JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Ning Li,Xiaoyu Lu,Min Fang,Zhixia Qiu,Xijing Chen,LiLi Ren,Pingkai Ouyang,Guoguang Chen
Triacontanol (TA), a natural compound with various health benefits, is extensively used as a nutritional supplement. The therapeutic and nutraceutical applications of TA are limited due to its poor aqueous solubility. PEGylated triacontanol (PEGylated TA) was designed to improve the solubility and pharmacokinetics of TA. After PEGylation, the solubility (∼250 g·L–1 versus 9 × 10–14 g·L–1), body residence (MRT, 9.40 ± 2.03 h versus 2.59 ± 0.705 h, p < 0.001), and systemic exposure (AUC0–inf, 29.1 ± 5.33 μM·h versus 0.529 ± 0.248 μM·h, p < 0.001) of TA were all significantly increased compared to pristine TA. When intravenously administered (6.85, 22.8, and 68.5 μmol·kg–1) in rats, PEGylated TA exhibited a slow clearance (44.8 ± 8.62, 47.9 ± 5.18, and 46.9 ± 16.5 mL·h–1·kg–1), long elimination half-life (8.76 ± 0.96, 10.4 ± 1.66, and 11.1 ± 2.81 h), and abundant systemic exposure (AUC0–t, 155 ± 24.2, 523 ± 56.2, and 1709 ± 245 μM·h). Meanwhile, its metabolite TA showed a high AUC0–t (28.4 ± 5.14, 151 ± 25.4, and 797 ± 184 μM·h) and slow elimination (t1/2, 10.1 ± 2.03, 7.78 ± 1.74, and 6.82 ± 0.58 h). Our results demonstrated that PEGylated TA has superior pharmacokinetics, which enhanced its nutritional and pharmacodynamic potency, and thus warrants further investigations.
研究领域:
药理学
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营养学
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药物化学
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产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2024
·
IF 4.9
Shiqin Dong,Haiyang He,Zhilian Qiu,Liguo Peng,Shuang Qin,Jianjun Fang,Dianwen Liu,Peilun Shen
This study explores the selective depression mechanism of pyrite by proanthocyanidins (PC) during chalcopyrite-pyrite flotation separation. The selective inhibition effect of inhibitor PC was examined through flotation experiments. The depression mechanism of PC on pyrite was analyzed employing X-ray photoelectron spectroscopy (XPS) analysis, selective adsorption tests, adsorption experiments, contact angle measurement, and zeta potential measurement. The artificial mixed mineral flotation test of chalcopyrite-pyrite at a ratio of 1:12 was conducted under pH 7, PC concentration of 75 mg/L, and PAX concentration of 18.75 mg/L. The copper concentrate exhibited a recovery rate of 88.97%, with a copper grade of 29.43%. The sulfur grade in copper concentrate was 40.35%, and the pyrite recovery rate was 1.97%. PC can be used as a potential depressant of pyrite. adsorption experiments and Zeta potential measurement indicated that PC treatment significantly impeded PAX adsorption on the pyrite surface, as confirmed by XPS test results and Ion adsorption analysis.
研究领域:
矿物加工工程
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环境科学
·
材料化学
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产品关联
DOI
高影响因子
JOURNAL OF FOOD PROCESS ENGINEERING
·
2019
·Vol. 42
·期 4
·e13023
·
IF 1.448
Ishmael Ayim,Haile Ma,Evans Adingba Alenyorege,Yuqing Duan
The effect of brown, oolong, and green teas’ extract on the in vitro inhibition of starch digestibility of cassava, corn, plantain, and yam was explored. The starches exhibited moderately low hydrolysis rate and had moderate resistant starch ratios. Tea metabolites after extraction at different temperatures were quantified and correlated to starch inhibition at 1% introduction using principal component analysis (PCA). Total polyphenols (TP), (−)-epigallocatechin (EGC), (−)-gallocatechin gallate (GCG), (−)-catechin gallate (CG), and (−)-epigallocatechin gallate (EGCG) were positively correlated with starch digestion inhibition especially in the first and second hours of digestion. The (+)-catechin (C) and Total flavonoids (TF) in the teas, however, had a negative correlation with starch inhibition. Green tea extracts were more effective in starch digestion inhibition followed by brown tea and then oolong. TP, EGC, GCG, CG, and EGCG from green tea had the strongest inhibitory effect on starch digestion and that purified extracts of these compounds could be used at a statistically optimized combination to formulate diets with improved hypoglycemic potential. Practical applications In order to identify key components in tea responsible for hypoglycemic effect, tea extracts from three different source and their starch inhibitory properties were analyzed using starches from four plant sources. To this end, key components in the tea varieties were identified with potential hypoglycemic effect. Therefore, diets with potential hypoglycemic effect could be formulated using purified extracts from tea such as TP, (−)-epigallocatechin, (−)-gallocatechin gallate, (−)-catechin gallate, and (−)-epigallocatechin gallate under optimized conditions.
研究领域:
食品科学
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营养学
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植物化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Jielong Zhou,Bo Wang,Xiandong Hao,Zhiyong Xu,Wenbo Zhao
In the absorption of SO 2 , it is very important for industrial applications to set up mathematical models to describe the changes in physical–chemical properties and the absorption dynamic processes. However, most of the research only pays attention to the molecular structure of absorbent. Few works have investigated the mathematical models in the absorption processes. To make up for the research gap in this area, a binary absorbent composed of 2-(dibutylamino)ethanol (DBEA) and 1-Ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim][TfO]) were developed for SO 2 capture in the present work. A systematic mathematical model was proposed to accurately predict the viscosity and density of the absorption system with different absorbent compositions, SO 2 absorption capacities, and temperatures. Additionally, the absorption kinetics and thermodynamics were analyzed across varying absorbent compositions and SO 2 -containing gas flows, enabling dynamic prediction of the absorption process. Furthermore, the correlation between desorption residuals and desorption temperature was investigated, along with an analysis of SO 2 /CO 2 selectivity and the cyclic SO 2 absorption performance. This work provides a robust framework for rational screening and design of alkanolamine-IL hybrid solvents, bridging the gap between experimentally empirical solvent development and theoretical prediction.
研究领域:
化学工程
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环境科学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Sen Liu,Hao Ling,Hongxia Gao,Paitoon Tontiwachwuthikul,Zhiwu Liang
To give better guidance of tertiary alkanolamine selection with proper structures for postcombustion CO2 capture, effects of the alkanol chain structure and intramolecular hydrogen bond were investigated. First, water solubilities of 2.5 M aqueous solutions were experimentally investigated for 11 tertiary alkanolamines, and data of boiling point and vapor pressure for pure chemicals were collected also. The physical property results showed a biphasic phenomenon were observed in 2.5 M fresh 1-diethylamino-2-propanol (1DEA2P) solution and CO2-loaded 4-diethylamino-2-butanol (4DEA-2B) solution, and 1-dimethylamino-2-propanol (1DMA2P) and 1DEA2P have a dramatically relative lower boiling point and a higher vapor pressure, indicating the existence of an intramolecular hydrogen bond, especially in amines with branched alkanol chains. In addition, the pH values for fresh and equilibrium CO2-loaded amine solutions (2.5 M, 313 K), equilibrium CO2 solubility (2.5 M, 313 K, and 15 kPa), first-order reaction rate constant (0.1–0.4 M and 313 K), and dissociation constant (293–333 K) were measured, and the results showed amines with linear alkanol chains can have relatively strong basicity, absorption capacity, and a reaction rate with CO2 owing to weaker influences of the intramolecular hydrogen bond. Finally, the CO2 capture performance was comprehensively compared by ΔrGm and ΔrHm screening methods as well as the fast solvent screening method with cyclic capacity, and the results further confirmed that amines with linear alkanol chains can present better CO2 capture performance, like 3-dimethylamino-1-propanol (3DMA1P) and 3-diethylamino-1-propanol (3DEA1P). It also suggests that the selection or design of tertiary alkanolamines should with the linear alkanol chain instead of branched to have better CO2 capture performance for industrial applications.
研究领域:
化学工程
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2014
·
IF 2.302
An-Lin Zhang,Li-Wen Yang,Nian-Fa Yang,Jing Zhang
Several C 3 -symmetric trialkanolamines can be efficiently obtained via molecular sieve-assisted epoxide ring opening with ammonia in high yields (up to 90%) and regioselectivity up to 100%. These trialkanolamines were effective for the asymmetric alkynylation of aldehydes and the propargyl alcohols were obtained in high yields (up to 92%) and high enantiomeric excesses (up to 95%). The 1 H NMR spectra support that there could be a complex mixture of polynuclear Ti(IV)-based species form from the interaction of Ti(IV) with ligand.
研究领域:
有机化学
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催化化学
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产品关联
DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 5
·1066
·
IF 3.098
Lingxi Li,Minna Zhang,Shuting Zhang,Yan Cui,Baoshan Sun
Anthocyanin-flavanol pigments, formed during red wine fermentation and storage by condensation reactions between anthocyanins and flavanols (monomers, oligomers, and polymers), are one of the major groups of polyphenols in aged red wine. However, knowledge of their biological activities is lacking. This is probably due to the structural diversity and complexity of these molecules, which makes the large-scale separation and isolation of the individual compounds very difficult, thus restricting their further study. In this study, anthocyanins (i.e., malvidin-3-glucoside, cyanidin-3-glucoside, and peonidin-3-glucoside) and (–)-epicatechin were first isolated at a preparative scale by high-speed counter-current chromatography. The condensation reaction between each of the isolated anthocyanins and (–)-epicatechin, mediated by acetaldehyde, was conducted in model wine solutions to obtain ethyl-linked anthocyanin-flavanol pigments. The effects of pH, molar ratio, and temperature on the reaction rate were investigated, and the reaction conditions of pH 1.7, molar ratio 1:6:10 (anthocyanin/(–)-epicatechin/acetaldehyde), and reaction temperature of 35 °C were identified as optimal for conversion of anthocyanins to ethyl-linked anthocyanin-flavanol pigments. Six ethyl-linked anthocyanin-flavanol pigments were isolated in larger quantities and collected under optimal reaction conditions, and their chemical structures were identified by HPLC-QTOF-MS and ECD analyses. Furthermore, DPPH, ABTS, and FRAP assays indicate that ethyl-linked anthocyanin-flavanol pigments show stronger antioxidant activities than their precursor anthocyanins.Keywords:anthocyanin;antioxidant activity;ethyl-linked anthocyanin-flavanol pigment
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2023
·
IF 2.6
Qinghai Long,Shuo Wang,Xin Yin,Shufeng Shen
Nonaqueous solvents containing secondary alkanolamines and 2-alkoxyethanols, have recently gained significant attention for energy-efficient CO 2 capture process. However, the information of physicochemical property, particularly involving 2-(hexyloxy)ethanol (EGHE), is very limited for mass transfer and process modeling development. In this work, densities and viscosities were measured for binary mixtures of EGHE with 2-(methylamino)ethanol, 2-(ethylamino)ethanol and 2-(butylamino)ethanol at temperatures of (293.15–353.15)K and atmospheric pressure in the entire concentration range. The excess/deviation properties were derived from the experimental data and fitted by the Redlich-Kister equation to estimate the binary interaction parameters. The variation of excess properties with solvent composition and temperature was also discussed in terms of intermolecular interactions. The calculated from the proposed correlations matched well with the experimental values, with AARDs within 0.01% and 1.60% for density and viscosity respectively.
研究领域:
化学工程
·
物理化学
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Jia Liu,Bin Yang,Yuting Wang,Fengming Zhang,Xin Liu,Shiyue Niu,Yue Yuan,Shuyun Bi
Cadmium sulfide quantum dots (CdS QDs) were synthesized with 3-mercaptopropionic acid (MPA) as protective agent, which were characterized by TEM, UV–vis, fluorescence, XRD and TGA. Based on the fluorescence quenching of 3-MPA-CdS QDs, the indirect methods for the determination of furazolidone (FZD) and nitrofurantoin (NFT) were established. The interaction between FZD/NFT and CdS QDs was investigated by using fluorescence, resonance light scattering, UV–vis and FT-IR. The analyses of Stern-Volmer and fluorescence lifetime indicated that the two quenching systems were all static. The binding constant ( K a ) of FZD/NFT-CdS QDs was 1.20 × 10 4 /1.81 × 10 4 L/mol at 293 K, respectively. Hydrogen bond or van der Waals force was the main binding force between CdS QDs and drugs. Under optimum experimental conditions, the concentration of FZD/NFT was respectively highly correlated with the fluorescence intensity ratio in the range of 0.27 – 36.03/0.57 – 28.58 μg mL −1 . The interference experiments showed that the methods had good selectivity. The limit of detection (LOD) for FZD/NFT was 0.02/0.01 μg mL −1 . The contents of FZD and NFT in fish samples were determined, and the recoveries were 97.41–99.52 % and 96.64–100.49 %, respectively.
研究领域:
分析化学
·
药物分析
·
食品安全检测
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Mingxi Jia,Weidong Bai,Jing Deng,Wen Li,Qinlu Lin,Feifei Zhong,Feijun Luo
Octacosanol , a naturally occurring higher fatty alcohol , possessed numerous biological effects. However, octacosanol limited solubility in water due to its lipophilic nature and large structure, resulting in poor absorption and low bioavailability. To overcome this challenge, we developed a simple, environmentally friendly, and energy-efficient O/W nanoemulsion synthesis process. The nanoemulsion achieved an average droplet size of approximately 30 nm, exhibited excellent dispersibility and stability at room temperature for 60 days, and showcased robust storage properties insensitive to ambient temperature, pH, NaCl, and sucrose. Remarkably, the preparation process of the nanoemulsion maintained the biological activity of octacosanol while demonstrating significantly enhancing antioxidant activity compared to octacosanol suspension. Additionally, the nanoemulsion displayed negligible cytotoxic effects on Caco-2 cells. Significantly, the octacosanol nanoemulsion exhibited a 5.4-fold enhancement in transmembrane transport efficiency when compared to the suspension in Caco-2 cell monolayers. Additionally, in an in vivo experiment, there was a notable 2.9-fold increase in rat intestinal absorption. These findings could provide valuable insights into the development of octacosanol nanoemulsion, supporting its future applications and paving the way for the design of stable nanoemulsion systems for other lipophilic and sparingly soluble substances.
研究领域:
药剂学
·
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Bingke Yang,Haojie Li,Zhen Yao,Lili Xing,Xuetao Wang,Yilin Zhu
In the study, ammonia borane alcoholysis with different types of alcohols (CH3OH, CH3CH2OH, (CH2OH)2) for hydrogen production are investigated, and the effects of different pressures and temperatures on the adsorption properties are also investigated using the DFT calculation and experimental method. In the ammonia borane alcoholysis, NH3BH3 molecules and alcohols molecules (R-OH) are first adsorbed onto the active metal surface, where the hydroxyl groups in the R-OH molecules are activated and the O-H bonds are broken to produce the intermediates H* and *O-R. Further a strong interaction between the B in NH3BH3 and the O in *O-R occurs and the B-N bond is broken, forming the intermediate products *NH3, *BH2-O-R and another H*, H2 molecule is released during B-O bonding with one of the H originated from the hydroxyl group and the other originated from the *HB in the NH3BH3 molecule. The energy barriers for the ammonia borane alcoholysis with CH3OH, CH3CH2OH and (CH₂OH)₂ are 28.23 kcal/mol, 37.5 kcal/mol and 42.32 kcal/mol, respectively, which results in a different alcoholysis rate of ammonia borane AB/CH3OH> AB/CH3CH2OH> AB/(CH2OH)2 at the macroscopic level. The high pressure enhances the adsorption properties of ammonia borane and alcohol molecules, while the high temperature decreases the adsorption properties. The adsorption capacities of ammonia borane and alcohols on the active metal Ru (101) are CH3OH (0.32 mmol/g) < NH3BH3 (1.03 mmol/g) < CH3CH2OH (1.05 mmol/g) < (CH2OH)2 (1.31 mmol/g) specifically. The results of this study provide a theoretical basis for the regulation of hydrogen production from ammonia borane alcoholysis.
研究领域:
化学工程
·
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioengineering
·
2024
·Vol. 3
·期 2
·172-188
·
IF 0
Xiangchun Meng,Yishu Sun,Tao Xu,Lihua Tang,Yaning Chang,Yingjun Zhou
Octacosanol is a plant natural product with the potential to ameliorate alcoholic liver injury. However, its poor solubility limits its application in the food industry. This study first verified that octacosanol has a favorable effect on acute and subchronic alcoholic liver injury in mice by protecting the gastric mucosa and ameliorating disease levels. Additionally, octacosanol microcapsules were prepared under the optimal drying conditions of the feed flow rate of 400 mL/h and drying temperature of 180°C to improve the ameliorative effects of octacosanol, with moisture content, water activity, dispersibility, and solubility of 1.53%, 0.16%, 89.84%, and 95.30%, respectively. The microcapsules had a spherical structure, and the droplet sizes after redissolution ranged from 0.061 to 4.63 µm. Instrumental measurements and simulated digestion experiments have shown that microencapsulation enhanced the solubility and thermal stability of octacosanol, with 90.88% of the octacosanol being continuously released. As expected, microencapsulation significantly enhanced the effect of octacosanol in ameliorating alcoholic liver injury by determining the disease index in the mice model. This study demonstrated the beneficial effects of octacosanol on alcoholic liver injury and explored a viable method to improve its solubility and bioaccessibility, thereby enhancing its therapeutic efficacy for the treatment of alcoholic liver injury.
研究领域:
食品科学
·
药理学
·
生物医学工程
✓ 已验证
DOI
危险品化学品经营许可证（带存储）