Environmental Science and Ecotechnology
·
2024
·
IF 14
Zhenglu Wang,Jindong Xu,Wei Du
The coexistence of caffeine (CF) and ketamine (KET) in surface waters across Asia has been widely reported. Previous studies have implied that CF and KET may share a mechanism of action. However, the combined toxicity of these two chemicals on aquatic organisms remains unclear at environmental levels, and the underlying mechanisms are not well understood. Here we demonstrate that KET antagonizes the adverse effects of CF on zebrafish larvae by modulating the gamma-aminobutyric acid (GABA)ergic synapse pathway. Specifically, KET (10–250 ng L −1 ) ameliorates the locomotor hyperactivity and impaired circadian rhythms in zebrafish larvae induced by 2 mg L −1 of CF, showing a dose-dependent relationship. Additionally, the developmental abnormalities in zebrafish larvae exposed to CF are mitigated by KET, with an incidence rate reduced from 26.7% to 6.7%. The competition between CF and KET for binding sites on the GABA-A receptor ( in situ and in silico ) elucidates the antagonistic interactions between the two chemicals. Following a seven-day recovery period, the adverse outcomes of CF exposure persist in the fish, whereas the changes observed in the CF + KET groups are significantly alleviated, especially with KET at 10 ng L −1 . Based on these results, it is imperative to further assess the environmental risks associated with CF and KET co-pollution. This pilot study underscores the utility of systems toxicology approaches in estimating the combined toxicity of environmental chemicals on aquatic organisms. Moreover, the nighttime behavioral functions of fish could serve as a sensitive biomarker for evaluating the toxicity of psychoactive substances.
研究领域:
生态毒理学
·
神经生物学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yunning Chen,Xiaoyan Zhang,Lingling Wang,Xueying Cheng,Qingkun Shang
An Fe-HQLC/TiO 2 (HQLC: 8-hydroxyquinoline-7-carboxylic) flower composite was synthesized and characterized. Phenol and four antibiotics: ciprofloxacin, tetracycline, amoxicillin and erythromycin can be efficiently and rapidly degraded by the Fe-HQLC/TiO 2 flower under visible light. The results indicated that more than 95% of the four antibiotics could be removed within 15 min. The photodegradation products of the four antibiotics were studied by high-performance liquid chromatography and high-resolution liquid chromatography-mass spectrometry. It was found that the adsorption characteristics of the antibiotics and their degradation products had a great influence on the photocatalytic activity of the photocatalyst and on the degradation rate of the antibiotics in recycling. Although the Fe-HQLC/TiO 2 flower did not degrade the four antibiotics completely, the parent structure of the antibiotics was destroyed to some extent. Therefore, the environmental toxicity and cytotoxicity of the antibiotics were significantly decreased. Compared with other related research works, there are a few photocatalysts capable of efficient and rapid removal of antibiotics.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiaohong Zhang,Junfan Niu,Zhiyuan Zhou,Gang Tang,Guangyao Yan,Yulu Liu,Jialu Wang,Gaohua Hu,Jianhua Xiao,Weiyao Yan,Yongsong Cao
The low bioavailability of pesticides has resulted in serious resource waste, environmental pollution, and potential threats to human health. Polymeric micelles for the delivery of pesticides can obviously reduce the drift, and photolysis as well as the risks of poisoning during the application of pesticides. Herein, an amphiphilic polymer, octaneacylhydrazone propylcellulose pyruvate (OPP), was prepared by conjugating octanehydrazide with propylcellulose pyruvate and used as a micellar carrier to improve the utilization efficiency of pyraclostrobin (PYR). The results showed that OPP exhibited a lower critical micelle concentration (9.99 mg/L) than classical surfactant Tween. The prepared PYR-loaded OPP micelles (POM) exhibited excellent pH and cellulase dual responsive release properties with a pesticide loading rate of 8.94%, which could efficiently prevent PYR from photolysis to prolong the effective duration. The fungicidal activities of POM against Sclerotinia sclerotiorum and Botrytis cinerea were better than that of PYR in vitro and in vivo . Furthermore, the acute toxicity of POM to zebrafish was decreased more than eleven-fold compared with that of PYR technical. Therefore, the prepared POM with excellent fungicidal activities may be a potential alternative to conventional formulations of PYR, and OPP would be used as a promising polymeric carrier for the highly efficient delivery of pesticides.
研究领域:
材料科学
·
农业科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Siyu Zhang,Boyu Jia,Weilin Huang,Changdong Ke,Yuekang Chen,Yanping Deng,Guining Lu,Zhi Dang,Chuling Guo
The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na+, Mg2+, Ca2+) could enhance interaction between NNP and Shewanella oneidensis, thereby inducing biological effects. Settling experiments and dynamic light scattering analyses showed that NNP-cell interaction increased in the order of Ca2+ ≈ Mg2+ > Na+, which can be attributed to the decreased electrostatic repulsion, as confirmed by extended Derjaguin–Landau–Verwey–Overbeek theory calculations. Although coexposure to NNP and cations did not result in significant lethality, extracellular electron transfer (EET) to insoluble electron acceptors was significantly inhibited by coexposing to NNP and Ca2+ (NNP+Ca2+, by 37%) or Mg2+ (NNP+Mg2+, by 20%), but not by NNP alone or NNP and Na+ treatments. Two-dimensional correlation spectroscopy indicated that membrane proteins predominantly mediate bacterial interactions with NNP. Physical membrane damage and structural alterations of membrane proteins were observed following coexposure to NNP+Ca2+ and NNP+Mg2+, impairing the direct EET pathways. Transcriptomic and physiological analyses further revealed that NNP+Ca2+ upregulated persister marker genes (spoT, ppx, relA) and induced ATP depletion, triggering cellular dormancy and suppressing membrane protein-mediated processes. By contrast, NNP+Mg2+ exposure activated protective responses, including two-component systems and flagellar assembly, consistent with the milder impairment of EET. Notably, these effects were absent in treatments with either cations alone or NNP alone. These findings reveal an overlooked ecological impact of NNP and underscore the potential for distinct bacterial responses to NNP in varying aquatic environments.
研究领域:
环境微生物学
·
纳米毒理学
·
分子环境科学
·
微生物电化学
·
膜生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 11
·6161-6179
·
IF 6.123
Xu Kaihui,Hasi Qimeige,Mu Xiaotong,Xiao Chaohu,Zhang Yuhan,Jiang Xiaoqian,Xu Juanjuan,Chen Lihua,Li An
The efficient elimination of petroleum hydrocarbon (PH) pollution remains a big challenge due to their easy accumulation and severe environmental toxicity. In this study, we demonstrated a novel nanocellulose based hydrophobic/lipophilic macroporous sponge loaded with microorganisms (B10NCS-DTMS, sponge prepared from nanocellulose: NCS, the NCS was immobilized 10 times: B10NCS, The B10NCS surface was sprayed with modified n-dodecyltrimethoxysilane: B10NCS-DTMS) for efficient elimination of PH pollution in water. Compared with the materials previously studied, this microporous/ superwetting structure can load more microorganisms and provide space and nutrients for the growth and reproduction of microorganisms, and mixed microorganisms have an excellent synergistic degradation effect, which greatly improves the degradation potential. We modified the surface of material loaded with microorganisms by using high stability modified long chain silane solution, which showed excellent selective adsorption performance. As expected, using a petroleum n-hexadecane solution with a concentration of 5% as model oily wastewater, B10NCS-DTMS possesses both a superior selective absorption of about 99% within 12 h and a high degradation rate of 95.85% within 96 h. In addition, B10NCS-DTMS showed more strong tolerance under different pH, temperature, and initial concentration conditions. Compared with other studies, the B10NCS-DTMS has the advantages of high biological activity, scalable manufacturing, no secondary pollution, and green and high efficiency, which might pave a new way to efficiently eliminate PH pollution from water. Graphical Abstract
研究领域:
环境科学
·
材料科学
·
生物技术
·
污染控制
✓ 已验证
产品关联
DOI
高影响因子
Environmental Science and Ecotechnology
·
2022
·
IF 9.371
Dantong Jia,Ruijie Zhang,Jian Shao,Wei Zhang,Leilei Cai,Weiling Sun
Exposure to trace-level heavy metals and antibiotics may elicit metabolic disorder, alter protein expression, and then induce pathological changes in zebrafish embryos, despite negligible physiological and developmental toxicity. This study investigated the single and combined developmental toxicity of fluoroquinolones (enrofloxacin [ENR] and ciprofloxacin [CIP]) (≤0.5 μM) and heavy metals (Cu and Cd) (≤0.5 μM) to zebrafish embryos, and molecular responses of zebrafish larvae upon exposure to the single pollutant (0.2 μM) or a binary metal-fluoroquinolone mixture (0.2 μM). In all single and mixture exposure groups, no developmental toxicity was observed, but oxidative stress, inflammation, and lipid depletion were found in zebrafish embryos, which was more severe in the mixture exposure groups than in the single exposure groups, probably due to increased metal bioaccumulation in the presence of ENR or CIP. Metabolomics analysis revealed the up-regulation of amino acids and down-regulation of fatty acids, corresponding to an active response to oxidative stress and the occurrence of inflammation. The up-regulation of antioxidase and immune proteins revealed by proteomics analysis further confirmed the occurrence of oxidative stress and inflammation. Furthermore, the KEGG pathway enrichment analysis showed a significant disturbance of pathways related to immunity and tumor, indicating the potential risk of tumorigenesis in zebrafish larvae. The findings provide molecular-level insights into the adverse effects of heavy metals and antibiotics (especially in chemical mixtures) on zebrafish embryos, and highlight the potential ecotoxicological risks of trace-level heavy metals and antibiotics in the environment.
研究领域:
环境毒理学
·
水生生物学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2016
·
IF 5.267
Guilu Pi,Yiming Li,Mutai Bao,Lili Mao,Haiyue Gong,Zhining Wang
The potential toxicity of existing chemical dispersants on the marine environment has motivated the search for environmentally friendly dispersants with excellent dispersion ability. Here, an effective Pickering emulsifier is developed based on the synergy of natural biopolymer, Xanthan Gum (XG), and silica nanoparticles. The oil–in–seawater emulsion stabilized by a combination of XG and silica demonstrates great stability and smaller droplet size, which is favorable for the following natural degradation of oil. The synergistic emulsification mechanism has been investigated systematically. The presence of XG favors the adsorption of silica nanoparticles at the oil–seawater interface and also is considerably effective in enhancing the viscosity of continuous phase. These contributions of XG slow down the droplet coalescence and creaming significantly. Confocal laser scanning microscope (CLSM) and scanning electron microscope (SEM) images of emulsions indicate a thick layer of aggregated XG/silica particles at the oil–water interface. This thick layer provides an effective steric barrier. In this study, the synergy between XG and silica not only enhances the dispersion effectiveness, but also reduces the amount of nanoparticles dramatically. This finding opens up a new path for the development of a novel, high efficiency, ecologically acceptable, and cheaper dispersant for emulsifying crude oil following a spill.
研究领域:
环境科学
·
材料科学
·
化学工程
·
海洋生物学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jie Zhao,Yunning Chen,Renquan Guan,Xueying Cheng,Zhengkai Wu,Nana Zhao,Qingkun Shang,Yingnan Sun
In this paper, we successfully constructed two composite photocatalysts TiO 2 @PDI-NapSO 3 H and Fe-TiO 2 @PDI-NapSO 3 H by utilizing water-soluble PDI derivatives to bond with TiO 2 or iron-doped TiO 2 . Their photocatalytic performance to degrade phenol and diclofenac sodium (DCF) under visible light were investigated. The results show that PDI-NapSO 3 H can effectively improve the optical absorption properties of TiO 2 . Furthermore, the oxygen vacancy produced by doping of Fe in TiO 2 prevents the recombination of photogenerated carriers effectively. The larger conjugate plane of PDI-NapSO 3 H provides a convenient channel for the migration and separation of photogenerated carriers. Thus almost 99 % of phenol or DCF can be degraded by Fe-TiO 2 @PDI-NapSO 3 H within 90 or 120 min, respectively. However, the photocatalytic activity of Fe-TiO 2 @PDI-NapSO 3 H is better. The rate of phenol degradation is much higher than that of TiO 2 @PDI-NapSO 3 H. Further, through the photoelectric response characteristic analysis, radical trapping experiment and EPR test, the effects mechanism of the energy band structure, photogenerated carrier separation efficiency on the photocatalytic performance of Fe-TiO 2 @PDI-NapSO 3 H were discussed. In addition, the possible degradation pathways of DCF and the reasons for the obvious reduction of environmental toxicity after photocatalytic degradation were proposed.
研究领域:
环境科学
·
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xueying Cheng,Renquan Guan,Yunning Chen,Yingnan Sun,Qingkun Shang
A Z-scheme heterojunction photocatalyst (TiO 2 (B)/BiOCl 0.7 I 0.3 -P) was constructed (B: bronze phase; BiOCl 0.7 I 0.3 : a solid solution of BiOCl and BiOI in a molar ratio of 7:3; P: polyvinylpyrrolidone). The open channels parallel to the b-axis between the axial oxygen atoms in the bronze TiO 2 , the unique layered structure of BiOCl and the excellent light absorption characteristics of BiOI create excellent conditions for the absorption and utilization of light, the separation and transmission of photo-generated carriers in the photocatalytic process. TiO 2 (B)/BiOCl 0.7 I 0.3 -P can almost completely degrade and mineralize fomesafen within 20 min, and the environmental toxicity of the degradation products is significantly reduced. Combined with high-resolution mass spectrometry, the degradation pathway of fomesafen was proposed. In addition, TiO 2 (B)/BiOCl 0.7 I 0.3 -P can also quickly and effectively degrade phenol and acetaminophen, indicating that it has good universality. To eliminate the harm caused by various herbicides to the ecological environment, photocatalytic technology will play an increasingly important role.
研究领域:
环境科学
·
材料科学
·
化学
·
光催化
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Di Liu,Yunning Chen,Renquan Guan,Jie Zhao,Huimin Jin,Siyi Zhang,Qingkun Shang
In this paper, a type of heterojunction photocatalyst S-Tyr-NDI-Tyr/TiO 2 was prepared by self-assembly of tyrosine-substituted naphthamide (NDA) and bonding with titanium dioxide. The self-assembly process and driving force of monomer M-Tyr-NDI-Tyr were simulated by theoretical calculation. Taking atenolol as the target pollutant, the photocatalytic performance of the heterojunction photocatalyst under visible light was studied, and the degradation products were analyzed by mass spectrometry. The environmental toxicity of photocatalytic process was evaluated by luminescent bacteria. The principle of high photocatalytic activity of S-Tyr-NDI-Tyr/TiO 2 heterojunction photocatalyst was proposed by analyzing the fluorescence spectrum, photocurrent density and resistance, electron paramagnetic resonance spectrum, free radical capture experiment and energy band position of S-Tyr-NDI-Tyr/TiO 2 heterojunction photocatalyst. In addition, the photocatalytic degradation of different pollutants by S-Tyr-NDI-Tyr/TiO 2 heterojunction photocatalyst was also studied. This work will provide a useful example for the further development of new and efficient organic supramolecular/inorganic semiconductor composite photocatalysts.
研究领域:
材料科学
·
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）