FOOD CHEMISTRY
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2022
·
IF 9.231
Jiawen Ji,Changsheng Li,Bingjie Zhang,Wenjuan Wu,Jianli Wang,Jianhui Zhu,Desheng Liu,Rumin Gao,Yongqiang Ma,Sen Pang,Xuefeng Li
N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ) can pose a threat to human health through the food chain because of their ubiquitous presence in the environment and the biotoxicity on organisms. In this work, we developed modified QuEChERS methods coupled with high performance liquid chromatography tandem mass spectrometry (HPLC/MS-MS) to explore whether 6PPD and 6PPDQ are present in fish and honey. The proposed methods showed acceptable limits of quantification (0.00043-0.001 mg/kg), linearity (R 2 > 0.99), recovery (73.3%-108.3%), matrix effect (70.4%-95.6%) and repeatability (RSD < 8.4%). Accordingly, 6PPD and 6PPDQ have been discovered in snakehead , weever and Spanish mackerel fish, while none of which have been detected in the honey samples. The results of our work contributed to increasing public attention to 6PPD and 6PPDQ in agricultural products and provided important reference for the analysis of them.
研究领域:
食品科学
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环境科学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Qi Jiang,Donghui Zhang,Naifan Hu,Yunfei Ma,Huibin Jin,Yunhao Zhao,Ming Zhang,Bin Li,Zhenzhen Huang,Bifeng Yuan,Ying Zhu,Jianbo Tian,Xiaoping Miao
Screening environmental pollutants that are harmful to the cardiometabolic status and understanding their key toxic pathways are crucial for effective clinical intervention. Based on exposure data of 46 chemicals in a nationally representative 13,286 people, logistic regression and mixture modeling were used to preliminarily identify environmental pollutants with significant impacts on 12 indicators for cardiometabolic disorders. A total of 15 chemicals were found to be associated with the integrated latent class, among which four chemicals (perfluorononanoic acid [PFNA], perfluorooctanoic acid [PFOA], thiocyanate, and thallium) also contributed significantly to the mixture effect. We constructed the adverse outcome pathways (AOPs) for nine significant toxicants in both models of individual chemicals and the mixture for each cardiometabolic disorder. Notably, fluoroalkyl substances affect multiple aspects of hyperlipidemia by activating PPARα. We performed molecular docking and in vitro experiments to verify and supplement the toxicological mechanism of PFNA. Through binding to PPARα, PFNA increased the levels of downstream molecules including CD36 (fatty acid transfer), ACSL1 (fatty acid activation), and CPT1a (intracellular transfer for β-oxidation) and ultimately promoted the accumulation of triglycerides and lipid droplets in HepG2 cells. These markers, together with key events for other metabolic phenotypes, may be potential targets for scientific research or clinical treatment.
研究领域:
环境医学
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毒理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS TECHNOLOGY
·
2018
·
IF 1.232
Jie Yang,Hairong Chu,Mingxin Zhu,Haiqin Zhou,Yanhua Xu
In order to solve the disadvantages of most of the photocatalyst, ZnFe2O4 is chosen as the magnetic material and prepared ZnFe2O4/Ag3PO4 composite photocatalysts. ZnFe2O4 is prepared by hydrothermal method, the ZnFe2O4/Ag3PO4 is prepared by precipitation method, which supported Ag3PO4 on the surface of ZnFe2O4. The synthesis method of ZnFe2O4/Ag3PO4 not only simplifies the preparation process, but also improves the photocatalytic activity by suppressing the electron-hole recombination. These methods have important significance for the function alization and stability of photocatalytic materials. Moreover, the ZnFe2O4/Ag3PO4 is characterised by a series of testing means, such as SEM, XRD and EDS, etc. At the same time, this work realizes the effective control of environmental pollutants and lay the foundation for the research of organic pollution remove.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Jie Cheng,Kaidian Zhang,Jiashun Li,Yuyong Hou
Increased hazardous substances application causes more environmental pollution and risks for human health. Microalgae are the important biological groups in marine ecosystem, and considered to be sensitive to environmental pollutants. Therefore, toxicity test on marine microalgae could provide the most efficient method for aquatic toxicity assessment, and could also be used as the early warning signals in aquatic ecosystem . In view of this, our study aimed at investigating the toxicity potential of two typical organic compounds, and screening out novel photosynthetic indicators for the risk assessment of environmental pollutants. In this study, benzyl alcohol and 2-phenylethanol were chosen as the target organic compounds, and preliminary toxicity mechanism of these organic compounds on marine cyanobacterium Synechococcus sp. PCC7002 was investigated with chlorophyll fluorescence technology. Results showed that PCC7002 could be affected by benzyl alcohol or 2-phenylethanol stress, and the toxicity effect was concentration-dependent. And external benzyl alcohol and 2-phenylethanol stress damaged the oxygen evolving complex, and suppressed electron transport at the donor and receptor sides of photosystem II (PSII), influencing the absorption, transfer, and application of light energy. Furthermore, potential biomarkers were screened by half maximal inhibitory concentration (IC 50 ) on the basis of pearson correlation coefficient analysis, and fluorescence intensity difference between the I-step and P-step of OJIP curve (δF IP ) seems to be the most sensitive indicator for external stress. This study would be of significant interest to the biomarker community, and pave the way for the practical resource for marine pollution monitoring and assessment.
研究领域:
生态毒理学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Yuxue Chen,Luyong Wu,Yanyan Niu,Huihui Li,Tingting Sun,Miantai Ye,Lisi Wang,Baoli Wang,Fan Shi,Yucen Yao,Wei Sun
The recurrent proliferation and blooms of Sargassum have emerged as a major environmental challenge in tropical and temperate coastal regions, with profound implications for ecological balance, economic stability, and societal well-being. Levofloxacin (LVF), a fluoroquinolone antibiotic, is physiologically toxic and its residues and accumulation in the aquatic environment have become a serious threat to ecosystems and human health. This work presents a novel approach for the fluorescent detection of LVF, a common antibiotic in environmental waters, using carbon dots derived from the abundant invasive seaweed Sargassum aquifolium (Turner) C. Agardh. The Sargassum carbon dots (SACD) is prepared by a simple one-step hydrothermal method and can reduce the internal filtering effect (IFE) of LVF, thereby facilitating fluorescence detection of high-concentrations of LVF. SEM and TEM were used to characterize the structure, and SACD exhibited a spherical amorphous carbon with a partial lattice structure. The composition of SACD was further analyzed by using FTIR and XPS after synthesis. This method offers a wide detection range (1 μM–100 μM, R 2 = 0.9984) and low detection limit (0.3 μM) for LVF analysis, exhibiting high recovery rates (103.4 %–113.9 %) in spiked real environmental water samples, demonstrating its potential application performance. The SACD can selectively detect LVF in the presence of the common interfering substances, which SACD has promising applications in environmental pollutant detection. This study proposes a sustainable approach to utilizing and mitigating the impact of invasive seaweeds, highlighting the potential for converting biological waste into valuable resources for environmental monitoring and protection.
研究领域:
海洋生物学
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环境科学
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Junqiu Zhai,Han Zhang,Wenzhi Zhu,Jiewei Deng,Xinyan Li,Tiangang Luan
Simultaneous in situ monitoring of base excision repair (BER) correlated enzymes like apurinic/apyrimidinic endonuclease 1 (APE1) and flap endonuclease 1 (FEN1) in living cells offers valuable insights into their roles in disease development and cytotoxicity caused by pollutants, but comprehensive analysis is currently hindered by diverse enzyme functions and limited methods. In this study, we developed a dual-activatable DNA fluorescent probe (AP-FLAP) to simultaneously visualize APE1 and FEN1 activities, revealing the BER-related DNA damage caused by various environmental pollutants within living cells. The AP-FLAP probe was designed by ingeniously integrating a dumbbell structure containing a 5′ flap and a hairpin structure containing AP sites into a single oligonucleotide probe. APE1 specifically hydrolyzed the AP sites, releasing a 5-carboxy-X-rhodamine (ROX) signal, while FEN1 recognized and cleaved the 5′ flap, releasing a 6-carboxyfluorescein (FAM) signal. The probe allowed for independent determination of APE1 and FEN1 activities with good specificity and sensitivity. Subsequently, we applied the AP-FLAP probe to investigate base damage induced by 1-methylphenanthrene (1-MP) and 6-chlorobenzo[a]pyrene (6-Cl-BaP) in human umbilical vein endothelial cells (HUVECs). Significant base damage by 1-MP and 6-Cl-BaP exposure was revealed, with a positive correlation of damage degree with different exposure concentrations from 0.1 to 100 μM. Notably, 6-Cl-BaP caused significant damage even at 0.1 μM, in a concentration-dependent manner. Our work provides a powerful tool for elucidating BER molecular mechanisms and DNA damage repair under environmental exposure and opens new avenues for developing multifunctional nucleic acid probes for a wide range of applications in chemical biology and biomedical research.
研究领域:
分子生物学
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细胞生物学
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环境毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Nanomaterials
·
2018
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IF 2.207
Jiaxin Wang,Shuhan Wang,Wanqing Tian,Dong Yao,Lining Sun,Liyi Shi,Jinliang Liu
Pollution caused by copper is one of the key factors of environment contamination. As one of the heavy metals, copper is hard to decompose in nature; the biological enrichment of which may lead to severe damage to health. Cu2+ detection, thus, possesses a bright application prospect both in environment protection and in human health. In this paper, a dual-functional fluorescence-magnetic composite nanoplatform has been designed to sensitively detect, meanwhile, capture, and remove Cu2+ in the solution of water and ethanol (1 : 1, v/v). The core-shell structure nanoparticle synthesized by using Fe3O4 as core and SiO2 as shell is covalently bonded with rhodamine derivatives on the silica layer to construct the nanoplatform. The emission is increased upon the addition of Cu2+, showing fluorescence turn on effect for the detection, and the limit of detection is as low as 1.68 nM. Meanwhile, Cu2+ ions are captured by the coordination with rhodamine derivatives and can be removed with the help of magnetic field.
研究领域:
环境科学
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材料科学
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分析化学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Yuying Zhang,Lei Yan,Longxing Wang,Haijun Zhang,Jiping Chen,Ningbo Geng
N , N ′-substituted p -phenylenediamines (PPDs) are widely used antioxidants in rubber tires, which could be released and accumulated in road dusts with rubber tires wear. As ozonation product of N -(1,3-dimethylbutyl)- N′ -phenyl- p -phenylenediamine (6PPD), 6PPD-quinone (6PPD-Q) exhibited higher toxicity to coho salmon. However, studies on their environmental behaviors are still limited. Road dust is the major medium PPDs exist, which significantly affects the levels of PPDs in other mediums, especially surface water and particulate matter. In this study, road dust samples were collected in 55 major cities of China to explore the distribution characteristics of PPDs and 6PPD-Q. The concentrations of total PPDs (ΣPPDs) and 6PPD-Q in urban trunk road dust samples were in the ranges of 7.90–727 and 3.00–349 ng/g, with median concentrations of 68 and 49 ng/g, respectively. 6PPD and 6PPD-Q are the dominant components in most road dusts. The functional region-dependent pollution characteristics of PPDs and 6PPD-Q give the first finding that urban tunnel road was the highly polluted region, followed by urban trunk roads. Suburban road dusts had a lower pollution level. Moreover, the estimated daily intake (EDI) of PPDs and 6PPD-Q for children was much higher than adults.
研究领域:
环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 54
·32652-32661
·
IF 3.119
Yu Gao,Kun Qian,Baotong Xu,Fu Ding,Valerian Dragutan,Ileana Dragutan,Yaguang Sun,Zhenhe Xu
The generation of hydrogen-based energy and environmental remediation using sunlight is an emerging topic of great significance for meeting the ever-growing global need. However, the actual photocatalytic performance is still far below expectations because of the relatively slack charge-carrier separation and migration as well as insufficient spectral absorption in semiconductors. Therefore, the rational construction of heterojunctions is considered as an effective approach to solving the above issues. In this context, we have, for the first time, designed and synthesized a two-dimensional 2D-on-2D heterostructure, based on 2D Ag-doped ZnIn2S4 nanoplates deposited on 2D g-C3N4 nanosheets (denoted as g-C3N4/Ag:ZnIn2S4). This construct benefits from improved visible-light absorption by unveiling a greater number of catalytically active sites, effectively enhancing charge-carrier separation and relocation. Detailed analysis has proved that under visible-light irradiation, the optimized g-C3N4/20 wt% Ag:ZnIn2S4 nanocomposite has substantially upgraded photocatalytic activity in hydrogen formation by water splitting (hydrogen evolution rate of up to 597.47 μmol h−1 g−1) and in residual dyestuff degradation (methyl orange, MO; degradation rate constant of 0.1406 min−1). Noteworthily, these two exceptionally high values respectively represent 30.73 and 5.42 times enhancements vs. results obtained with bare g-C3N4. Another strong point of our g-C3N4/Ag:ZnIn2S4 is its impressive recyclability for 20 runs, with no relevant metal release in the aqueous solution following photocatalysis. This work introduces new, superior access to highly efficient photocatalysts founded on 2D/2D nanocomposites serving both the production of hydrogen as an energy carrier and environmental remediation.
研究领域:
材料科学
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环境科学
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能源科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yuwei Hu,Yijing Jiang,Lingyu Ni,Zhengjie Huang,Lei Liu,Qinfei Ke,He Xu
Due to the frequent spill accidents during crude oil exploration and transport, to rapidly cleanup crude oil and eliminate the environmental pollution of oil spill is in high demand. In this work, a three-dimensional graphene aerogel (MEGA) with high elasticity, photothermal conversion capacity and adsorption capacity was prepared for rapid removal of crude oil. The results showed that the as-prepared MEGA exhibited a layered structure, the octahedral HKUST-1 nanoparticles and hydrophobic polydimethylsiloxane (PDMS) coatings were uniformly deposited on the surface. Such a hierarchical micro-nano porous structure not only improved the aerogel’s hydrophobicity (water contact angle in air up to 152.7°), but also endowed it with strong oil adsorption capacity (41–118 times of its own weight). Especially, the MEGA showed excellent photothermal conversion capacity. Under light irradiation, its temperature raised to 80 ℃ from room temperature in 100 s. As a result, the adsorption for one drop of crude oil by MEGA was shortened from 5 h to 40 s, comparing with that in dark condition. In addition, the MEGA showed remarkable elasticity and mechanical stability, it could maintain more than 90% efficiency after 10 adsorption-compression cycles. This study suggests that the prepared MEGA has great potential for rapid removal of crude oil.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2023
·
IF 4.5
Yongfei Huang,Junping Liang,Zhefeng Fan
Hydrazine is widely used as a wide range of industrial chemical reagents. Because of its toxicity and explosiveness, it poses a serious threat to human health and ecological security. Therefore, it is of great significance to develop a real-time tracing method for hydrazine. Here, a novel turn-on fluorescent probe SXNU-1 for the detection of hydrazine was synthesized based on phenothiazine. SXNU-1 showed excellent selectivity toward hydrazine over various competitive species. Vinyl group with cyano and ethylacetate groups in SXNU-1 could react with hydrazine to form Schiff's base , showing bright green fluorescence. The response mechanism was verified by theoretical calculation, 1 H NMR titration and HRMS. In addition, SXNU-1 can determine hydrazine in soil, water samples and test strip. Because SXNU-1 has good cell membrane permeability, it can monitor different concentrations of hydrazine in HeLa cells. Therefore, we believe that SXNU-1 has great potential in the analysis and monitoring of environmental pollutants.
研究领域:
分析化学
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环境科学
·
生物医学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Lan Qiu,Xiaoyuan Guo,Hojae Shim,Tianwei Hao,Zhiwei Liang,Shanquan Wang,Zhenmei Lu,Qihong Lu,Zhili He
The polychlorinated aromatic antimicrobial agent triclosan (TCS) is widely used to indiscriminately and rapidly kill microorganisms. The global use of TCS has led to widespread environmental contamination, posing significant threats to ecosystem and human health. Here we reported a newly isolated Pseudomonas sp. W03 for degrading TCS metabolically at concentrations up to 10 mg/L. This strain exhibited optimal degradation activity at 30°C and pH 7.0, and retained substantial activity at pH 4.0, although it was sensitive to alkaline conditions. Genomic analysis of strain W03 revealed a circular chromosome comprising 6075,907 bp with a GC content of 65.08 %. A novel TCS degradation pathway, involving dechlorination, oxidation, ether bond fission, and reoxidation processes, was identified. Also, the study mapped the global distribution of analogous Pseudomonas using 16S rRNA gene sequences, revealing their widespread presence in diverse aquatic environments, with a significant abundance in wastewater systems. These findings indicated that these bacteria play a critical ecological role in both natural and engineered environments, particularly in the degradation of organic pollutants. This study enhances our understanding of microbial degradation of emerging contaminants and presents a promising candidate for bioremediation strategies aimed at mitigating TCS-related water pollution.
研究领域:
微生物学
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环境科学
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生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）