SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Yue-Yue Chang,Hai-Long Wu,Tong Wang,Huan Fang,Gao-Yan Tong,Yue Chen,Zhao-Yang Wang,Wei Chen,Ru-Qin Yu
In this study, a series of green, interference-free fluorimetric detection methods of the excitation-emission matrix coupled with the second-order calibration methods were proposed for the determination of ibrutinib and pralatrexate in various complicated biological fluids. The second-order advantage of the proposed method can overcome the problem of poor selectivity caused by the wide spectra of the fluorescence method. Even in the presence of uncalibrated interferences and severe peak overlap, the signal of pure substance and accurate quantitative results were still obtained. The average recoveries of the three methods were 94.5–104.9% for Alternating Trilinear Decomposition (ATLD) algorithm, 95.5–105.8% for Alternating Normalization Weighted Error (ANWE) algorithm and 94.4–105.7% for Parallel Factor Analysis (PARAFAC) algorithm, respectively. For ATLD, ANWE and PARAFAC, the relative standard deviations (RSD) were lower than 9.2%, 6.8% and 9.2%, and the RMSEPs were less than 8.1, 8.4 and 8.6 ng mL −1 , respectively. In addition, the elliptic joint confidence region (EJCR) was adopted to further prove the accuracy of the three methods. The results showed that the three methods can accurately be quantified without significant difference. Good figures of merit parameters were also obtained. Among them, the limit of detection (LOD) and limit of quantification (LOQ) of ibrutinib and pralatrexate were in the range of 0.11–0.76 ng mL −1 and 0.21–1.12 ng mL −1 , respectively, which were lower than the corresponding blood concentrations. These results indicate that the proposed method provides a promising, alternative and universal analysis strategy for clinical drug monitoring.
研究领域:
分析化学
·
药物分析
·
临床医学
✓ 已验证
DOI
高影响因子
Chemical Science
·
2015
·Vol. 7
·期 2
·1487-1495
·
IF 9.211
Guosheng Chen,Junlang Qiu,Jianqiao Xu,Xu'an Fang,Yan Liu,Shuqin Liu,Songbo Wei,Ruifen Jiang,Tiangang Luan,Feng Zeng,Fang Zhu,Gangfeng Ouyang
Carbohydrates are known to be involved in a wide range of biological and pathological processes. However, due to the presence of multiple hydroxyl groups, carbohydrate recognition is a particular challenge. Herein, we reported an ultrasensitive solid-phase microextraction (SPME) probe based on phenylboronic acid (PBA) functionalized carbon nanotubes (CNTs) for direct in vitro or in vivo recognition of carbohydrates in biofluids as well as semi-solid biotissues. The coating of the proposed probe possessed a 3D interconnected porous architecture formed by the stacking of CNTs. As a result, the binding capacity toward carbohydrates was excellent. The proposed approach was demonstrated to be much superior to most carbohydrate sensors, including higher sensitivity, wider linear range, and excellent qualitative ability in multi-carbohydrate systems. Thus, this approach opens up new avenues for the facile and efficient recognition of carbohydrates for important applications such as glycomics.
研究领域:
分析化学
·
生物化学
·
医学检测
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2020
·Vol. 412
·期 12
·2893-2901
·
IF 3.637
Chen Jingqi,Liu Xiaowei,Hou Xialing,Chen Yingying,Xing Feifei,Feng Lingyan
A label-free fluorescent nanoprobe for iodide ion (I − ) detection was developed based on the direct fluorescence quenching of spermine-functionalized carbon dots (SC-dots), whether in complex biological fluids or living cells. The positively charged SC-dots were fabricated via one-step microwave synthesis and exhibited excellent optical properties. Due to the strong quenching ability of I − , SC-dots were utilized for I − detection with high sensitivity and excellent selectivity, which offered a relatively low detection limit of 0.18 μM. This strategy was also successfully applied for I − detections in human serum and HeLa cells. The detection process is facile, highly sensitive and selective, providing a new insight into the potential applications of SC-dots for anion nanoprobe designs in clinical diagnosis and other biologically related areas.
Graphical abstract
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 112
·92762-92768
·
IF 3.84
Daquan Wang,Ying Hu,Lingjie Meng,Xiaochi Wang,Qinghua Lu
Highly cross-linked and monodisperse polyphosphazene (PZS) nanoparticles exhibiting strong fluorescence were prepared by the facile one-pot polycondensation of hexachlorocyclotriphosphazene and 4′,5′-dibromofluorescein (DBF). Fluorescent DBF units were ‘immobilized’ and ‘isolated’ in the cross-linked structures to effectively overcome their concentration-quenching effect and improve their photobleaching properties. The resulting DBF–PZS nanoparticles emitted bright yellow fluorescence at all concentrations and exhibited excellent resistance to photobleaching as well as interference from bio-molecules such as proteins, ascorbic acid and uric acid. Intriguingly, the fluorescence of the DBF–PZS nanoparticles was linearly quenched by DA in the range of 0.5 to 15 μg mL−1 DA concentration via photoinduced charge transfer. Therefore, the use of DBF–PZS nanoparticles represents a simple but effective, highly sensitive and selective detection method with a direct read out for DA in biological fluids.
研究领域:
材料科学
·
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energy Storage
·
2024
·
IF 8.9
Shenhui Tan,Xuelai Zhang
In this paper, a novel binary eutectic phase change material (DA-HDL EPCM) and ternary composite phase change material (HDL-DA-CA/EG CPCM) are proposed for the temperature range of 10–20 °C and 2–8 °C. Compared with traditional ternary phase change materials (2–8 °C), CPCM has higher latent heat value and economic performance. The ternary CPCM uses dodecyl alcohol (DA) and 1,6 hexadiol (HDL) as the main eutectic phase change energy storage materials, and n-capric acid (CA) as the temperature modifier. A kind of HDL-DA-CA/EG composite phase change material (CPCM) was prepared by vacuum adsorption method, which solved the problems of low thermal conductivity and easy leakage of ternary CPCM. Differential scanning calorimeter (DSC), scanning electron microscope (SEM), thermal property analyzer (TCA) and high and low temperature alternating test chamber were used to characterize the thermal properties, microstructure, thermal conductivity and cyclic stability of related PCM. Experimental results: The final ratio of CPCM is 43.61%DA + 25.6%HDL + 23.08%CA + 7.7%EG, the phase transition temperature is 2.9 °C, the latent heat of phase transition is 181.3 J/g, and the thermal conductivity is 1.90 W/mK. After 500 cycles, the phase transition temperature of CPCM has little change, and the latent heat of phase transition is 169.8 J/g, which is reduced by 6.34 %, not more than 10 %, and has good stability. Finally, the simulation application data show that CPCM has a good application prospect in fruit and vegetable cold chain logistics.
研究领域:
材料科学
·
食品科学
·
物流工程
✓ 已验证
产品关联
DOI
高影响因子
HEAT AND MASS TRANSFER
·
2020
·Vol. 56
·期 9
·2769-2777
·
IF 1.867
Zhang Shihua,Zhang Xuelai,Xu Xiaofeng,Zhao Yi
The effect of nanomaterials on the thermal behavior of Decanoic-Caprylic Acid (DA-CA) binary eutectic mixture was investigated experimentally. Different high thermal conductivity nanomaterials, including nano-sized iron oxide (Fe 2 O 3 ), nano-sized copper (Cu), hydroxylated multi-walled carbon nanotubes (MWCNT-OH), and dispersant Span-60, were added into DA-CA, respectively. The nanomaterial-enhanced phase change materials (NePCMs) were prepared by the ultrasonic oscillation method. The effects of nanomaterials on the cool storage performance of DA-CA were studied from the types and concentrations of nanomaterials. The experimental results showed that as the nanomaterials mass concentration increased, the thermal conductivity increased first and then gradually stabilized. The thermal conductivity trend for the composites added to the nanomaterials was: 0.40 g·L −1 Fe 2 O 3 > 0.10 g·L −1 MWCNT-OH > 0.30 g·L −1 Cu. DA-CA + 0.40 g·L −1 Fe 2 O 3 exhibited the best thermal properties, and its thermal conductivity increased by 36.8%, and the thermal storage time decreased by 38%. After 500 times thermal stability test, the NePCMs still maintained the appropriate phase change temperature and high latent heat. Therefore, this material has potential as part of the cold chain logistics for fruit and vegetable preservation.
研究领域:
材料科学
·
热能工程
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Junmei Fan,Ruitao Zhu,Wei Han,Hongfei Han,Liping Ding
Flavonoids are a kind of natural polyphenols which are closely related to human health, and the identification of flavonoids with similar structures is an important but difficult issue. We herein easily constructed a powerful fluorescent sensor ensemble by using surfactant cetyltrimethylammoniumbromide (CTAB) encapsulating two commercially available fluorescent probes ( F1 and F2 ) with multi-wavelength emission. Fluorescence measurements illustrate the present sensor ensemble exhibits turn-off responses to flavones and flavonols but ratiometric responses to isoflavones, owing to different FRET processes. The heat map and linear discriminant analysis (LDA) results show that this single sensor can effectively distinguish 6 flavonoids belong to three subgroups by collecting the fluorescence variation at four typical wavelengths. Moreover, it can be applied to identify different flavonoids even in biofluids like serum and urine, providing potential practical application.
研究领域:
分析化学
·
生物医学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Nutrition
·
2022
·
IF 6.59
Qian Yun-Fang,Yu Jia-Yi,Yu Ying-Jie,Xie Jing,Yang Sheng-Ping
In order to study the effects of the compound preservatives (curcumin and piperine (CP)) and vacuum packaging (VP) on the quality of salmon during cold chain logistics suffered from temperature abuse, the physiochemical indexes (texture, water holding capacity (WHC), total volatile basic nitrogen (TVB-N), thiobarbituric acid reactive substances (TBARS), free amino acids (FAA) contents), microbial indicators (total mesophilic bacteria count (MBC), total psychrotrophic bacteria count (PBC), H2S-producing bacteria count (HSBC)) were determined, and the moisture changes were explored by near-infrared (NIR) spectroscopy and low-field nuclear magnetic resonance (LF-NMR). The results showed that the treatment of curcumin and piperine in combination with vacuum packaging could maintain the quality of salmon suffered from temperature abuse most effectively. At the end of storage, the MBC of VP+CP was only 4.95 log CFU/g, which was about 1 log CFU/g lower than the control sample stored at the same condition. The combined treatment also retarded the increase of TVB-N, TBARS, and the decrease of hardness, springiness, and a* value, as well as water migration in salmon, contributing to higher water holding capacity and better appearance. Besides, VP+CP retarded the decrease of free glutamate, which contributed to umami taste. Due to the biological activity and safety of the preserves, the combined treatment could be a promising method for preservation of seafood.
研究领域:
食品科学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Kai Liu,Zhifeng He,Yingying Luo,Pengcheng Lin,Ying Chen
Cold chain logistics plays an extremely important role in the storage and transportation of perishable products. Nowadays, phase change materials (PCMs) have been applied in emerging cold chain logistics to overcome the problems of low stability, high energy consumption, and high cost in mechanical refrigeration-based cold chain logistics. Mass production of high-performance phase change cold storage materials toward cold chain logistics is still a major challenge. Herein, self-repairing brine phase change gels (BPCMGs) massively fabricated by ionic cross-linking, covalent cross-linking, and hydrogen bond cross-linking are proposed. Brine containing 23.3% sodium chloride (NaCl) is selected as the phase change component because its phase change temperature is suitable for the cold storage demand of aquatic products. The proposed BPCMGs demonstrate superior thermophysical properties in terms of no phase separation, no supercooling, high form stability, high latent heat, high thermal conductivity, high cyclic stability, and high self-repairing rate. Meanwhile, the BPCMGs present high cost-effectiveness. Given these advantages, BPCMGs are utilized to assemble smart cold storage equipment for the storage and transportation of aquatic products. The cold storage time reaches 36.73 h for aquatic products when the stored cold energy is 364078 J. The location and temperature of the refrigerated products are monitored in real-time. The state-of-the-art BPCMGs provide diversified possibilities for the advanced smart cold chain.
研究领域:
材料科学
·
冷链物流
·
能源存储
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Environmental Science
·
2023
·
IF 4.6
Häfner Franziska,Monzon Diaz Oscar Rodrigo,Tietjen Sarah,Schröder Corinna,Krause Ariane
Recycling nutrients is essential for closing nutrient loops within a circular economy. Using locally available resources such as human excreta to produce bio-based recycling fertilizers can substitute mineral fertilizers and thereby promote environmentally friendly food production. To better understand the fertilizer potential and nitrogen value of human excreta, three novel and safe recycling products were evaluated in a field experiment. Two nitrified urine fertilizers (NUFs) and one fecal compost were applied alone or in combination, and compared against the commercial organic fertilizer vinasse. In addition, the uptake of pharmaceuticals was assessed for treatments with compost application. White cabbage (Brassica oleracea var. capitata f. alba) was cultivated in plots in three different soil types (sand, loam or silt) treated with the fertilizers according to plant needs and mineral soil nitrogen content. The two NUFs resulted in marketable yields similar to those of vinasse in all soil types. Combining fecal compost with a NUF led to increased marketable yield compared to compost alone. The highest yield was recorded from the sandy soil, where vinasse and NUF treatments led to comparable yields, as expected in organic productions systems (up to 72 t ha−1). The cabbage yield and total aboveground fresh biomass followed the following trend in all soils: NUFs ∼ vinasse ≥ compost + NUF ≥ compost. Nitrogen uptake in the cabbage heads and total biomass was significantly higher in sand (69.5–144 kg ha−1) than loam (71.4–95.8 kg ha−1). All compost treatments alleviated the effect of soil type and resulted in comparable nitrogen uptake and yield in all soil types. Plant uptake of pharmaceuticals (Carbamazepin) was higher in sand than in loam, and concentration in the edible part was lower than in the outer leaves. In conclusion, NUF alone appears to be a promising successful fertilizer substitute in horticultural food production. The combined application of NUF and compost led to slightly lower crop yields, but may increase soil carbon content in the long term, promoting climate-friendly food production.
研究领域:
农业科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
·
2020
·
IF 3.255
Rahul Narayanan,Xiaowei Song,Hao Chen,Richard N. Zare
Polytetrafluoroethene, commonly known as Teflon, is a plastic famous for its inertness, strength, and nonstick properties, allowing its repeated use in many applications. We report the use of a triangularly cut Teflon substrate to take the place of paper in a form of spray mass spectrometry. A conducting wire (gold) at high potential (positive or negative) makes contact with a drop of the liquid sample at the apex of the triangle, causing a spray of droplets to be directed toward the heated inlet of a mass spectrometer. Saccharides, drugs, illegal additives, peptides, proteins, bilirubin, and vancomycin give mass spectra with high signal-to-noise (S/N) ratios, allowing detection at the nanogram per milliliter (ng/mL) level. Examination of each of these analytes demonstrates that Teflon spray is several orders of magnitude more sensitive than paper spray under the same conditions. Teflon spray ionization mass spectrometry is applied to the metabolomic and lipidomic profiling of biological fluid samples. Detection of polycyclic aromatic hydrocarbons is achieved with Teflon spray at 10 μg/mL concentrations. These experiments show the advantage of using Teflon over a normal paper substrate in detecting many environmentally and biologically relevant systems with high sensitivity and S/N ratio.
研究领域:
分析化学
·
环境科学
·
生物医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiang Feng,Yang Pan,Ke Lei,Lanlan Wu,Jiang Li,Jie Zhang,Shaoyun Guo
Polymeric damping materials with a wide temperature or frequency range present significant challenges, especially when used for vibration attenuation at ultra-low temperatures or ultra-high frequencies, as the chain motions are frozen in these extreme environments. In our previous studies, polydimethylsiloxane (PDMS) polymer-fluid-gels (PFGs) dampen vibrations over a relatively wide temperature or frequency range; however, their lower-temperature limit is −55 °C, and their upper-frequency limit is about 150 Hz due to the symmetry and regularity of dimethylsiloxane molecular structure. In this work, the regularity is broken by introducing the second monomers of hexaethylcyclotrisiloxane, and diethyl-modified polydimethylsiloxane (PEMS) PFGs with 20 % diethyls are prepared, breaking through the effective damping limits of ultra-low temperature to −123 °C and ultra-high frequency to 10 10 Hz. Ultra-low temperature (about −120 °C) experiments show that the falling ball impact absorption capacity of the PEMS PFGs is over 2500 % and 1400 % higher than that of commercial silicone rubber (Sylgard 184) and the PDMS PFGs. Ultra-high frequency tests demonstrate that PEMS PFGs can completely attenuate ultrasonic shocks of 40 kHz, while Sylgard 184 and the PDMS PFGs can’t suppress vibrations of such high frequency.
研究领域:
材料科学
·
振动工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）