BIORESOURCE TECHNOLOGY
·
2022
·
IF 11.889
Weiming Li,Lihui Lu,Chi Cheng,Nanqi Ren,Shang-Tian Yang,Meng Liu
In this study, mannitol and mannitol-rich seaweed were fermented to investigate the relationship between substrate reduction degree and hydrogen production performance. The results showed that acetate was required in mannitol fermentation with an optimum acetate/mannitol mass ratio of 1:5. Hydrogen production and yield of mannitol fermentation reached 123.76 mL and 2.12 mol/mol-mannitol, respectively, 42.02 % and 26.95 % higher than that of glucose, respectively. The acetate was fully assimilated and the butyrate selectivity reached 100 % in the effluent. Redox potential and electron distribution showed that mannitol increased the overall electron input from mannitol and acetate, leading to the increase in hydrogen and butyrate generation. Hydrogen yield reached 2.33 mol/mol-mannitol with brown algae hydrolysate, which was the highest ever reported. This study demonstrated that substrate with a higher reduction degree could yield higher hydrogen and showed the great application potential of brown algae fermentation for the co-production of hydrogen and butyrate.
研究领域:
微生物学
·
可再生能源
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2014
·
IF 3.785
Zhichao Wang,Qingyong Li,Xiuhua Zhao,Baihe Sun,Qiaochu Zhu,Wenqing Gao,Changlong Hua
The purpose of this work is to prepare a formulation using mannitol coupling Camptothecin (CPT) nanoparticles (CPT-NPs) to circumvent the difficult solubilization practice based on central composite experimental statistical design. CPT-NPs were prepared with a high-pressure homogenization technique method. The independent variables considered for the optimization of CPT-NPs were percentage of CPT in raw material (CPT and mannitol), concentration of CPT in working liquid, cycles numbers and homogenizer pressure for drug loading efficiency, particle size and polydispersity index. Analysis of variance (ANOVA) statistical test was used to assess the optimization. The optimized CPT-NPs showed an appropriate drug loading efficiency (18.09 ± 2.13%), a homogeneous particle size (165.33 ± 37.23 nm) and a low polydispersity index (0.29 ± 0.01). The CPT-NPs group show higher inhibition ratio (79.95%) of H22 tumor growth in vivo compared with TPT and CPT at the same dose. Changes in mice body weight demonstrate CPT-NPs have the lower toxicity. The results of biodistribution studies indicated the obviously superiority of CPT-NPs in increasing the accumulation of CPT within tumor. Overall, CPT-NPs under optimum conditions are considered to be potentially feasible to overcome formulation challenges for drug delivery.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 55
·期 7
·2994-3004
·
IF 3.442
Ji Jun,Wang Yinghui,Zhang Xuelai,Chen Yue,Munyalo Jotham Muthoka,Liu Sheng
Supercooling of phase change materials (PCMs) during solidification is a major problem in cold thermal energy storage (CTES), which reduces energy efficiency and aggravates energy waste. This study focuses on the supercooling characteristics of PCMs under heterogeneous nucleation, which provides a new idea for researching the influence of different dispersants on the supercooling degree of aqueous solution. The optimal ratios of CNTs water dispersant (TNWDIS) and polymer polyacrylic acid sodium (PAAS) to multi-walled carbon nanotubes (MWCNTs) in mannitol aqueous solution are determined through microstructure and cooling characteristics. How these two surfactants and MWCNTs with different concentrations and particle sizes influence the supercooling degree of nanofluids are investigated. The results indicate that the effect of PAAS is greater than that of TNWDIS. Furthermore, under the action of two dispersants and particle sizes of MWCNTs, the fitting equations of supercooling changing with the concentration of MWCNTs are obtained. In the light of the heterogeneous nucleation theory, with the enlargement of the particle size and the diminution of the contact angle affected by the dispersants, the interfacial free energy of heterogeneous nucleation of PCMs on the surface of nanoparticles is reduced. The supercooling degree therefore decreases. Specifically, the nucleation mechanism is deduced and analyzed through the contact angle and nucleation free energy formula.
研究领域:
能源存储
·
材料科学
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 2
·1-9
·
IF 2.8
Zhao Yanna,Wang Yuqi,Zhang Ting,Bai Xiaowei,Zhang Yingying
This paper presents the development of recyclable and repairable dynamic ester cross-linked network bio-based Vitrimer (IMT-PER-COO). Pentaerythritol (PER) is used as the crosslinking agent in IMT-PER-COO to form a topological network through hydroxyl groups in PER and isocyanate groups in 1,6-hexamethylene diisocyanate (HDI). At 150 ℃, the carbamate bond is simultaneously broken and associated, and the topological network is remapped to achieve the goal of material self-repair. The results showed that the successful synthesis of IMT-PER-COO was confirmed by FTIR, XRD and XPS. The DMA test confirmed the movement of the polymer chain segment at high temperature. In addition, with the increase of PER content, the glass transition temperature (Tg) of the material increased, and the thermal stability and mechanical properties were improved. The repairability of the IMT-PER-COO material has also been confirmed. This technology introduces bio-based IMT into the covalent adaptive network, which has great potential for the further development of environmentally friendly materials.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yandong Xu,Xing Zheng,Benyan Tang,Xiaorong Yang,Patricia Vit,Milena Popova,Vassya Bankova,Liming Wu,Kai Wang
Stingless bee honey (SBH) has garnered attention as a natural sweetener and functional food, recognized for its exceptional biological activity and distinctive flavor. Compared to honeybee honey, SBH has lower annual production but commands a higher market value, making it more susceptible to adulteration. During an analysis of trehalulose in SBH, we unexpectedly identified the naturally occurring sugar alcohol, mannitol. The presence of mannitol in SBH was confirmed using UHPLC/Q-TOF-MS, 1 H and 13 C NMR analyses. A systemic analysis of 104 SBH samples from various stingless bee species revealed mannitol in all samples, with concentrations ranging from 0.06 g to 13.49 g/100 g. The detection of previously neglected mannitol levels in SBH offers additional evidence supporting its health benefits. This study not only highlights the potential application of SBH in the food industry but also introduces mannitol as a distinctive marker for detecting SBH adulteration.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2024
·Vol. 26
·期 9
·5452-5459
·
IF 9.3
Xinyi Shen,Yulin Liu,Na Li,Haiyan Ju,Xiaowei Fu,Liang Jiang,Yao Xiao,Ping He,Jingxin Lei
Existing polyethylene glycol (PEG)-based phase change materials (PCMs) with recyclability are not chemically recyclable because the raw materials of the PCMs cannot be obtained after recycling. Herein, we used a facile method to prepare a PEG-based form-stable PCM (FSPCM) using mannitol as the supporting material. The intermolecular hydrogen bonding between mannitol and PEG is strong, which gives rise to a PCM solid state even at 90 °C and prevents the leakage that normally occurs with pure PEG. More importantly, the FSPCM can be chemically recycled using butyl acetate, which is a satisfactory solvent for PEG but cannot dissolve mannitol. Thus, PEG and mannitol are obtained, with recycling rates greater than 90% for each. Additionally, there are high latent heat values for this PEG-based FSPCM, as well as excellent thermal stability and thermal reliability, suggesting the remarkable ability for thermal energy storage and thermal management.
研究领域:
材料科学
·
能源工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 43
·45444
·
IF 1.86
Fuchen Zhang,Qiuxia Wang,Lipeng Wang,Yongping Bai
This article describes the implementation of plant-derived isosorbide (IS) and isomannide (IM) in the copolymerization modification of poly(ethylene terephthalate). The effects of the two comonomers on the optical, crystallization, and thermal properties of the resulting copolyesters were studied using the following analytical methods: proton nuclear magnetic resonance; differential scanning calorimetry; X-ray diffraction; thermogravimetry; and ultraviolet-visible spectroscopy. As comonomers, IS and IM increased the transmittance and reduced the haze of the copolyesters. Moreover, while IM improved the optical properties more than did IS, both monomers improved the optical properties of the copolyesters by lowering its crystallization ability. After the copolymerization modification, the crystallization rate of the copolyesters was reduced, decreasing the crystallinity and crystal size and thereby reducing the light transmission interference. The comonomers also altered the light absorption properties of the copolyesters and conferred a substantial increase in the transmittance of near-infrared (NIR) wavelengths. These changes in optical properties exhibit the potential of these comonomers for applications in optical materials and NIR detectors. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45444.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Lu Liu,Baojie Liu,Xiangyu Li,Zenglin Wang,Linlin Mu,Chengrong Qin,Chen Liang,Caoxing Huang,Shuangquan Yao
The effect of mannitol (MA) on the poplar separation using mannitol-assisted oxalic acid (M/OA) pretreatment was revealed. The effects of reaction parameters on the separation efficiency were studied. The optimized conditions were OA 7.0%, MA 7.0%, temperature 150 °C, and time 60 min. The hemicellulose separation was 79.08%. The separation of cellulose and lignin decreased from 12.43% and 21.82–8.58% and 16.11%, respectively, under hemicellulose separation similar to those of conventional OA pretreatment. Smooth fiber surfaces with less lignin deposition were observed. There were more β-O-4 and fewer β-β in lignin. Additionally, larger amounts of aliphatic hydroxyl groups and smaller amounts of phenolic hydroxyl groups were observed, which implies that MA addition prevented lignin from condensing. An effective and environmentally friendly separation of hemicellulose was achieved by M/OA pretreatment. This provides a practical approach for resolving the stubborn problems of lignin cleavage and condensation during organic acid pretreatment.
研究领域:
生物化学
·
生物质能
·
林产化学工程
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 21
·3939
·
IF 3.06
Qin Shu,Jianan Wu,Qihe Chen
As a novel natural compound delivery system, liposomes are capable of incorporating lipophilic bioactive compounds with enhanced compound solubility, stability and bioavailability, and have been successfully translated into real-time clinical applications. To construct the soy phosphatidylcholine (SPC)–cholesterol (Chol) liposome system, the optimal formulation was investigated as 3:1 of SPC to Chol, 10% mannosylerythritol lipid-A (MEL-A) and 1% betulinic acid. Results show that liposomes with or without betulinic acid or MEL-A are able to inhibit the proliferation of HepG2 cells with a dose-effect relation remarkably. In addition, the modification of MEL-A in liposomes can significantly promote cell apoptosis and strengthen the destruction of mitochondrial membrane potential in HepG2 cells. Liposomes containing MEL-A and betulinic acid have exhibited excellent anticancer activity, which provide factual basis for the development of MEL-A in the anti-cancer applications. These results provide a design thought to develop delivery liposome systems carrying betulinic acid with enhanced functional and pharmaceutical attributes.Keywords:Liposomes;betulinic acid (BA);mannosylerythritol lipid-A (MEL-A);HepG2;anticancer activity
研究领域:
药剂学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
·
2022
·Vol. 46
·期 11
·15722-15732
·
IF 4.672
Yu Bai,Wenjuan Qiu,Shuangfeng Wang
Summary At present, there are few kinds of phase change materials that suitable for medium temperature heat storage. Among them, sugar alcohols have broad application prospects in the heat storage at medium temperature due to their suitable phase transition temperature. In this work, eutectic phase change material (PCM) was prepared with D-mannitol as PCM and KBr as melting point modifier. Expanded graphite (EG) was used as thermally conductive support network to prepare shape-stable composite phase change material (CPCM). The prepared CPCM—10% EG/PCM has an appropriate phase transition temperature (136.88°C), high phase melting enthalpy (215.7 J/g), and good photothermal conversion (81.9%). The thermal conductivity of 10% EG/PCM reached 6.01 W/(m K), which is approximately 10 times higher than D-mannitol (0.603 W/(m K)). Because of its excellent thermal properties, the applications of CPCM in energy storage and photothermal conversion can be further broadened.
研究领域:
材料科学
·
能源存储
·
太阳能利用
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF THERMOPHYSICS
·
2020
·Vol. 41
·期 5
·1-12
·
IF 0.794
Mo Songping,He Lijuan,Jia Lisi,Chen Ying,Cheng Zhengdong
Thermophysical properties are important parameters that influence the performance of phase change materials (PCMs) and heat transfer fluids. Micro/nanoencapsulation is an effective technique for preventing leakage and enhancing thermophysical properties of PCMs. In the present study, novel d -mannitol nanocapsules with inorganic shells were synthesized as a medium-temperature PCM. The nanocapsulation was confirmed by scanning electronic microscopy. The specific heat and thermal diffusivity of the nanocapsules and their suspension with heat transfer oil as base fluid were measured by a differential scanning calorimeter and light flash apparatus. The thermal conductivity of the nanocapsule suspension was measured using a hot-disk thermal constants analyzer. The viscosity of the nanocapsule suspension was measured by a rotational rheometer. The results show that the thermal conductivity and thermal diffusivity of the nanocapsules were enhanced compared to the bulk of the PCM due to the inorganic shell. The specific heat, thermal conductivity, and viscosity of the nanocapsule suspension were increased compared to the base fluid. The potential of the nanocapsule suspension as a heat storage and transfer fluid was evaluated.
研究领域:
材料科学
·
热力学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 3
·715
·
IF 4.2
Zhe Li,Xiaosui Luo,Qiong Li,Zhengji Jin,Abid Naeem,Weifeng Zhu,Lihua Chen,Yi Feng,Liangshan Ming
Porous materials are widely used as an effective strategy for the solubilization of insoluble drugs. In order to improve the solubility and bioavailability of low water-solubility drugs, it is necessary to prepare porous materials. Mannitol is one of the most popular excipients in food and drug formulations. In this study, porous mannitol was investigated as a drug carrier for low water solubility drugs. Its fabrication, drug loading, and drug release mechanisms were investigated. Porous mannitol was fabricated using the co-spray–antisolvent process and utilizing polyvinylpyrrolidone K30 (PVP K30) as the template agent. Porous mannitol particles were prepared by changing the proportion of the template agent, spraying the particles with mannitol, and eluting with ethanol in order to regulate their pore structure. In subsequent studies, porous mannitol morphology and characteristics were determined systematically. Furthermore, curcumin and ibuprofen, two poorly water-soluble drugs, were loaded into porous mannitol, and their release profiles were analyzed. The results of the study indicated that porous mannitol can be prepared using PVP K30 as a template and that the amount of template agent can be adjusted in order to control the structure of the porous mannitol. When the template agent was added in amounts of 1%, 3%, and 5%, the mannitol pore size increased by 167.80%, 95.16%, and 163.98%, respectively, compared to raw mannitol. Molecular docking revealed that mannitol and drugs are adsorbents and adhere to each other by force interaction. The cumulative dissolution of curcumin and ibuprofen-loaded porous mannitol reached 69% and 70%, respectively. The release mechanism of curcumin and ibuprofen from drug-loaded mannitol was suitable for the Korsmeyer–Peppas kinetic model. In summary, the co-spray–antisolvent method proved effective in fabricating porous materials rapidly, and porous mannitol had a remarkable effect on drug solubilization. The results obtained are conducive to the development of porous materials.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）