Journal of Materials Chemistry C
·
2019
·Vol. 8
·期 1
·132-138
·
IF 6.641
Rui Wang,Qing Wu,Xiantao Jiang,Taojian Fan,Jia Guo,Cong Wang,Feng Zhang,Yali Gao,Meng Zhang,Zhengqian Luo,Han Zhang
Two-dimensional (2D) InSe has recently attracted increasing attention due to its outstanding electrical transport property, excellent photo-response, and direct band gap characteristics. In this contribution, few-layer InSe was successfully fabricated via a facile liquid phase exfoliation (LPE) method. Compared with other 2D materials, the photothermal response measurements demonstrate that InSe has excellent photothermal conversion efficacy. A novel Vernier-cascaded photothermal fiber sensor with high sensitivity that takes advantage of the photothermal effect of few-layer InSe has been proposed and demonstrated for the first time. The experimental results have shown that the photothermal optical sensitivity and spectral shifts of the MZI (Mach–Zehnder interferometer)–MKR (microfiber knot ring) Vernier sensor and the Vernier part are 0.126 nm mW−1, 12.22 nm and 0.0047 nm mW−1, 0.49 nm, respectively. A maximum sensitivity amplification factor of ∼26.8 is realized. Our present work can provide more possibilities of 2D materials that can be utilized towards cascade sensors.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Zhihao Feng,Xiaoyi Li,Changxiang Fang,Junying Li,Rongfei Wang,Weihua Hu
Oblique-incidence reflectivity difference (OIRD) is a newly established method to monitor various surface processes and shows great prospect for real-time and label-free immunoassay , yet its sensitivity needs essential improvement to meet the requirement of practical applications. In this work, a label-free OIRD immunoassay biochip was developed with improved sensitivity by using standard glass slide coated with polystyrene (PS) microsphere monolayer as the substrate. The immunoassay sensitivity of this biochip was found to be greatly improved compared with the conventional biochip built on glass slide. Further on-chip ELISA and optical calculation suggests that the improvement is not only associated with high capture efficiency of this biochip towards its target, but is also benefited from the porous PS monolayer enhanced intrinsic OIRD sensitivity via optical interference enhancement and effective dielectric constant effect. This work may provide valuable insight into the development of high performance label-free OIRD bio-detection devices.
研究领域:
生物技术
·
光学检测
·
免疫学
✓ 已验证
DOI
高影响因子
SOLID STATE NUCLEAR MAGNETIC RESONANCE
·
2018
·
IF 2.674
Xiaobing Lou,Ming Shen,Chao Li,Qun Chen,Bingwen Hu
Many pharmaceutical samples have notably long 1 H T 1 (proton spin-lattice relaxation time), leading to lengthy experiments lasting several days in solid-state NMR studies. In this work, we propose the use of ball milling on the pharmaceutical samples to reduce the 1 H T 1 , which also leads to enhanced sensitivity in { 1 H}- 13 C Cross-Polarization (CP) experiments due to reduced particle sizes and increased surface areas of the samples. Experimentally, we determined that depending on the substrates and milling time, the signal-to-noise ratio (S/N) of a 1D 13 C CP spectrum can be increased by a factor of 3–6, which means that the experimental time can be shortened by a factor of 9–36. Furthermore, the application of simple ball-milling within a short time avoids the amorphization of the studied samples such that no signal due to amorphous state is observed in the 13 C CP spectrum. This simple ball milling method used for sensitivity enhancement can be further applied in the SS-NMR studies of pharmaceutical samples.
研究领域:
药学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2016
·
IF 4.035
Wenjie Gao,Henghui Li,Yanyan Liu,Yuhong Liu,Xiaojun Feng,Bi-Feng Liu,Xin Liu
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become an important technology for glycan analysis due to its ease of operation, short analysis time and impurity tolerance. However, the low ionization efficiency of N-glycans led to the difficulty in analyzing glycans of low abundance in complex biological samples due to the lack of basic site for protonation. Therefore, highly sensitive method for the glycans analysis is in urgent demand. Here we report a new strategy to introduce a permanent charge at the reducing end of N-linked glycans by a one pot reaction , where glycosylamines that were obtained by rapid deglycosylation within 5 min were labeled with N-succinimidyloxycarbonylmethyl tris (2,4,6- trimethoxyphenyl) phosphonium bromide (TMPP-Ac-OSu). With TMPP-Ac labeling, more than 50 fold enhancement in the sensitivity of method was achieved for neutral glycans from ribonuclease B (RNase B) in comparison to their native counterparts. In combination with methylamidation of sialic acid residues, this novel developed strategy could also be used for sialylated glycans analysis from sialoglycoproteins and complex serum sample. As a result, more than 50 glycans were detected with only 25 nL human serum sample.
研究领域:
分析化学
·
生物化学
·
质谱分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemElectroChem
·
2015
·Vol. 3
·期 3
·480-486
·
IF 0
Weiliang Guo,Xingyu Lin,Fei Yan,Bin Su
Graphical Enhanced and antifouling bipolar ECL analysis : An indium tin oxide bipolar electrode modified by vertical silica mesochannels (SMCs) is prepared for ECL imaging analysis. The SMCs offer not only a significant enhancement effect on the Ru(bpy) 3 2+ ECL intensity but also the molecular sieving ability against surface biofouling. The sensor can be used for sensitive ECL analysis in real media, such as human blood serum. This paper describes a miniaturized bipolar electrode (BPE) sensor that is constructed with an indium tin oxide (ITO) microband and a slice of poly(dimethylsioxane) (PDMS). The ITO microband modified by vertically ordered silica mesochannels (SMCs) functions as the BPE. Owing to the uniform pore size of ≈2–3 nm in diameter and negatively charged surface, the SMCs can significantly accelerate the mass transport of positively charged species via strong electrostatic interactions. Thus, an increase of more than two orders of magnitude in sensitivity for tri- n -propylamine (TPrA) analysis was achieved for the electrochemluminescence (ECL) of tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) at a relatively low concentration (10 μ m ). Moreover, the SMC film with ultrasmall channels can effectively serve as an antifouling layer of the underlying ITO electrode to prevent the access of undesired large molecules, allowing the electrochemical detection in real complex media, such as atropine and l -proline in human blood serum.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
DOI
SENSORS
·
2024
·Vol. 24
·期 14
·4477
·
IF 3.4
Junyi Wang,Yanpei Xu,Yutong Song,Qi Wang
Hematite (α-Fe2O3) is widely used in sensor sensitization due to its excellent optical properties. In this study, we present a sensitivity-enhanced surface plasmon resonance alcohol sensor based on Fe2O3/Au. We describe the fabrication process of the sensor and characterize its structure. We conduct performance testing on sensors coated multiple times and use solutions with the same gradient of refractive indices as the sensing medium. Within the refractive index range of 1.3335–1.3635, the sensor that was coated twice achieved the highest sensitivity, reaching 2933.2 nm/RIU. This represents a 30.26% enhancement in sensitivity compared to a sensor with a pure gold monolayer film structure. Additionally, we demonstrated the application of this sensor in alcohol concentration detection by testing the alcohol content of common beverages, showing excellent agreement with theoretical values and highlighting the sensor’s potential in food testing.
研究领域:
传感器技术
·
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Liang Dong,Hanjiao Chen,Yongyan Ning,Yaowen He,Ying Yu,Ying Gao
Photochemical vapor generation (PVG) is emerging as an alternative sample introduction method in the field of atomic spectrometry. The addition of transition metals can largely improve the PVG yields of elements with the enhancement of 1.4 to 30 000-fold, based on previous reports. In this work, the use of vanadium species as novel “sensitizers” in PVG was first reported, tellurium (Te) was selected as the target. The efficient photochemical reduction of Te was observed in the presence of 9% (v/v) formic acid (FA), 20%(v/v) acetic acid (AA), and 40 mg L–1 of V(V) (existing as VO3–) with the conversion efficiency of 87 ± 3%. Under the selected conditions, there was no significant difference in analytical sensitivity between Te(IV) and Te(VI), making the direct detection of total Te possible. The limit of detection (LOD, 3σ) was 2.9 ng L–1 for Te with inductively coupled plasma mass spectrometry (ICP MS) measurement. Good precisions of 2.3% and 2.2% (relative standard deviations, RSD) for seven times replicate measurement of 0.5 μg L–1 Te(IV) and Te(VI) standard solutions were obtained. The sensitivity was enhanced about 55-fold compared to that using traditional direct solution nebulization. The method was applied for the determination of trace Te in three water samples and two certified reference materials of sediment with satisfactory results. The possible mechanism was investigated. The generation of volatile vanadium along with (CH3)2Te was found in PVG for the first time. The new findings in this work will be helpful for exploration of efficient “sensitizers” in PVG and further expanding the scope of elements amenable to PVG as well.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2024
·
IF 1.8
Yang Mingpeng,Cheng Jinghan,Zhao Xingqiang,Cai Jun,Zhou Wangping
In recent years, wearable sweat sensors have garnered significant attention for real-time monitoring of human physiological information because of their ability to continuously and non-invasively detect multiple sweat biomarkers. Among these, potentiometric sensors stand out for their low power consumption, low cost, compact design, and real-time monitoring capabilities, making them an ideal alternative for sweat analysis. However, enhancing the sensitivity of ion-selective electrodes (ISEs), a critical parameter of potentiometric sensors, remains a challenging research focus. In this work, the sensitivity of K + ISEs was significantly enhanced by doping two-dimensional nanoparticles graphitic carbon nitride (g-C₃N₄) into the ion-to-electron transducer of the electrode via electrodeposition. The calibration curve slope of the K + potentiometric sensors with doped g-C 3 N 4 reached 59.6 mV/dec, representing a 33% increase in sensitivity compared to the control sensor without g-C₃N₄. Furthermore, the developed sensors demonstrated excellent repeatability, and anti-interference capabilities. Finally, the feasibility of the prepared sensors was further validated in artificial sweat. The large specific surface area of g-C₃N₄ combined with the excellent conductivity of PEDOT: PSS, significantly improved the sensitivity of ISEs in this study. This innovative approach paves a new avenue for the application of two-dimensional materials in potentiometric sensors, potentially advancing the field of real-time sweat analysis. Graphical abstract
研究领域:
材料科学
·
生物医学工程
·
传感器技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xi Qin,Jiguang Han,Yingjun Chai,Bing Cao,Ankang Li,Haibo Zeng,Xiaoming Li
Organic–inorganic hybrid perovskites have been recognized as potential candidates in direct X-ray detectors and have triggered tremendous interest in the past years. The blade coating method meets the requirements of large area and low cost for perovskite X-ray detectors, while the low compactness resulting from solvent evaporation limits the charge collection efficiency (CCE) and device sensitivity. Most of the reports are focused on the melioration of perovskite films to increase device sensitivity; there are still problems of low CCE. Herein, we introduce an intercalation-electrode device structure and achieve a ∼20-fold sensitivity enhancement. Carrier distribution throughout the thick films is simulated, and the electrode intercalating site can be optimized according to the mobility-lifetime factor to achieve the highest CCE. A methylamine thiocyanate (MASCN) additive-assisted coating strategy is developed, and pinhole free thick films with regrown particles are obtained without frequently used hot/soft pressing. A sensitivity level of ∼105 μC Gyair–1 cm–2 as well as a detection limit of 77 nGyair s–1 is achieved under low bias, which is among the best performance for polycrystalline perovskite direct X-ray detectors. This work provides a universal device structure design to overcome carrier loss through a long transport distance and enhances the CCE for ultrahigh sensitivity.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2013
·Vol. 139
·期 5
·1016-1022
·
IF 3.969
Jiarun Tu,Wensheng Cai,Xueguang Shao
Enhancing the sensitivity of analytical methods by improving the signal quality is a universal goal in analytical chemistry. In analytical electrochemistry systems, the double layer charging current has been an obstacle to the accurate measurement of the faradaic current despite theoretical and experimental efforts. In this study, a method for sensitivity enhancement for potential step voltammetry is developed using chemometric resolution. Trilinear decomposition is used to extract the net faradaic current and double layer charging current directly from the data matrix of the decaying curves measured at different potentials. The feasibility of the method is proven using simulated data and further validated by two experimental datasets of diffusion and adsorption control reactions. Compared with the conventional approach that records the current data at a later pulse time, the voltammogram of the extracted net faradaic current is an ideal sigmoid curve with a horizontal baseline, even for the samples of very low concentration. More importantly, the analytical sensitivity can be greatly improved when the net faradaic current is used for quantitative determination.
研究领域:
分析化学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 18
·2703-2709
·
IF 1.9
Biao Ma,Song-Fang Xie,Lei Liu,Fang Fang,Zhi-Yong Wu
A crucial challenge in development of robust paper-based analytical devices (PADs) is the lack of sensitivity. Electrokinetic stacking is a kind of unique sample preconcentration for low-abundant charged species, which can be integrated to PADs to enhance the sensitivity. In this work, we bring new insights into the mechanism underlying an electrokinetic stacking technique based on a field amplified stacking (FAS) effect implemented on a simple paper fluidic channel. Here, we reveal that the acid–base titration reaction between the cations/anions in the background electrolyte (BGE) and the OH−/H+ ions from water electrolysis plays an essential role in the development of the electric field gradient. This was experimentally confirmed by changing the BGE type, monitoring the current variation and pH characterization. Based on the new knowledge, the paper-based FAS was successfully extended to stack cationic analytes. Eventually, a model protein of bovine hemoglobin (BHb) in its anion form was 150-fold stacked within 60 s. This work shows that the sensitivity of PADs can be greatly enhanced with effective use of this simple and low cost electrokinetic stacking technique.
研究领域:
分析化学
·
生物医学工程
·
电泳技术
✓ 已验证
产品关联
DOI
高影响因子
Nanophotonics
·
2019
·Vol. 9
·期 2
·327-336
·
IF 6.908
Yuting Zhao,Shuaiwen Gan,Leiming Wu,Jiaqi Zhu,Yuanjiang Xiang,Xiaoyu Dai
Germanium selenide (GeSe) nanosheets are stable and inexpensive and considered to have a great potential for photovoltaic applications, however we have demonstrated that GeSe nanosheets are also promising for sensing technology, in this paper. By spin-coating the GeSe nanosheets on the surface of noble metal (Au), we have obtained a surface plasmon resonance (SPR) sensor with significantly enhanced sensitivity, and the performance of the sensor is closely related to the thickness of the GeSe film. By detecting different refractive index solutions, we have obtained the optimized sensitivity with 3581.2 nm/RIU (which is nearly 80% improvement compared to traditional SPR sensors) and figure of merit with 14.37 RIU −1 . Moreover, the proposed SPR sensor was vastly superior in sensing Pb 2+ heavy metal ions after coating it with chitosan and GeSe composite. A maximum sensitivity of 30.38 nm/μg/l has been verified, which is nearly six times better than that of conventional SPR sensor. Our results demonstrated that GeSe nanosheets overlayer with modified SPR sensor has its great potential in heavy metal detection and chemical-specific molecular identification.
研究领域:
纳米技术
·
光学
·
传感器
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）