNT@ZIF-8 loadings, arising mainly from the elevated surface activity, facilitated generation of reactive oxygen species, and gradual release of zinc ions. Moreover, remarkable photothermal properties were demonstrated by temperature elevation of nearly 16 °C under near-infrared irradiation for only 20 s. The proposed methodology affords an exceptional combination of excellent air filtration, self-sterilization and photothermal properties, which may motivate development of ecofriendly and functional protective membranes for personal healthcare.
研究领域:
材料科学
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环境科学
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生物医学工程
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产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Chenglin Zhang,Jiangpeng Li,Qiuchen He,Ziming Zhao,Wenjun Jiang,Su Zhan,Feng Zhou
Deactivating the concentration of marine microorganisms is suitable and proper for ballast water treatment. In here, a promising strategy has been presented to create massive oxygen vacancies synergistic with metallic Bi nanoparticles on ZnWO4 for inactivating marine bacteria in seawater, demonstrating that the paramount incorporation of metallic Bi nanoparticles and 2BZWO (Bi/ZnWO4) samples exhibits superior photocatalytic sterilization, in which the sterilization efficiency of 2BZWO is 2.83 times that of pure ZnWO4. The co-incorporation of metallic Bi nanoparticles and oxygen vacancies significantly enhanced the absorption of visible light and enrichment of the photogenerated electrons, promoting the separation of charge carriers. Moreover, first-principles calculations demonstrate that the coeffect of metallic Bi nanoparticles and oxygen vacancies guided the reconfiguration of the active sites and electrons flowing direction. Results from this study provide a creative strategy on controllable Bi/ZnWO4 synthesis to manipulate the photocatalytic inactivation of marine bacteria.
研究领域:
环境科学
·
微生物学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）