A Novel Gelatin-Based Sustained-Release Molluscicide for Control of the Invasive Agricultural Pest and Disease Vector Pomacea canaliculata
Pomacea canaliculata, one of the 100 most destructive invasive species in the world, and it is an important intermediate host ofAngiostrongylus cantonensis. The molluscicides in current use are an effective method for controlling snails. However, most molluscicides have no slow-release effect and are toxic to nontarget organisms. Thus, these molluscicides cannot be used on a large scale to effectively act on snails. In this study, gelatin, a safe and nontoxic substance, was combined with sustained-release molluscicide and was found to reduce the toxicity of niclosamide to nontarget organisms. We assessed the effects of gelatin and molluscicide in controllingP. canaliculatasnails and eggs. The results demonstrated that the niclosamide retention time with 1.0% and 1.5% gelatin sustained-release agents reached 20 days. Additionally, the mortality rate ofP. canaliculataand their eggs increased as the concentration of the niclosamide sustained-release agents increased. The adult mortality rate ofP. canaliculatareached 50% after the snails were exposed to gelatin with 0.1 mg/L niclosamide for 48 h. The hatching rate ofP. canaliculatawas only 28.5% of the normal group after the treatment was applied. The sustained-release molluscicide at this concentration was less toxic to zebrafish, which means that this molluscicide can increase the safety of niclosamide to controlP. canaliculatain aquatic environments. In this study, we explored the safety of using niclosamide sustained-release agents with gelatin againstP. canaliculata. The results suggest that gelatin is an ideal sustained-release agent that can provide a foundation for subsequent improvements in control ofP. canaliculata.Keywords:invasive species;biological material carrier for sustained drug;Pomacea canaliculatacontrol;environmental safety
危险品化学品经营许可证（带存储）