MOLECULES
·
2023
·Vol. 28
·期 21
·7307
·
IF 4.6
Yecheng Lei,Xiao Lei,Anqi Zhu,Shijie Xie,Tiantian Zhang,Chuo Wang,Anning Song,Xiaoming Wang,Guangwen Shu,Xukun Deng
Acetaminophen (APAP)-induced liver injury is a common hepatic disease resulting from drug abuse. Few targeted treatments are available clinically nowadays. The flower bud ofRosa rugosahas a wide range of biological activities. However, it is unclear whether it alleviates liver injury caused by APAP. Here, we prepared an ethanol extract ofRosa rugosa(ERS) and analyzed its chemical profile. Furthermore, we revealed that ERS significantly ameliorated APAP-induced apoptosis and ferroptosis in AML-12 hepatocytes and dampened APAP-mediated cytotoxicity. In AML-12 cells, ERS elevated Sirt1 expression, boosted the LKB1/AMPK/Nrf2 axis, and thereby crippled APAP-induced intracellular oxidative stress. Both EX527 and NAM, which are chemically unrelated inhibitors of Sirt1, blocked ERS-induced activation of LKB1/AMPK/Nrf2 signaling. The protection of ERS against APAP-triggered toxicity in AML-12 cells was subsequently abolished. As expression of LKB1 was knocked down, ERS still upregulated Sirt1 but failed to activate AMPK/Nrf2 cascade or suppress cytotoxicity provoked by APAP. Results of in vivo experiments showed that ERS attenuated APAP-caused hepatocyte apoptosis and ferroptosis and improved liver injury and inflammation. Consistently, ERS boosted Sirt1 expression, increased phosphorylations of LKB1 and AMPK, and promoted Nrf2 nuclear translocation in the livers of APAP-intoxicated mice. Hepatic transcriptions of HO-1 and GCLC, which are downstream antioxidant genes of Nrf2, were also significantly increased in response to ERS. Our results collectively indicated that ERS effectively attenuates APAP-induced liver injury by activating LKB1/AMPK/Nrf2 cascade. Upregulated expression of Sirt1 plays a crucial role in ERS-mediated activation of LKB1.Keywords:extract ofRosa rugosa;acetaminophen;liver injury;Sirt1;Nrf2
研究领域:
药理学
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肝脏病学
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植物化学
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DOI
PubMed
高影响因子
Scientific Reports
·
2019
·Vol. 9
·期 1
·1-9
·
IF 4.011
Yang Yushan,He Haishan,Li Yougui,Qiu Jian
Robust, buoyant, superhydrophobic PVB/SiO 2 coatings were successfully formed on wood surface through a one-step solvothermal method and a nanoimprint lithography method. The as-prepared PVB/SiO 2 /wood specimens were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), thermogravimetric/differential thermogravimetric (TG–DTG) analyses. The superhydrophobic property and abrasion resistance of rose-petal-like wood were measured and assessed by water contact angle (WCA) and sand abrasion tests. The results show that PVB/SiO 2 /wood not only exhibited a robust superhydrophobic performance with a WCA of 160° but also had excellent durability and thermostability during the sand abrasion tests and against corrosive liquids. Additionally, the as-prepared PVB/SiO 2 /wood specimens show high buoyancy.
研究领域:
材料科学
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表面工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yihua Zheng,Chengchun Zhang,Jing Wang,Yan Liu,Chun Shen,Junfeng Yang
Hypothesis Bionics and dynamic interface wetting intensely appeal to many research communities due to their unique practical implications. The rose petals had a highly robust dynamic water-retaining capacity under heavy precipitation. We predicted that the roses became more “hydrophilic” at higher Weber numbers . Experiments Fresh rose petals were directly impacted by droplets, and facile artificial petal-like substrates and superhydrophobic substrates were used in the comparative analysis. The wetting dynamics of the droplet (e.g., topography, bounce dynamics, contact time, three-phase contact lines, and oscillations) were investigated when interacting with four selected target substrates. Findings The present work first time investigated the dynamic wetting rule of the sticky superhydrophobic substrates (SSHS). Simulated and experimental investigations confirmed that the unique coupling synergy between the pinning effect and the inhomogeneous micropapillaes resulted in lopsided contact line velocities, which remarkably suppressed the lateral oscillation and rebounding. This may be a new strategy when designing dynamic water-repellent surfaces and open a promising avenue for emerging areas such as super-efficiency energy conversion and harvesting.
研究领域:
材料科学
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生物物理学
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DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 4
·3969-3972
·
IF 1.338
Meng Yongde,Sun Yanjie
In the present study, biosynthesis of silver nanoparticles was carried out using Rosa chinensis flower extract as reducing agent. The characterization of silver nanoparticles was done by UV-VIS spectrum. The morphology and size of silver nanoparticles were determined by transmission
electron microscope (TEM) image. The crystallization of silver nanoparticles was confirmed by X-ray diffraction (XRD) measurements. The Fourier transform infrared (FT-IR) analysis was used to confirm the possible involvement in the formation and stabilization of synthesized silver nanoparticles
by the extract of Rosa chinensis flower. Antibacterial activity of silver nanoparticles was studied against Gram positive Staphycoccus aureus and Gram negative Escherichia coli.
研究领域:
纳米生物学
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微生物学
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植物化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Yang Xu,Baoping Zhu,Hanwen Ge,Shenglin Wang,Bin Li,Huanfei Xu
High-value utilization of agricultural wastes such as rose petals promotes the development of the dual carbon economy. In this study, rose petals were pretreated by microwave-assisted deep eutectic solvent (DES). Choline chloride-ethylene glycol (ChCl-EG) was used as the basis for the addition of P-toluenesulfonic acid (TsOH) or Ferric chloride (FeCl 3 ). Forming ternary DESs, as well as designing quaternary DESs with a synergistic effect. The effects of different types of multicomponent DES on treating anthocyanins , cellulose , and lignin in rose flowers were explored. The results showed that the highest anthocyanin extraction of 173.71 mg/g and the highest lignin removal of 40.80 % could be achieved after tetrad DES pretreatment when the molar ratio was ChCl:EG:TsOH:FeCl 3 = 1:2:0.3:0.3. The interaction energy between anthocyanins and DES was calculated using density functional theory (DFT), and the maximum was −543.14 kcal/mol. This study demonstrated that DES pretreatment can provide novel insights for the utilization of roses in high-value.
研究领域:
农业废弃物利用
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生物化学
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可持续发展
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Shaolei Kang,Hualin Wang,Li Xia,Minmin Chen,Linlin Li,Junfeng Cheng,Xingjiang Li,Shaotong Jiang
In this work, a colorimetric film was designed for shrimp freshness monitoring by incorporating rose anthocyanins (RAs) in polyvinyl alcohol/okra mucilage polysaccharide (PVA/OMP) composite film. The presence of OMP changed the film-forming solution from Newtonian to non-Newtonian fluid. The addition of OMP and RAs decreased the crystalline of PVA due to the hydrogen bonds among RAs, OMP and PVA. An appropriate content of RAs and OMP could improve the film mechanical and barrier properties. The colorimetric film showed distinguishable color changes at pH 2–12 and was high sensitive to volatile ammonia. The target film of PVA/OMP-RAs could effectively monitor shrimp freshness in real time and the color changes were easily distinguished by naked eye, suggesting its potential in intelligent packaging for freshness monitoring of aquatic products and meat foods.
研究领域:
食品科学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Sinian Jiang,Bin Zhang,Xinyu Liu,Jingchun Cao,JunJie Ge,Kexin Men,Yuxiong Jiang,Xiaocong Wang
As a promising anode for lithium-ion batteries (LIBs), silicon (Si) has been studied due to its high specific capacity. However, significant volume change during charge-discharge process has seriously impeded its practical application. Compounding with carbon is one of the methods to solve this problem. In this paper, biomass carbon is prepared by high temperature carbonization of Chinese rose petals. Different mass ratios of Si nanoparticles are embedded in the biomass carbon to produce C@Si composites. The as-prepared C@Si composites are assembled into LIBs to investigate their electrochemical performance. As an anode material for LIBs, the manufactured C@Si composite material (Si-25 wt%) manifests a stable cycling performance (524 mAh•g −1 at 0.1 A•g −1 after 100 cycles), a long cycle life (581 mAh•g −1 at 1 A•g −1 after 400 cycles) and excellent rate capability. And its initial coulombic efficiency at the current density of 1 A•g −1 (99.62 %) is much larger than that of pure nano-Si (29.45 %). The electrochemical impedance spectroscopy (EIS) results indicate that the C@Si composite materials can behave as an ideal capacitor. This study reveals the possibility of changing flower petals to carbon material and the potential applications in the field of LIBs.
研究领域:
材料科学
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能源存储
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产品关联
DOI
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Shengkai Luo,Yi Hou,Song-Qing Hu
Improvement of activity and property in polyphenol oxidases (PPOs) by protein engineering may contribute to synthesis of theaflavin (TF1) in industrial processes. Here, the potential noncatalytic residues of PPO from Rosa chinensis (RcPPO) were selected by sequence alignment, structural analysis and surface residues prediction and the mutants were gained by semi-rational site-directed mutagenesis. Mutants L173F, A174K and N334I possessed 10.48, 9.74 and 7.13 times increases respectively in preference for diphenols over monophenols. Enzymatic activity, half-life at 40 and 50 °C of the most active mutant RcPPO-FKI increased to 2.67, 2.62 and 3.37 times respectively in comparison with wild type, implying that activity and thermostability of RcPPO through mutation were improved. The improvement of activity and thermostability in the mutant should be ascribed to more hydrogen bonds formed by the conserved catalytic histidine residues with substrate, reduced fluctuation of the loop regions and increased hydrogen network of the mutational amino acids, revealed by molecular dynamics simutation and molecular docking. Moreover, the yield of TF1 was improved by catalysis of mutant RcPPO-FKI with higher synthetic efficiency of TF1 in comparison with some reported catalysts and as a promising alternative to commercial mushroom tyrosinase. PPOs with enhanced performances provide the robust candidate for industrial application.
研究领域:
生物化学
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蛋白质工程
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食品科学
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DOI
高影响因子
Joule
·
2023
·
IF 39.8
Kai Deng,Hao Feng,Ying Zhang,Dong Liu,Qiang Li
Summary To maximize product purity, current density and efficiency has never been demonstrated simultaneously for the membrane-less water electrolyzers that eliminate the use of a membrane or a diaphragm, as well as their unfavorable issues. Here, we successfully addressed the trade-offs by leveraging the rose-petal-effect-mimetic (RPEM) design strategy. We mimicked nature by alternating water-repellent and water-adhesive building blocks; the resultant RPEM electrode is in the Cassie-impregnating wetting state, which is ideal for efficient bubble-less gas evolution reactions. A bubble-less HER at a current density of 4.2 A cm −2 , one order of magnitude larger than that of any known bubble-less electrodes, was demonstrated by the RPEM electrode. Based on this, we further constructed the RPEM electrolyzer and demonstrated membrane-less water electrolysis at 1 A cm −2 current density, simultaneously with 61.5% electrolysis efficiency and 0.003% hydrogen crossover, remarkably outperforming the state-of-the-art membrane-less water electrolyzer.
研究领域:
材料科学
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能源技术
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DOI
高影响因子
Advanced Optical Materials
·
2024
·Vol. 12
·期 36
·2401657
·
IF 8
Yunjie Xia,Mengnan Sun,Li Zhang,Shuyan Qi,Yaru Jia,Zihou Li,Mingkun Wang,Shunxiang Li,Aiguo Wu,Bo Chen
Surface-enhanced Raman spectroscopy (SERS) detection is a crucial technology for rapid sensing and “fingerprinting”, achieved through the combination of Raman spectroscopy and arrays of noble metal nanoparticles (NPs). This study introduces a low-cost biomimetic-inspired approach to fabricate rose petal structured micro/nano hierarchical structures with silver (Ag) film, serving as a reliable SERS substrate. These substrates are thoroughly compared by replicating the upper surface of rose petals of different colors into a transparent polydimethylsiloxane (PDMS) mixture and subsequently sputtering Ag film of varying thicknesses. Ultimately, the white negative rose PDMS replica is chosen, demonstrating a high enhancement factor, good batch-to-batch reproducibility, high stability, and high sensitivity for crystal violet (CV), an organic contaminant with mutagenic and toxigenic properties. In a proof-of-concept experiment, the multiplex detection capability of this SERS substrate is demonstrated by analyzing a combination of two sets of analytes (CV and methylene blue as well as CV and Nile blue A). Furthermore, this SERS substrate is utilized to test tau protein and amyloid β peptides, both recognized biomarkers of Alzheimer's disease. This study illustrates that the proposed 3D SERS substrate exhibits significant potential for the highly sensitive and rapid detection of biomolecules in practical applications.
研究领域:
材料科学
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生物医学
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分析化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yanlong Shao,Jie Zhao,Yong Fan,Zhenping Wan,Longsheng Lu,Zhihui Zhang,Weihua Ming,Luquan Ren
Superhydrophobic surface with tunable water adhesion has attracted great interests due to its unique performances in manipulating the status of water stay and roll-off. Herein, inspired by two typical superhydrophobic models of rose petal and lotus leaves, a superhydrophobic surface that can reversibly transform between the Cassie-Baxter state and the Cassie impregnating state has been developed by regulating the shape memory polymer SMP micro/nanostructures. The superhydrophobic surface with intact micro/nanostructure arrays exhibits excellent self-cleaning properties with extraordinary low water adhesive force, whereas the superhydrophobic surface with compressed microstructure arrays demonstrates high water adhesion. In response to the heating triggered deforming-restoring action, the switchable superwetting transition between those two models can be easily realized by their transformed morphologies. Due to the good shape memory effect of the polymer, the structured SMP assay surfaces can display a multiply switchable transition between the “lotus-effect” and the “rose-petal effect”, revealing a great potential for rewritable liquid patterns, controlled droplet transportation.
研究领域:
材料科学
·
表面工程学
✓ 已验证
DOI
高影响因子
Open Chemistry
·
2019
·Vol. 17
·期 1
·841-848
·
IF 1.512
Xiao-Fang Hu,Zong-Bao Ding,Yue Chen,Jiang-Fu Luo,Jian-Min He,Tian-Peng Yin
Flower teas are widely consumed across the world because of their beneficial health effects. The antioxidant activities of methanol extracts from ten common flower teas in China were evaluated using four antioxidant assays. The total phenolic (TPCs) and total flavonoid contents (TFCs) were also investigated. Most of these flower teas exhibited potent antioxidant effects, of which rosae rugosae flos exerted the strongest antioxidant effects in four assays. Rosae rugosae flos also exerted the highest TPC, while fragrans showed the highest TFC. Correction analysis indicated that phenolics play a key role in the antioxidant effect of flower teas, while flavonoids were poorly correlated with antioxidant activity. The results supported the consumption of flower teas as functional foods and their application as sources of natural antioxidants in the food industry.
研究领域:
食品科学
·
药理学
·
植物学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）