Atmospheric fine particulate matter (PM2.5) poses threats to the cardiovascular system. Red blood cells (RBCs) are the most abundant cells in blood, which are actively involved in multiple hematological diseases, such as blood clot formation and thrombosis. Exploring how PM2.5 with spatiotemporal heterogeneity influences the hematological system by targeting RBCs would help gain insights into the deleterious effects of PM2.5 and provide clues for finding the causative components therein. Herein, the PM2.5 samples collected from 3 urban sites in Beijing (i.e., Chaoyang, Shunyi, and Yanqing districts) during 4 seasons of 2022 were studied for their toxicities to mouse RBCs, and the main contributing components were further explored through chemical analysis and correlation measure. The results showed that exposure to PM2.5 samples decreased adenosine triphosphate (ATP) levels and increased phosphatidylserine (PS) externalization of RBCs, causing cell morphological deformity. The Pearson correlation analysis showed that the aromaticity of the dissolved organic matter (DOM) in PM2.5 samples was positively correlated with PS exposure of RBCs, showing that the lignin-like compounds were the potential contributors. The negative correlation of zeta potentials of PM2.5 samples with PS exposure of RBCs showed the particle-derived bioactivities of this airborne pollutant. The simulative test based on artificial nanomaterials of carbon black (CB) and oxidized CB (OCB) confirmed the crucial role of particulate carbon in PM2.5-induced effects on RBCs, and soot with a certain oxidation degree was, thus, recognized as another contributor, given its ubiquitous existence in PM2.5 samples. This study, for the first time, revealed PM2.5-induced PS exposure of RBCs, and the causative components of DOM and soot were unraveled. Considering the inevitable contact of airborne PM2.5 with RBCs in the blood circulatory system, the findings obtained herein would help bridge the gap between PM2.5 exposure and the risk of cardiovascular diseases, like thrombogenesis.
Jie Yu,Hui Yang,Haijun Ji,Xin Zhang,Rui Wang,Shuainan Zhao,Runguo Wang,Liqun Zhang
Most rubber products come from petrochemical resources, which are increasingly in short supply. Rubber products that formed irreversible chemical bonds in the vulcanization process are difficult to recycle, resulting in a serious waste of resources. Therefore, it is important to prepare a kind of reprocessable biobased elastomers. Using furfuryl methacrylate (FMA) as the modified monomer, poly(dibutyl itaconate-myrcene-furfuryl methacrylate) (PDBIMFA) was synthesized by high-temperature emulsion polymerization successfully. The structure and compositions of PDBIMFA were characterized by Fourier transform infrared and 1H NMR, and the effects of different FMA contents on the structures and properties of PDBIMFA were systematically studied. Based on the Diels–Alder reaction, bismaleimide (BMI) and carbon black (CB) were introduced into PDBIMFA as cross-linking agents and reinforcing fillers, respectively, by the melt blending method, and PDBIMFA-BMI elastomer materials and CB/PDBIMFA-BMI elastomer composites with thermo-reversible cross-linking characteristics were prepared. The effects of the ratio of FMA and BMI on the mechanical properties of PDBIMFA-BMI were studied. PDBIMFA-BMI and CB/PDBIMFA-BMI were reprocessed twice, and the recovery rate of tensile strength was both more than 90%. The addition of CB was found to play a reinforcing role in the elastomer and with the introduction of the amount of CB, the reprocessability of composite remained at a good level. It is hoped that this research will provide a new strategy for the sustainable development of bio-based elastomer materials.
危险品化学品经营许可证（带存储）