Food Chemistry-X
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2024
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IF 6.5
Jinman He,Wanli Zhang,Gulden Goksen,Mohammad Rizwan Khan,Naushad Ahmad,Xinli Cong
In this study, zein-pectin nanoparticles loaded with Wampee [ Clausena lansium (Lour.) Skeels] (WEO) were developed. The particle size of the nanoparticles is 515.9 nm, polydispersity index is 0.4 and zeta potential is −39.3 mV. Subsequently, the ZWP was incorporated into sodium alginate (SA)-based film (ZWP-S). The films were then analyzed to determine their physical properties and thermal stability, and also to examine their microstructure and intermolecular forces using SEM, FTIR, and XRD techniques. Additionally, the films were evaluated for their antimicrobial and antioxidant activity, as well as their ability to sustain the release of WEO. Overall, the ZWP-S film conferred excellent functional properties, including UV barrier performance, mechanical properties (21 % increase in tensile strength), water sensitivity, stability, more compact structure, high antioxidant activity and long-lasting antimicrobial activity, surpassing those of the control film. Consequently, it was applied as a novel coating for preserving strawberries, rotting rate of strawberries was reduced by 43 % at 6d, yielding promising results in prolonging the freshness of the fruit.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Luyuan Yang,Haiquan Li,Fructueux Modeste Amona,Yanzhu Li,Ziqi Sha,Chengbin Shi,Lixuan Cao,Fangxu Bu,Yipeng Pang,Yi Liu
Infected wounds remain a critical clinical challenge, predominantly driven by Staphylococcus aureus ( S. aureus, especially methicillin-resistant S. aureus , MRSA) biofilm formation, which triggers a vicious cycle of persistent infection, sustained inflammation, and progressive oxidative stress. Current clinical interventions fail to achieve simultaneous bacterial eradication, modulation of inflammation, and tissue regeneration, often with biocompatibility risks, whereas natural polysaccharide-based biomaterials offer a promising engineering strategy to address this dilemma. Herein, based on the nano-cocktail synthesis concept, we developed a caffeic acid (CA)-loaded nanocomposite (CA@ZSH) via green self-assembly from natural carbohydrate polymers (sodium alginate, SA; hyaluronic acid, HA) and zein for comprehensive infected wound therapy. CA was encapsulated in a homogeneous inner matrix of zein and bioactive polysaccharide HA, enabling stable drug loading/sustained release, along with HA-mediated regulation of inflammation and pro-regeneration. This core nanocomplex was further coated with polysaccharide SA as a hydrophilic shell to enhance colloidal stability and maintain a moist wound-healing microenvironment. CA@ZSH exhibited potent anti- S. aureus /MRSA activity via biofilm disruption, plus excellent free radical-scavenging, anti-inflammatory properties, and biocompatibility. In vivo , it markedly accelerated wound healing by upregulating CD31 and VEGF, thereby promoting wound closure, collagen deposition, and angiogenesis. This study provides a facile and robust polysaccharide-based nanotherapeutic engineering strategy for the management of wounds infected with drug-resistant bacteria. Polysaccharide-based self-assembled CA@ZSH nanocomposites for synergistic anti-bacterial, anti-oxidant, and anti-inflammatory therapy of Staphylococcus aureus -infected wounds. The nanoplatform is fabricated via green self-assembly of natural carbohydrate polymers (sodium alginate and hyaluronic acid), zein and caffeic acid, which eradicates bacterial biofilms, scavenges excessive ROS to restore redox homeostasis, and upregulates CD31 and VEGF to accelerate angiogenesis and collagen deposition, achieving comprehensive repair of infected full-thickness skin wounds. Download: Download high-res image (149KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Fazhu Li,Tingting Yang,Guanghua Xia,Zhongyuan Liu,Dawei Yu,Zhidong Liu,Liming Zhang,Jiamei Wang
ACP treatment enhanced encapsulation and controlled release of curcumin / resveratrol. • ACP promoted hydrogen bonding and electrostatic interactions in nanoemulsions • ZCR/SA-NE-3 min showed excellent emulsifying and antioxidant activity. • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles effectively reduced TVC and MDA levels in refrigerated tilapia • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles extended the shelf life of refrigerated tilapia from 4 to 8 days. Oxidative degradation and microbial contamination cause quality deterioration of aquatic products under refrigeration, posing a major challenge to their preservation. In this study, zein-curcumin-resveratrol‐sodium alginate nanoparticles (ZCR/SA NPs) were pretreated with atmospheric cold plasma (ACP) for 1–4 min. The ACP-modified NPs were further fabricated into antioxidant nanoemulsions (NEs), and the influences of ACP pretreatment on the physicochemical properties, encapsulation efficiency, and sustained-release performance of the resultant NEs were systematically explored. The ACP treatment significantly improved the loading efficiency and controlled release of curcumin and resveratrol ( P < 0.05). FT-IR and XRD analyses indicated the formation of stronger hydrogen bonding and electrostatic interactions within the NEs system, which improved structural stability. Among all samples, ZCR/SA-NEs-3 min exhibited the best emulsifying properties (ESI = 358.57 ± 14.60 min, EAI = 30.51 ± 1.52 m 2 /g) and strong antioxidant activity (DPPH: 74.7 ± 1.67%, ABTS: 76.4 ± 2.17%). Importantly, ZCR/SA-NEs-3 min could significantly delay the spoilage process of tilapia fillets during 8 days of storage. Compared with the control group, the total viable count decreased from 8.07 ± 0.04 to 5.20 ± 0.04 lg₁₀ CFU/g, the malondialdehyde content dropped from 1.57 ± 0.03 to 0.49 ± 0.01 mg MDA/kg, and the shelf life was extended from 4 days to 8 days. This study not only revealed the mechanism underlying property improvement of NEs by ACP-modified NPs, but also provided an eco-friendly and innovative strategy for efficient preservation of aquatic products. Download: Download high-res image (265KB) Download: Download full-size image
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FOOD CHEMISTRY
·
2026
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IF 10.4
Zhihang Xu,Hong He,Jian Du,Peng Shan,Chenglong Fu,Jinwen Hu,Yehan Tao,Chao Li,Yanna Lv,Haisong Wang
Anthocyanin-based pH-responsive indicators are promising for food freshness monitoring, but UV exposure during transportation and retail display causes chromophore degradation and fading. Herein, core–shell sodium alginate/cinnamaldehyde/zein/anthocyanin nanoparticles (SCZC) were fabricated via a multiscale protection strategy. Anthocyanins were confined in a hydrophobic zein core through hydrophobic and π–π interactions, while cinnamaldehyde-assisted interfacial densification and a sodium alginate shell provided diffusion barriers against external stresses. After incorporation into a carboxymethyl cellulose (CMC) matrix, the CMC film containing 0.4 g SCZC nanoparticles (C/SCZC-0.4) exhibited improved UV and visible-light stability, with ΔEab values of only 5.21 after 4 h of UV irradiation and 5.22 after 8 days of visible-light exposure. Compared with the free-anthocyanin CMC film (C/C), C/SCZC-0.4 reduced anthocyanin migration in water from 84.34% to 35.65%, while improving oxygen barrier performance and tensile strength to 2.32 cm 3 ·μm·m −2 ·day −1 ·kPa −1 and 30.0 MPa. The label retained pH/ammonia responsiveness and visually distinguished seafood freshness. Download: Download high-res image (208KB) Download: Download full-size image
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FOOD HYDROCOLLOIDS
·
2026
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IF 13.8
Qiaochun Chen,Yuanyuan Chen,Qian Zhou,Mingfu Wang
Galangin (Gal), a hydrophobic flavonoid prevalent in galangal, exhibits remarkable inhibitory effects against the formation of β -carboline, a subclass of heterocyclic amines. However, its poor aqueous water solubility hinders its application in water-based food systems, such as braised meats. To address this issue, Gal-loaded zein/pectin nanoparticles (ZGP-NPs) were designed to integrate the potential inhibitory effects of Gal and pectin against HAs formation while improving Gal dispersion in aqueous systems. The nanoparticle formulation was optimized, achieving high encapsulation efficiency (96.07%) and loading capacity (7.93%) at a Gal concentration of 2 mg/mL. Microstructural and physicochemical characterization revealed successful encapsulation, yielding uniform spherical particles with an average size of 123.42 nm. ZGP-NPs demonstrated satisfactory stability across different chemical and physical conditions. In brine models and braised lamb applications, ZGP-NPs significantly suppressed β -carboline formation, achieving 35.43–68.30% (free type) reductions in β -carbolines in brine model systems, and 10.58–28.24% (free type) and 31.72–55.22% (free + bounded type) reductions in braised lamb. Mechanistic insights suggest that ZGP-NPs may suppress β -carboline generation via trapping of aldehydes (precursors for β -carboline formation), free radical scavenging, and direct binding of β -carbolines. This work demonstrates a pioneering strategy for mitigating HAs using polyphenol-encapsulated nanoparticles, providing a novel, efficient, and cost-effective approach for improving meat safety.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Mengna Zhang,Qinchao Zhu,Tingmei Chu,Wei Xia,Hualing Xie,Jianchang Jin,Gongshuai Song,Xichuang Guo,Jinyan Gong
Peimine (P) and curcumin (CM) possess significant bioactivities but suffer from poor water solubility, low bioavailability, and limited stability. To address these challenges, P-CM self-assembled microparticles (SMPs) were prepared via non-covalent interactions and systematically characterized. The results demonstrated that optimal self-assembly reaction conditions occurred at pH 9, 25 °C, and a P:CM molar ratio of 1:1, yielding uniform nanoparticles (284 nm, PDI = 0.202) with a zeta potential of −19.77 mV. P-CM SMPs exhibited superior antioxidant activities, with ABTS, DPPH radical scavenging activity and FRAP values of 62.69%, 34.18%, and 81.02%, respectively, as well as enhanced anti-inflammatory activity compared to their individual components. To further improve stability and control release, the P-CM SMPs were encapsulated in a hollow zein-chitosan (HZ-CH) composite, achieving high encapsulation efficiency (96.0%). HZ-CH-SMPs exhibited storage stability over time and sustained-release behavior under simulated gastrointestinal conditions. This study provides a theoretical basis for designing delivery strategies integrating molecular self-assembly and protein-polysaccharide encapsulation to overcome solubility and bioavailability limitations of bioactive compounds in functional foods.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Xiaomin Luo,Weihua Shen,Yonghang Liang,Shanshan Wang,Zhiyun Du
Oxyresveratrol (OXY), a plant-derived polyphenol, exhibits promising bioactivities but encounters practical constraints owing to its poor water solubility and instability. To address these challenges, OXY-loaded nanocomplexes were fabricated via the antisolvent precipitation method using zein, sodium caseinate (SC), and sodium alginate (SA) as a delivery matrix. The optimized OXY-zein/SC/SA complexes possessed a median size centered at 220 nm, a surface potential of −32 mV, an encapsulation efficiency of 83.86 %, and a loading capacity of 9.45 %. Morphological observation (using Scanning Electron Microscopy and Transmission Electron Microscopy) confirmed the formation of a spherical core-shell structure. Evidence for the strategic construction of the complex framework was provided by a convergence of Fourier Transform-Infrared spectroscopy, X-ray Diffraction, and Nuclear Magnetic Resonance spectroscopy data. Thermogravimetric and Derivative Thermogravimetry profiles showed higher decomposition temperatures, confirming enhanced stability from the structural design. Molecular dynamics simulations revealed that stable binding between OXY-zein and SC was primarily driven by hydrogen bonding and surface complementarity, while SA modulated the microenvironment through structural rearrangement and steric shielding. Kinetic modeling indicated that the incorporation of SC and SA shifted the release behavior from Fickian diffusion to a complex mechanism governed by matrix erosion and structural relaxation. The stable nanocomplexes outperformed native OXY in radical scavenging capacity while also maintaining excellent biocompatibility with Caco-2 cells and high tolerance to fluctuations in salinity and pH. These findings elucidate the formation mechanisms of the OXY-zein/SC/SA system, establishing a theoretical framework for the delivery of hydrophobic polyphenols in functional foods and nutraceuticals.
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Food Packaging and Shelf Life
·
2026
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IF 10.8
Feng Xiao,Yimeng Zhang,Haoran Wang,Ji Wei,Linlin Li,Hualin Wang
Ethylene (C 2 H 4 ), a natural plant hormone, accelerates the ripening and senescence of fruits and vegetables (F&V), posing significant challenges to their post-harvest preservation. Herein, we develop a C 2 H 4 scavenging nanofiber membrane by chemically modifying zein (ZN) with (3-mercaptopropyl) triethoxysilane (MPTES). This modification reduces the hydroxyl content while introducing sulfhydryl groups on zein chain. The typical membrane of ZN-MPTES3 demonstrates excellent hydrophobic property with a water contact angle (WCA) of > 140°, and can maintain structural integrity after 24 h of water immersion. Additionally, the MPTES grafting enhances the membrane's roughness. At 25 °C, the ZN-MPTES3 membrane effectively extends the shelf-life of bananas through a thiol-ene click reaction with C 2 H 4 , which is accelerated under UV exposure (365 nm), further enhancing the preservation efficacy. These results demonstrate the potential of the ZN-MPTES electrospun membrane as a sustainable and effective platform for the preservation of post-harvest F&V.
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Nanomedicine-Nanotechnology Biology and Medicine
·
2026
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IF 4.3
Kun Ma,Zicheng Liu,Senchao Chai,Qingxian Fang,Ruifan Xu,Wenrong Zhu,Yu Liu,Tong Zhang,Zhaoming Guo,Changhao Cui,Jianqiang Xu,Shigang Guo,Yang Chen
Glioblastoma (GBM) is one of the most malignant and lethal primary brain tumors, and the blood-brain barrier (BBB) poses a significant challenge to its treatment. In this study, disulfiram-loaded Zein Janus nanoparticles (Lf/M2pep@ZEN-DSF) were developed using the Pickering emulsion method for enhanced GBM therapy. Lactoferrin (Lf) was modified to one side of the Janus nanoparticles to facilitate BBB penetration and GBM targeting, while M2pep peptides were modified to the opposite side for targeting tumor-associated macrophages (TAMs). The results demonstrated that Lf/M2pep@ZEN-DSF effectively crossed the BBB and targeted brain tissues. Additionally, the Janus nanoparticles selectively targeted M2-polarized TAMs via M2pep and repolarized them into the M1 subtype for GBM therapy. Furthermore, the Janus nanoparticles significantly enhanced intracellular reactive oxygen species (ROS) generation in GBM cells. In vivo studies confirmed that the nanoparticles significantly increased drug accumulation in the brain and prolonged the survival of GBM-bearing mice. Immunohistochemical analysis revealed that Lf/M2pep@ZEN-DSF treatment induced M2-to-M1 TAM repolarization, effectively remodeling the tumor immune microenvironment. These findings collectively indicate that Lf/M2pep@ZEN-DSF is a promising nanomedicine with favorable biosafety for enhanced GBM treatment.
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FOOD HYDROCOLLOIDS
·
2026
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IF 13.8
Xuyue Xu,Yi Qin,Xiao Feng,Chengcheng Gao,Linghan Meng,Zhenjiong Wang,Weiwei Cheng,Yan Zhang,Xiaozhi Tang
Zein, a hydrophobic amino acid-rich storage protein from maize endosperm, holds considerable promise for food-packaging applications. However, conventional zein films are predominantly fabricated by solvent-casting methods, which are less amenable to large-scale production. This research focused on evaluating how the integration of glycerol, decanoic acid, and potassium hydroxide influences the structural and physical features of zein films fabricated through thermal pressing. Thermal processing promoted the rearrangement of disulfide bonds and induced limited non-disulfide polymerization, accompanied by varying degrees of deamidation, without significant protein degradation. Potassium hydroxide promoted depolymerization and reduced porosity, whereas glycerol improved the dispersion of decanoic acid during melt processing. Potassium hydroxide, decanoic acid, and glycerol collectively enhanced the zein melt fluidity, thereby exerting a synergistic plasticizing effect that resulted in films with favorable extensibility. When the contents of glycerol, decanoic acid, and potassium hydroxide were 25%, 10%, and 4.5%, respectively, the hot-pressed film demonstrated well-balanced overall performance. This work provides both theoretical insight and practical evidence to support the solvent-free processing of thermoplastic zein-based films.
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FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Fangyuan Wei,Caihong Shi,Hongyue Wang,Wanxuan Li,Xindi Zhang,Xiangrong Zhang
Sodium carboxymethyl cellulose (CMC)-based films integrated with zein and magnolol complexes were prepared for food packaging with antimicrobial and antioxidant properties. The results showed that the secondary structure of zein changed upon complexation with magnolol. The scavenging ability of the complexes on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2′-azinobis-(3-ethylbenzthiazoline-6- sulphonate) (ABTS) radicals was significantly higher than that of zein alone. The zein-magnolol complexes (ZMC) were then loaded into CMC to form a hydrogel film. The radical sca v enging rates of DPPH and ABTS of CMC/0.5 ZMC (the proportion of ZMC in film solution at 0.5, v /v) were 32.24 % and 91.30 %, respectively, which were significantly higher than CMC film. The incorporation of the complexes also improved the mechanical properties, with a more than 3-fold increase in elongation at break (EB) value. In addition, the complexes-loaded hydrogel film also inhibited the growth of S. aureus , a common bacterium that can cause food poisoning. Cytotoxicity tests have revealed that the studied films are non-toxic, presenting good compatibility. The film also successfully maintained the nutrients in fresh-cut jackfruit by mitigating lipid peroxidation and the increase in malondialdehyde content during 8-day storage. Overall ZMC loaded CMC film provides a promising approach for food preservation against ultra-violet light, oxidation and microbial growth.
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Frontiers in Pharmacology
·
2025
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IF 4.8
Peiyan Wang,Tianlu Wang,Hui Zhang,Pei Sun,Changqing Yuan,Yiqing Guo,Zhaochen Liu,Mengyu Jiao,Jingwen Chi,Kexin Wang,Jing Deng,Xiaofei Yu
Chemotherapy-induced oral mucositis is a common complication in cancer therapy. Multiple studies demonstrate that doxepin mouthwash is effective in controlling CIOM pain, while research on its ulcer healing effects and underlying mechanisms remains limited. Additionally, local adhesive formulations of doxepin for oral application are still lacking. In this study, we developed a bilayer oral patch using 3D-printing technology for the localized sustained release of doxepin hydrochloride. This patch demonstrated favorable characteristics, including thinness, flexibility, and excellent mucosal adhesion, while promoting ulcer healing in CIOM animal models. Further investigation revealed that the healing mechanism involves the alleviation of oxidative stress and attenuation of excessive inflammatory responses. The doxepin hydrochloride patch developed in this study provides a novel pharmaceutical option for clinical management of CIOM.
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