Journal of Neuroinflammation
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2018
·Vol. 15
·期 1
·1-12
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IF 5.193
Gao Bo,Wu Yu,Yang Yuan-Jian,Li Wei-Zu,Dong Kun,Zhou Jun,Yin Yan-Yan,Huang Da-Ke,Wu Wen-Ning
Background Epilepsy is a common neurological disorder and is not well controlled by available antiepileptic drugs (AEDs). Inflammation is considered to be a critical factor in the pathophysiology of epilepsy. Sinomenine (SN), a bioactive alkaloid with anti-inflammatory effect, exerts neuroprotective activity in many nervous system diseases. However, little is known about the effect of SN on epilepsy.Methods The chronic epilepsy model was established by pentylenetetrazole (PTZ) kindling. Morris water maze (MWM) was used to test spatial learning and memory ability. H.E. staining and Hoechst 33258 staining were used to evaluate hippocampal neuronal damage. The expression of nucleotide oligomerization domain (NOD)-like receptor protein 1 (NLRP1) inflammasome complexes and the level of inflammatory cytokines were determined by western blot, quantitative real-time PCR and enzyme-linked immunosorbent assay (ELISA) kits.Results SN (20, 40, and 80 mg/kg) dose-dependently disrupts the kindling acquisition process, which decreases the seizure scores and the incidence of fully kindling. SN also increases the latency of seizure and decreases the duration of seizure in fully kindled rats. In addition, different doses of SN block the hippocampal neuronal damage and minimize the impairment of spatial learning and memory in PTZ kindled rats. Finally, PTZ kindling increases the expression of NLRP1 inflammasome complexes and the levels of inflammatory cytokines IL-1β, IL-18, IL-6, and TNF-α, which are all attenuated by SN in a dose- dependent manner.Conclusion sSN exerts anticonvulsant and neuroprotective activity in PTZ kindling model of epilepsy. Disrupting the kindling acquisition, which inhibits NLRP1 inflammasome-mediated inflammatory process, might be involved in its effects.
研究领域:
神经病学
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药理学
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炎症研究
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Zongsheng Liu,Meng Ma,Bangdong Ge,Yi Zheng,Si Chen,Yanqin Shi,Huiwen He,Yulu Zhu,Xu Wang
Functionalization and high performance of polycarbonate (PC) is hardly achieved by using traditional flame retardants, which will improve the flame retardancy of PC at the expense of mechanical strength, thermal stability and transparency. Herein, a linear macromolecular of polydiphenyl phenyl borosiloxane (PDPBS) was synthesized by dehydration polycondensation in order to solve the conflict between fire safety and high performance of PC. Due to the role of PDPBS in catalyzing char formation and helping to form dense char layer during the combustion process of PC composites, and the outstanding flexibility of siloxane segments with excellent compatibility with PC matrix, PC/PDPBS composites can maintain almost the same transparency as that of PC and obtain excellent flame retardancy. The results of burning tests showed that the PC composites with 3 wt% PDPBS passed the UL 94V-0 rating with a LOI value of 29.1%. Meanwhile, the peak of heat release rate (PHRR) and total heat release rate (THR) of PC/PDPBS-3 decreased by 12% and 15% respectively, and the ignition time (TTI) increased by 9%. More importantly, the PC/PDPBS-3 composite maintains a transparency at 87.5%. In addition, the tensile strength and elongation at break remained at the same level as that of neat PC. In a word, the addition of PDPBS can not only improve the flame retardancy of PC, but also keep its outstanding transparency and excellent mechanical properties. This work provides a new method for obtaining PC with both flame retardant and transparent properties, and also broadens the application of PC in electronic appliances and automobiles.
研究领域:
材料科学
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高分子化学
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消防安全工程
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产品关联
DOI
高影响因子
NEUROCHEMICAL RESEARCH
·
2025
·Vol. 50
·期 5
·1-12
·
IF 3.8
Huang Manqian,Tang Meiling,Liu Lu
Epilepsy is a chronic neurological disorder featured by abnormal neural discharges that can lead to cognitive impairment. Salidroside (Sal), a biologically active component, protects neurons against various insults. The current study aims to explore the therapeutic potential of Sal in epilepsy and elucidate the mechanisms underlying its effects. We established a rat model of status epilepticus (SE) using pentylenetetrazol-kindling. SE rats were treated with Sal. Assessment of seizure latency and epileptic stage scores were performed. Cognitive function of rats was evaluated using a novel object recognition test and a Morris water maze test. Neuronal damage and hippocampal pathology were examined, alongside microglial and astrocyte activation, complement C3-C3a receptor (C3-C3aR) pathway involvement, and inflammatory factor levels. Sal prolonged seizure latency, decreased epilepsy stage scores, and improved cognitive performance compared to untreated SE rats. Furthermore, Sal suppressed the activation of C3-C3ar, microglia, and astrocytes, while decreasing the levels of inflammatory factors, which ameliorated hippocampal damage and neuronal loss. Sal may attenuate epilepsy and cognitive dysfunction by downregulating complement C3-C3aR pathway-mediated activation of microglia and astrocytes.
研究领域:
神经病学
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药理学
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神经药理学
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免疫学
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分子生物学
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神经科学
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产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
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2023
·
IF 4.6
Mengling Dong,Tao Li,Jiacheng Xu,Tiantian Zhang,Yan Sun,Ning Li,Zuliang Wu,Jing Li,Erhao Gao,Jiali Zhu,Shuiliang Yao,Yong Huang
Methane (CH 4 ) is the second largest greenhouse gas; its emission should be controlled. A plasma reactor coupled with a catalyst was used to control CH 4 emission via oxidation. Compared with the traditional catalytic process, the activity of Pd/ZrO 2 /Al 2 O 3 catalyst is significantly improved, the light-off temperature ( T 50 ) is at a level of 290 °C. X-ray photoelectron spectroscopy characterization results proved that synergetic effect of plasma and catalysis on CH 4 oxidation was due to the increase in the amount of lattice oxygen on zirconia after plasma oxidation and the enhancement of the oxidation of Pd 0 to PdO on 1.0Pd/10ZrO 2 /γ-Al 2 O 3 catalyst. An operando plasma diffuse reflectance infrared Fourier transform spectroscopy mass spectrometer was used to demonstrate that CH 4 oxidation on Pd/ZrO 2 /Al 2 O 3 catalyst. It was found that 1.0Pd/10ZrO 2 /γ-Al 2 O 3 with plasma can efficiently promote CH 4 oxidation and convert surface formate and carbonate to gaseous CO 2 and H 2 O. The plasma-generated O atoms can react with surface H 2 O to yield reactive OH radicals which can obviously improve CH 4 oxidation at a temperature higher than 130 °C, this finding provides important enlightenment for the development of catalysts for plasma catalytic oxidation of CH 4 . The mechanism of CH 4 plasma-catalysis oxidation was discussed.
研究领域:
环境科学
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催化
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等离子体化学
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材料科学
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产品关联
DOI
高影响因子
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