POLYMER
·
2018
·
IF 3.483
Haofei Li,Hongbo Wang,Dongfei Zhang,Ziyang Xu,Wenguang Liu
Recently, we have constructed a high strength and thermoplastic supramolecular poly( N -acryloyl glycinamide) (PNAGA) hydrogel which can be developed as printable bioinks. However, the PNAGA hydrogel is low in stiffness and toughness, potentially limiting its application as load-bearing soft tissue scaffolds. In this work, we fabricate a supramolecular polymer double-network hydrogel based on hydrogen bonding crosslinked PNAGA and Fe 3+ -coordination crosslinked sodium carboxymethyl cellulose (CMC). The combined hydrogen bonding and ionic crosslinks contribute to high-strength nonswellable PNAGA/CMC-Fe hydrogels (Tensile strength of 2.9 MPa and compressive strength of 7.3 MPa at 80% strain without fracture) and stiffness (Young's modulus of 1.2 MPa and compressive modulus of 1.5 MPa). Furthermore, these reversible double physical crosslinks enable the PNAGA/CMC-Fe hydrogels to dissipate energy efficiently with a high toughness (12.3 MJ m −3 ) and tear energy (3700 J m −2 ), meanwhile imparting self-recoverability, anti-fatigue ability and self-healability to the network. This cytocompatible supramolecular polymer double network hydrogel with excellent multifaceted mechanical performances are promising to exploited as load-bearing soft tissue engineering scaffolds .
研究领域:
生物材料学
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组织工程
·
高分子科学
·
再生医学
·
生物力学
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2018
·Vol. 25
·期 10
·5807-5819
·
IF 3.809
Sun Zhuangzhi,Du Shanqi,Li Fei,Yang Lu,Zhang Dan,Song Wenlong
A nanocomposite soft actuator based on porous high-conductivity electrode membrane, which was composed of biopolymer cellulose mixed with chitosan and highly conductive nanoparticles generated by reduced graphene oxide encapsulated multi-walled carbon nanotube, was developed in this paper. No new substance was discovered in the regenerated electrode layer through the scanning analysis from FT-IR and XRD. Actuators exhibited significant enhancement in peak to peak displacement, which was 3.64 times increased than the traditional value at 5 V 0.1 Hz. With the test of solid-state electric double layer capacitor, actuators showed the highest specific capacitance (10.695 F g −1 ) at the current density of 1 A g −1 , the lowest internal resistance (9.2 Ω g −1 ) in the frequency range of 10 5 –10 −2 Hz, and the lowest energy density (901 Wh kg −1 ) at the current density of 10 A g −1 , which demonstrated the absolute advantages in the conductivity and channels for electrons. These findings suggest that research on porous high-conductivity electrode layer holds great promise in the further study of higher performance actuators.
研究领域:
生物材料学
·
纳米医学
·
组织工程
·
柔性电子学
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生物力学
·
智能驱动系统
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 138
·期 7
·49856
·
IF 2.52
Donglei Liu,Xufeng Dong,Huiying Liu,Yiping Zhao,Min Qi
Motivated by a need to replicate structural and viscoelastic properties of soft tissue, such as cartilage, the structural hydrogels with viscoelastic feature have been of interest in biomedical application. However, the effect of pore alignment on their viscoelastic properties has been largely underestimated. This work prepared cellulose nanocrystal (CNC)/collagen hydrogels with different pore orientations, including horizontally aligned pores, random pores and vertically aligned pores, and integrated them into a multilayered hydrogel with multi-structure which mimics cartilage construct. The stress relaxation rate (τ 1/2 ), creep rate (γ 1/2 ), storage modulus ( G′ ) and loss modulus ( G″ ) increased in the order of the vertical, random, multi-structural, and horizontal. G′ value of the horizontal increased up to 300% relative to the vertical in the strain amplitude and frequency sweep. Maxwell–Weichert and Variable Network Density models were used to explain phenomena, and the experimental curves fitted well with the theoretical models. These results reveal that the viscoelastic properties of hydrogel can be influenced by pore orientation except conventional component concentration.
研究领域:
生物材料
·
组织工程
·
生物力学
·
高分子科学
·
再生医学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Zengqiang Wang,Shaoyu Lü,Yanhui Liu,Tao Li,Jia Yan,Xiao Bai,Boli Ni,Jing Yang,Mingzhu Liu
Designing muscle-inspired hydrogels that possess structure and bioactivity similar to muscles is an eternal pursuit in material sciences and tissue engineering. However, the development of a muscle-inspired hydrogel via the formation of noncovalent interactions remains challenging, and its application in sustained loading situations such as cyclic stresses is limited. Herein, H-bonds and microcrystalline domains were introduced, and a noncovalent muscle-inspired hydrogel was developed to mimic both the physical structure and functionality of muscles at the macroscopic level. The hydrogel exhibited excellent mechanical properties (a fracture strength of 2.16 ± 0.08 MPa, fracture strain of 830 ± 23%, elastic modulus of 275 ± 9 KPa, and toughness of 7.04 ± 0.80 MJ/m3), a large energy dissipation (2.00 ± 0.27 MJ/m3 at 600% elongation), and a rapid self-recovery (92 ± 1% toughness recovery within 20 min). Antifatigue behavior of the muscle-inspired hydrogel was observed upon successive tensile and compressive cyclic loadings. Under 100 cycles of loadings, the robustness of the hydrogel has been maintained and even improved, which are achieved due to strain-induced orientation. Furthermore, the hydrogel was found to be self-healed. This hydrogel promises to be among the most relevant drivers for the development of new-generation muscle-inspired hydrogels in the next decade.
研究领域:
材料科学
·
组织工程
·
高分子化学
·
生物力学
·
软材料
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Zhuochen Lv,Ting Shu,Jing Ren,Leitao Cao,Ying Pei,Zhengzhong Shao,Shengjie Ling
Mechanical training is an operation where a sample is cyclically stretched in a solvent. It is accepted as an effective strategy to strengthen and stiffen the highly hydrated silk materials (HHSMs). However, the detailed reinforcement mechanism of the process still remains to be understood. Herein, this process is studied by the integration of experimental characterization and theoretical analysis. The results from time-resolved Fourier transform infrared spectroscopy and real-time birefringent characterization reveal that the silk proteins rapidly formed a molecular cross-linking network (MCN) during the mechanical training. The cross-links were the β-sheet nanocrystals generated from the conformation transition of silk proteins. With the progress in mechanical training, these MCNs gradually remodeled to a highly oriented molecular network structure. The final structure of the silk proteins in HHSMs is highly similar to the structural organization of silk proteins in the natural animal silk. The training process significantly improved the mechanical strength and modulus of the material. With regards to the dynamic behavior of conformation transition and MCN orientation, the structural evaluation of silk proteins during mechanical training was divided into three distinct stages, namely, the MCN-forming stage, MCN-orienting stage, and oriented-MCN stage. Such division is in complete agreement with the three-stage viscoelastic behavior observed in the cyclic loading and unloading tests. Hence, a five-parameter viscoelastic model has been established to elucidate the structure–property relationship of these three stages. This work improves in-depth understanding of the fundamental issues related to structure–property relationships of HHSMs and thus provides inspiration and guidance in the design of soft silk functional materials.
研究领域:
材料科学
·
高分子物理
·
生物力学
·
软物质工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）