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Nano-Micro Letters · 2025 ·Vol. 17 ·期 1 ·1-13 · IF 36.3

High-Reliability Thermoreceptors with Minimal Temporal and Spatial Variations Through Photo-Induced Patterning Thermoelectrics

Du Chunyu,Hu Yue,Xiao Xiao,Manshaii Farid,Liang Lirong,Chen Jun,Chen Guangming

A novel photobase generator is specifically designed for the fabrication of high-resolution sensing devices. Similarities in pain perception mechanism between thermoelectric-based artificial thermoreceptor and biological nociceptor. Emulation common nociceptive behaviors and pain response under excessive temperature stimuli.

CAS / MDL: 6674-22-2

研究领域: 生物医学工程 · 材料科学 · 神经生物学

✓ 已验证产品关联 DOI PubMed 高影响因子

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NATURE STRUCTURAL & MOLECULAR BIOLOGY · 2025 · IF 10.1

Structure and function of a broad-range thermal receptor in myriapods

Chen Xiaoying,Yuan Licheng,Wen Han,Ma Qingxia,Deng Zhenfeng,Xu Yongan,Yao Zhihao,Wang Yunfei,Yang Shilong,Su Nannan,Yang Fan

Broad-range thermal receptor 1 (BRTNaC1), activated by heat at low extracellular pH, was recently identified in myriapods. Although the overexpression of BRTNaC1 leads to robust heat-activated current with a cation selectivity profile, the structure of this receptor and how it is gated by proton and heat remain to be investigated. Here we determine cryogenic electron microscopy structures of BRTNaC1 in the apo, proton-induced and heated states. Based on these structures, patch-clamp recordings and molecular dynamic simulations, we found that a ‘twist the wrist’ mechanism is used for proton activation of BRTNaC1, while heat induces broad conformational changes in BRTNaC1, including rotation and shift in the transmembrane helices to open this channel. Moreover, as testosterone inhibited BRTNaC1 activation, we identified four clustered residues important for such inhibition. Therefore, our study has established the structural basis for ligand and temperature gating in the BRTNaC1 ion channel.

CAS / MDL: 7447-41-8

研究领域: 神经科学 · 结构生物学 · 离子通道研究

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High-Reliability Thermoreceptors with Minimal Temporal and Spatial Variations Through Photo-Induced Patterning Thermoelectrics

Structure and function of a broad-range thermal receptor in myriapods