Materials Science & Engineering C-Materials for Biological Applications
·
2014
·
IF 2.736
Ruixue Yin,Wentao Wu,Kemin Wang,Wen Jun Zhang
In this work, hydroxyapatite (HA) was first dispersed into cyclic acetal unit based monomers (EHD), and then EHD/HA composites were obtained by in-situ photopolymerization. FTIR and XRD analyses were used to successfully confirm the chemical composition of this composite. Real-time FTIR revealed that there was no significant effect on the photopolymerization process until the HA content was up to 30%. Several samples of such a composite with different loading amounts of HA were prepared to study effects of HA concentrations on the EHD/HA composite in particular in terms of SEM, TG, DMA, water contact angel and in-vitro biocompatibility. The results appeared that the loading of HA could significantly improve the thermal stability, mechanical properties and in vitro biocompatibility of the EHD/HA composite compared with EHD networks.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Ruixue Yin,Nan Zhang,Wentao Wu,Kemin Wang
Cyclic acetals based biomaterial without acidic products during hydrolytic degradation is a promising candidate for tissue engineering applications; however, low hydrophilicity is still one limitation for its biomedical application. In this work, we aim to achieve non-water-swellable cyclic acetal networks with improved hydrophilicity and surface wettability by copolymerization of cyclic acetal units based monomer, 5-ethyl-5-(hydroxymethyl)-β,β-dimethyl-1, 3-dioxane-2-ethanol diacrylate (EHD) and methoxy poly(ethylene glycol) monoacrylate (mPEGA) under UV irradiation, to avoid swelling of conventional hydrogels which could limit their applicability in particular of the mechanical properties and geometry integrity. Various EHD/mPEGA networks were fabricated with different concentrations of mPEGA from 0 to 30%, and the results showed photopolymerization behavior, mechanical property and thermal stability could not be significantly affected by addition of mPEGA, while the surface hydrophilicity was dramatically improved with the increase of mPEGA and could achieve a water contact angle of 37° with 30% mPEGA concentration. The obtained EHD/mPEGA network had comparative degradation rate to the PECA hydrogels reported previously, and MTT assay indicated it was biocompatible to L929 cells.
研究领域:
生物材料
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Ke Li,Xiaoyi Sun,Hua Yin,Kun Yang,Pei Dai,Ling Han,Longgui Zhang,Riwei Xu
Preparing biobased high-performance thermosetting resins is one of the most important factors for sustainable development. In this work, two kinds of phthalonitrile resins containing spirocycle acetal structures were synthesized from pentaerythritol and renewable vanillin and isovanillin by an efficient two-step process. The structures of vanillin- and isovanillin-based phthalonitrile (VPN and IVPN) monomers were characterized by Fourier transform infrared (FTIR), NMR, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and elemental analysis. The curing behaviors of these monomers were studied by differential scanning calorimetry and FTIR. The thermal stability and dynamic mechanical properties of the cured resins were investigated by thermogravimetric analysis and dynamic mechanical thermal analysis. The processing properties were studied by a rheological analysis. Compared with traditional petroleum-based phthalonitrile resins such as bisphenol A and bisphenol, cured VPN and IVPN resins exhibited good thermal stability and thermomechanical properties, high glass transition temperature (Tg), and excellent processability.
研究领域:
材料科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Honglei Zhang,Yizi Zhu,Jingxuan Ma,Yuqing Ma,Lijie Jin,Jing Li,Rui Yang,Gengshen Song
Lipid nanoparticle (LNP)-mRNA-based tumor immunotherapy needs to address challenges such as low efficacy of mRNA delivery, targeted protein expression, and compromised innate immunogenicity. Here, we screen a panel of 16 cyclic acetal-based ionizable lipid nanoparticles by in vitro and in vivo assays to develop a more effective and safer system specifically for tumor immunotherapy and mRNA delivery. Furthermore, by incorporating a cyclic acetal-based adjuvant lipid YK-TLR-001, two optimized cyclic acetal-based LNP formulations (YK-712 and YK-716) are demonstrated to enhance mRNA expression in the spleens and to induce exceptional maturation of antigen-presenting cells (APCs) and to promote antigen presentation. Moreover, animal studies treated with these formulations show activated cellular immunogenicity in healthy mice and inhibited tumor growth in the B16F10 melanoma model. Thus, the cyclic acetal-based LNPs with YK-TLR-001 present a promising direction in the design of mRNA vectors for the advancement of mRNA tumor immunotherapy.
研究领域:
生物医学工程
·
免疫学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Wangchao Yuan,Songqi Ma,Sheng Wang,Qiong Li,Binbo Wang,Xiwei Xu,Kaifeng Huang,Jing Chen,Shusen You,Jin Zhu
Thermosets are very versatile owing to their high dimensional stability, chemical resistance and thermal and mechanical properties; however, they are difficult to be recycled or reworked because of their permanent cross-linked structure. In this paper, we synthesized a novel fully bio-based diepoxy monomer via acetalization of lignin derivative vanillin with bio-based polyol erythritol followed by reacting with bio-derived epichlorohydrin. Due to the degradability of dicyclo diacetal structure in the diepoxy monomer, the cross-linked epoxy network could be readily decomposed (completely dissolved in 1 M HCl solution at 50 °C within 40 min). While it was stable under neutral and basic conditions even during hot-humid aging test. Meanwhile, due to the rigidity of the dicyclo diacetal structure, it showed high glass transition temperature of 184 °C, and its modulus (4.7 GPa) and hardness (0.30 GPa) are even higher than those of conventional bisphenol A epoxy resin.
研究领域:
材料科学
·
有机化学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）