Nano-Micro Letters
·
2024
·Vol. 16
·期 1
·1-14
·
IF 31.6
Geng Yaqi,Chen Guoyin,Cao Ran,Dai Hongmei,Hu Zexu,Yu Senlong,Wang Le,Zhu Liping,Xiang Hengxue,Zhu Meifang
The thermoregulating function of skin that is capable of maintaining body temperature within a thermostatic state is critical. However, patients suffering from skin damage are struggling with the surrounding scene and situational awareness. Here, we report an interactive self-regulation electronic system by mimicking the human thermos-reception system. The skin-inspired self-adaptive system is composed of two highly sensitive thermistors (thermal-response composite materials), and a low-power temperature control unit (Laser-induced graphene array). The biomimetic skin can realize self-adjusting in the range of 35–42 °C, which is around physiological temperature. This thermoregulation system also contributed to skin barrier formation and wound healing. Across wound models, the treatment group healed ~ 10% more rapidly compared with the control group, and showed reduced inflammation, thus enhancing skin tissue regeneration. The skin-inspired self-adaptive system holds substantial promise for next-generation robotic and medical devices.
研究领域:
生物医学工程
·
材料科学
·
再生医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Ying Zhu,Yiqun Wu,Shasha Li,Xiaoli Yuan,Juan Shen,Shiyao Luo,Zhongshi Wang,Rui Gao,Jun Wu,Liang Ge
Bismuthene nanosheet is a nontoxic and low-cost two-dimensional material, and has been reported with very limited biomedical applications. In this report, for the first time, we reported the utilization of bismuthene nanosheet for combined photothermal, photocatalytic and chemotherapy for cancer treatment. Partially oxidized bismuthene nanosheet was modified with polyethylene glycol (POBNS-PEG) and used as a drug delivery vehicle for the first time (antitumor drug doxorubicin (DOX) was used as a model drug, POBNS-PEG/DOX). POBNS-PEG itself shows a photothermal treatment ability under the near infrared light and this treatment can additionally promote better cellular uptake of POBNS-PEG and DOX. More importantly, POBNS-PEG was found to be able to reduce CO 2 in cancer cells to CO through photocatalytic pathways under red light irradiation for the first time. The generated CO could obviously reduce the inflammation caused by photothermal treatment and drug resistance of tumor cells caused by chemotherapy. These three combined functions bring the three-in-one multifunctional bismuthene nanosheets not only have a significant antitumor effect but also reduce the side effects, making it with high clinical potentials.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
药学
✓ 已验证
DOI
高影响因子
Small
·
2023
·
IF 13.3
Qingsong Ye,Deyuan Zheng,Kaiyuan Chen,Haiheng Xu,Zefeng Yang,Jiqiu Wen,Yiqiao Hu,Jinhui Wu
Stroke is the second leading cause of death worldwide, and hypoxia is a major crisis of the brain after stroke. Therefore, providing oxygen to the brain microenvironment can effectively protect neurons from damage caused by cerebral hypoxia. However, there is a lack of timely and effective means of oxygen delivery clinically to the brain for acute cerebral hypoxia. Here, a phase-change based nano oxygen carrier is reported, which can undergo a phase change in response to increasing temperature in the brain, leading to oxygen release. The nano oxygen carrier demonstrate intracerebral oxygen delivery capacity and is able to release oxygen in the hypoxic and inflammatory region of the brain. In the acute ischemic stroke mouse model, the nano oxygen carrier can effectively reduce the area of cerebral infarction and decrease the level of inflammation triggered by cerebral hypoxia. By taking advantage of the increase in temperature during cerebral hypoxia, phase-change oxygen carrier proposes a new intracerebral oxygen delivery strategy for reducing acute cerebral hypoxia.
研究领域:
神经科学
·
纳米技术
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Abdullkhaleg Ali Albashari,Yan He,Yu Luo,Xingxiang Duan,Jihea Ali,Mingchang Li,Dehao Fu,Yangfan Xiang,Youjian Peng,Song Li,Lihua Luo,Xingjie Zan,Tushar Kumeria,Qingsong Ye
Spinal cord injury (SCI) commonly induces nerve damage and nerve cell degeneration. In this work, a novel dental pulp stem cells (DPSCs) encapsulated thermoresponsive injectable hydrogel with sustained hydrogen sulfide (H 2 S) delivery is demonstrated for SCI repair. For controlled and sustained H 2 S gas therapy, a clinically tested H 2 S donor (JK) loaded octysilane functionalized mesoporous silica nanoparticles (OMSNs) are incorporated into the thermosensitive hydrogel made from Pluronic F127 (PF-127). The JK-loaded functionalized MSNs (OMSF@JK) promote preferential M2-like polarization of macrophages and neuronal differentiation of DPSCs in vitro. OMSF@JK incorporated PF-127 injectable hydrogel (PF-OMSF@JK) has a soft consistency similar to that of the human spinal cord and thus, shows a high cytocompatibility with DPSCs. The cross-sectional micromorphology of the hydrogel shows a continuous porous structure. Last, the PF-OMSF@JK composite hydrogel considerably improves the in vivo SCI regeneration in Sprague–Dawley rats through a reduction in inflammation and neuronal differentiation of the incorporated stem cells as confirmed using western blotting and immunohistochemistry. The highly encouraging in vivo results prove that this novel design on hydrogel is a promising therapy for SCI regeneration with the potential for clinical translation.
研究领域:
神经科学
·
干细胞研究
·
生物材料
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Friction
·
2022
·Vol. 11
·期 7
·1194-1211
·
IF 4.924
Mao Xiaowei,Chen Kexin,Zhao Yanlong,Xiong Chunrong,Luo Jing,Wang Yuguang,Wang Bo,Zhang Hongyu
Osteoarthritis is associated with the significantly increased friction of the joint, which results in progressive and irreversible damage to the articular cartilage. A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis. In the present study, bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages, a biomimetic self-adhesive dopamine methacrylamide—poly(2-methacryloyloxyethyl phosphorylcholine) (DMA—MPC) copolymer was designed and synthesized via free radical polymerization. The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles (bMSNs) by the dip-coating method to prepare the dual-functional nanoparticles (bMSNs@DMA—MPC), which were evaluated using a series of surface characterizations including the transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectrum, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug, i.e., diclofenac sodium (DS). In addition, the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d. Furthermore, the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). In summary, the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Xin Huang,Huijuan Jing,Xiaojing Du,Li Wang,Xingran Kou,Zhonghua Liu,Shijia Wu,Hongxin Wang
In the work, a novel filamentou sodium alginate (SA) /ε-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte ε-PL and anionic natural polysaccharide SA. The SA/PL fiber exhibits good antibacterial activity, low cytotoxicity, anti-hemolysis, bioadhesion, and environmental friendliness due to its natural raw materials and green preparation process. In vivo experiments have shown that the SA/PL fiber can promote the healing and repair of skin wounds on the backs of mice via resistance to pathogen infection, reduction of inflammation, and anti-allogeneic allergy of the wound. In summary, these results demonstrate that the SA/PL fiber is a green and biosafe multifunctional natural polymer material, with potential applications in suturing wound.
研究领域:
生物材料
·
生物医学工程
·
组织工程
·
伤口愈合
·
聚合物科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）