PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Shuang Gao,Yue Xiu,Yan Zhang,Meiqing Li,Fengrui Li,Lixia Zhao,Ying Fu,Fei Ye
BACKGROUND Diniconazole (DCZ) is a poorly water-soluble triazole fungicide. However, the water solubility of DCZ can be significantly enhanced by inclusion complexation with cyclodextrins. In order to improve the properties and bioavailability of pesticide fungicides DCZ, a new system of nanofibers was prepared by electrospinning and cyclodextrin encapsulation. RESULTS The possibility of DCZ entering the hydroxypropyl-γ-cyclodextrin (HP-γ-CD) cavity was evidenced by molecular simulation and then DCZ/HP-γ-CD inclusion complex nanofibers were prepared by electrospinning. The formation of DCZ/HP-γ-CD complexes was confirmed by the results of scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance ( 1 H-NMR) and X-ray diffraction (XRD) characterization. Then the physical and antifungal properties of DCZ/HP-γ-CD inclusion complex nanofibers were investigated. The results showed that the thermal stability of DCZ/HP-γ-CD inclusion complex nanofibers was increased by 32 °C and the water solubility in HP-γ-CD solutions was increased by 7.5 times. Through water solubility researches and in vitro release researches, DCZ/HP-γ-CD inclusion complex nanofibers could quickly form a transparent solution and had a sustained release function. The antifungal researches showed that the antifungal performance of DCZ/HP-γ-CD inclusion complex nanofibers increased by 2.05 times. CONCLUSIONS Based on the new system of DCZ/HP-γ-CD inclusion complex nanofibers, the performance of the fungicide DCZ was improved and the bioavailability was improved to comply with the ‘reduction and efficiency’ effect of green chemistry. © 2025 Society of Chemical Industry.
研究领域:
农药化学
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药物递送系统
·
纳米材料
·
农业化学
·
药剂学
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分子药剂学
·
绿色化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Renfei Zhu,Chunlan Liu,Jingyu Wang,Li Zou,Fan Yang,Xia Chi,Jiansheng Zhu
Titanium dioxide nanoparticles (n-TiO 2 ) could enhance the bioavailability and toxicity of coexisting organic contaminants in the aquatic environment. This study attempted to investigate the combined effects of n-TiO 2 and difenoconazole (DIF) on the neurodevelopment of zebrafish and the underlying mechanisms. In this study, zebrafish embryos were exposed to n-TiO 2 (100 μg/L), DIF (0, 0.1 and 0.5 mg/L) and their mixtures from 4 to 96 h post fertilization (hpf) and neurotoxicity was evaluated. Our results indicated that n-TiO 2 adsorbed DIF into the brain of zebrafish and significantly enhanced the bioaccumulation of DIF and n-TiO 2 in the 0.5 mg/L co-exposure group. 100 μg/L n-TiO 2 was not developmentally toxic to the zebrafish larvae, but it exacerbated DIF-induced neurobehavioral alterations in the zebrafish larvae. n-TiO 2 also aggravated DIF-induced suppression of central nervous system (CNS) neurogenesis in Tg ( HuC:egfp ) zebrafish, motor neuron axon length in Tg ( hb9:egfp ) zebrafish, and downregulation of neurodevelopmental genes ( elavl3 , ngn1 , gap43 , gfap and mbp ). In addition, DIF elevated oxidative stress by accumulation of reactive oxygen species (ROS) and inhibition of antioxidant enzymes, and triggered apoptosis by upregulation of p53 , bax , bcl-2 and caspase-3 , which were markedly intensified in the presence of n-TiO 2 . Moreover, vitamin C (VC) ameliorated n-TiO 2 /DIF-induced abnormal locomotor behaviors and neurotoxicity by inhibiting oxidative stress and apoptosis, indicating that oxidative stress and apoptosis are involved in n-TiO 2 /DIF-induced neurotoxicity. Taken together, our data indicated that n-TiO 2 enhanced the accumulation of DIF and heightened oxidative stress and apoptosis, thereby inducing neurotoxicity. This study exemplifies the importance of the toxicity assessment of chemical mixtures and novel insights to mitigate their combined toxicity.
研究领域:
环境毒理学
·
神经科学
·
水生生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2024
·
IF 3.3
Xiaomeng Ji,Jiajia Guo,Yeyun Ma,Shuai Zhang,Zuwang Yang,Yuanyuan Li,Kaixin Ping,Yue Xin,Zibo Dong
Difenoconazole (DFZ) is a fungicidal pesticide extensively employed for the management of fungal diseases in fruits, vegetables, and cereal crops. However, its potential environmental impact cannot be ignored, as DFZ accumulation is able to lead to aquatic environment pollution and harm to non-target organisms. Quercetin (QUE), a flavonoid abundant in fruits and vegetables, possesses antioxidant and anti-inflammatory properties. In this article, carp were exposed to 400 mg/kg QUE and/or 0.3906 mg/L DFZ for 30 d to investigate the effect of QUE on DFZ-induced respiratory toxicity in carp. Research shows that DFZ exposure increases reactive oxygen species (ROS) production in the carp's respiratory system, leading to oxidative stress, inflammation, and damage to gill tissue and tight junction proteins. Further research demonstrates that DFZ induces mitochondrial dynamic imbalance and gill cell apoptosis. Notably, QUE treatment significantly reduces ROS levels, alleviates oxidative stress and inflammation, and mitigates mitochondrial dynamics imbalance and mitochondrial apoptosis. This study emphasizes the profound mechanism of DFZ toxicity to the respiratory system of common carp and the beneficial role of QUE in mitigating DFZ toxicity. These findings contribute to a better understanding of pesticide risk assessment in aquatic systems and provide new insights into strategies to reduce their toxicity.
研究领域:
水生毒理学
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环境科学
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药理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2017
·
IF 4.162
Xiao-jing Mao,Jing Li,Dan Liu,Ting Qiao,Liyun Ma,Xiao Sun,Li Xu,Zhi-guo Shi
The demand for fast chromatographic enantioseparation aroused the hot research in stationary phase matrix. In the present study, the flow-through silica, which is characterized by hierarchical pores of through pores in several hundred nanometer range and mesopores about 20 nm, was attempted for fast enantioseparation. Thanks to the large surface area and full openness of the through pores, the flow-through silica had comparable cellulose derivative loading amount as the commercial wide-pore silica, which was impracticable for most of the core-shell particles and sub-2-μm fully porous silica. In addition, the backpressure was about two times lower in the case of the flow-through silica of the same particle size to the commercial wide-pore silica, due to the highly porous structure of the former. Another appreciated merit of the flow-through silica in small size (~2 µm) was the less dependence of column efficiency on the flow rate . All of the above features rendered the flow-through silica a tremendous potential for fast enantioseparation with desired enantioselectivity , especially suitable for the polysaccharide chiral selector.
研究领域:
分析化学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2019
·Vol. 42
·期 16
·2679-2686
·
IF 2.516
Weixuan Yao,Zhefeng Fan,Suling Zhang
A zirconium terephthalate metal-organic framework-incorporated poly( N -vinylcarbazole- co -divinylbenzene) monolith was fabricated in a capillary by a thermal polymerization method. The optimized monolith had a homogeneous structure, good permeability, and stability. The monolith could be used for the effective enrichment of fungicides through π-π interactions, electrostatic forces, and hydrogen bonds. The potential factors that affect the extraction efficiency, including ionic strength, solution pH, sample volume, and eluent volume, were investigated in detail. The monolith-based in-tube solid-phase microextraction coupled with ultra-high-performance liquid chromatography and high-resolution Orbitrap mass spectrometry was performed for the analysis of five fungicides (pyrimethanil, tebuconazole, hexaconazole, diniconazole, and flutriafol) in environmental samples. Under the optimized conditions, the linear ranges were 0.005–5 ng/mL for pyrimethanil, 0.01–5 ng/mL for flutriafol, and 0.05–5 ng/mL for other fungicides, respectively, with coefficients of determination ≥0.9911. The limits of detection were 1.34–14.8 ng/L. The columns showed good repeatability (relative standard deviations ≤9.3%, n = 5) and desirable column-to-column reproducibility (relative standard deviations 5.3–9.4%, n = 5). The proposed method was successfully applied for the simultaneous detection of five fungicides in water and soil samples, with recoveries of 90.4–97.5 and 84.0–95.3%, respectively.
研究领域:
分析化学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2021
·Vol. 44
·期 10
·2113-2120
·
IF 3.645
Suling Zhang,Ziluo Hua,Hongting Zhao,Weixuan Yao,Yuanzhao Wu,Defeng Fu,Jiancong Sun
In this work, defective Zr-based metal–organic framework was successfully synthesized and evaluated as a dispersive micro-solid-phase extraction sorbent for efficient preconcentration and determination of fungicides in complex water samples. The defective Zr-based metal–organic framework crystal with increased adsorption capacity was successfully synthesized by employing formic acid as the modulator. The extraction conditions, including the pH, extraction time, desorption solvent and desorption time, were comprehensively investigated. Under optimum conditions, it was found that dispersive micro-solid-phase extraction method, coupled with liquid chromatography/mass spectrometry, exhibited a good linear relationship with correlation coefficients greater than 0.9980. The relative standard deviations of inter-day and intra-day precisions ranged from 2.6 to 9.2% and the limits of detection ranged from 0.004 to 0.036 μg/L. These merits, combined with their satisfactory recoveries (>80%), suggested the great potential of defective Zr-based metal–organic framework as a new adsorbent for efficient extraction of trace fungicides. This method exhibits good application potential for the pretreatment of fungicides from environmental water samples.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Jian Zhu,Shuang Zhang,Guo-jun Weng,Jian-jun Li,Jun-wu Zhao
By using gold nanorods with silver coating as the sacrificial templates, we prepared spiky yolk-shell AuAg bimetallic nanorods with uniform interior gap via galvanic replacement reaction. The length and number of Au tips of the spiky yolk-shell AuAg nanorods can be tuned simultaneously by altering HAuCl 4 volume. The influence of HAuCl 4 volume and the sliver layer thickness on the SERS activity of spiky yolk-shell AuAg nanorods are studied. When the sliver layer is thin, the interior gap has not been shielded completely and the outer shell has obvious tips, thus the surface-enhanced Raman scattering (SERS) activity has the strongest enhancement with an enhancement factor (EF) of 4.9 × 10 5 . The spiky yolk-shell AuAg nanorods with the strongest SERS activity are used as SERS substrates to detect thiram. The results demonstrate that the SERS intensity increases linearly with the logarithmic concentration of thiram in the range of 10 −3 M to 10 −7 M. The detection limit is as low as 97 nM, which is lower than the maximum pesticide residue limit (29 µM) in fruits stipulated by the US Environmental Protection Agency (EPA). Therefore, the spiky yolk-shell AuAg bimetallic nanorods have important practical application value in pesticide detection.
研究领域:
材料科学
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分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2016
·
IF 2.857
Shuaihua Zhang,Qian Yang,Wenchang Wang,Chun Wang,Zhi Wang
A hybrid material of the zinc-based metal–organic framework-5 and graphene oxide (metal–organic framework-5/graphene oxide) was prepared as a novel fiber coating material for solid-phase microextraction (SPME). The SPME fibers were fabricated by covalent bonding via chemical cross-linking between the coating material metal–organic framework-5/graphene oxide and stainless steel wire. The prepared fiber was used for the extraction of five triazole fungicides from fruit and vegetable samples. Gas chromatography coupled with microelectron capture detector (GC-μECD) was used for quantification. The developed method gave a low limit of detection (0.05–1.58 ng g–1) and good linearity (0.17–100 ng g–1) for the determination of the triazole fungicides in fruit and vegetable samples. The relative standard deviations (RSDs) for five replicate extractions of the triazole fungicides ranged from 3.7 to 8.9%. The method recoveries for spiked fungicides (5, 20, and 50 ng g–1) in grape, apple, cucumber, celery cabbage, pear, cabbage, and tomato samples were in the range of 85.6–105.8% with the RSDs ranging from 3.6 to 11.4%, respectively, depending on both the analytes and samples. The metal–organic framework-5/graphene oxide coated fiber was stable enough for 120 extraction cycles without a significant loss of extraction efficiency. The method was suitable for the determination of triazole fungicides in fruit and vegetable samples.
研究领域:
分析化学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Quality and Safety
·
2022
·
IF 3.949
Liu Yang,Xu Xinxin,Liu Liqiang,Xu Liguang,Kuang Hua,Xu Chuanlai
As a typical triazole fungicide, penconazole (PEN) is widely used in agriculture but has been proven to be toxic. In this study, we designed a new hapten to prepare a highly sensitive and specific anti-PEN monoclonal antibody (mAb) and established a gold nanoparticle-based lateral-flow immunoassay (LFIA) for the detection of PEN residues in watermelon and cucumber. The 50% inhibitory concentration (IC50) of the mAb was 0.42 ng/mL and the LFIA strip had a visual limit of detection (vLOD) of 2.5 ng/g and a cut-off value of 10 ng/g in watermelon and cucumbers. The calculated limit of detection (LOD) of the LFIA strip was 0.36 ng/g for watermelon and 0.29 ng/g for cucumber. The LFIA strip also gave a recovery rate of 92.5%–109.0% for watermelon samples and 92.5%–106.7% for cucumber samples. These results using the LFIA strip are highly consistent with those seen using liquid chromatography–tandem mass spectrometry. Thus our developed LFIA strip represents a potentially reliable tool for the rapid on-site screening for PEN in watermelons and cucumbers.
研究领域:
农业科学
·
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Haili Sun,Juanjuan Feng,Jiaqing Feng,Mingxia Sun,Yang Feng,Min Sun
In order to develop environmentally friendly, economical and facile preparation method of carbon aerogels (CAs), the waste printing paper as the raw material was combined with graphene oxide and carboxylic multi-walled carbon nanotubes to produce CAs (ρ = 44 mg cm −3 ). The CAs with different composition were investigated, the addition of graphene oxide led to the reduction of adsorption sites and the reduction of extraction performance. But the carbon nanotubes made CAs have a better pore structure. The CAs as adsorbent were loaded into a pipette-tip for solid-phase extraction of hexaconazole and diniconazole. Coupled with gas chromatography, an analytical method was established under the optimized conditions. The limits of detection were between 0.08 and 0.32 mg kg −1 , the linear ranges were 0.96–200.0 mg kg −1 and 0.24–200.0 mg kg −1 . The relative recoveries were in the range of 81.0–119%. The results indicated that the method had potential application for the determination of triazole fungicides.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2022
·Vol. 46
·期 2
·2200661
·
IF 3.614
Wenhui Li,Ying Gu,Zikun Liu,Rimao Hua,Xiangwei Wu,Jiaying Xue
A novel solid-phase microextraction device coated with an efficient and cheap thin film of polyurethane was developed for trace determination of 13 widely used pesticides in fruit and tea beverages. A round-shaped polyurethane film covering the bottom of a glass vial was fabricated as the sorbent to exhibit a superior capacity for preconcentrating target compounds and reducing matrix interferences. After optimization of the key parameters including the film type, extraction time, solution pH, ionic strength, desorption solvent, and conditions, this device allowed an efficient adsorption-desorption cycle for the pesticides accomplished in one vial. Coupled with gas chromatography-electron capture detection, the polyurethane-coated thin film microextraction method was successfully established and applied for the analysis of real fruit and tea drinks, showing low limits of detection (0.001–0.015 μg/L), wide linear ranges (1.0–500.0 μg/L, r 2 > 0.9931), good relative recoveries (77.2%–106.3%) and negligible matrix effects (86.1%–107.5%) for the target pesticides. The proposed approach revealed strong potential of extending its application by flexibly modifying the type or size of the coating film. This study provides insights into the enrichment of contaminants from complex samples using inexpensive and reusable microextraction devices that can limit the environmental and health impact of the sample preparation protocol.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 5
·955-963
·
IF 7
Yang Liu,Liqiang Liu,Xinxin Xu,Chuanlai Xu,Liguang Xu
As a commonly used crop fungicide with proven adverse effects against various organisms, the excessive use of flutriafol (FTF) has resulted in accumulation of a large amount of residues in crops. In this study, a novel hapten was designed by introducing a long interval arm on its benzene ring allowing sufficient exposure of the FTF active site, for the production of a highly sensitive and specific monoclonal antibody with a half-inhibitory concentration of 1.77 ng mL−1. Furthermore, for the first time, a gold nanoparticle-based lateral flow immunoassay (LFIA) was developed for the quantitative detection of FTF in foods with a visual limit of detection in rice, tomatoes, and grapes of 0.5 mg kg−1, 0.2 mg kg−1 and 0.5 mg kg−1, respectively, and a cutoff value of 4 mg kg−1, and a calculated limit of detection of 0.045 mg kg−1, 0.035 mg kg−1 and 0.060 mg kg−1, respectively. The recoveries in spiked samples ranged from 90.2% to 110.1% and these results indicated that the gold nanoparticle-based LFIA developed in this study for the rapid detection of FTF in food is a reliable on-site detection method.
研究领域:
农业化学
·
食品科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）