COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Weifeng Lin,Guanglong Ma,Jiang Wu,Shengfu Chen
Poly(sulfobetaine methacrylate) (pSBMA) and poly(carboxybetaine methacrylate) (pCBMA) are two well-known zwitterionic polymers known for their excellent antifouling properties. In this work, these two zwitterionic polymers were compared both in vitro and in vivo . Both of them exhibited excellent antifouling properties and low macrophage uptake although there were negligible differences in resistance to nonspecific protein adsorption of their hydrogels and cell internalization of their star polymers. However, it is found that the β- Cyclodextrin-CBMA (CD-CBMA) showed a circulation time one order of magnitude longer than CD-SBMA, which implied that small differences in vitro may lead to a dramatic difference in vivo . This work demonstrated that pCBMA showed greater potential than pSBMA in biomedical applications.
研究领域:
生物材料学
·
医学工程
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DOI
PubMed
高影响因子
CELLULOSE
·
2020
·Vol. 28
·期 2
·1139-1152
·
IF 4.21
Gao Simeng,Su Jing,Wang Wencong,Fu Jiajia,Wang Hongbo
In this work, a novel formulation of polysulfobetaine, poly (sulfobetaine-acrylamide-allyl glycidyl ether) (PSPB-AM-AGE), was synthesized and grafted onto cotton. The synthesis of PSPB-AM-AGE and its grafting on the cotton fabrics were confirmed by FTIR, XPS and SEM. The PSPB-AM-AGE treated cotton fabrics exhibited a high level of antibacterial rate against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) , which are 95.18% and 98.74%, separately, as well as a good laundry durability. The mechanical tests showed that the essential cotton properties can be largely preserved in the treatment process. Moreover, the hydrophilicity, air and water permeability of the cotton were improved after treated with PSPB-AM-AGE, indicating a better wearing comfort performance. The whiteness of the cotton fabrics did not decrease significantly.
The safety evaluation demonstrated that PSPB-AM-AGE had no cytotoxicity. The developed antibacterial finishing introduced a new method to apply polysulfobetaine interfaced on cellulose, providing great potential for biomedical fabric application.
研究领域:
材料科学
·
纺织工程
·
生物医学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Chunli Yu,Yao Hu,Yuqin Zhang,Wei Luo,Jing Zhang,Peilun Xu,Jun Qian,Jun Li,Jianfeng Yu,Jin Liu,Wenguang Zhou,Shengxi Shao
In industrial-scale cultivation of microalgae, salinity stress often stimulates high-value metabolites production but decreases biomass yield. In this research, we present an extraordinary response of Arthrospira platensis to salinity stress. Specifically, we observed a significant increase in both biomass production (2.58 g L −1 ) and phycocyanin (PC) content (22.31%), which were enhanced by 1.26-fold and 2.62-fold, respectively, compared to the control, upon exposure to exogenous glycine betaine (GB). The biochemical analysis reveals a significant enhancement in carbonic anhydrase activity and chlorophyll a level, concurrent with reductions in carbohydrate content and reactive oxygen species (ROS) levels. Further, transcriptomic profiling indicates a downregulation of genes associated with the tricarboxylic acid (TCA) cycle and an upregulation of genes linked to nitrogen assimilation, hinting at a rebalanced carbon/nitrogen metabolism favoring PC accumulation. This work thus presents a promising strategy for simultaneous enhancement of biomass production and PC content in A. platensis and expands our understanding of PC biosynthesis and salinity stress responses in A. platensis .
研究领域:
生物技术
·
分子生物学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2012
·
IF 3.456
Miao Wang,Jiang Yuan,Xiaobo Huang,Xianmei Cai,Li Li,Jian Shen
Grafting-from has proven to be a very effective way to create high grafting densities and well-controlled polymer chains on different kinds of surfaces. In this work, we aim to graft zwitterionic brush from cellulose membrane (CM) via ARGET-ATRP (Activator Regenerated by Electron Transfer ATRP) method indirectly for blood compatibility improvement. Characterization of the CM substrates before and after modification was carried out by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle measurements, X-ray photoelectron spectroscopy analysis, and atomic force microscopy, respectively. The results demonstrated zwitterionic brushes were successfully grafted on the CM surfaces, and the content of the grafted layer increased gradually with the polymerization time. The platelet adhesion, hemolytic test and plasma protein adsorption results indicated the cellulose membrane had significantly excellent blood compatibility featured on lower platelet adhesion and protein adsorption without causing hemolysis. The functionalized cellulose substrate could have a great potential usage for biomedical applications.
研究领域:
生物材料学
·
医学工程
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Yijuan Chen,Jiaxuan Luo,Nan Zhang,Wenjuan Yu,Jiexian Jiang,Guanghui Dai
Plant essential oils are the powerful candidates to develop natural insect management agents. Their chemical compounds along with their biological activity are often affected by many factors. However, the relationships between the composition and bioactivity of the compounds are not well understood. In this study, eight plant essential oils were screened, and the main compounds from the most effective oil showing insecticidal properties against third-instar larvae of the beet armyworm ( Spodoptera exigua Hübner) were evaluated for comparative and synergistic interactions by topical application. The results indicated that Salvia hispanica L. essential oil showed significant insecticidal activity against S. exigua compared with the other seven essential oils. Fifteen major compounds were identified from S. hispanica via gas chromatography-mass spectrometry, with the most abundant compound (α-thujone) possessing the highest insecticidal activity. Several combinations of the four major compounds (α-thujone, (+)-camphor, 1,8-cineole, and α-caryophyllene) from S. hispanica exhibited synergistic insecticidal activities. This study demonstrates the potential of S. hispanica essential oil and α-thujone as effective botanical insecticides in the control of beet armyworm and provides a better understanding of essential oil compound-pest interactions.
研究领域:
植物学
·
昆虫学
·
农业科学
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DOI
高影响因子
RSC Medicinal Chemistry
·
2025
·
IF 3.6
Zhenyuan Wang,Mi Wang,Qingsheng Tao,Yufei Li,Hao Wang,Mei Zhang,Xueli Liu,Jiaheng Zhang
Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.
研究领域:
化妆品科学
·
药物化学
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材料工程
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产品关联
DOI
PubMed
高影响因子
SCIENTIA HORTICULTURAE
·
2025
·
IF 4.2
Jianbin Shi,Dongfang Fang,Yong Sui,Tian Xiong,Xueling Chen,Chuanhui Fan,Deshun Zhou,Fang Cai,Xin Mei
Sweet potato ( Ipomoea batatas L.) leaves are rich in polyphenols and consumed as leaf vegetable in world. The content and composition of polyphenols are diversity at different harvesting period. This study investigated the changes of total polyphenols content (TPC), antioxidant capacity, and polyphenol fractions content of sixteen varieties of SPLs during growth stage. The results showed significant diversity in the concentrations of active compounds in different genotypes and growth stages. TPC ranged from 27.45 to 243.82 mg CAE/g DW among the varieties over various growth stages, with G3 and E1 varieties exhibiting relatively high TPC and antioxidant capacity. Twelve polyphenol fractions were identified in SPLs. Correlation analysis demonstrated a significant positive relationship between antioxidant capacity and the content of monosubstituted caffeoylquinic acids (3-caffeoylquinic acid, 5-caffeoylquinic acid, 4-caffeoylquinic acid) and disubstituted caffeoylquinic acids (3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid). Principal component analysis highlighted the superior performance of the E1 variety in terms of polyphenol content and antioxidant capacity.
研究领域:
植物学
·
食品科学
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2015
·
IF 4.09
Hai-ming Chen,Xiong Fu,Zhi-gang Luo
To investigate the impact of each functional group on the emulsifying properties of sugar beet pulp pectin (SBPP), seven enzymes were studied in a particular order. Compositions of SBPP and enzymatically modified SBPPs were determined, and the structures of SBPPs were characterized by FT-IR. In addition, the contribution of each functional group was evaluated based on the variation in emulsion characteristics. The results showed that protein, ferulic acid-araban/galactan-protein complexes and ferulic acid played important roles in improving the surface activity, emulsifying capacity and emulsifying stability of SBPP and the extent of the decrease in the emulsifying activity followed the order: ferulic acid > ferulic acid-arabinogalactan-protein complexes > protein. The decrease of methyl ester groups mainly affected the particle sizes of the emulsion. In addition to particle sizes, the cream index of the emulsion increased with the hydrolysis of acetyl groups. Arabinose and galactose less affected emulsifying properties than other functional groups.
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
PLoS One
·
2014
·Vol. 9
·期 6
·e100731
·
IF 3.534
Ke Xu,Ping Xu
Lactic acid is an important chemical with various industrial applications, and it can be efficiently produced by fermentation, in which Bacillus coagulans strains present excellent performance. Betaine can promote lactic acid fermentation as an effective osmoprotectant. Here, positive effect of betaine on fermentation by B. coagulans is revealed. Betaine could enhance lactic acid production by protecting l -LDH activity and cell growth from osmotic inhibition, especially under high glucose concentrations and with poor organic nitrogen nutrients. The fermentation with 0.05 g/L betaine could produce 17.9% more lactic acid compared to the fermentation without betaine. Beet molasses, which is rich in sucrose and betaine, was utilized in a co-feeding fermentation and raised the productivity by 22%. The efficient lactic acid fermentation by B. coagulans is thus developed by using betaine and beet molasses.
研究领域:
微生物学
·
生物工程
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2013
·
IF 3.334
Chunying Luo,Xixi Wang,Ge Gao,Lian Wang,Yongxin Li,Chengjun Sun
The study systematically investigated free, conjugate and total phenolics (phenolic acids and flavonoids) in leaves of 19 Chinese and one American sweetpotato cultivars grown in China. Three extraction/hydrolytic methods (direct extraction and acidic and basic hydrolysis) for sample preparation were employed to obtain different forms of phenolics. Twenty-nine phenolics were separated and identified using HPLC–DAD and HPLC–ESI–MS/MS. Three quercetin glycosides were characterised for the first time from this plant. Contents of the principal phenolics identified were determined by the HPLC–DAD procedure, which was validated in terms of linearity, precision, accuracy and limit of detection and quantification. Moreover, to the best of our knowledge, it is the first to reveal and demonstrate artifacts of esterification during acidic methanolic and ethanolic hydrolysis, and chromatographic behaviours, UV spectra and MS data of 20 hydroxycinnamic acid methyl and ethyl esters were obtained using acidic methanolic and ethanolic hydrolysis.
研究领域:
植物化学
·
食品科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Shaobo Zhang,Xinghui Yang,Bin Tang,Lingjun Yuan,Kui Wang,Xiangyu Liu,Xingli Zhu,Jianna Li,Zaochuan Ge,Shiguo Chen
We report a facile and environment-friendly finishing method for cotton fabrics using zwitterionic sulfopropylbetaine (ISB) and quaternary ammonium salt (IQAS) with reactive isocyanate group (NCO) as antimicrobial finishing agents via dipping–padding–drying process. The results showed that ISB and IQAS can be covalently bound onto the cotton fabric surface, imparting exellent antifouling activity and bactericidal activity, respectively. The dually finished cotton fabrics exhibited excellent bactericidal and antifouling performance without significantly affect their water vapor permeability and air permeability. All the finished cotton fabrics exhibited improved breaking strength, tearing strength, bursting strength and hydrophilicity compared to raw cotton fabrics. Atomic force microscope research results indicated that the adhesion force between bacterial and finished cotton fabric surfaces increased with the QAS content, and they can be tailored by changing the ISB/IQAS ratio. Most importantly, non-leaching antimicrobial and antifouling cotton fabrics did not induce skin stimulation and toxic effects to animals because ISB and IQAS were chemically bound to cotton fabrics, ensuring that our finishing method have great potential for industrial and healthcare applications, including but not limited to fabrics, surgical equipment water purification systems, packaging and public health settings.
研究领域:
材料科学
·
生物医学工程
·
纺织工程
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产品关联
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 9
·1783
·
IF 4.967
Qicheng Chen,Nan He,Jing Fan,Fenhong Song
Due to their splendid advantages, deep eutectic solvents have attracted high attention and are considered as analogues of ionic liquids. Deep eutectic solvents (DESs) are homogeneous mixtures formed by two or three green and cheap components through hydrogen bond, which is divided into hydrogen bond acceptors (HBA) and hydrogen bond donors (HBD). Recently, Betaine has been widely used as a hydrogen bond acceptor. In this work, four DESs were synthesized by blending betaine as HBA and 1,2-propanediol as HBD in four molar ratios (1:3.5, 1:4, 1:5, 1:6). Then, the physical properties of these DESs were measured. The density values were measured within the temperature range (293.15 K to 363.15 K) at atmospheric pressure, whereas the surface tension and viscosity data were determined in four and seven temperatures between 293.15 K and 353.15 K. The relationship between the density and surface tension with temperature have been analyzed and have been fitted as a linear function. The commonly used Arrhenius model was used to describe the dependence between viscosity and temperature. The results of this study are important not only for the DESs’ industrial applications but also for the research on their synthesis mechanism and microstructure.Keywords:deep eutectic solvents;betaine;1,2-propanediol;physical property
研究领域:
化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）