Journal of Functional Biomaterials
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2023
·Vol. 14
·期 4
·225
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IF 4.8
Min Xing,Haifeng Zhang,Ling Zhang,Wenhao Qian
The formation of bacterial biofilms and the contamination of treatment water within dental unit waterlines can lead to a risk of secondary bacterial infections in immunocompromised patients. Although chemical disinfectants can reduce the contamination of treatment water, they can also cause corrosion damage to dental unit waterlines. Considering the antibacterial effect of ZnO, a ZnO-containing coating was prepared on the surface of polyurethane waterlines using polycaprolactone (PCL) with a good film-forming capacity. The ZnO-containing PCL coating improved the hydrophobicity of polyurethane waterlines, thus inhibiting the adhesion of bacteria. Moreover, the continuous slow release of Zn ions endowed polyurethane waterlines with antibacterial activity, thus effectively preventing the formation of bacterial biofilms. Meanwhile, the ZnO-containing PCL coating had good biocompatibility. The present study suggests that ZnO-containing PCL coating can realize a long-term antibacterial effect on the polyurethane waterlines by itself, providing a novel strategy for the manufacture of autonomous antibacterial dental unit waterlines.Keywords:polyurethane;dental unit waterlines;ZnO;antibacterial
研究领域:
材料科学
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医学
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微生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Research and Technology-JMR&T
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2025
·
IF 6.6
Hong Bian,Xiukai Chen,Wenjun Yu,Boyang Huang,Zizhao Guan,Yanyu Song,Le Fu,Duo Liu,Xiaoguo Song
In conventional dental implant procedures, glass-ceramic dental crowns were traditionally bonded to titanium (Ti) abutment using organic glue cementation. However, degradation of the adhesive could result in crown loss. Therefore, it is crucial to explore alternative strategies for bonding the crown and abutment. In this study, we propose employing dissimilar brazing as a new approach for joining these two components. To assess its feasibility, Ti/ZrO 2 –SiO 2 nanocrystalline glass-ceramic (ZS-NCGC) joints were fabricated by brazing using Ni/Zr composite foils. The corrosion behavior and mechanism of the Ti/ZS-NCGC joint in artificial saliva were investigated. The complex interface of the Ti/ZS-NCGC joint increased the corrosion current and decreased the impedance, resulting in slightly lower corrosion resistance than the Ti substrate. However, after soaking the Ti/ZS-NCGC joint in acidic artificial saliva for 7 days, no pitting corrosion appeared, demonstrating excellent corrosion resistance. In addition, after adding highly destructive F ions, corrosion mainly occurred on layered α-(Ti, Zr), blocky (Ti, Zr) 2 Ni, and (α-(Ti, Zr) + (Ti, Zr) 2 Ni) eutectoid structure. The findings presented herein demonstrate the significant potential of dissimilar brazing in facilitating the robust bonding between glass-ceramic dental crowns and Ti abutment.
研究领域:
材料科学
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牙医学
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DOI
高影响因子
BMC Chemistry
·
2025
·Vol. 19
·期 1
·1-12
·
IF 4.6
Yin Tingting,Li Qiaowen,Sun Huan,Zheng Jin,Wang Yuanyuan,Luo Yi,Wang Li
Background This work intended to assess the disinfection efficacy of hypochlorous acid (HA) and silver nanoparticles (AgNP) disinfectants in disinfecting the dental unit waterlines (DUWL) during comprehensive oral treatment and explore their potential applications in the oral medical environment. Methods: Firstly, AgNP solution was prepared and evaluated through X-ray diffraction (XRD), field emission transmission electron microscope (FE-TEM), and stability tests. Subsequently, 15 dental units were selected and randomly assigned to three groups, each receiving a different disinfection method. Specifically, one group (5 units) received HA disinfectant (HA group), one group (5 units) received AgNP disinfectant (AgNP group), and another group (5 units) received a combination of HA and AgNP disinfectant (HA + AgNP group). Bacterial counts before and after disinfection were compared and analyzed at four sites on the dental units: high-speed handpiece tubing, mouthwash, ultrasonic scaler, and three-way syringe. Results The growth of biofilm on the waterlines was observed using scanning electron microscopy (SEM) and laser confocal microscopy (LCM). The results indicated that AgNP solution was successfully prepared and demonstrated excellent stability. There was no significant difference in the average weekly number of patients treated across the three groups ( P > 0.05). After disinfection, bacterial counts were significantly reduced in all groups. Compared to the HA and AgNP groups, the HA + AgNP group exhibited a markedly lower bacterial count, with statistical significance ( P < 0.05). The compliance rates observed during the first disinfection and two weeks post-disinfection were slightly lower in the HA and AgNP groups compared to the HA + AgNP group, although no significant statistical difference was found ( P > 0.05). SEM images revealed uneven biofilm plaques on the inner surface of the pipes prior to disinfection, embedded within a dense matrix, while the biofilm was visibly disrupted post-disinfection. LCM software analysis showed that, compared to the HA and AgNP groups, the HA + AgNP group had a significantly lower percentage of live bacteria on the biofilm post-disinfection ( P < 0.05). Conclusion Compared to any single disinfectant regimen, the combined use of HA and AgNPs effectively inhibited bacterial growth and exerted a significant destructive effect on biofilms. Therefore, this combination is expected to be a viable option for disinfection of DUWL in the oral healthcare setting. Clinical trial number Not applicable.
研究领域:
口腔医学
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微生物学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jiaxin Wu,Zhi Li,Xingliang Meng,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
Promoting mechanical strength and osteoinductivity properties is crucial for dental implants materials. Herein, we synthesized silicocarnotite (CPS) powder via a hydrothermal method, and mixed it with zirconia to create a composite material for preparing four slurries: xCPS-(1−x)ZrO 2 (x = 0, 1/6, 1/3, and 1/2 vol%). The optimal printing parameters for each slurry were investigated. Following the printing of the slurries, debinding was performed on them in the temperature range of 25 °C–600 °C in nitrogen atmosphere and 600 °C–1000 °C in air atmosphere, respectively, followed by sintering at 1350 °C for 2 h. The graded zirconia-based composite ceramics prepared using stereolithography (SLA) exhibited excellent mechanical properties, including a flexural strength of 742.37 ± 22.52 MPa, Vickers hardness of 7.29 ± 0.15 GPa, fracture toughness of 5.34 ± 0.29 MPa m 1/2 , and a relative density of 96.3 %. Compared with zirconia ceramics, the graded composite ceramics displayed higher surface roughness. The graded composite ceramics degraded and released Ca, Si, and P ions, promoting MC3T3-E1 cells proliferation, adhesion, and osteogenic differentiation. These findings suggest that ZrO 2 -CPS/ZrO 2 graded composite ceramics synthesized via SLA holds great potential as dental implants with high osteoinductivity.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xujie Yang,Xinru Wang,Xing Wang,Xinke Li,Hanwen Xin,Jinghui Zhou,Dayin Sun
Lignin, a natural polyphenol polymer, is a biocompatible, cost-effective and accessible material. To fully utilize the benefits of lignin, it is crucial to transform its complex macromolecules into nanoscale particles in a single solvent. In this research, an assembly-mediated internal cross-linking method in single solvent was proposed to manufacture cross-linked lignin colloidal particles with nanoscale particle size controlled to be around 50 nm. Then, cross-linked lignin composite particles with a unique “patchy” structure for dental cleansing were obtained by rapidly grafting the cross-linked lignin colloidal particles onto the surface of silica microspheres through the bridging effect of silane coupling agent. The resulting composite particles have rivets with adjustable hardness, significantly lower than traditional abrasives like silica in both hardness and modulus. Through the group cleansing behavior of soft interlocking, a breakthrough has been achieved in the high solid content agglomeration friction mode of traditional abrasives, which effectively reduces tooth wear and exhibits an excellent plaque removal effect.
研究领域:
材料科学
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口腔医学
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生物材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 129
·期 6
·3373-3381
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IF 1.395
Xiaoxu Liang,Qiting Huang,Fang Liu,Jingwei He,Zhengmei Lin
To prepare antibacterial dental resin, a series of novel urethane dimethacrylates quaternary ammonium methacrylate monomers (UDMQAs) with different substituted alkyl chain length were synthesized, and their structures were confirmed by FTIR and 1 H-NMR spectra. The obtained UDMQAs were used to replace 2,2-Bis[4-(2-hydroxy-3-methacryloyloxypropyl)-phenyl]propane (Bis-GMA) totally as base monomers of dental resin and mixed with Tri-ethyleneglycol dimethacrylate (TEGDMA) at the mass ratio of 50/50. The properties of these prepared resins like antibacterial activity, double bond conversion (DC), polymerization shrinkage, flexural strength (FS), and modulus (FM), water sorption and sol fraction were investigated. The most commonly used dental resin Bis-GMA/TEGDMA (50wt/50wt) was chosen as a reference. The results showed that UDMQAs could endow dental resin with antibacterial activity. Compared with Bis-GMA-based dental resin, UDMQAs-based resin had the same or higher DC, lower polymerization shrinkage, lower flexural strength and modulus, and higher water sorption and sol fraction. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
研究领域:
材料科学
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牙医学
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高分子化学
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DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2022
·
IF 6.364
Shuo Wang,Lian Peng,Chengnan Song,Chengyu Wang
Digital light processing (DLP) 3D printing technology was applied to manufacture thin dental porcelain veneers. The prepared thin dental porcelain veneers showed excellent translucency and appearance. The median and mean particle sizes of the printed glass powders were 10.11 µm and 12.03 µm, respectively, with a unimodal distribution. The green glass compacts were printed layer by layer, with an individual layer thickness of 50 µm. The results showed that, according to the thermal expansion coefficient (TEC) and the thermogravimetry/differential scanning calorimetry (TG/DSC), the debinding procedure of the green glass compacts was annealed at 320 °C for 120 min and 570 °C for 120 min, respectively. The results of the classical sintering kinetics models and SEM examination demonstrated that the glass compacts were sintered at 790 °C for 5 min. The flexural strength and the chemical solubility of the sintered glasses were 132.58 ± 25.83 MPa and 18 μg·cm −2 , respectively. Both flexural strength and chemical solubility met ISO 6872 criteria.
研究领域:
材料科学
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牙科学
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生物医学工程
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产品关联
DOI
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Bing Cao,Yingfei Ma,Jian Zhang,Yanan Wang,Yating Wen,Yun li,Ruixue Wang,Donghai Cao,Ruiping Zhang
Oral biofilm is the leading cause of dental caries, which is difficult to completely eradicate because of the complicated biofilm structure. What's more, the hypoxia environment of biofilm and low water-solubility of conventional photosensitizers severely restrict the therapeutic effect of photodynamic therapy (PDT) for biofilm. Although conventional photosensitizers could be loaded in nanocarriers, it has reduced PDT effect because of aggregation-caused quenching (ACQ) phenomenon. In this study, we fabricated an oxygen self-sufficient nanodroplet (PFC/TPA@FNDs), which was composed of fluorinated-polymer (FP), perfluorocarbons (PFC) and an aggregation-induced emission (AIE) photosensitizer (Triphenylamine, TPA), to eradicate oral bacterial biofilm and whiten tooth. Fluorinated-polymer was synthesized by polymerizing (Dimethylamino)ethyl methacrylate, fluorinated monomer and 1-nonanol monomer. The nanodroplets could be protonated and behave strong positive charge under bacterial biofilm acid environment promoting nanodroplets deeply penetrating biofilm. More importantly, the nanodroplets had extremely high PFC and oxygen loading efficacy because of the hydrophobic affinity between fluorinated-polymer and PFC to relieve the hypoxia environment and enhance PDT effect. Additionally, compared with conventional ACQ photosensitizers loaded system, PFC/TPA@FNDs could behave superior PDT effect to ablate oral bacterial biofilm under light irradiation due to the unique AIE effect. In vivo caries animal model proved the nanodroplets could reduce dental caries area without damaging tooth structure. Ex vivo tooth whitening assay also confirmed the nanodroplets had similar tooth whitening ability compared with commercial tooth whitener H 2 O 2 , while did not disrupt the surface microstructure of tooth. This oxygen self-sufficient nanodroplet provides an alternative visual angle for oral biofilm eradication in biomedicine.
研究领域:
医学
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材料科学
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牙科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2025
·
IF 6.2
Xin Zhou,Yongxia Yao,Xian Tong,Zengqi Ye,Jiancheng Yu,Yue Huang,Zhaoping Chen,Weiqu Wang,Li Zhu,Jixing Lin,Zhe Zhao,Jianfeng Ma
In this study, lithium disilicate glass-ceramic green bodies were prepared using digital light processing technology, utilizing a precursor slurry with good rheological and photocuring properties. The green bodies underwent debinding, nucleation, and crystallization, followed by densification at the glass melting temperature. We investigated the effects of crystallization time and densification time on the microstructure, mechanical properties, translucency, chemical solubility, and cytotoxicity of the glass-ceramics. The results showed that precise control of densification balanced internal defects and molding quality. Increased crystallization and densification times significantly improved crystallinity, density, flexural strength, and translucency. However, fracture toughness was only enhanced by crystallization time, with intergranular being the fracture main mode. The preferred samples exhibited strength, toughness, and translucency parameters of 284.5 MPa, 2.3 MPa·m 1/2 , and 12.3, respectively. Additionally, these samples showed good resistance to cold and hot aging, chemical solubility, and cytocompatibility, meeting the clinical requirements for dental restorations.
研究领域:
材料科学
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生物医学工程
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口腔医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of the Mechanical Behavior of Biomedical Materials
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2022
·
IF 4.042
Yue Tang,Lei Lei,Dan Yang,Jing Zheng,Qihang Zeng,Heng Xiao,Zhongrong Zhou
The lack of wear resistance is always a challenge for clinical applications of resin-based dental composites (RBDCs). In this study, the role of the calcium release from RBDCs in the adsorption and lubrication of salivary proteins was investigated, aiming to provide useful insights concerning the development of high-performance RBDCs. Three experimental RBDCs with distinct calcium-releasing capabilities were prepared using calcium phosphate particles as inorganic fillers. Salivary protein adsorption and film-forming on RBDC surfaces were characterized by atomic force microscopy, while the mechanical properties and lubricating effect of salivary pellicle were examined using nano-indentation/scratch techniques. Results showed that calcium release from RBDCs plays a crucial role in mediating the electrostatic interaction between salivary proteins and composite surface, thereby promoting the formation of salivary pellicle with a multi-layer structure. The mechanical properties and lubricating effect of the pellicle are positively related to the level of calcium release. In sum, for RBDCs with robust calcium release, saliva provides effective lubrication to resist composite wear. Incorporating calcium compounds is a promising way to improve the wear resistance of RBDCs in the oral cavity.
研究领域:
牙科学
·
生物材料学
✓ 已验证
DOI
高影响因子
International Journal of Implant Dentistry
·
2024
·Vol. 10
·期 1
·1-11
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IF 3.1
Cui Boyu,Bai Tianyi,Wu Qiyou,Hu Yibo,Liu Yihong
Purpose Osteoporotic individuals who have dental implants usually require a prolonged healing time for osseointegration due to the shortage of bone mass and the lack of initial stability. Although studies have shown that intermittent teriparatide administration can promote osseointegration, there is little data to support the idea that pre-implantation administration is necessary and beneficial. Methods Sixty-four titanium implants were placed in the bilateral proximal tibial metaphysis in 32 female SD rats. Bilateral ovariectomy (OVX) was used to induce osteoporosis. Four major groups ( n = 8) were created: PRE (OVX + pre-implantation teriparatide administration), POST (OVX + post-implantation administration), OP (OVX + normal saline (NS)) and SHAM (sham rats + NS). Half of rats ( n = 4) in each group were euthanized respectively at 4 weeks or 8 weeks after implantation surgery, and four major groups were divided into eight subgroups (PRE4 to SHAM8). Tibiae were collected for micro-CT morphometry, biomechanical test and undecalcified sections analysis. Results Compared to OP group, rats in PRE and SHAM groups had a higher value of insertion torque ( p < 0.05). The micro-CT analysis, biomechanical test, and histological data showed that peri-implant trabecular growth, implants fixation and bone-implant contact (BIC) were increased after 4 or 8 weeks of teriparatide treatment ( p < 0.05). There was no statistically difference in those parameters between PRE4 and POST8 subgroups ( p > 0.05). Conclusions In osteoporotic rats, post-implantation administration of teriparatide enhanced peri-implant bone formation and this effect was stronger as the medicine was taken longer. Pre-implantation teriparatide treatment improved primary implant stability and accelerated the osseointegration process.
研究领域:
口腔医学
·
骨生物学
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 5
·1795-1804
·
IF 6.183
Dan-Lei Yang,Ya-Nan Cui,Qian Sun,Mei Liu,Hao Niu,Jie-Xin Wang
The accumulation of bacteria at the margin of dental resin composites is the main reason for secondary caries, which may further cause failure of prosthodontics. Therefore, antibacterial activity is highly required. However, the addition of antibacterial agents or fillers weakens the mechanical or aesthetic properties of composites. In this work, regular-shaped SiO2–ZnO complex clusters (CCs) constructed by spray-drying technology can enhance the antibacterial activity while maintaining the mechanical and aesthetic properties of dental resin composites. The results show that the regular shape and closely packed structure of nanoparticle clusters were not corrupted by the introduction of ZnO particles. As compared to resin composites filled with SiO2 nanoparticle clusters, the comprehensive performances of composites containing SiO2–ZnO CCs were further improved, and the composites filled with 70 wt% Si66Zn4 (CCs composed of 66/70 SiO2 and 4/70 of ZnO) exhibited superior antibacterial capability (antibacterial ratio >99.9%) and acceptable depth of cure, degree of conversion, and biocompatibility. The cooperation of different fillers is highly essential for resin composites to achieve enhanced multifunctional performance.
研究领域:
材料科学
·
口腔医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）