CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Jiaxin Wu,Zhi Li,Xingliang Meng,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
Promoting mechanical strength and osteoinductivity properties is crucial for dental implants materials. Herein, we synthesized silicocarnotite (CPS) powder via a hydrothermal method, and mixed it with zirconia to create a composite material for preparing four slurries: xCPS-(1−x)ZrO 2 (x = 0, 1/6, 1/3, and 1/2 vol%). The optimal printing parameters for each slurry were investigated. Following the printing of the slurries, debinding was performed on them in the temperature range of 25 °C–600 °C in nitrogen atmosphere and 600 °C–1000 °C in air atmosphere, respectively, followed by sintering at 1350 °C for 2 h. The graded zirconia-based composite ceramics prepared using stereolithography (SLA) exhibited excellent mechanical properties, including a flexural strength of 742.37 ± 22.52 MPa, Vickers hardness of 7.29 ± 0.15 GPa, fracture toughness of 5.34 ± 0.29 MPa m 1/2 , and a relative density of 96.3 %. Compared with zirconia ceramics, the graded composite ceramics displayed higher surface roughness. The graded composite ceramics degraded and released Ca, Si, and P ions, promoting MC3T3-E1 cells proliferation, adhesion, and osteogenic differentiation. These findings suggest that ZrO 2 -CPS/ZrO 2 graded composite ceramics synthesized via SLA holds great potential as dental implants with high osteoinductivity.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
International Journal of Implant Dentistry
·
2024
·Vol. 10
·期 1
·1-11
·
IF 3.1
Cui Boyu,Bai Tianyi,Wu Qiyou,Hu Yibo,Liu Yihong
Purpose Osteoporotic individuals who have dental implants usually require a prolonged healing time for osseointegration due to the shortage of bone mass and the lack of initial stability. Although studies have shown that intermittent teriparatide administration can promote osseointegration, there is little data to support the idea that pre-implantation administration is necessary and beneficial. Methods Sixty-four titanium implants were placed in the bilateral proximal tibial metaphysis in 32 female SD rats. Bilateral ovariectomy (OVX) was used to induce osteoporosis. Four major groups ( n = 8) were created: PRE (OVX + pre-implantation teriparatide administration), POST (OVX + post-implantation administration), OP (OVX + normal saline (NS)) and SHAM (sham rats + NS). Half of rats ( n = 4) in each group were euthanized respectively at 4 weeks or 8 weeks after implantation surgery, and four major groups were divided into eight subgroups (PRE4 to SHAM8). Tibiae were collected for micro-CT morphometry, biomechanical test and undecalcified sections analysis. Results Compared to OP group, rats in PRE and SHAM groups had a higher value of insertion torque ( p < 0.05). The micro-CT analysis, biomechanical test, and histological data showed that peri-implant trabecular growth, implants fixation and bone-implant contact (BIC) were increased after 4 or 8 weeks of teriparatide treatment ( p < 0.05). There was no statistically difference in those parameters between PRE4 and POST8 subgroups ( p > 0.05). Conclusions In osteoporotic rats, post-implantation administration of teriparatide enhanced peri-implant bone formation and this effect was stronger as the medicine was taken longer. Pre-implantation teriparatide treatment improved primary implant stability and accelerated the osseointegration process.
研究领域:
口腔医学
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骨生物学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
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IF 5.268
Yajing Liu,Jin Wu,Hao Zhang,Yizhen Wu,Chunbo Tang
In order to improve early osseointegration and long-term survival rate of implants, a multifunctional titanium surface that promotes osteogenesis and antibacterial properties is expected. Incorporation of bioactive trace elements such as magnesium ions was proved a promising method to improve osseointegration of titanium. Phytic acid has strong chelating ability with multivalent cations, which has been used in surface modification. Moreover, phytic acid was proved antibacterial potential. Herein, to improve the osteogenic and antibacterial properties, a phytic acid-magnesium (PA-Mg) layer was introduced on titanium using phytic acid as a cross-linker molecule. No obvious changes of the surface characterization were observed by scanning electron microscopy and atomic force microscopy. X-ray photoelectron spectroscopy confirmed that the PA-Mg layer covalently bond to the Ti surface, and the thickness of the PA-Mg layer was about 150 nm. Besides, improved hydrophilic and more protein adsorption were observed on Ti-PA-Mg. Notably, a relatively controlled magnesium release was also observed on Ti-PA-Mg. Human bone mesenchymal stem cells showed better adhesion, proliferation, and osteogenic differentiation on Ti-PA-Mg samples, indicating improved biocompatibility and osteoinductivity. Moreover, Ti-PA-Mg had better antibacterial properties against porphyromonas gingivalis than Ti. Overall, the PA-Mg layer on Ti surface improved the osteogenic and antibacterial properties, which may have promise for use in dental implantation.
研究领域:
生物材料
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生物医学工程
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牙科材料
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表面化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2022
·Vol. 105
·期 8
·5069-5081
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IF 4.186
Wenmin Zhang,Jinhuan Ke,Guowen Qian,Jiandong Ye
Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramics with outstanding mechanical properties and aesthetic origins are expected to be used in dental implant applications. However, tetragonal zirconia ceramics are not bioactive, which affect the osseointegration and reliability as dental implant materials. Herein, in this study, Y-TZP ceramics were modified by grain-boundary activation via coating a bioactive glass (BG) sol with different content on the crystal surfaces of zirconia powder and followed by being gelled, dried, granulated, low-temperature treated, molded and sintered at 1450°C for 3 h in air. The effects of BG content on the morphology, phase compositions, mechanical properties, in vitro mineralization ability and cell biological properties of the bioactivity modified Y-TZP ceramics were evaluated. The BG additive did not affect the tetragonal–monoclinic phase transformation of ZrO 2 . However, the addition of BG decreased the flexural strength of the modified Y-TZP ceramics compared to that of Y-TZP. The in vitro mineralization results showed that a homogeneous apatite layer was produced on the surface of the Y-TZP ceramics when they were immersed in the simulated body fluid for 21 days. The cell response results indicated that the bioactive surface modification of Y-TZP ceramics could promote cell adhesion, propagation and osteogenic differentiation performance. Thus, our research results suggest that the highly bioactive Y-TZP ceramics could be a potential candidate for dental implant material.
研究领域:
材料科学
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生物材料
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牙科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 6
·2230-2242
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IF 6.6
Ziming Liao,Luyao Zhang,Weiwei Lan,Jingjing Du,Yinchun Hu,Yan Wei,Ruiqiang Hang,Weiyi Chen,Di Huang
Titanium (Ti) has been widely used as a dental implant material due to its excellent mechanical property and good biocompatibility. However, its poor biological activity severely limits its ability to bond with bony tissues. To ameliorate this situation, a preparation method of ultra-high bonding nano-hydroxyapatite (n-HA) coating on the Ti surface is urgently needed. Here, Ti phosphate/n-HA (TiP–Ca) composite coatings with ultra-high bonding were prepared by a two-step hydrothermal treatment. The TiP coating was first formed in situ on the pure Ti substrate and then n-HA crystals further grew on the TiP surface. The formation mechanism of composite coating and reasons for increased bonding strength were systematically investigated. The results show that the TiP–Ca coating remains stable and exhibits an ultra-high bonding strength with the Ti implant (up to 783.30 ± 207.46 N). An effective solution was designed to address the problems of easy peel off. Cell experiments showed that TiP–Ca could promote the adhesion of MC3T3-E1 and expression of OCN, Runx2, and ALP. In vivo evaluation further confirmed that the TiP–Ca composite coating significantly enhanced osseointegration. The designed coating shows great potential in clinical application of implants.
研究领域:
材料科学
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生物材料
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牙科种植学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Gang Yang,Rongrong Deng,Yincheng Chang,Hongbo Li
Developing titanium-based dental implants with both excellent antibacterial properties and good osseointegration is crucial for the success of the implant operation and the long-term durability of the implant. In this study, a polydopamine-based coating was created by attaching TiO 2 nanosheets-cyanine composites onto the titanium surface, enabling the integration of effective photothermal antibacterial therapy with osseointegration. The exceptional dual-photothermal conversion abilities of polydopamine and cyanine in the coating resulted in outstanding photothermal antibacterial and antibiofilm therapy against four types of bacteria. Furthermore, TiO 2 nanosheets promoted the adhesion, proliferation and early osteogenic differentiation of osteoblasts. In an infected dental implant model in rats, the developed coating exhibited potent antibacterial activity and remarkable osteogenic differentiation in the bone, leading to increased bone formation around the implants. This innovative approach, combining photothermal therapy with osteogenic two-dimensional nanomaterials, presents a novel method for surface functionalization of implants to achieve effective antibacterial and osseointegration capabilities.
研究领域:
生物材料
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牙科种植学
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光热疗法
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组织工程
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生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2016
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IF 3.014
Yu Bai,Yulong Bai,Jingjun Gao,Wen Ma,Juan Su,Ruilin Jia
Poor mechanical properties and a relatively low stability in physiological environments have significantly limited hydroxyapatite (HA) for many practical implant applications. In this study, we developed a reduced graphene oxide/fluorhydroxyapatite (rGO/FHA) biocomposite with enhanced mechanical properties, dissolution resistance, biocompatibility and antibacterial activity. rGO and fluorine (F) are simultaneously incorporated into HA to form the rGO/FHA composite by an in situ chemical synthesis method and spark plasma sintering technology. The uniform distribution of rGO and the good interfacial bonding help to improve the hardness by 86% and the fracture toughness by 137%. The chemical stability of the rGO/FHA composite is evaluated by determining the Ca 2+ ion release. The result indicates that the substitution of F − ions into the HA structure has a positive effect on the dissolution resistance of HA. The in vitro bioactivity assessment shows that the osteoblast adhesion and proliferation ability on the rGO/FHA composite are improved. In addition, a higher alkaline phosphate activity is also detected in cells cultured on the rGO/FHA composite. More importantly, it is observed that the rGO/FHA composite can effectively inhibit the adhesion and proliferation of Streptococcus mutans . These findings suggest that the rGO/FHA biocomposite would be highly useful as a dental implant material.
研究领域:
材料科学
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生物材料
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生物医学工程
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牙科材料
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Jiaojiao Li,Xiaoqin Wu,Zhaojia Liang,Zhangao Wei,Zirui Chen,Yankai Wang,Wei Li,Weibo Zhang,Runhuai Yang,Hua Qiu,Xiangyang Li,Quanli Li,Jialong Chen
Osteogenesis surrounding dental implants is initiated by a series of early physiological events, including the inflammatory response. However, the persistence of an anti-infection surface often results in compromised histocompatibility and osseointegration. Here, we presented a programmed surface containing both silver nanoparticles (AgNPs) and silver ions (Ag + ) with a heterogeneous structure and time-dependent functionalities. The AgNPs were located at the surface of the heparin-chitosan polyelectrolyte coating (PEM), whereas Ag + was distributed at both the surface and inside of the coating under optimized conditions (pH=4). The optimized coating (Ag-4) exhibited potent bactericidal activity at the early stage (12 and 24 h after inoculation) and a sustained antibacterial efficacy in the subsequent stage (one or two weeks), as it gradually depleted. Furthermore, compared to coatings with sustained high silver concentrations in bacteria-cell coculture experiments, the degradable Ag-4 coating demonstrated improved cytocompatibility, better cell viability, and morphology over time. At a later stage (within one month), the in vivo test revealed that Ag-4-coated titanium had superior histocompatibility and osteogenesis outcomes compared to bare titanium in a bacteria-exposed environment. The programmed surface of dental implants presented in this study offers innovative ideas for sequential antibacterial effects and osseointegration.
研究领域:
牙科学
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生物材料
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生物医学工程
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2020
·
IF 6.155
Hui Liu,Rui Liu,Ihsan Ullah,Shuyuan Zhang,Ziqing Sun,Ling Ren,Ke Yang
Implant-related infection and early bone integration are the main risk factors of implants for long-term service, to overcome these difficulties, SLA-TiCu surface was prepared by sandblasting and large-grits etching (SLA) treatment on a novel antibacterial titanium-copper alloy (TiCu), which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants. Effects of SLA-TiCu surface on the adhesion, proliferation, apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen ( Staphylococcus aureus ) were studied. Compared to the following surfaces: sandblasting and large-grits etched pure titanium (SLA-Ti), mechanically ground pure titanium and TiCu alloy (M-Ti and M-TiCu), these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions (alkaline phosphates (ALP), collagen type I (COL I), Runt-related transcription factor 2 (RUN × 2), and osteopontin (OPN)). Moreover, SLA-TiCu surface could maintain a sustainable release of Cu 2+ ions and effectively inhibited the viability of bacteria. This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity, making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants .
研究领域:
材料科学
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生物材料
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骨科
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牙科
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2021
·Vol. 36
·期 9
·1866-1882
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IF 3.089
Wu Jin,Liu Yajing,Zhang Hao,Wu Yizhen,Chu Zhuangzhuang,Wu Qirong,Lu Mengmeng,Tang Chunbo
Abstract In this study, we presented that human bone mesenchymal stem cells (hBMSCs) showed superior adhesion and proliferation behaviors on polished silicon nitride (Si 3 N 4 ). Also, compared to Ti and ZrO 2 , Si 3 N 4 enhanced the osteogenic activities of hBMSCs indicated by increases in alizarin red S (ARS) staining, Ca 2+ concentration, and mRNA expression of RUNX2, OPN, OCN, and COL1. Furthermore, colony formation assays demonstrated significantly better antibacterial activities against oral pathogens Porphyromonas gingivalis (Pg), Staphylococcus aureus (SA), and Escherichia coli ( E. coli ) on Si 3 N 4 surface than Ti and ZrO 2 . Live/dead bacterial staining showed a large amount of dead Pg on Si 3 N 4 surfaces. The fact that Si 3 N 4 demonstrated advantages in osteogenic and antibacterial activities over Ti and ZrO 2 might be a reason for its potential use as non-metallic dental implant materials. However, more detailed studies with resolution techniques and preclinical studies are needed to confirm the Si 3 N 4 ’s osteogenic and antibacterial properties. Trial registration number PJ2019-066-001; date of registration: Jun 2019. Graphic abstract
研究领域:
牙科学
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生物材料
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细胞生物学
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微生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the Mechanical Behavior of Biomedical Materials
·
2023
·
IF 3.9
Rongfang Zou,Lunan Bi,Yang Huang,Yadi Wang,Yan Wang,Lin Li,Jiayin Liu,Lu Feng,Xiaoxia Jiang,Bin Deng
For decades, titanium has been the preferred material for dental implant fabrication. However, metallic ions and particles can cause hypersensitivity and aseptic loosening. The growing demand for metal-free dental restorations has also promoted the development of ceramic-based dental implants, such as silicon nitride . In this study, silicon nitride (Si 3 N 4 ) dental implants were fabricated for biological engineering by photosensitive resin based digital light processing (DLP) technology, comparable to conventionally produced Si 3 N 4 ceramics. The flexural strength was (770 ± 35) MPa by the three-point bending method, and the fracture toughness was (13.3 ± 1.1) MPa · m 1/2 by the unilateral pre-cracked beam method. The elastic modulus measured by the bending method was (236 ± 10) GPa. To confirm whether the prepared Si 3 N 4 ceramics possessed good biocompatibility , in vitro biological experiments were performed with the fibroblast cell line L-929, and preferable cell proliferation and apoptosis were observed at the initial stages. Hemolysis test, oral mucous membrane irritation test, and acute systemic toxicity test (oral route) further confirmed that the Si 3 N 4 ceramics did not exhibit hemolysis reaction, oral mucosal stimulation, or systemic toxicity. The findings indicate that Si 3 N 4 dental implant restorations with personalized structures prepared by DLP technology have good mechanical properties and biocompatibility, which has great application potential in the future.
研究领域:
牙科材料
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生物医学工程
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材料科学
·
生物相容性测试
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Xiaoyan Li,Ailin Wei,Haosen Zhao,Zhenfei Wang,Yang Lyu,Jie Nie,Yu Chen
Hydrogels possess inherent characteristics that render them promising for the prevention of peri-implantitis. Nonetheless, hydrogels with singular network structures are incapable of concurrently achieving the desired adhesion and mechanical properties. In this work, a carboxymethyl resistant starch/polyacrylic acid semi-interpenetrating (CMRS/PAA semi-IPN) hydrogel was successfully prepared in one step. Its morphology, structure, mechanical properties, and adhesion properties were systematically assessed, which revealed a homogeneously porous structure with a commendable mechanical strength of 67.317 kPa and an adhesion strength of 63 kPa. Ciprofloxacin (Cip) was loaded in the CMRS/PAA hydrogel via in situ compounding. The in vitro kinetic study of drug release shows that the slow drug release efficiency exceeds 90 % in the weakly acidic microenvironment at the infection site after 72 h, indicating enhanced antimicrobial properties. The Cip-loaded hydrogel also exhibits a remarkable bacterial inhibition rate exceeding 99 % against the pathogenic bacterium P. gingivalis and good cytocompatibility and hemocompatibility in vitro . In summary, the current work explored a novel solution and direction for the development of anti-infective medical materials applicable to dental implants .
研究领域:
材料科学
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生物医学工程
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牙科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）