ACS Applied Polymer Materials
·
2024
·
IF 4.4
Xiang Zhang,Xiaoning Liu,Jun Hu,Pan Zhang,Ziming Xu,Dan Wang,Weiping Xu
Hydrogels, known for their unique physical and chemical properties, hold significant potential for various applications. However, the inherent conflict between achieving both high strength and toughness often results in suboptimal mechanical performance, which significantly restricts their practical use. The shell of Discinisca tenuis is a layered natural biomaterial that exhibits high strength and toughness due to slight layer loosening during hydration, inspiring the design of tough hydrogels. Inspired by this biological process, this study developed a biomimetic layered hydrogel using a layered membrane hydration approach, optimizing the structural integrity through hot pressing to mimic the slight layer loosening observed in Discinisca tenuis shells after hydration, resulting in both high strength (55.26 MPa) and high toughness (21.04 MJ/m3). The research results indicate that slight layer loosening after hydration enables the biomimetic layered hydrogel to maintain high structural integrity, facilitating effective interlayer load transfer and achieving high strength, while also reducing spatial constraints, which improves ductility and results in high toughness. Additionally, the excellent energy dissipation capacity of the layered structure gives the hydrogel outstanding impact resistance, comparable to commercial materials like foamed polyethylene, silicone, and energy-absorbing rubber, indicating broad application prospects. In summary, this research proposes a general preparation strategy for tough hydrogels based on biomimetic principles, expected to advance the field of hydrogels.
研究领域:
材料科学
·
生物学
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DOI
高影响因子
BMC Oral Health
·
2025
·Vol. 25
·期 1
·1-15
·
IF 3.1
Li Huanying,Liu Gengbo,Liu Xiaohao,Wu Buling
Section
Background
Currently, many biomimetic mineralization materials fail to bind effectively to collagen, which significantly limits their remineralization efficacy. To address this limitation, we designed MMP2-derived peptides (MDPs) on the basis of the strong affinity domain of collagen: MDP-a and MDP-3DSS.
Section
Methods
Surface plasmon resonance (SPR) was used to measure the binding force of MDPs to collagen. Inductively coupled plasma-mass spectrometer (ICP-MS) was used to evaluate the effects of peptides on the adsorption of calcium ions by collagen. Transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) were employed to analyze the stabilizing effect of MDPs on amorphous calcium phosphate (ACP) and the mineralization effect on collagen. Scanning electron microscopy (SEM), mechanical tests, and the CCK-8 assay were employed to evaluate the remineralization effect of MDPs on demineralized dentin and their biocompatibility.
Section
Results
The results of the present study demonstrated that MDPs strongly bind to collagen (18 µM for MDP-a and 18.9 µM for MDP-3DSS) and can promote calcium ion adsorption by collagen (p < 0.0001). Furthermore, MDPs have been shown to stabilize ACP and induce intrafibrillar mineralization. In vitro studies revealed that both surface and cross-sectional dentin slices treated with MDPs presented dense mineral deposition. This deposition effectively occluded the dentinal tubules and resulted in enhanced mechanical properties. The tubule plugging rate, the elastic modulus and microhardness of the MDPs group were greater than those of the control group (p < 0.01). Moreover, MDP-3DSS demonstrated the most significant remineralization potential. Additionally, MDPs treatment did not affect the activity of human dental pulp stem cells (hDPSCs) (p > 0.05).
Section
Conclusion s
The present study successfully developed and evaluated two novel biomimetic mineralized peptides, MDP-a and MDP-3DSS. It is necessary to conduct further research to explore the possibility of clinical transformation of MDPs.
研究领域:
口腔生物学
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生物材料学
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牙体牙髓病学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 6
·4860-4868
·
IF 3.086
Li Hao,Yu Sirong,Han Xiangxiang
Inspired by the self-cleaning property of the lotus leaf surface, a novel biomimetic coating with superhydrophobicity is introduced in this article. Moreover, the morphologies, crystal structures and chemical composition of the specimens were investigated using field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), energy dispersive spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR). After electrodeposition of the Zn coating, a ZnO coating with micro and nano structures (perpendicular to the substrate surface) was obtained on an X90 pipeline steel surface after it was processed with the appropriate hydrothermal treatment time. The water contact angle (CA) of the ZnO coating, which had upright micro and nano structures, was about 137.85° without chemical modification. After further modification with a low-surface-energy material, the ZnO coating presented superhydrophobicity with the water CA of 157.59° and the sliding angle (SA) was less than 10°. Therefore, this study changed the traditional application of the deposited coating that was mostly used as a protective layer and might open up a new application field for deposited metal coatings to fabricate microstructures with functional applications, including superhydrophobic coatings.
研究领域:
材料科学
·
表面工程
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DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Xiaofang Wang,Huiming Wang,Meining Zhang
Disulfide bonds exist widely in channel protein and play an essential role in matter exchange and signal transduction (e.g., rhodopsin, canonical transient receptor potential 5 (TRPC5)). The research on disulfide bond in nanochannel is significant for the cognition of their biological functions. However, the fragility of biological channel limits the in-situ study and practical application. Herein, an innovative biologically-inspired artificial nanochannel based on disulfide bond (NCDS) with excellent durability, adjustable surface property is proposed. The constructed NCDS has a multi-response to UV-light, thiol (e.g., cysteine (Cys)) or pH stimulation, and can obtain reversibility after regulation by hydrogen peroxide (H 2 O 2 ) or H + . The biomimetic NCDS shows great potential in biosensor and intelligent response design. This study also shines new light to channel protein based on disulfide bond that despite the nanochannel has specificity, it will be modulated by the change of nature environment, such as UV-light and chemical microenvironment (e.g., redox state and pH), which might be the reason of some disease.
研究领域:
生物物理学
·
纳米科技
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生物化学
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DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 19
·14821
·
IF 4.6
Huan Xu,Dengwei He,Huimin Tao
Methicillin-resistant Staphylococcus aureus (MRSA) has spread across diverse global environments, and MRSA-related infection is a major threat to public health. Implant-associated infection (IAI) caused by MRSA remains a tough global clinical problem. Conventional antibiotic therapy has limited efficacy in treating MRSA-related IAI, and antibiotic abuse has resulted in the emergence of multidrug-resistant bacteria. Hence, there is a necessity to explore more effective approaches to deal with MRSA-related IAI. Herein, inspired by neutrophil extracellular traps (NETs) released by neutrophils to kill microorganisms, this study proposes a novel biomimetic nano-NET strategy using an epsilon-poly- l -lysine-coated CuO 2 nanoplatform, denoted as PCPNAs. The function-adaptive nanoplatform exhibited excellent Fenton-like performance, including robust ROS generation and GSH scavenging ability. PCPNAs showed >90% cell viability in mammalian cells and reduced bacterial burden by 7.65 log 10 CFU in vitro . Moreover, the positively charged PCPNAs could easily bind to negatively charged MRSA cells through charge-coupling and simultaneously exerted a trapping effect on MRSA cells. Notably, PCPNAs self-assembled into web-like structures to physically trap and kill biofilm bacteria, achieving 99.58% biofilm eradication. Furthermore, PCPNAs showed satisfactory biocompatibility in vivo and displayed ideal anti-bacterial and anti-inflammatory effects in a mouse model with implant-associated infection. With further development and optimization, the biomimetic nano-NET strategy based on PCPNAs provides a new therapeutic option for the treatment of MRSA-related implant-associated infection. Schematic of a biomimetic nano-NET strategy based on PCPNAs for the treatment of MRSA-related implant-associated infections.
研究领域:
医学
·
微生物学
·
纳米医学
·
感染病学
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产品关联
DOI
PubMed
高影响因子
Matter
·
2025
·
IF 17.5
Yakun Gao,Biao Ma,Gangsheng Chen,Chengtao Xu,Ziyan Kong,Yanjie Chen,Chao Zhao,Duxin Chen,Wenwu Yu,Hong Liu
DNA data storage has emerged as a promising solution to address the challenges of data explosion due to its high storage density and durability. However, traditional storage architectures require substrate replacement and the use of environmentally unfriendly chemicals for multistep operations, hindering seamless and sustainable storage. Here, we report liquid metal (LM)-DNA, an integrated and sustainable DNA storage architecture that leverages a responsive liquid metal as a functionality-adaptive storage medium. LM-DNA allows cascaded storage operations within a single medium, including enzymatic DNA synthesis, hermetic encapsulation through thermal activation, and electrokinetic decapsulation driven by the electrocapillary effect. The green enzymatic DNA data writing and physical data encapsulation/decapsulation avoid toxic chemicals, ensuring a more sustainable route for DNA storage. Furthermore, the fluidity of liquid metal enables biomimetic operations such as file splitting, merging, and reshaping, offering unprecedented flexibility in information management. LM-DNA provides a promising foundation for advancing sustainable and biomimetic information storage technologies.
研究领域:
生物技术
·
材料科学
·
数据存储
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Jiong Li,Guoyong Du,Chunping Deng,Huatao Zhang,Lijuan Dai
In recent years, modified membranes for oil–water separation have garnered significant attention. However, the complexity of the process, low efficiency, and serious oil contamination have been the main obstacles to its application. Hence, there is an urgent need to explore simple, environmentally friendly modification methods. Inspired by adhesive bioproteins and diatomaceous silica, this study presents a simple, low-cost, and environmentally friendly biomimetic coating strategy to prepare a highly efficient oil–water separation membrane with convenient separation and excellent resistance to oil fouling. Using pyrogallic acid (PG) and silane coupling agent KH550, a one-step modification of the poly(vinylidene fluoride) (PVDF) microfiltration membrane (MF) was conducted, transitioning the surface wettability of the PVDF membrane from highly hydrophobic to superhydrophilic. This resulted in layered nanoscale papillary structures on the PVDF–MF surface, imparting superhydrophilicity and underwater superoleophobicity, along with excellent oil–water separation capability. Under a transmembrane pressure of 0.85 bar, systematic testing of the modified membrane demonstrated that the stable flux of the emulsion is approximately 950 L m–2 h–1, with an oil rejection rate exceeding 99% and significantly improved fouling resistance, as well as excellent chemical stability and salt resistance. The “green” in situ biomimetic silicification strategy is equally applicable to inert materials such as polytetrafluoroethylene (PTFE) membranes, demonstrating its significant potential for application on other materials.
研究领域:
材料科学
·
环境工程
·
表面化学
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产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 44
·28422-28432
·
IF 4.036
Xuejun Li,Dongyan Li,Zhining Liu
Micelle-entrapped silica xerogel (M-Silica xerogel) was biomimetically synthesized to combine the advantages of micelles and silica xerogel to load poorly water-soluble drug itraconazole (ITZ). Tween 20, tween 40, and tween 80 were applied to prepare micelles as the templates for M20-Silica xerogel, M40-Silica xerogel, and M80-Silica xerogel, respectively. During the silica frame construction, the surfactant formed a micelle as the porous template, silicon hydroxyl groups interacted with the hydrophilic parts of the micelle, and polyethylenimine catalyzed silica polycondensation owing to its amino groups, resulting in the formation of the M-Silica xerogels. The results showed that the particle size of the sub-particles from the M40-Silica xerogel was larger than from the M20-Silica xerogel, and the M80-Silica xerogel was the largest among these three samples, demonstrating that the emulsifying ability had a direct impact on the particle size of the M-Silica xerogel. The M-Silica xerogel had a large pore size in the range of 10–50 nm. Small mesopores (2–5 nm) dominated the pore size of the M20-Silica xerogel, while medium mesopores (5–10 nm) occupied most the pore distribution of the M40-Silica xerogel, and large mesopores (10–50 nm) shouldered most the pore distribution for the M80-Silica xerogel. Among these three drug-loaded carriers, the M40-Silica xerogel with the largest amount of medium mesopores presented the best ITZ-release behavior, demonstrating that medium mesopores facilitated drug release, while small mesopores impeded drug release and large mesopores were not favorable to retaining amorphous drugs in the pores.
研究领域:
药剂学
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材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Xiaobin Yang,Linlin Yan,Feitian Ran,Yifeng Huang,Duo Pan,Yongping Bai,Lu Shao
Water purification polymeric membranes are critical for defending water safety and mitigating water crisis stress. They are hampered by membrane hydrophobicity for undesirable filtration performance and troublesome fouling issues. Membrane interface hydrophilization with good hydrophilicity and well-behaved adhesion are highly desired. Here, inspired by bio-protein adhesives and silicified diatom shells, a facile one-step biomimetic silicification method by tannic acid and 3-glycidyloxypropyltrimethoxysilane was explored at ambient conditions. The silicification method is green and cost-effective. The as-decorated membranes boosted hydrophilicity with outstanding rigid test tolerance. The silicification conditions could be regulated by resultant surface chemistry. The hydrophilized microfiltration membrane realized cyclable oily emulsion purification with flux over 2580 L m −2 h −1 and oil repulsion over 99.2%. It also demonstrates outstanding repulsion to crude oil. The as-decorated ultrafiltration membrane displayed an improved protein interception (BSA interception above 94.1%, water flux about 424 L m −2 h −1 ) and antifouling (73.2% enhancement) capacity. The as-presented biomimetic silicification hydrophilization strategy could potentially promote the development of high-performance water purification membranes and efficient energy-water nexus system.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Ziyue Gao,Minghao Li,Haoxu Yu,Shuai Huang,Faze Chen
Spontaneous liquid transport is increasingly being applied in various fields such as microfluidics, fuel cells, phase change heat transfer, water harvesting, etc. However, long-distance spontaneous liquid transport with path-customizable motion trajectories is still challenging. Drawing multi-inspirations from the wedge-shaped structures of iris petals, the continuous structures of bamboo joints, and the microgroove structures of Nepenthes mouth edge, we fabricate a modular, pump-free biomimetic liquid transport platform by 3D printing and surface modification. The platform is composed of sequential wedge notches, and a crescent-shaped groove is designed at the joint of every two connected wedge structures. The platform is characterized by path-customizable liquid transport trajectories and can be used to achieve long-distance liquid transport without the need of external energy fields, and the multi-level nested structures along the depth significantly facilitates the liquid transport. Experimental study and theoretical force analysis show that the crescent-shaped grooves enable the liquid to overcome joint barriers by converting potential energy accumulated at joints into kinetic energy, achieving a maximum velocity of 18 mm/s. Taking advantage of the flexibility of 3D printing and long-distance transport capability, the modular structure of the platform enables customization of the transport distance and trajectory. By assembling 14 bamboo-like wedge-shaped units in series, we realized a transport distance up to 350 mm, which could be further increased by connecting more units. Furthermore, we develop various modular and multifunctional liquid transport platforms for anti-gravity transport, liquid diversion, and customized transport trajectories, which demonstrate that our design strategy could be an available solution for path-customizable liquids transport in fields like bio-sensing, fuel cells, etc.
研究领域:
微流控技术
·
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2020
·
IF 4.469
Guolin Zheng,Dan Zhang,Chuang Zheng,Yajuan Yao,Zhu Long
Inspired by the defects of superoleophobic surface with poor friction resistance and the complicated preparation method, the bio-dopamine was utilized and the friction-durable superoleophobic composite coating was successfully obtained via Schiff base reaction and self-assembly. Dopamine contains the phenolic hydroxyl groups that can react with an amine group or a thiol group. Polydopamine is formed via dopamine self-polymerization under aerobic and weakly alkaline conditions. Additionally, polydopamine can adhere to the surface of virtually all materials. First, the self-polymerization of folic acid induced dopamine to form polydopamine micro-nanoparticles under weakly alkaline conditions. Second, 3,5-Bis(trifluoromethyl)aniline reacted with the phenolic hydroxyl groups of polydopamine nanoparticles via Schiff base reaction. Ammonium hexafluorosilicate was adsorbed on the surface of polydopamine microspheres via electrostatic interactions. Then, the self-assembly behavior of fs-81 and fs-63 with ammonium hexafluorosilicate occurred on polydopamine nanoparticles via electrostatic interactions. Accordingly, the surface roughness was further increased, for which the limitation of traditional methods of using additional nanoparticles to construct hierarchical rough surface was broken. Eventually, the superoleophobic composite coating was applied to the surface of cotton fabric. The results showed that the contact angles of the cotton fabric surface with edible oil, ethylene glycol and glycerol were greater than 150° in the air, respectively, after two cycles of self-assembly modification. The contact angles between the cotton fabric surface and edible oil droplets were still greater than 150°after 25 mechanical abrasion cycles. In addition, the surface free energy of cotton fabric was decreased by 64.1 % after finishing the coating.
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Ju Huang,Leting Yang,Wei Wang,Bin Yu,Chengfei Cao,Zhuyun Bi,Jue Wang,Jian Shen,Lei Song
Constructing fire-protective coatings has been to be an effective strategy for reducing fire hazards of polymeric materials. However, it remains a huge challenge to fabricate high-performance flame retardant coatings with biodegradability, excellent mechanical and thermal properties, as well as strong adhesion. Herein, inspired by snails exhibiting strong adhesion to a variety of surfaces by interfacial hydrogen-bonding, a biomimetic , highly adhesive, supramolecular nano-coating consisting of a tannic acid (TA)-functionalized hexagonal boron nitride nanosheets (TA-BNNS), TA and polyvinyl alcohol (PVA) was prepared by using a hydrogen-bond self-assembly strategy of solvent volatilization regulation. TA-BNNS was prepared via an efficient and green ball milling exfoliation method under mild conditions. Dynamically regulating the hydrogen bonds between PVA and TA molecules through the volatilization of ethanol was to achieve physical cross-linking. Then such a nanocoating was applied for surface treatment of rigid polyurethane foam (RPUF), which exhibiting excellent flame retardant properties. Compared to pure RPUF, the peak heat release rate (PHRR) and peak smoke production rate (PSPR) of the TA/PVA@BNNS coated RPUF were reduced by ~52.4 % and ~53.4 %, respectively. Therefore, this work provides new approach to the design and manufacture of green, efficient and non-toxic flame retardant materials.
研究领域:
材料科学
·
化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）