ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Xinyan Wan,Dezhang Ren,Yunjie Liu,Jun Fu,Zhiyuan Song,Fangming Jin,Zhibao Huo
An efficient esterification of succinic anhydride (SA) to dimethyl succinate (DMS) using ZnO in methanol was investigated for the first time. ZnO is commercial, low cost, noncorrosive and environmentally friendly metallic oxide and can promote remarkably the production of DMS from SA in excellent yields with high selectivity. The highest yield of DMS of 100% was achieved at the temperature of 140 °C for 10 h. The results indicated that reaction temperature and time had significant influences on the yield of DMS. Mechanism study found that ZnO was first dissolved to form a Zn species, and then redeposited to ZnO during the reaction, which was crucial for SA conversion. The redeposited ZnO could be reused at least 4 times without the loss of the activity. Moreover, the reaction of ethanol and SA was also effective to give excellent yield at the optimal conditions. The present study demonstrates a promising greener way for the synthesis of DMS from biomass-derived SA.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Yangyi Huang,Lin Zhang,Mengqi Yan,Qinan Huang,Yuning Zhang,Yanqun Ren,Weiping Luo
In this research, the solubilities of adipic acid in sec-butyl alcohol (SBA), isobutyl alcohol (IBA), and n-octyl alcohol (NOA); glutaric acid in n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, SBA, IBA, tert-butyl alcohol (TBA), and NOA; and succinic acid in SBA, IBA, TBA, and NOA were determined by the dynamic laser method from 302.65 to 352.95 K at atmospheric pressure (101.3 kPa). Furthermore, the solubilities of three dibasic acids in straight-chain alcohols of different lengths and alcohol isomers were compared. Meanwhile, X-ray diffraction was used to detect the change of the crystal form before and after dissolution. Additionally, the experimental data were correlated by two models (Apelblat model and the modified nonrandom two liquid activity coefficient model), showing that the model matched well with the experimental data. The most accurate model is selected for every system after calculating the Akaike information criterion of each model.
研究领域:
物理化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Xiaoxiao Sheng,Weiping Luo,Qinbo Wang
The solubilities of succinic acid in binary cyclohexanone + cyclohexanol solvent mixtures at 304.25–354.65 K, in binary cyclohexane + cyclohexanol solvent mixtures at 300.15–346.15 K, in binary cyclohexane + cyclohexanone solvent mixtures at 297.65–351.25 K, and in ternary cyclohexanol + cyclohexanone + cyclohexane solvent mixtures at 306.95–343.15 K were determined by the synthetic method at atmospheric pressure. The experimental solubility data in binary solvent mixtures were correlated by the Apelblat equation and nonrandom two-liquid (NRTL) activity coefficient model, and the calculated solubility data by the models have a good agreement with the experimental data. Then, the solubilities of succinic acid in ternary cyclohexanol + cyclohexanone + cyclohexane solvent mixtures were predicted by the NRTL model and compared with the experimental solubility data. Finally, the solubilities of succinic acid in the three studied binary solvent mixtures were compared with the solubilities of glutaric acid and adipic acid in the same solvent systems at 303.15–343.15 K. The result shows that in the three studied solvent mixtures, glutaric acid with an odd number of carbon atoms is much more soluble than succinic acid and adipic acid with an even number of carbon atoms. The reasons for this “odd–even effect” phenomenon are the interlayer packing of molecule chains and the twist of the carbon chains.
研究领域:
化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Fuqiong Lei,Qinbo Wang,Xing Gong,Binwei Shen,Wenming Zhang,Qing Han
The solubilities of succinic acid in acetic acid + water solvent mixtures at (303.2 to 333.2) K and acetic acid + cyclohexane solvent mixtures at (303.2 to 343.2) K were determined. It was found that the solubility of succinic acid in acetic acid + cyclohexane mixtures increases with increasing mass fraction of acetic acid at constant temperature. However, for the system of acetic acid + water solvent mixtures, acetic acid with the mass fraction of 0.20 shows the best dissolving capacity for succinic acid. The experimental data were well-correlated with universal quasi-chemical (UNIQUAC) equations, and the solubilities calculated by the model were in good agreement with experimental data.
研究领域:
物理化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Biomolecules
·
2019
·Vol. 9
·期 9
·486
·
IF 4.694
Xuan Li,Mingyu Mao,Yanan Zhang,Kaifan Yu,Weiyun Zhu
Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle in all aerobic organisms, and is also a vital microbial metabolite in the gut. Although succinate is known to regulate intestinal metabolism and immune function, its role in the protection of the intestinal epithelial barrier function and inflammation is poorly characterized. In this study, we evaluated the effects of succinate on intestinal epithelial barrier function and inflammation in pigs. Twenty-four growing pigs were distributed into three groups (n= 8) and received either a basal diet (control group) or the same diet supplemented with 0.1% succinate or 1% succinate. The diet supplemented with 1% succinate led to alterations in the intestinal morphology. We confirmed in vitro that 5 mM succinate treatment modulated intestinal epithelial permeability by increased transepithelial electrical resistance (TEER) in intestinal porcine epithelial cell (IPEC)-J2 cells. Furthermore, succinate treatment increased the abundance of tight junction proteins claudin-1, zona occluden (ZO)-1, and ZO-2 in the jejunum in vivo and in vitro. In addition, dietary succinate supplementation promoted the expression of inflammatory cytokines interleukin (IL)-25, IL-10, IL-8, and IL-18 in the jejunum. Taken together, these data identify a novel role of succinate in the modulation of intestinal epithelial barrier function, which may be a nutritional target to improve gut health in animals.Keywords:succinate;intestinal epithelial barrier;intestinal inflammation;pigs
研究领域:
营养学
·
免疫学
·
动物科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Sile Shi,Mengqi Yan,Bao Tao,Weiping Luo
In this study, the solid-liquid equilibrium (SLE) data of succinic acid (SA) and glutaric acid (GA) and adipic acid (AA) in N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMAC), dimethyl sulfoxide (DMSO), 1-Methyl-2-pyrrolidinone (NMP) and sulfolane were determined by using the method of dynamic laser at atmospheric pressure. The experimental SLE data indicates that within the temperature range studied (286.25–358.75 K), the solubilities of SA, GA and AA in above five solvents is proportional to the temperature. Meanwhile, three thermodynamic models (Apelblat model, λh model, the modified nonrandom two liquid (NRTL) activity coefficient model) were used to correlate the experimental data, the results show that the correlated data is generally consistent with the experimental data. The result of Akaike Information Criterion (AIC) analysis filter out the best model for every system. In addition, the thermodynamic functions (dissolution enthalpy, entropy, Gibbs energy) were obtained from the SLE data by calculating the van't Hoff equation.
研究领域:
化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
FISH & SHELLFISH IMMUNOLOGY
·
2019
·
IF 3.298
Yafei Duan,Yun Wang,Dalin Xiong,Jiasong Zhang
The intestine is important for nutrition, metabolism and immunity. Succinate (SA) plays a vital role in the physiological homeostasis of animal intestines. However, the effects of dietary SA on the intestinal immunity and metabolism in shrimp are not clear. In this study, we investigated the immune and metabolic responses in the intestine of Litopenaeus vannamei that were fed diets consisting of different levels of SA: 0 g/kg (Con) and 10 g/kg (SA) for 56 days. The results from a RNA-seq analysis identified 6005 differentially expressed genes (DEGs), including 2728 upregulated genes and 3277 downregulated genes, which were grouped into 312 pathways. The DEGs were most enriched in pathways related to protein synthesis and amino acid metabolism , including “ribosome”, “aminoacyl-tRNA biosynthesis”, “pyrimidine metabolism”, and “arginine and proline metabolism”; additionally, carbohydrate and lipid metabolism pathways were also activated. A large number of immune-related genes were associated with mucus barrier modification, antimicrobial activity , pathogen attachment and recognition, antioxidant activity , and apoptosis. The expression patterns of several candidate genes involved in the immune response and nutrition metabolism were detected by qPCR. This study provides insight into the transcriptomic modulating mechanisms associated with intestinal immunity and the metabolism of L. vannamei in response to the intake of dietary SA.
研究领域:
水产养殖学
·
分子生物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FISH & SHELLFISH IMMUNOLOGY
·
2018
·
IF 3.185
Yafei Duan,Yun Wang,Jiasong Zhang,Yongxu Sun,Jun Wang
Organic acids acts as an growth promoter and antimicrobial agent in aquaculture. The present study investigated the effects of a natural organic acid - succinic acid (SA) on the growth, digestive enzymes , immune response and resistance to ammonia stress of Litopenaeus vannamei . The shrimps were firstly fed with diets containing different levels of SA: 0% (Control), 0.25% (SA1), 0.50% (SA2), and 1.0% (SA3) ( w / w ) for 56 days, followed by an acute ammonia stress for 48 h. The results indicated that dietary of SA improved the growth of shrimp, and increased the survival rate of shrimp after ammonia stress for 48 h. The amylase , lipase and pepsin activity increased in hepatopancreas in three SA group, while trypsin activity was only increased in the SA1 and SA2 groups. At 56 d, T-NOS activity, proPO and HSP70 gene expression level increased in the three SA group, PO activity increased in the SA1 and SA2 groups, T-AOC content and Toll gene expression level increased in the SA2 and SA3 groups, Trx and SOD gene expression level increased in the SA2 group, while Imd , GS and GDH gene expression level was no changes. After exposure to ammonia stress for 48 h, immune biochemical parameters (T-AOC and PO) and genes ( proPO , HSP70 , Trx and GDH ) expression level increased in the three SA group, T-NOS activity, Toll , Imd and GS gene expression level increased in the SA2 and SA3 groups, while SOD gene expression level increased in the SA1 and SA2 groups. These results indicated that SA improved growth, enhanced digestive and immune capacities of L. vannamei against ammonia stress, and may be a potential feed additive for shrimp. The optimal dietary supplementation dosage is 0.50% ( w / w ) in diet.
研究领域:
水产养殖学
·
生物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FLUID PHASE EQUILIBRIA
·
2013
·
IF 2.379
Xinmin Jiang,Yonghong Hu,Zhongbin Meng,Wenge Yang,Fei Shen
Data on corresponding solid–liquid equilibrium of succinic acid in different aqueous solvent mixtures was measured with temperature range from 278.15 K to 333.15 K under atmospheric pressure by employing the gravimetric method. The experimental results indicated that the solubility of succinic acid in the binary mixtures increases with increasing both temperature and mass fraction of organic solvents. The experimental data were well-correlated with the modified Apelblat equation, the λh equation and the van’t Hoff equation. In addition, the calculated solubilities showed good agreement with the experimental results. It was found that the modified Apelblat equation could obtain the better correlation results than the other two models. The standard enthalpy, standard entropy, and Gibbs free energy change of solution of succinic acid were calculated from the solubility data by using the modified Apelblat model. Moreover, the experimental data and model parameters would be useful for optimizing the process of purification of succinic acid in industry.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
BIOTECHNOLOGY LETTERS
·
2024
·
IF 2
Zhao Shuo,Zeng Yu,Li Ying,Wang Zhen,Chen Li,Chen Kequan
This investigation probes the role of the electron mediator, neutral red (NR), in the electrosynthesis process, specifically examining its effect on the production of succinic acid by Actinobacillus succinogenes . Our findings reveal that NR, when integrated into the cell membrane, is pivotal for sustaining MEC efficiency. Nevertheless, it is susceptible to both intrinsic and MECs-induced degradation. Notably, during the exponential growth phase of the bacteria, NR is readily incorporated into the cell membrane. However, the supplemental addition of NR fails to significantly enhance the MEC’s capacity for succinic acid synthesis, no matter what stage of bacterial growth. And significant depletion of membrane-associated NR is not adequately compensated by the NR present in the fermentation liquid. The ORP feedback-regulated MECs adeptly conserve the NR on the cell membrane, which is essential for maintaining the efficiency of long-term electrosynthesis. The presence of NR on the cell membrane is essential for the functionality of MECs, yet its external replenishment hard. Implementing precise electro-potential regulation strategies can effectively diminish the degradation of NR, thus maintaining the system’s efficiency.
研究领域:
微生物学
·
电化学工程
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2020
·
IF 3.644
Xiao Yiwen,Zhang Zhibin,Wang Ya,Gao Boliang,Chang Jun,Zhu Du
Succinic acid is an important chemical and raw material widely used in medicine, food, biodegradable materials, fine chemicals, and other industrial fields. However, traditional methods for purifying succinic acid from fermentation broth are costly, poorly efficient, and harmful to the environment. In this study, an efficient method for purifying succinic acid from the fermentation broth of Escherichia coli NZN111 was developed through crystallization and co-crystallization with urea. First, the filtrate was collected by filtering the fermentation broth, and pH was adjusted to 2.0 by supplementing sulfuric acid. Crystallization was carried out at 8°C for 4 h to obtain succinic acid crystals. The recovery rate and purity of succinic acid were 73.4% and over 99%, respectively. Then, urea was added to the remaining solution with a mass ratio of urea to residual succinic acid of 4:1 (murea/mSA). The second crystallization was carried out at pH 2 and 4°C for 12 h to obtain succinic acid-urea co-crystal. The recovery rate of succinic acid residue was 92.0%. The succinic acid-urea crystal was further mixed with phosphorous acid (4.2% of the mass of succinic acid co-crystal) and maintained at 195°C for 6 h to synthesize succinimide, and the yield was >80%. This novel and efficient purification process was characterized by the significantly reduced urea consumption, and high succinic acid recovery (totally 95%), and high succinimide synthesis yield (80%). Thus, this study potentially provided a novel and efficient strategy for the industrial production of succinic acid and succinimide.
研究领域:
生物工程
·
化工
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS COMMUNICATIONS
·
2016
·
IF 3.389
Xiaomin Xiang,Bin Zhang,Guoqiang Ding,Jinglei Cui,Hongyan Zheng,Yulei Zhu
The oxidation of furfural in H 2 O 2 and H 2 O 2 –Mg(OH) 2 system were systematically investigated and a rational explanation for the reaction mechanism was proposed. 2-formyloxyfuran, from selective oxidation of HC O group in furfural, was a crucial intermediate. The addition of Mg(OH) 2 suppressed the oxidation of furan ring of furfural and enhanced selectivities of 2(5H)-furanone (44.8%) and succinic acid (38.0%). FT-IR, Gaussian calculation and experimental results indicated that the process of furfural oxidation with H 2 O 2 is homogeneous, and the synergy between dissolved Mg 2 + cations and OH − ions facilitates the HOO − attacking the carbon atom of HC O other than the C C bound of furan ring.
研究领域:
化学工程
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）