ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Yamin Shen,Yue Li,Yingying Quan,Wenjie Jin,Yuxin Wang,Baobao Liu,Yang Wang
s Streptococcus suis ( S. suis ) represents a significant bacterial pathogen, with its zoonotic transmission from infected or deceased pigs to humans posing a serious threat to public health. The type IV secretion system (T4SS), a critical virulence factor of S. suis , is tightly regulated by diverse environmental conditions. This study explores the influence of environmental variables, including temperature, incubation duration, monosaccharides, and metal ions, on the regulation of T4SS in S. suis and its associated pathogenicity. Results revealed that T4SS expression peaked during the stabilization phase at 37 °C, with galactose markedly enhancing T4SS expression relative to glucose. Zinc ions specifically enhanced the expression of the T4SS effector SspA among various metal ions. Moreover, zinc exposure significantly augmented both T4SS and virulence gene expression capabilities in S. suis . Zinc-treated S. suis exhibited enhanced adhesion, invasion, and colonization capacity in Hep-2 cells, Raw264.7 cells, and mouse models. These findings provide a deeper comprehension of the environmental modulation of T4SS in S. suis , paving the way for advanced studies into its mechanisms of pathogenicity.
研究领域:
微生物学
·
感染病学
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DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Yuanfang Huo,Xinyi Tan,Xianzhen Dong,Xinyue Liang,Kun Liu,Hao Zhang,Zhiqiang Li,Junwei Yang,Zixuan Pang,Yawei Yao,Aixi Yu,Honglian Dai
After injury, the imbalance of the regeneration microenvironment caused by inflammation, oxidative stress, insufficient neurovascularization, and inadequate energy supply affects nerve regeneration. Drug-delivery nerve conduits play a role in repairing the regenerative microenvironment. However, traditional drugs often fail to cross the blood-nerve barrier and lack multifunctionality, limiting the effectiveness of conduit therapy. Therefore, it is necessary to construct a multifunctional conduit that regulate the regeneration microenvironment timely and effectively. Herein, a photo-responsive hydrogen sulfide (H 2 S) composite nerve conduit, artificially controlled H 2 S release, is developed. A new structure of zinc-citric acid organic metal framework (Zn-CA MOFs) is utilized to improve its drug loading rate, achieving the joint regulation of the nerve regeneration microenvironment by H 2 S and Zn 2+ . In addition, RGD modification of polyester amide (P(CL-MMD-MAC)-RGD)) combined with aligned structure is used to improve the performance of the conduit. Relevant results demonstrate that H 2 S and Zn 2+ can regulate inflammatory response and oxidative stress and promote mitochondrial function recovery and angiogenesis. Furthermore, the aligned structure can promote cell adhesion and guide cell directed migration. Overall, this study provides a method of combining gas neurotransmitters with ions to improve the nerve regeneration microenvironment, accelerate nerve regeneration, and restore motor function.
研究领域:
生物医学工程
·
神经科学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
He Meng,Li Rui,Cheng Chuanqi,Liu Cuibo,Zhang Bin
The high Faradaic efficiency (FE) of the electrocatalytic deuteration of organics with D 2 O at a large current density is significant for deuterated electrosynthesis. However, the FE and current density are the two ends of a seesaw because of the severe D 2 evolution side reaction at nearly industrial current densities. Herein, we report a combined scenario of a nanotip-enhanced electric field and surfactant-modified interface microenvironment to enable the electrocatalytic deuteration of arylacetonitrile in D 2 O with an 80% FE at −100 mA cm −2 . The increased concentration with low activation energy of arylacetonitrile due to the large electric field along the tips and the accelerated arylacetonitrile transfer and suppressed D 2 evolution by the surfactant-created deuterophobic microenvironment contribute to breaking the trade-off between a high FE and large current density. Furthermore, the application of our strategy in other deuteration reactions with improved Faradaic efficiencies at −100 mA cm −2 rationalizes the design concept.
研究领域:
化学工程
·
电化学
·
催化科学
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产品关联
DOI
PubMed
高影响因子
AICHE JOURNAL
·
2021
·Vol. 67
·期 10
·e17368
·
IF 3.993
Yu-Xia Li,Meng-Meng Jin,Shu Shi,Shi-Chao Qi,Xiao-Qin Liu,Lin-Bing Sun
Cu + -containing materials have great potentials in various applications like adsorptive desulfurization. Nevertheless, their applications are severely obstructed by poor stability of Cu + in air. Here, we first clarify the mechanism of Cu + oxidation by first-principle calculations and demonstrate that moisture accelerates Cu + oxidation dramatically. Then, the microenvironment of Cu 2 O-modified HKUST-1, a typical metal-organic framework, is adjusted from hydrophilic to hydrophobic with polydimethylsiloxane coating (producing Cu 2 O@HK@P). This isolates moisture from pores and enhances the stability of Cu + significantly even under oxygen atmosphere. Cu + in Cu 2 O@HK@P preserves well after exposed to air for 6 months, while Cu 2 O@HK lose almost all Cu + for 2 weeks. The optimal Cu 2 O@HK@P can remove 540 μmol g −1 of thiophene from hydrous fuel, which is much superior to Cu 2 O@HK (227 μmol g −1 ) and most reported adsorbents. Our strategy can also be applied to stabilize Cu + in various materials including zeolite, mesoporous silica, and activated carbon.
研究领域:
材料科学
·
催化
·
能源化学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Chuanwei Shi,Peng Liu,Yeping Liu,Zhexu Gai,Fei Yang,Yanzhao Yang
The microenvironment around the wounds of chronic disease patients often exhibits weakly alkaline conditions, primarily due to defects in the patients' blood glucose regulation, tissue hypoxia, accumulation of metabolic products, and bacterial infection and growth. To regulate the wound microenvironment across a broad pH range, a Fe-doped ZIF-8 nanozyme loaded with glucose oxidase (Fe-ZIF-8@GOx) was synthesized via a one-step in situ growth method. This nanozyme, with ZIF-8 serving both as a protective matrix and immobilization scaffold, enhances the enzyme's operational microenvironment and maintains functionality across a wide pH range. It exhibits the activities of cascade glucose oxidase (GOx), catalase-like (CAT-like), and peroxidase-like (POD-like) enzymes. When Fe-ZIF-8@GOx nanozymes encounter high glucose levels at the site of weakly alkaline chronic ulcers, the GOx particles catalyze the reduction of local pH, simultaneously triggering CAT-like enzyme activity to release O₂ and improve the wound microenvironment. The subsequent pH reduction induces the controlled release of iron ions, enabling Fe 2+ to react with endogenously produced hydrogen peroxide to generate reactive oxygen species (ROS), conferring a distinctive guest–carrier synergistic antibacterial effect. Both in vitro and in vivo studies confirm that this material effectively reduces inflammation, modulates macrophage polarization, enhances collagen deposition, and promotes angiogenesis, ultimately accelerating wound healing under chronic diabetic conditions. Thus, our work not only overcomes microenvironmental limitations in antibacterial therapy but also offers a promising strategy for treating chronic diabetic infections.
研究领域:
生物医学工程
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纳米技术
·
微生物学
·
药理学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Guangcan Huang,Tongxin Liu,Haoxin Peng,Yabo Xie,Qiang Chen,Jian-Rong Li
Mixed-matrix membranes (MMMs) incorporating Metal-Organic Frameworks (MOFs) represent a promising approach for gas separation, which can combine the advantages of selective adsorbents and processable polymers, and display great potential in the gas separation process. However, the further application of MMMs is severely impeded owing to the non-ideal interface between fillers and polymer matrix . In this work, a series of MIL-101(Cr) nanofillers, equipped with different kinds of counter anions were introduced to regulate the chemical microenvironment of the MMMs and improve the interfacial relationship between inorganic filler and polymer. The filler of MIL-101-HNO 3 exhibits improved dispersibility in solvents and heightened interface relationship with the polymer matrix (PIM-1) due to its optimal particle size and distinctive exposure of crystallographic planes. Moreover, gas sorption isotherms reveal that the MIL-101-HNO 3 MOF show reduced N 2 adsorption capacity. Therefore, the MOF filler of MMMs were optimized rationally by microenvironment regulate strategy, leading to the MIL-101-HNO 3 /PIM-1 MMMs achieve high CO 2 permeability and exceptional CO 2 /N 2 ideal selectivity (CO 2 = 14879 barrer, CO 2 /N 2 = 24.3), surpassing the latest 2019 upper bound. That makes MIL-101-HNO 3 /PIM-1 a potential candidate for the selective removal of CO 2 from stack gas and provides new insights into the regulation of the MMMs nanofiller microenvironment.
研究领域:
材料科学
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化学工程
·
环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Guangjun Ji,Cunyao Li,Pan Gao,Miao Jiang,Lei Ma,Guoqing Wang,Guangjin Hou,Li Yan,Yunjie Ding
Tuning the microenvironment surrounding single atom metals is an effective but challenging way to regulate the performance of single atom catalysts (SACs). Herein, we prepared a series of P, N-abundant porous organic polymers (P&N-POPs) with diverse framework flexibility and coordination ability to serve as SACs’ carriers. The microenvironment (coordination site, coordination number) surrounding Rh and the equilibrium of ea / ee -HRh(CO) 2 P 2 active species were effectively regulated in Rh/P&N-POPs catalysts. Our study shows that the specific active ee -HRh(CO) 2 (P) 2 species confined in the flexible polymeric skeleton endowed the Rh/ m PPh 3 &PPD-POP with superior activity (TOF = 2000 h −1 ), selectivity of aldehydes (93.5 %), ratio of linear aldehyde to branched aldehyde (l/b ratio = 15.9), favorable stability (10 recycling runs without activity loss) and extensive substrate applicability (19 kinds of olefins) in hydroformylation reactions. Multiple characterization techniques (EXAFS, STEM, in-situ FTIR etc.) were employed to get insights into this effective strategy to regulate the performance of single atom catalysts (SACs).
研究领域:
催化化学
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Hui Cai,Meng Rong,Siqi Liang,Qike Wang,Qiyu Meng,Shan Ni,Huizhou Liu,Liangrong Yang
Efficient recovery of rare earth elements (REEs) from wastewater is crucial for environmental remediation and the sustainable development of resources. Nevertheless, achieving efficient and selective REEs extraction in the systems containing low-concentration REEs and high-concentration competing metal ions remains a challenge. Here, we report on the fabrication of two-dimensional defective carbon nitride (DGCN-K) with extended nanoporous furnished oxygen-enriched sites, which is achieved through re-arrangement of framework structural unit using a flexible polycondensation-ion-thermal strategy. The extended nanoporous and continuous transmission nanochannels establish a dedicated structure microenvironment surrounding the active sites center, promoting the effective ion diffusion and increasing the accessibility of active sites. Meanwhile, the incorporation of abundant electronegative cyano and hydroxyl group modifies coordination microenvironment, improving hydrophilicity and strengthening interaction affinity with REEs. Consequently, DGCN-K shows excellent REEs adsorption performance, achieving high adsorption capacity (Nd(III) 146.25 mg/g, Dy(III) 180.82 mg/g, Lu(III) 204.34 mg/g,) within short adsorption equilibrium time (30 min). Furthermore, DGCN-K possesses high REEs selective removal rate in the mixed binary system and actual leaching tailings. This study provides a feasible microenvironment regulation strategy for the construction of 2D defective carbon nitride with oxygen-enriched sites and extended nanoporous for synergistically enabling efficient recovery of REEs.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Ting Jiang,Bo Zhang,Shun Shen,Yanyan Tuo,Zimiao Luo,Yu Hu,Zhiqing Pang,Xinguo Jiang
Due to the rich stroma content and poor blood perfusion, pancreatic ductal adenocarcinoma (PDA) is a tough cancer that can hardly be effectively treated by chemotherapeutic drugs. Tumor microenvironment modulation or advanced design of nanomedicine to achieve better therapeutic benefits for PDA treatment was widely advocated by many reviews. In the present study, a new photothermal therapy strategy of PDA was developed by combination of tumor microenvironment modulation and advanced design of biomimetic gold nanorods. On one hand, biomimetic gold nanorods were developed by coating gold nanorods (GNRs) with erythrocyte membrane (MGNRs). It was shown that MGNRs exhibited significantly higher colloidal stability in vitro, stronger photothermal therapeutic efficacy in vitro, and longer circulation in vivo than GNRs. On the other hand, tumor microenvironment modulation by cyclopamine treatment successfully disrupted the extracellular matrix of PDA and improved tumor blood perfusion. Moreover, cyclopamine treatment significantly increased the accumulation of MGNRs in tumors by 1.8-fold and therefore produced higher photothermal efficiency in vivo than the control group. Finally, cyclopamine treatment combined with photothermal MGNRs achieved the most significant shrinkage of Capan-2 tumor xenografts among all the treatment groups. Therefore, with the integrated advantages of tumor microenvironment regulation and long-circulation biomimetic MGNRs, effective photothermal therapy of PDA was achieved. In general, this new strategy of combining tumor microenvironment modulation and advanced design of biomimetic nanoparticles might have great potential in PDA therapy.
研究领域:
肿瘤学
·
纳米技术
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2025
·Vol. 17
·期 8
·4783-4795
·
IF 5.1
Hao Yang,Yi Zhuang,Yulin Jiang,Huilun Xu,Zheng Liu,Yubao Li,Shuyu Zhang,Tao Guo,Lin Qi,Li Zhang
Continuous microenvironment modulation is an ongoing challenge in wound dressing, which includes excessive exudate absorption, oxygen delivery, bacterial inhibition and angiogenesis. Herein, we developed an in situ construction strategy to fabricate a self-retaining double-layered wound dressing, where the top layer precursor was composed of Ca2+-containing polyvinyl butyral (PVB) solution dispersed with hydroxypropyl methylcellulose (HPMC) particles, and the bottom one consisted of sodium alginate (Alg) solution blended with Ag-doped mesoporous bioactive glass powders (Ag-MBG). When in use, both precursors were simultaneously squeezed out from the twin nozzles connected to the individual chambers of a twin-chambered syringe, whereby Ca2+ in the top layer rapidly migrated downwards to crosslink Alg in the bottom layer, leading to the formation of an Alg/Ag-MBG (AA) functional hydrogel for filling an irregular wound. Meanwhile, with the rapid evaporation of low-boiling solvents, the top layer changed into a PVB/HPMC (PH) membrane covering the AA hydrogel and adhering to the surrounding healthy skin to fix the dressing. Practically, HPMC particles in the top layer acting as “micropumps” could drain the wound exudate out, while Ag-MBG in the bottom layer endowed the dressing with anti-bacterial, hemostatic, and pro-healing functions. The integrally constructed PH-AA dressing achieved over 99% bacterial elimination against both E. coli and S. aureus. Biological assessments indicated that the double-layered dressing possessed excellent biocompatibility and enhanced wound healing, demonstrating a wound closure rate of >97% at day 15. This study provides a facile method to directly construct multi-layer dressings on wounds to meet various wound care requirements.
研究领域:
生物材料学
·
组织工程
·
医学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Weikun Li,Xin Tan,Yanling Liang,Nuoya Chen,Diyi Feng,Yinghua Tao,Tao Liu,Xiaojing Wu,Huiqing Lu,Ling Liu,Feiling Feng,Liqin Ge
Currently, treatments for infected diabetic wounds remain a significant clinical challenge due to the complex wound microenvironment. Combination therapies, capable of synergizing multiple functions, have demonstrated promise in accelerating infected diabetic wound repair. Here, a novel self-powered multifunctional microneedle patch (termed GDZ@mMNP-PENG) was developed to regulate the microenvironment of infected diabetic wounds. The GDZ@mMNP-PENG combines a self-powered piezoelectric nanogenerator (PENG) with a multifunctional microneedle patch loaded with GA@DFO@ZIF-8 nanoparticles (GDZ@mMNP). The PENG in the system collects and converts biomechanical motion to electrical stimulation (ES) in order to promote neovascularization and collagen deposition in infected diabetic wounds. The GDZ@mMNP continuously releases deferoxamine in response to acidic microenvironment and ES. The incorporation of GA@DFO@ZIF-8 nanoparticles impart the GDZ@mMNP with excellent antibacterial (antibacterial rate exceeded 96 %) and antibiofilm capabilities. Moreover, the GDZ@mMNP with abundant phenolic hydroxyl groups also exhibits excellent tissue adhesion, antioxidant, anti-inflammation, and hemostatic properties. In vitro experiments demonstrate that the GDZ@mMNP-PENG effectively enhances cell proliferation and migration. In vivo assay and proteomic analysis demonstrate that the GDZ@mMNP-PENG can down-regulate Staphylococcus aureus infection and neutrophil extracellular trap formation, as well as up-regulate HIF-1 signaling pathway to synergistically regulate the inflammatory microenvironment and neovascularization in infected wounds, thereby accelerating infected diabetic wound healing. Overall, this study offers a new combination strategy for infected diabetic wound healing.
研究领域:
生物医学工程
·
材料科学
·
再生医学
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产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Yu Han,Jiaxiang Ma,Dongqing Liu,Yan Yang,Tao Zhang,Min Wang,Daxin Liang,Liping Wen,Jun Ma,Wei Wang
Ion-sieve adsorbents are effective materials in practical applications for extracting liquid lithium. However, it is greatly suppressed in adsorption capacity and selectivity (Li/Mg) under natural near-neutral conditions of seawater or salt lakes, due to the interference of in situ released H+ and Mg2+ impurity. This paper proposes an adsorbent with a microenvironment-modulating function as a solution. The introduction of quaternary ammonium groups into the carrier accelerates the migration of H+, while preventing the diffusion of Mg2+ by electrostatic repulsion. Besides, it can also prestore OH–, effectively consuming the generated hydrogen ions in situ. Based on the rational design, the alkali consumption of the microenvironment-modulating strategy is dramatically reduced to 1/144 of the traditional alkali-adding method. Additionally, adsorption performance is significantly promoted under natural pH conditions, with a maximum 33 times higher separation factor (selectivity) and 4 times higher adsorption capacity than commercial ion-sieve adsorbents. This development indicates the feasibility of using microenvironment modulation for effective lithium extraction and inspires the development of next-generation high-performance adsorbents.
研究领域:
材料科学
·
环境工程
·
化学工程
·
可持续能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）