MOLECULES
·
2021
·Vol. 26
·期 11
·3265
·
IF 4.412
Yuhao Sun,Xiaolin Chen,Hong Liu,Song Liu,Huahua Yu,Xueqin Wang,Yukun Qin,Pengcheng Li
Avian leukosis virus subgroup J (ALV-J) is an immunosuppressive virus which has caused heavy losses to the poultry breeding industry. Currently, there is no effective medicine to treat this virus. In our previous experiments, the low-molecular-weightSargassum fusiformepolysaccharide (SFP) was proven to possess antiviral activity against ALV-J, but its function was limited to the virus adsorption stage. In order to improve the antiviral activity of the SFP, in this study, three new SFP long-chain alkyl group nanomicelles (SFP-C12M, SFP-C14M and SFP-C16M) were prepared. The nanomicelles were characterized according to their physical and chemical properties. The nanomicelles were characterized by particle size, zeta potential, polydispersity index, critical micelle concentration and morphology. The results showed the particle sizes of the three nanomicelles were all approximately 200 nm and SFP-C14M and SFP-C16M were more stable than SFP-C12M. The newly prepared nanomicelles exhibited a better anti-ALV-J activity than the SFP, with SFP-C16M exhibiting the best antiviral effects in both the virus adsorption stage and the replication stage. The results of the giant unilamellar vesicle exposure experiment demonstrated that the new virucidal effect of the nanomicelles might be caused by damage to the phospholipid membrane of ALV-J. This study provides a potential idea for ALV-J prevention and development of other antiviral drugs.Keywords:Sargassum fusiforme;polysaccharide;long-chain alkyl group;antiviral activity;ALV-J
研究领域:
兽医学
·
药理学
·
分子生物学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2015
·Vol. 34
·期 1
·59-68
·
IF 1.835
Chen Feng,Wan De-cheng,Jin Ming,Pu Hong-ting
Silica-supported branched polyethylenimine (Sil@PEI) is a conventional adsorbent and shows a limited affinity to anionic surfactants and small dyes ( K = 10 6 –10 7 L/mol). If the PEI is alkylated with cetyl groups (C16), the K of the resulting adsorbents (Sil@PEI@C16- x , where x is the fraction of PEI units being alkylated) is significantly improved. Optimization shows that Sil@PEI@C16-0.15 can best reduce aqueous surfactants to a residue around 10 −10 mol/L; while Sil@PEI@C16-0.6 can reduce even small aqueous dyes to a residue below 10 −10 mol/L, nearly 10 5 -fold lower than that by Sil@PEI. The adsorbents are well recyclable. It is believed that in the case of dyes, the dense cetyl shell can isolate the PEI from the bulky water and thus suppress the competitive binding by water; while in the case of surfactants, the semiclosed cetyl shell can simultaneously meet electrostatic complement and hydrophobic complement to the surfactants.
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 39
·18450-18460
·
IF 3.3
Yao Shen,Fang Lin,Kang Wang,Xitao Wang
CaO-doped γ-Al2O3 beads were prepared by an alginate assisted sol–gel method, followed by grafting with alkyl groups and impregnation of NbCl5 to construct multi-functionalized γ-Al2O3 beads for efficient catalytic conversion of glucose to 5-hydroxymethylfurfural (5-HMF). Doping with CaO improved the binding capacity of the catalyst with glucose and increased the Lewis acid amount. However, a high CaO content would cover the Lewis acid sites of γ-Al2O3, resulting in a lower isomeric conversion of glucose to fructose. When the C8–Ca(10%)–γ-Al2O3 catalyst was loaded with Nb2O5, intermediate fructose was consumed rapidly resulting in complete conversion of glucose, which indicated that conversion of glucose to 5-HMF involved the isomeric conversion of glucose to fructose followed by dehydration of fructose to 5-HMF. This was necessary to balance hydrophilic isomerization reactions with restraining the rehydration of 5-HMF by hydrophobic modification. This is similar to the reaction in which a medium with a certain amount of water was beneficial for glucose isomerization. Under the synergistic effect of Lewis acid provided by γ-Al2O3 and Brønsted acid offered by Nb2O5, C8–Ca(10%)–γ-Al2O3–Nb(3%), a glucose conversation rate of 100% and the highest yield of 5-HMF (68.4%) were achieved in the reaction medium with a dimethylsulfoxide/H2O (V/V) ratio of 4 : 1, a catalyst amount of 33 mg, a reaction temperature of 140 °C and a reaction time of 4 h.
研究领域:
化学工程
·
催化
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 60
·期 15
·2383-2394
·
IF 3.046
Chuyao Wang,Yunyun Xue,Hua Tian,Zihao Zhao,Shuyang Shen,Lifeng Fang,Ronglu Cui,Jun Han,Baoku Zhu
As biomaterials, it is essential for polyurethane (PU) to have excellent antibacterial activity and biocompatibility at the same time. Herein, quaternary ammonium groups, sulfonic groups, and alkyl groups simultaneously introduced hyperbranched poly(amidoamine) (HPA-QSA) was synthesized, which was further used to blend with PU and prepared as films. HPA-QSA/PU blend films showed strong antibacterial activity to kill more than 99.99% of both Gram-positive and Gram-negative bacteria due to the quaternary ammonium groups and long alkyl groups, as well as good biocompatibility through protein-resistance, cytotoxicity, hemolysis assays under the combined action of cations and anions. Moreover, they exhibited stable antibacterial activity and low cytotoxicity in aquatic solutions. Overall, HPA-QSA/PU films prepared by facile blending process exhibit great promise as low-cost, effective antibacterial, good biocompatible materials, indicating an appealing prospect in biomedical fields. Graphical
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Tao Ge,Bingyi Zhou,Jingyao Xu,Yulu Wei
Ionic liquids (ILs) were selected and applied to investigate the best coal desulfurization through orthogonal tests. FTIR, XPS, SEM and contact angle tests were used to characterize the effect on the physical and chemical structures in coal for revealing the coal desulfurization mechanism by ILs-H 2 O 2 system. The orthogonal test results showed that reaction temperature and reaction time were the main influencing factors for the desulfurization rates of coal in the ILs-H 2 O 2 system, and the ILs synergy could effectively improve the desulfurization rates of H 2 O 2 . The maximum coal desulfurization rates of [BMIM][HSO 4 ], [BMIM][OTF], and [BMIM][BF 4 ] ionic liquids were 30.7%, 30%, and 33.2%, respectively. The results indicated that the alkyl groups in coal were oxidized and the contents of oxygen-containing functional groups such as hydroxyl and carbonyl increased. Coal surface underwent swelling, the internal pores increased and new pores and cracks were generated. The wettability of coal improved substantially. In addition, the physical structures changes in coal facilitated the contact between the extractant and the sulfur-containing structures. The contents of thiols and sulfides in coal significantly decreased and were oxidized to sulfoxides and sulfones, with some further oxidized to soluble sulfites or sulfates. Thus achieving removal from coal.
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Guibin Li,Chunyu Ru,Fengmei Cheng,Duo Qi,Shiyuan Zhou,Yi Li
In the present work, a novel poly(arylene ether ketone) with a unique molecular design that included concentrated flexible sulfoalkyl groups and a silane cross-linked network (C-SPAEK) was prepared and used as a PEM for DMFCs . The chemical structures , sulfonation degree and phase-separated morphology were characterized and identified by 1 H NMR, FT-IR and SAXS. The resulting copolymers exhibited excellent thermal stability (T 5% >263.8 °C) and mechanical properties (tensile strength>52.88 MPa). Additionally, the high IEC values and obvious hydrophilic/hydrophobic phase-separated structure (d > 2.71 nm) ensured that the C-SPAEK membranes possessed high proton conductivities . The C-SPAEK PEMs also displayed enhanced methanol resistance and dimensional stability, which were much better than those of a recast Nafion membrane under the same conditions. The C-SPAEK-0.4 membrane maintained a low methanol absorption of less than 48.7%, even in 4 M methanol solution. In particular, the C-SPAEK-0.6 membrane exhibited the best comprehensive performance, with a high proton conductivity (0.164 S cm −1 ), low methanol uptake (52.1%) and permeability (3.63 × 10 −7 cm 2 s −1 ), and maximum power density (83.2 mW cm −2 ), when immersed in 2 M methanol at 80 °C in a DMFC single-cell. These results suggested that the C-SPAEK membranes were sufficiently tough and had the potential to overcome the problems caused by the high methanol permeability of PEMs. The unique molecular design of C-SPAEK guaranteed a rare combination of high proton conductivity and enhanced methanol resistance, which are the key determining factors for DMFC applications .
研究领域:
材料科学
·
电化学
·
高分子化学
·
燃料电池技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）