Foaming can be a challenge in many herbal extract processing, particularly with membrane technology involved. The foaming behavior of saponins and herbal solution containing saponins in the static system were investigated to gain more fundamental understanding on the correlations of foaming behavior- solution environment properties. To identify the cause and effects of foaming behavior under various conditions, foaming ability, foam sizes, as well as the physical properties (i.e. surface tension, zeta potential, viscosity, conductivity and pH) of the saponin solutions were characterized. The surface tension of mimic solution with the presence of saponins, polysaccharides and proteins was measured at 43.21 N/m, similar to the result of Sijunzi Decoction herbal extracts at 40.99 N/m, while other properties differed substantially. Foaming was confirmed to cause pressure drop in the dynamic concentration by reverse osmosis, while the foam height might pose insignificant impact on the magnitude of pressure drop. Significant feed pressure drop from 1.2 MPa to 1.0 MPa was observed in dynamic reverse osmosis concentration test of herbal extracts operated, while the pressure drop was negligible when operated at lower pressure operation (<0.6 MPa) with the same feed flow rate.
Monoammoniuma Glycyrrhizinate is a great substitute for antibiotics in treating acute lung injury and can reduce the range of problems caused by antibiotic resistance. However, Monoammoniuma Glycyrrhizinate is not widely used in clinical practice due to its poor water solubility and the frequent use of large doses of drugs can cause adverse reactions in other organs. To solve this problem, we use electrostatic spray technology to produce microspheres which can be inhaled directly into the lungs and allow for slow release of the drug in the lungs, and they have smooth surface and good biocompatibility. In animal models, we find out that the MAG-encapsulated microspheres group show the best treatment effect compared to other treatment groups and may attenuate the activity of the LPS-activated Nuclear Factor signaling pathway. Therefore, this therapeutic strategy could potentially deliver the drug precisely to the lung, avoid these side effects, and provide a more scientifically effective way to treat pulmonary diseases with potential medicine.
Hao Zhang,Nan Tang,Xia Yu,Zhongkai Guo,Zhen Liu,Xiaoming Sun,Min-Hui Li,Jun Hu
To date, flexible sensors derived from hydrogel materials have been popularly adopted in the field of wearable electronic devices. It is urgent and prospective to create a high-performance and multi-functional hydrogel by simple and green methods to satisfy the various demands for long-term direct human contact. Herein, a sustainable physical double network hydrogel is prepared by natural glycyrrhizic acid (GL) and biocompatible polyvinyl alcohol (PVA) in water/glycerol solvent, which exhibits high mechanical properties, good biocompatible, anti-freezing and anti-drying ability. Inspired by the reducing abilities of GL, a gradient silver nanoparticles layer can be constructed in situ on the hydrogel surface without additional reducing agents. It not only affords the UV-light shielding and antibacterial effect for the hydrogel, but also effectively improves the sensing performance. The simultaneous realization of desired properties enables the hydrogel to be assembled into a sensor to detect all-dimensional human motion with high sensitivity, stability and durability. Benefiting from the renewable raw material, non-toxic reagent and facile preparation process, this work provides new insight and inspiration for the design of flexible sensors with high performance, multi-functionality and sustainability.
危险品化学品经营许可证（带存储）