Frontiers of Environmental Science & Engineering
·
2013
·Vol. 8
·期 6
·952-959
·
IF 0.886
Ma Dongdong,Gao Hongwen
Phytoremediation technology is regarded as a simple and efficient way to remove heavy metals from contaminated soil. A reasonable disposal of metal hyperaccumulators is always a major issue in waste reuse and resource-saving. The heavy metal-accumulating Cynondon dactylon (L.) was investigated where heavy metals were desorbed by a facile acid-treatment. The result indicated that more than 90% of heavy metals (Zn, Pb and Cu) was extracted from Cynondon dactylon with 0.2 mmol ·L −1 HCl. The plant residue was used to adsorb heavy metals ions. The adsorption fitted the Langmuir isotherm model with the saturation adsorption capacity of 9.5 mg ·g −1 Zn 2+ , 36.2 mg·g −1 Pb 2+ and 12.9 mg·g −1 Cu 2+ , and the surface complexation and the backfilling of heavy metal-imprinting cavities existed simultaneously during the adsorption. The treatment of wastewaters indicated that the plant residue exhibited a high removal rate of 97% for Cu. Also, the material could be recycled. The method offers a new disposal approach for heavy metal hyper-accumulator.
研究领域:
环境科学
·
植物学
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DOI
高影响因子
Agronomy-Basel
·
2023
·Vol. 13
·期 2
·442
·
IF 3.7
Tian Hao,Zhimin Yang,Jianfeng Liang,Jingjin Yu,Jun Liu
Drought stress is one of the crucial factors affecting plant growth and development in turfgrass species, especially during the summer season. Exogenous plant growth regulators are an effective and convenient approach to mitigating the adverse effects of drought stress on plant growth. The objectives of this study were to reveal the effects of exogenous carnosine or chitosan on turf performance and physiological indexes in bermudagrass (Cynodon transvaalensis×C. dactylon) in response to drought stress. Bermudagrass was foliar sprayed with carnosine or chitosan, and dose-dependent effects on turf quality were observed under drought stress. Under drought stress, foliar application of either carnosine (0.03%) or chitosan (10 mg L−1) significantly increased turf quality, chlorophyll content, leaf relative water content, and decreased electrolyte leakage, malonaldehyde, and hydrogen peroxide content in comparison with untreated control in bermudagrass. Moreover, exogenous carnosine treatment significantly enhanced the activities of both catalase and peroxidase, but chitosan application only increased catalase activity. The results of this experiment were beneficial to the development of new plant growth regulators and would provide helpful insights for turf management under drought-stressed conditions.Keywords:bermudagrass;drought stress;carnosine;chitosan;antioxidant enzymes
研究领域:
植物学
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园艺学
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环境科学
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DOI
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2025
·Vol. 39
·期 5
·e70068
·
IF 1.7
Sanwen Li,Qing Shao,Hongqun Qiao
Schisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch B have not been publicly reported. This study aimed to investigate the preclinical concomitant toxicokinetics of multiple administration of Sch B. Sch B was administered orally to rats and dogs at 150, 300, and 600 mg/kg/day and 50, 100, and 200 mg/kg/day, respectively, for 26 weeks. Plasma concentrations of Sch B were determined by a validated HPLC–MS/MS method. According to the toxicokinetic results, significant gender differences were observed in the rats, and females had higher exposures than males for each dosing group. Toxicokinetic analysis demonstrated a notable accumulation in the plasma of dogs during the repeated administration of Sch B, and the degree of accumulation increased with the increase of the dose. The findings of this study indicated that there were differences in the concomitant toxicokinetics of Sch B between rats and dogs. These results can inform clinical studies and provide valuable insights for future human Sch B risk assessments.
研究领域:
药理学
·
毒理学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Heliyon
·
2020
·
IF 0
Tao Feng,Zhongshan Hu,Yanzun Tong,Lingyun Yao,Haining Zhuang,Xiao Zhu,Shiqing Song,Jun Lu
Chicken liver is a main protein source to prepare attractant for dog food. However, animal proteins are costly. Seeking high quality and low-cost protein sources has been a goal for the industry. Mushroom Lentinus edodes (L. edodes) and Mealworm Tenebrio molitor (T. molitor) are novel protein sources, showing high potential as raw material of attractants. In this paper, chicken liver, L. edodes, and T. molitor were used as three different protein sources to prepare attractants. Their palatability to dogs were then compared. Firstly, the enzymatic hydrolysis process of three proteins was optimized, with a degree of hydrolysis of 54.82%, 36.10% and 30.14% for chicken liver, L. edodes , and T. molitor respectively. Secondly, volatile compounds of three attractants were identified by HS-SPME/GC-MS and SDE/GC-MS. Using OAV and PLRS method, it was found that bis(2-methyl-3-furyl) disulfide, indole, methional, 2-(methyl thio) phenol, γ -butyrolacton, furfuryl alcohol, acetic acid and isovaleraldehyde were the key components. Although both T. molitor and L. edodes attractant showed less palatability than that of chicken liver, they could be readily improved via adding key palatable volatile compounds. The ingestion rate of dog food with attractant showed a similar trend and was higher than that of food without attractant.
研究领域:
食品科学
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动物营养学
✓ 已验证
DOI
PubMed
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 4.384
Tianming Dai,Weifan Jiang,Min Wang,Zizheng Guo,Renke Dai
Generally, two-period cross-over design is used in bioequivalence (BE) study. High intra-subject variability of gefitinib was reported in a clinical BE study, and significant changes in gefitinib exposures were observed among different periods in our previous BE study in dogs. Therefore, commercial gefitinib tablets from the same batch were used in the present study and assigned to two groups: the testing drug (GF1) group and the reference drug (GF2) group. A single-oral-dose, two-period cross-over study with a 7-day washout (approximately 24 half-lives) under fasting condition was conducted in 12 dogs to explore the factors. The results showed that the mean values of AUC (0–t) , AUC (0-∞) , C max and T max of these two GF1 and GF2 groups were similar. However, the GF1 and GF2 did not meet the acceptance criteria of bioequivalence with 90% confidence intervals, since the values obtained were 76.22%-117.43% for AUC (0-t) and 87.55%-131.59% for C max . ANOVA revealed a significant difference between the two periods ( P < 0.05). Interestingly, the mean AUC (0-t) of gefitinib in the period 2 was 2.3-fold greater than that in the period 1, while C max in the period 2 was 1.7-fold higher than that in the period 1. However, the volume of distribution was significantly decreased, becoming 0.4-fold lower in the period 2. No statistically significant difference in the half-life and T max was observed between the two periods ( P < 0.05). The pharmacokinetic alteration might come from the different physiological absorption and/or metabolism between periods. Since a 7-day washout interval was applied, DDI risk from P450s and/or P-gp would not play a significant role in the non-bioequivalence. As regard the variability, the intra-subject variation crossing the periods was much larger than the inter-subject variation within each period. The absorption and/or metabolism function of the gut bacteria might play an important role in the increasing exposure of gefitinib in the second period, especially with the comparison with the analysis from the high-fat-diet treatments in humans. Therefore, further studies might be needed to evaluate whether the assessment of bioequivalence could be facilitated by a much longer washout interval allowing the recovery of gut bacteria.
研究领域:
药理学
·
临床医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2013
·
IF 2.111
Wang Hongchun,Li Jun,Lv Bo,Lou Yuanlai,Dong Liyao
Herbicide resistance or tolerance in weeds mediated by cytochrome P450 monooxygenase is a considerable problem. However, cytochrome P450 mediated resistance or tolerance in weeds was less studied. Thus, in this work, the role of the cytochrome P450 monooxygenase in the different responses of Poa annua and Alopecurus aequalis to fenoxaprop-P-ethyl was studied. We found that the effect of fenoxaprop-P-ethyl could be synergized by piperonyl butoxide (PBO) in P. annua , but not by malathion. After being treated with fenoxaprop-P-ethyl (containing mefenpyr-diethyl), the contents of cytochrome P450 and cytochrome b 5 in P. annua increased significantly compared to plants treated with mefenpyr-diethyl only or untreated plants. However, the increase was less in A. aequalis , which was susceptible to fenoxaprop-P-ethyl. The activities of ρ-nitroanisole O-demethylase (PNOD), ethoxyresorufin O-deethylase (EROD), ethoxycoumarin oxidase (ECOD) and NADPH-dependent cytochrome P450 reductase mediated by cytochrome P450 monooxygenase increased in P. annua after treatment with fenoxaprop-P-ethyl, especially the activities of ECOD and cytochrome P450 reductase. Besides this, cytochrome P450 monooxygenase activity toward fenoxaprop-P-ethyl in P. annua increased significantly compared to untreated or treated with mefenpyr-diethyl plants and treated or untreated A. aequalis . Cytochrome P450 monooxygenase may play an important role in the different responses to fenoxaprop-P-ethyl in P. annua and A. aequalis .
研究领域:
植物学
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农学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Huina Luo,Huimin Ruan,Cailing Ye,Wenkang Jiang,Xin Wang,Shengfeng Chen,Zhisheng Chen,Dongsheng Li
Animal cell culture technology in the production of slaughter-free meat offers ethical advantages with regards to animal welfare, rendering it a more socially acceptable approach for dog meat production. In this study, edible plant-derived scaffold was used as a platform for cell expansion to construct cell-cultured dog meat slices. Primary dog skeletal muscle satellite cells (MSCs) and adipose stem cells (ASCs) were isolated and cultured as seed cells, and 3D spheroid culture in vitro promoted MSCs and ASCs myogenic and adipogenic differentiation, respectively. Natural leaf veins (NLV) were produced as edible mesh scaffolds to create 3D engineered dog muscle and fat tissues. After MSCs and ASCs adhered, proliferated and differentiated on the PLV scaffolds, and muscle and fat slices were produced with cultured dog muscle fibers and adipocytes, respectively. These findings demonstrate the potential of plant-derived PLV in the production of cultured dog meat.
研究领域:
组织工程
·
细胞生物学
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生物技术
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食品科学
·
可持续农业
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2018
·Vol. 56
·期 8
·702-708
·
IF 1.037
Zou Qiaogen,Yan Ran,Liu Wei,Wei Ping
A sensitive, efficient and stable bioanalytical method has been developed and validated for determination of brexpiprazole in dog plasma with UPLC–MS-MS for the first time. Brexpiprazole and internal standard were extracted from plasma samples by liquid–liquid extraction and separated on an Acquity UPLC BEH C18 column. A gradient elution program was developed employing methanol and 10 mM ammonium acetate aqueous solution as mobile phases. The method was validated for parameters of selectivity, LLOQ, linearity, accuracy, precision, matrix effects and stability in accordance with the regulatory guidance on bioanalytical method validation. The validated method was applied in evaluating the pharmacokinetic profiles of brexpiprazole in beagle dogs after a single-dose oral administration of a 4 mg tablet.
研究领域:
药物分析
·
临床药理学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2018
·
IF 3.849
Dong Huang,Mengliu Zhang,Wei Chen,Dawei Zhang,Xinluan Wang,Huijuan Cao,Qian Zhang,Chunyan Yan
Cibotium barometz is a tropical and subtropical plant, mainly distributed in the Malaysian Peninsula and southern China. In China, C. barometz has tremendous commercial value in horticultural and medicinal applications. In the present study, alkaline soluble crude polysaccharides (CBBs) were extracted from water extraction residues of C. barometz with sodium hydroxide solution. After deproteinization and dialysis, CBBs were isolated and purified via DEAE-52 cellulose and Sephadex G-75 gel filtration chromatography to obtain two polysaccharide fractions (CBBP-2 and CBBP-3), with relative molecular weights of 10.7 kDa and 1.23 × 10 2 kDa, respectively. Chemical methods and nuclear magnetic resonance (NMR) studies indicated that CBBP-2 was composed of →4)- α - d -Glc p -(1→, →3)- α - l - R ha p -(1→, →3)- α - l -Ara f -(1→, →6)- β - d -Gal p -(1→, →3,6)- α - d -Man p -(1→ and α - d -GalA p -(1→, and CBBP-3 was composed of →6)- β - d -Gal p -(1→, →3)- α - l - R ha p -(1→, →3)- α - l -Fuc p -(1→, →3)- α - l -Ara f -(1→, →3,6)- α - d -Man p -(1→, β - d -GalA p -(1→ and α - d -Gal p -(1→. Morphological and conformational analyses indicated that CBBP-2 had a fragmented and sawdust-like structure. CBBP-3 had a neuron-like morphology, with a number of dendritic branches. Neither CBBP-2 nor CBBP-3 had a triple helix structure. Furthermore, MC3T3-E1 cells were selected to evaluate the osteogenic activities of CBBP-2 and CBBP-3 in an in vitro anti-osteoporosis assay, and the results revealed that CBBP-2 significantly promoted the differentiation of MC3T3-E1 cells at concentrations of 9.4 μM and 18.8 μM and promoted osteogenic mineralization at a low concentration at 4.7 μM. Overall, the systematic extraction, purification, structure identification and bioactivity assays of CBBP-2 and CBBP-3 showed that CBBP-2 could potentially be used as an anti-osteoporotic activity ingredient, with applications in health care and pharmaceutical industries.
研究领域:
药理学
·
生物化学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 27
·14326-14335
·
IF 14.511
Qihua Sun,Zhaofeng Wu,Zhangjie Qin,Xuan Chen,Chuanchuan Zhang,Biaobing Cao,Haiming Duan,Jun Zhang
Inspired by the similarity between the pleated structure of rose petals and the pleated structure of a dog's maxillary turbinate, porous biomass carbon materials with a pleated structure have been successfully prepared from rose petals by direct carbonization. Detailed SEM and TEM characterization showed that the carbonized rose tea (CRT) at 600 °C exhibited a mimetic structure very similar to the dog's maxillary turbinate. The trace K element was detected in the prepared CRT materials, which effectively improved the adsorption capacity of the CRT materials for NH3 as revealed by density functional theory based on first-principles calculations. As a result, the CRT sensor showed an ultra-high response (60.16k%) to 500 ppm NH3 with a theoretical detection limit of only 4.82 ppb, in addition to showing a fast recovery (2.0 s), excellent repeatability and long-term stability. Moreover, the formation of nanopores in the pleated structure of the CRT and the sensing mechanism of NH3 were analyzed. Through a simple, inexpensive and efficient method, this study provides a new strategy for the preparation of a high-performance gas sensor with a bionic structure by directly using the similarity between the biomass structure and dog nose structure.
研究领域:
材料科学
·
环境科学
·
仿生学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 59
·36923-36928
·
IF 3.108
Yueyue Yin,Yong Yang,Liangzhu Zhang,Yongsheng Li,Zhiyuan Li,Weiwei Lei,Yunfeng Ma,Zhengren Huang
Here, we report a facile synthesis of Pd/Au nano-dogbones (NDBs) by loading massive Pd nanoparticles on the two ends of Au nanorods (NRs) via a seed-mediated method. The as-prepared samples were investigated by using TEM, elemental analysis, UV-vis and FDTD simulation. The photocatalytic activity of Pd/Au NDBs was assessed by dehydrogenation of formic acid under visible-to-NIR light irradiation. The Pd/Au NDBs shows much higher enhanced reaction activity compared with samples with core–shell structure due to the increased electron and hole pair separation and total catalytic sites. More importantly, the introduction of Au NRs broadens the photoresponse range and improves the utilization of sunlight efficiently. This finding provides a rational approach to improve photocatalytic performance by forming dogbone structures via integrating plasmonic metals and conventional catalysts.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2023
·
IF 10.9
Zhangjie Qin,Zhaofeng Wu,Qihua Sun,Jun Sun,Min Zhang,Fengjuan Chen,Dongzhi Zhang,Changwu Lv,Haiming Duan
Inspired by the ordered tubular structure inside the dog nose and its olfactory receptors, this paper reports a biochar/SnO 2 composite based on waste disposable bamboo chopsticks (DBC) combined with tin dioxide (SnO 2 ) nanoparticles . The response of optimized biochar/SnO 2 composite reaches 4513 to 500 ppm NH 3 , and the response/recovery times are 50.4 s and 3.7 s, respectively. The biochar/SnO 2 composite displays the dog-nose-like ultra-fast response (1 s response up to 1100) to 500 ppm NH 3 at room temperature (25 °C), which makes the biochar/SnO 2 composite with the application promising for rapid detection of NH 3 . The optimized biochar/SnO 2 sensor also exhibits good selectivity and linear response with a theoretical detection limit as low as 34 ppb NH 3 . In addition, the biochar/SnO 2 sensor has reliable humidity immunity and long-term stability. Within a period of up to six months, the response fluctuation of biochar/SnO 2 sensor to 500 ppm NH 3 at 25 °C is less than 3.7%. However, the susceptibility of biochar/SnO 2 composite to the operating temperature need to be overcome. The biochar/SnO 2 composite was prepared by low-temperature pyrolytic carbonization (300 °C) with the advantages of abundant raw materials, low cost and green environmental protection, providing a new outlet for solid waste.
研究领域:
材料科学
·
环境科学
·
传感技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）