SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Zhigao Ma,Bingyan Jiang,Dietmar Drummer,Lu Zhang
An electrolyte solution incorporating sodium saccharin and an alkynyl compound was provided to electroform Ni-P-PTFE mold inserts with both low internal stress and good self-lubricating properties. The results showed that with 5 g·L −1 sodium saccharin and 1 mL·L −1 alkynyl compound, the internal stress reached a minimum of −114 MPa, an 82 % reduction from the −646 MPa observed without additives. The presence of sodium saccharin and alkynyl compound in the electrolyte solution reduced the hydrogen evolution reaction current from 15.2 to 12.9 mA at the operating cathode potential of −1 V and decreased the RTC (111) from 100 % to 90 %. The reduction of internal stress in the electrodeposited Ni-P-PTFE composites was attributed to the decreased hydrogenation strain, diminished Ni (111) texture intensity, and the partial incorporation of alkynyl compound reaction products into the deposits, which weakened the connections between crystallites. Finally, 5 g·L −1 sodium saccharin and 1 mL·L −1 alkynyl compound was applied to electroform Ni-P-PTFE mold insert with micro features. Only slightly pile-up defects at the corner of grooves were observed on the polymer chips demolded from Ni-P-PTFE mold insert, demonstrating its good self-lubricating property.
研究领域:
材料科学
·
电化学工程
✓ 已验证
产品关联
DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2014
·Vol. 12
·期 18
·2969-2978
·
IF 3.487
Jiajun Zhang,Pinhua Li,Lei Wang
A novel KOAc-promoted α-position C–H activation and alkynylation of ethers with alkynyl bromides to 2-alkynyl ethers has been developed under transition-metal-free and simple reaction conditions. In addition, this methodology can also be extended to the vinylation of ethers with vinyl bromides in excellent regio- and stereo-selectivity. A wide range of direct C(sp)–C(sp3) and C(sp2)–C(sp3) bonds has been formed through this protocol, which offers a new and alternative route.
研究领域:
有机化学
·
合成化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2013
·
IF 4.593
Yu-Peng Zhou,En-Bao Liu,Jin Wang,Hsiu-Yi Chao
Newly prepared gold(I) acetylide-based luminescent cation sensors 1c and 1d, which bear a novel three–armed flexible conformation, together with control molecule 2c, were synthesized in four steps. 1c and 1d exhibit the π → π* absorption of the acetylide ligands in fluid solutions and produce the 3(ππ*) emission of the acetylide ligands in the solid state and degassed THF solution. The 3(ππ*) emission of 1c in DMSO can be turned on upon addition of Ag+. The binding ratio between 1c and Ag+ as well as the binding constant log K were determined as 1:1 and 4.35 ± 0.12 respectively by UV–vis titration experiments. The formation of [1c·Ag]+ adduct, which leads to the appearance of new up-field peaks, was confirmed by 1H NMR spectroscopic titrations. The control 1H NMR titration experiments for the acetylide-free analogue 1a and single-armed analogue 2c indicate the acetylide groups and tripodal structures are responsible for the binding of Ag+. The control experiment for tripodal gold(I) acetylide analogue 1d suggests the change of PPh3 with P(2-Py)Ph2 induces similar binding affinity toward Ag+ but less selectivity toward Ag+. Free 1c also exhibits the anion binding affinity toward F–, but the Ag+ adduct [1c·Ag]+ shows less affinity toward F–.
研究领域:
分析化学
·
材料科学
·
配位化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Lijian Sun,Guifa Xiao,Xueren Qian,Xianhui An
We report a facile and effective method to fabricate clickable alkyne-functionalized cellulose fibers (ACFs) through in situ chemical oxidation copolymerization of 3-ethynylaniline and aniline under acidic aqueous solution. The effects of process variables on copolymer deposition onto CFs were investigated and suitable preparation conditions were identified. It was found that aniline significantly facilitated the polymerization of 3-ethynylaniline and shortened the preparation time of ACFs from 48 to 6 h. Antibacterial-modified cellulose fibers were prepared by binding β-cyclodextrin (β-CD) to cellulose fibers via click chemistry, followed by the inclusion of ciprofloxacin hydrochloride (CipHCl). The loading and releasing behaviors of CipHCl into/from click product (ACFs@Azide-β-CD) were also revealed. The load amount of CipHCl into ACFs@Azide-β-CD increased remarkably, and the release of CipHCl from ACFs@Azide-β-CD was prolonged. The ACFs@Azide-β-CD loaded with CipHCl exhibited higher and longer-term antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus ( S. aureu ) compared with CFs and ACFs.
研究领域:
材料科学
·
化学工程
·
生物材料
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PROTEOME RESEARCH
·
2023
·
IF 4.4
Mengmeng Zheng,Yanmei Zhang,Yao Xu,Ying Han,Yingli Wu,Jingwu Kang
Salvianolic acid A (SAA), a major active ingredient of Salvia miltiorrhiza Bunge (Danshen), displays strong antiproliferative activity against cancer cells. However, their protein targets remain unknown. Here, we deconvoluted the protein targets of SAA using chemoproteomics and phosphoproteomics. By using alkynylated SAA as a probe, we discovered that SAA is a covalent ligand that can modify cellular proteins via its electrophilic α,β-unsaturated ester moiety. The subsequent chemoproteomics profiling revealed that 46 proteins were covalently modified by SAA, including Raptor, a subunit of mTORC1 for recruiting substrates for mTORC1. Although gene ontology enrichment analysis of these proteins suggested that SAA displays a promiscuous protein interaction, phosphoproteomics profiling revealed that the SAA modulated phosphoproteins were mainly enriched in the signaling pathways of PI3K-Akt-mTOR, which is closely related to cell growth and proliferation. This was confirmed by the biochemical assay with purified mTORC1, a Western blot assay with phospho-specific antibodies, and a cellular thermal shift assay. Our work discovered that SAA is a covalent ligand for protein modification and mTORC1 is one of its targets. Moreover, our work demonstrated that the integrative profiling of chemoproteomics and phosphoproteomics can be a powerful tool for target deconvolution for bioactive natural products.
研究领域:
药理学
·
蛋白质组学
·
癌症研究
·
分子生物学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 45
·16893-16901
·
IF 8.307
Hai Zhong,Hongfang Yang,Jiaqi Shang,Biao Zhao,Jianping Deng
Micro/nanoparticles with surface microstructures have attracted tremendous attention due to their fascinating structures and properties. Herein, we present the first strategy for producing optically active polymer particles with varying surface microstructures via a template surface modification process in which achiral particles act as the template and helical substituted polyacetylene acts as the chiral component. To prepare the designed chiral-functionalized particles, template particles were first reacted with propargylamine to produce alkynylated template particles. The alkynylated templates further participated in the polymerization of chiral alkyne monomers through a surface grafting precipitation polymerization approach, resulting in achiral particles with surface microstructures covalently bonded with a chiral helical polymer. SEM images ascertain the production of chiral-functionalized particles showing various shapes (jar-like, golf ball-like, and raspberry-like particles). Furthermore, CD and UV-vis absorption spectra demonstrate that the grafted polyacetylene chains adopt a predominantly single-handed helical conformation, thereby affording composite particles with optical activity. Using the established protocol, numerous advanced chiral-functionalized micro/nanostructures are expected to be designed and constructed.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Jieyu Hu,Xingxing Yu,Xiumei Zhuang,Yan Sun,Junjie Wang,Haiting Ren,Shenghao Zhang,Yueshou Zhang,Hongxing Qiu,Yongjun Hu
The p53 gene is a known cancer marker. We report a novel protocol for the SERS tandem strategy to detect the p53 gene with high sensitivity. Herein, the click reaction between azide and alkyne was catalyzed by utilizing copper oxide nanoparticles (CuONPs), which were enriched by a T-DNA-triggered hybridization chain reaction (HCR). The T-DNA signal was amplified by establishing the correlation between the T-DNA signal and the concentration of CuONPs in a nonenzymatic isothermal environment. In contrast to other Raman reporters, we used alkynyl compounds as Raman reporters, which showed excellent characteristics in the Raman-silent region (1800–2800 cm −1 ). Therefore, the highly sensitive and highly selective SERS signals could be obtained in complex biological matrices. Due to utilizing multistep amplification strategies, including the nanoparticle-modified HCR polymer and “click” reaction, the limit of detection (LOD) and the limit of quantification (LOQ) of this sensor could be as low as 0.0174 pM and 0.0583 pM, respectively. The accuracy of the strategy expressed as the RSD was in the range of 3.14%–6.21%. The results indicated that the constructed sensor has excellent performance for the detection of the p53 gene in serum samples in a low concentration range, which suggests that the proposed enzyme-free SERS analytical sensor has good clinical application prospects.
研究领域:
生物技术
·
纳米技术
·
癌症研究
·
分析化学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）