BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Jianan Guo,Yujia Zhang,Changjun Zhang,Chuansheng Yao,Jingqi Zhang,Xiaoying Jiang,Zhichao Zhong,Jiamin Ge,Tao Zhou,Renren Bai,Yuanyuan Xie
AD is a progressive brain disorder. Because of the lack of remarkable single-target drugs against neurodegenerative disorders, the multitarget-directed ligand strategy has received attention as a promising therapeutic approach. Herein, we rationally designed twenty-nine hybrids of N -propargylamine-hydroxypyridinone. The designed hybrids possessed excellent iron-chelating activity (pFe 3+ = 17.09–22.02) and potent monoamine oxidase B inhibitory effects. Various biological evaluations of the optimal compound 6b were performed step by step, including inhibition screening of monoamine oxidase ( h MAO-B IC 50 = 0.083 ± 0.001 µM, h MAO-A IC 50 = 6.11 ± 0.08 µM; SI = 73.5), prediction of blood–brain barrier permeability and mouse behavioral research. All of these favorable results proved that the N -propargylamine-hydroxypyridinone scaffold is a promising structure for the discovery of multitargeted ligands for AD therapy.
研究领域:
神经科学
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药物化学
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生物医学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Pengpeng Li,Jiahao Zhang,Yike Jin,Zifan Xu,Guohua Sun
Helical micro-nanomaterials with intelligently controllable, multi-color circularly polarized luminescence (CPL) have garnered significant interest for their promising applications in chiral chemistry, photonics, and electronics. However, the precise and convenient fabrication of multi-color and white CPL-active flexible nanofibers featuring continuous helical topological structures remains challenging, particularly in the deformable solid nanomaterials. In this study, we employed a soft (polyurethane elastomer)/ hard (conjugated helical polymer/ cellulose/fluorescent dyes) bicomponent electrospinning strategy, through which helically chiral luminescent nanofibers with predominant single-handedness were spontaneously formed due to intercomponent strain mismatch. By constructing hierarchical helices from the molecular to the mesoscopic scale, we achieved a biomimetic chiroptical flexible material that exhibits unique chirality amplifications. This work reveals a previously unreported synergistic strategy for the construction of mesoscopic chiral luminescent helical nanofibers. Furthermore, owing to the excellent flexibility and designability of electrospun nanofibers, as well as the unique physical and optical properties provided by chiral helical polymers and mesoscopic helical micro-and nanofibers, the prepared multicolor and white CPL-active nanofibrous films demonstrate promising application prospects in circularly polarized LED devices, blue-light blocking films, and even as substitutes for flexible liquid crystal cells—highlighting the innovation and potential of this research system.
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DOI
高影响因子
Polymers
·
2025
·Vol. 17
·期 12
·1600
·
IF 4.9
Liugen Xu,Junwei Pi,Lei Feng,Junhao Wen,Minghai Zhao,Amjad Ali,Jianwei Lu,Li Guo
Glycopolypeptoids were synthesized and showed effective antifreeze activity, demonstrating their potential as novel antifreeze agents for cryopreservation. These polypeptide analogs offer improved stability and tunability compared with natural antifreeze glycoproteins (AFGPs) and existing synthetic mimics. Using the ring-opening polymerization of N-substituted N-carboxyanhydride monomers followed by click chemistry, glycopolypeptoids with controlled polymerization degrees and varied structures were designed and prepared. Their antifreeze performance was assessed via nanoliter osmometry and ice recrystallization inhibition assays, revealing a strong correlation between the molecular structure and antifreeze activity. The findings highlight glycopolypeptoids as a promising, cost-effective alternative to natural AFGPs, providing new insights into the development of biomimetic cryoprotectants. This study expands the understanding of synthetic antifreeze materials and offers a practical approach for improving cryopreservation efficiency in biomedical and industrial applications.
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yunpeng Li,Chunmei Xu,Yingchun Lu,Huipin Liu,Jun Zeng,Hanwen Duan,Chaoyi Zhu,Yuanlin Zhou,Yingjun Li
In nuclear research, high-performance oxygen barrier gloves are essential for glovebox operations. To enhance the oxygen barrier properties of the pure rubber material of the outer layer of the rubber gloves in glove boxes, Bi0 nanoparticles were in situ grown on acetylene-functionalized graphene oxide (A-rGO) to form Bi@A-rGO/CR membranes. These were evaluated for mechanical strength, oxygen barrier, and γ-ray shielding. Bi@A-rGO addition significantly improved the mechanical properties of CR and oxygen barrier, with a 126% increase in tensile strength to 11.12 MPa and 845% elongation at break at 2 wt % filler content. The oxygen permeation coefficient was reduced to 0.44 cm3 cm m–2 day–1 bar–1, surpassing GO/CR. The barrier enhancement is due to Bi-induced surface roughness on A-rGO, increasing oxygen molecule path length. Bi also provides γ-ray shielding, making Bi@A-rGO/CR a promising flexible material for oxygen barrier applications.
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jin Xu,Qirong Li,Jiugang Yuan,Xuerong Fan,Weidong Gao
Starch-based films suffer from brittleness and poor tensile properties, limiting their industrial applicability. In this study, magnetically modified starch (MMS) was prepared by covalently grafting azide-Fe 3 O 4 @SiO 2 nanoparticles onto the reducing ends of soluble starch via reductive amination and Cu(I)-catalyzed azide–alkyne cycloaddition (click chemistry). During film formation, application of a 1.4 T NdFeB magnetic field promoted chain alignment and crystallization. X-ray diffraction revealed a 19 % increase in crystallinity (from 9.6 % to 11.4 %), while FTIR analysis showed a 27 % enhancement in the (994 + 1047)/1022 ratio, indicating greater short-range molecular order. As a result, the tensile strength of MMS films increased to 19.8 ± 1.9 MPa, representing an 81.7 % improvement over native starch films (10.9 ± 1.4 MPa, p < 0.01). Meanwhile, the elongation at break decreased from 3.9 ± 0.8 % to 2.3 ± 0.3 %, reflecting enhanced molecular packing and reduced chain mobility. Superparamagnetic behavior ensured chain mobility only under field exposure, minimizing agglomeration after field removal. This work demonstrates a scalable, field-guided strategy to tailor starch film structure and performance, offering promising applications in eco-friendly packaging and biomedical materials.
研究领域:
材料科学
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食品科学
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高分子化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Luzhong Zhang,Jingjing Wei,Yuan Huang,Luqi Wang,Huasong Gao,Yumin Yang
Spinal cord injury (SCI) is a devastating condition without effective therapy currently available. The inflammatory cascade following SCI leads to neuronal apoptosis and glial cell activation. The utilization of local injectable hydrogels with immunotherapy drugs directly into injured nerve tissues represents a promising therapeutic strategy. Herein, injectable hydrogels grafted with clickable methylprednisolone (MP) and cellular adhesion peptide were developed using free radical polymerization for promoting nerve regeneration following SCI. MP conjugated hydrogels could modulate the immunoinflammatory microenvironment of SCI and sustain neuron survival. The multi-stiffness hydrogels were fabricated by adjusting concentration ratios to evaluate appropriate mechanical stimuli. In a model of dorsal root ganglion, MP grafted hydrogels with mechanical signals similar to those of adult rat spinal cords demonstrated superior efficacy in promoting dorsal root ganglion growth. MP grafted hydrogels could regulate the immune-inflammatory microenvironment, promote recovery of both motor function and sensory functions. The positive findings suggested that the interplay between immunomodulation and mechanical signals plays a crucial role in promoting nerve regeneration, indicating significant potential for hydrogels as a therapeutic approach for repairing SCI.
研究领域:
生物医学工程
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神经科学
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免疫学
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Jun-Yi Zhou,Yan-Qing Chen,Guang Hu,Haiyu Zhao,Jian-Bo Wan
Background N-acylethanolamines (NAEs) are a class of naturally occurring bioactive lipids that play crucial roles in various physiological processes, particularly exhibiting neuroprotective and anti-inflammatory properties. However, the comprehensive profiling of endogenous NAEs in complex biological matrices is challenging due to their low abundance, structural similarity and the limited availability of commercial standards. Here, we propose an integrated strategy for comprehensive profiling of NAEs that combines chemical derivatization and a three-dimensional (3D) prediction model based on quantitative structure-retention time relationship (QSRR) using liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-HRMS). Results After acetyl chloride (ACC) derivatization, the detection sensitivity of NAEs was significantly improved. We developed a QSRR prediction model to construct an in-house database for 141 NAEs, encompassing information on RT, MS 1 ( m/z ), and MS/MS spectra. Propargylamine-labeled fatty acids were synthesized as RT calibrants across various analytical conditions to enhance the robustness of the RT prediction model. NAEs in biological samples were then in-depth profiled using parallel reaction monitoring (PRM) acquisition. This integrated strategy identified and annotated a total of 50 NAEs across serum, hippocampus and cortex tissues from a 5xFAD mouse model of Alzheimer's disease (AD). Notably, the levels of polyunsaturated NAEs, particularly NAE 20:5 and NAE 22:6, were significantly decreased in 5xFAD mice compared to WT mice, as confirmed by accurate quantitation using ACC- d 0 / d 3 derivatization. Significance Our integrated strategy exhibits great potential for the in-depth profiling of NAEs in complex biological samples, facilitating the elucidation of NAE functions in diverse physiological and pathological processes.
研究领域:
生物化学
·
医学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiangyu Huang,Zucheng Shen,Qi Deng,Chengfei Zhao,Xiaofeng Cai,Shaoteng Huang,Mingbo Zhang,Yanzhuo Lv,Dongliang Yang,Junyang Zhuang,Ning Li
Diabetic foot ulcers (DFU) infections have been a major setback in wound healing, yet there is no effective therapeutic intervention. Here we report a nano-multidrug co-delivery system based on arginine-terminal butterfly-shaped peptide dendrimers (C&D@Z) that effectively kill bacteria and promote wound healing. Firstly, upon the near-infrared light irradiation, reactive oxygen species (ROS) was generated from the loaded photosensitizers, and then mediated bacteria killing. Next, the excessive ROS reacted with the designed butterfly-shaped dendrimers to generate sustained and abundant nitric oxide (NO), which exerted bactericidal action, as well as produced anti-inflammatory and angiogenesis effects. The co-delivery system, facilitated by the generation of NO, penetrated deeply into the biofilm, thereby effectively eliminating bacteria. The enhanced bactericidal and healing efficiency was investigated through biofilm penetration and wound healing experiments. Collectively, our system leveraged the highly-branched and cavity structures of the butterfly peptide dendrimer to realize the tight contact between the arginine groups and photosensitizer to achieve efficient conversion from ROS to NO, and the C&D@Z exhibited superior NO production, optimal photodynamic therapy utilization and effective penetration performance through cascade reaction between photodynamic therapy and NO therapy, may serve as a promising therapeutic approach for DFU infections.
研究领域:
纳米医学
·
药学
·
伤口愈合
·
感染性疾病
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Yixuan Xu,Huiping Dang,Changchang Teng,Dalong Yin,Lifeng Yan
Rapid propagation of tumor cells requires plenty of energy, which is adenosine triphosphate (ATP) dependent. ATP inhibition in tumors not only results in the starvation of tumor cells but also down-regulation of the level of heat shock proteins (HSPs), which usually increase during traditional photothermal therapy (PTT), especially when the temperature is up 50 °C. 2-deoxy-D-glucose (2DG) is an anti-glycolytic reagent and can be used as an efficient agent for ATP inhibition in tumors. Compared with typical PTT, low-temperature mild photothermal therapy (MPTT) is receiving more and more attention because it avoids the high temperatures causing damage to the normal tissue, and the increase of HSPs which decrease PTT. Here, multifunctional polypeptide nanoparticles pDG@Ahx conjugating both a NIR probe Ahx-BDP and 2DG into the side chain of the amphiphilic polypeptide have been prepared. In vitro and in vivo studies reveal that the as-prepared nanoparticles achieve a synergistic effect of starvation/MPTT/PDT (photodynamic therapy), and it provides a new strategy to NIR-I/II fluorescence imaging-guided starvation/MPTT/PDT synergy therapy for tumors.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 15
·1-18
·
IF 2.8
Ji Xiaoli,Qiao Ruochen,Xu Zhihao,Liu Jian,Ma Qianqian,Yuan Haoze,Xing Honglong
Fe 3 O 4 /SiO 2 nanocomposites (NCs) were prepared by the interaction of alkyne-functionalized ferric oxide (Fe 3 O 4 -Alk) nanoparticles (NPs) and azide-functionalized silicon dioxide (SiO 2 -N 3 ) NPs via the click reaction. The morphology and structure of the Fe 3 O 4 /SiO 2 NCs were investigated using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and infrared analyses, and the electromagnetic parameters were measured using a vector network analyzer. For the Fe 3 O 4 /SiO 2 nanocomposites obtained via the click reaction, the minimum reflection loss reached − 37.15 dB at 16.68 GHz and a matching thickness of 5.0 mm, and the bandwidth below − 10 dB ranged from 3.2 to 6.7 GHz and 15.7 to 17.6 GHz. The Fe 3 O 4 /SiO 2 composites synthesized via the click reaction exhibited better microwave absorption performance than the physically blended sample. This is mainly because Fe 3 O 4 and SiO 2 are covalently bonded through the click reaction in the composites, creating multiple heterogeneous interfaces, which enhance dielectric loss and impedance matching.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Junyu Chen,Yanqin Ma,Xinjian Cheng,Yufan Wu,Huizhi Chen,Cheng Liu
Natural polymer chitosan has many advantages, but the poor solubility limits its application. In this study, chitosan derivatives soluble in DCM, DMF, DMSO, H 2 O and other solvents were developed by introducing side chains into chitosan (CS). In addition, the fluorescent group on the side chain makes the chitosan derivative have the ability to detect 4-nitrophenol (4-NP). Firstly, a chain transfer agent containing C C (N3-NS) was synthesized with naphthalimide as the fluorescence unit. Then, using AIBN as initiator, an extensively soluble polymer with fluorescent moiety TP-NVP was synthesized by reversible addition-fragmentation chain transfer polymerization (RAFT) method using monomer N -vinyl pyrrolidone (NVP). Finally, the C C of TP-NVP was used to react with –NH 2 on CS to prepare PVP-g-chitosan, so that more CS was “pulled” by TP-NVP into the solvent. The solubility of the synthesized CS-PVP probe can be adjusted by adjusting the amount of NVP, up to 17.6 mg/mL. At the same time, the synthesized CS-PVP had a good detection effect on 4-NP, and the detection limit (LOD) was 0.054 μM. The HOMO-LUMO energy level of the probe was calculated by cyclic voltammetry (CV). In addition, CS-PVP was successfully loaded on a low background fluorescent test paper to achieve real-time visual intelligent determination of 4-NP in real samples with the help of a color scanning APP of a smartphone.
研究领域:
材料科学
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分析化学
·
生物医学工程
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DOI
高影响因子
ANALYST
·
2011
·Vol. 136
·期 24
·5302-5307
·
IF 3.913
Hongyue Guo,Changhu Chu,Yan Li,Bingcheng Yang,Xinmiao Liang
Ion chromatography (IC) is one of the most powerful analysis technologies for the determination of charged compounds. A novel click lysine stationary phase was prepared viaCu(I) catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) and applied to the analysis of inorganic ions. The chromatographic evaluation demonstrated good performance (e.g. the plate number of thiocyanate is ∼50 000 plates m−1) and effective separation ability for the common inorganic anions with aqueous Na2SO4 eluent. The separation mechanism was observed to be mainly dominated by ion exchange interaction. The retention of these analytes is highly dependent on the pH value of eluent. Compared with the lysine stationary phase prepared via the conventional manner, the click lysine exchanger demonstrated shorter retention time and better ion separation characteristics under the same chromatographic conditions, which is a great advantage for rapid separation and analysis of inorganic ions.
研究领域:
分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）