FOOD CHEMISTRY
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2022
·
IF 9.231
Zihan Jin,Israel Emiezi Agarry,Yunchang Li,Desheng Ding,Tian Cai,Kewei Chen
The type of carrier agent could impact pheophytin stability and bioaccessibility. Hence, it is important to have an elaborate understanding on the extent and type of pheophytin transformation during in vitro digestion of microcapsules. Four kinds of protein/polysaccharides complex were used to fabricate pheophytin microcapsules and investigated for pigments bioaccessibility. With different carriers, pheophytin pigments showed new characteristics influencing particle size and zeta potential during in vitro digestion. Pheophytin b was widely transformed to pheophorbide b , confirming pheophorbidation of the b series in proper condition. No 15 1 -hydroxy lactone chlorophyll or pheophytin derivatives were detected, indicating some protective effect of microencapsulation. Pheophytins loaded in gelatin-pectin complex exhibited a relatively higher recovery rate, micellarization rate, and bioaccessibility index. The result presented in this study shows that the type of carrier agent could initiate the removal of phytyl groups in pheophytins and also inhibit or mediate their bioaccessibility.
研究领域:
食品科学
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药剂学
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生物技术
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Xiao-Chen Liu,Ruixia Chen,Weizheng Sun,Leif H. Skibsted
Strontium as a bone health promoter was found to increase the bioaccessibility of essential calcium from solid calcium citrate tetrahydrate in aqueous suspensions. This is unexpected since calcium citrate binds calcium stronger than strontium with Δ H 0 ass, c = 5.07 kJ⋅mol −1 , Δ S 0 ass, c = 78.0 J⋅mol −1 ⋅K −1 for 1:1 Ca-Citrate complex formation and Δ H 0 ass, c = 1.67 kJ⋅mol −1 , Δ S 0 ass, c = 58.3 J⋅mol −1 ⋅K −1 for 1:1 Sr-Citrate complex formation as determined both electrochemically and by isothermal titration calorimetry. Calcium citrate tetrahydrate has reverse solubility around physiological temperature in contrast to strontium citrate pentahydrate. This difference results in opposite effect of strontium upon calcium ion liberation from calcium citrate suspensions at both low and high temperature compared to physiological temperature, for which strontium was found to stabilize solid calcium citrate tetrahydrate. This effect, confirmed by quantum mechanical calculation and by comparison of spontaneous aqueous supersaturation of calcium citrate and strontium citrate, is suggested to be involved in the positive effect of strontium on bone and teeth health. The conclusions provide a theoretical foundation for the research of molecular mechanisms among calcium, strontium, and citrate ions in relation to bone and teeth health.
研究领域:
营养学
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生物化学
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医学
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DOI
高影响因子
Foods
·
2024
·Vol. 13
·期 17
·2741
·
IF 4.7
Di Zhao
Arsenic (As) contamination in rice is a global public health concern, particularly in Asian countries where rice is the staple food. Current health-based limits for As in rice are typically derived from total As concentrations, resulting in overly stringent values. This study aimed to determine As bioaccessibility in rice, estimate dietary intakes of inorganic As (iAs) at different consumption rates, evaluate the cancer and non-cancer risks associated with iAs exposure through rice consumption, and assess the feasibility of deriving more accurate health-based limits for As in rice after incorporating rice As bioaccessibility. Bioaccessibility of As ranged from 60.7% to 104.5% in rice samples. Estimated iAs intake varied from 0.04 to 1.40 μg/kg BW/day at rice consumption rates of 100–300 g/day. Incorporating rice As bioaccessibility resulted in lower iAs intake estimates of 0.03–1.18 μg/kg BW/day. The non-cancer and cancer risks associated with iAs exposure are concerning for populations with higher rice consumption rates and elevated rice iAs concentrations. Health-based limits for iAs in rice for different regions across China are discussed after incorporating rice As bioaccessibility. This study contributes to the development of regional or national safety limits for As in rice, based on As bioaccessibility in rice.
研究领域:
环境科学
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公共卫生
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毒理学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Yang-xiao-xiao Shi,Jia-qi Cui,Feng Zhang,Ke-wei Li,Jun Jiang,Ren-kou Xu
Hexavalent chromium (Cr(VI)) is a toxic heavy metal and its mobility and bioaccessibility in soils are influenced by soil properties. In this study, the soil pH and organic carbon contents of Ultisol , Alfisol , and Inceptisol were adjusted before they were polluted with 230 mg kg −1 Cr(VI). Alkaline digestion, sequential extraction, and an in vitro experiment were conducted to study the valence state, species, and bioaccessibility of Cr in the soils. The results showed that a high soil pH was not favorable for reduction of Cr(VI); therefore the Cr(VI) and exchangeable Cr contents were positively related to soil pH. Soil organic carbon promoted the reduction of Cr(VI). Almost all Cr(VI) was reduced to Cr(III) when the soil organic carbon content reached 10 g kg −1 . Chromium bioaccessibility in simulated gastric and intestinal phase solutions was influenced by Cr(VI) and Cr(III) adsorption/desorption, dissolution/precipitation, and redox reactions. Chromium bioaccessibility differences between the gastric and intestinal phases were associated with the Cr(VI)/Cr(III) ratio. Acidic conditions and a high organic carbon content promoted the conversion of Cr(VI) to Cr(III). When soil pH was increased from 4.01 to 5.85, Cr(VI) in Alfisol without the addition of humic acid increased from 96.38 to 174.78 mg kg −1 , the exchangeable Cr proportion increased from 9.7% to 22.6%, and Cr bioaccessibility increased from 41.29% to 49.14% in the gastric phase and from 41.32% to 48.24% in the intestinal phase. When the organic carbon content increased from 3.95 to 9.28 g kg −1 in Alfisol, Cr(VI) content decreased from 167.66 to 20.52 mg kg −1 , which led to a decrease in Cr bioaccessibility from 49.15% to 13.8% in the gastric phase and from 45.85% to 7.67% in the intestinal phase. Therefore, acidic conditions and increasing soil organic carbon levels can reduce the health risk posed by Cr in soils.
研究领域:
环境科学
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土壤学
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
·
2023
·Vol. 125
·期 10
·2300015
·
IF 2.7
Juan Tian,Guilin Peng,Xiaodi Qu,Yunping Yao,Changmo Li
Thiamine (VB 1 ) is an essential water-soluble vitamin that is necessary in our daily diet. However, its instability when exposed to external factors poses a limitation on its application in the food industry. To address this issue and increase its application in fat-rich food systems, this study developed liposoluble VB 1 microcapsules via freeze-drying, utilizing β-cyclodextrin as a wall material and polyglycerol fatty acid ester as an emulsifying agent. The VB 1 microcapsules were characterized in terms of their particle size distribution, morphology, solubility, and stability in soybean oil, as well as their in vitro bioaccessibility. The results showed that the average particle size of VB 1 microcapsules was 83.73 μm with a nonuniform, somewhat wrinkled spherical structure. The solubility of the VB 1 microcapsules in soybean oil was increased to 142.86 mg kg –1 . The retention rates of VB 1 in soybean oil was found to be above 95% after 48 h of UV irradiation and 96.44% after heating for 7 days at 60°C. The presence of VB 1 microcapsules did not significant impact on the oxidation stability of soybean oil. The bioaccessibility of VB 1 in soybean oil was 82.81%. This work provides a useful and novel direction for the application of VB 1 in high-fat diets. Practical applications: VB 1 is one of the B-group vitamins that assists in maintaining normal glucose metabolism. However, it is readily inactivated when exposed to UV radiation, certain pH conditions, and other factors. In this work, the VB 1 microcapsules prepared by freeze-drying exhibited high liposolubility, stability, and bioaccessibility, rendering them suitable for applications in oil-based systems. This work not only provides a new delivery system to facilitate VB 1 supplementation in humans, but also helps to elucidate its application prospect of VB 1 in fat-rich foods, such as edible oil, butter, margarine, rich-fat dressings, and so on, thus improves the application value of VB 1 .
研究领域:
食品科学
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营养学
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产品关联
DOI
高影响因子
Environmental Sciences Europe
·
2024
·Vol. 36
·期 1
·1-12
·
IF 6
Wang Beibei,Zhang Liwen,Feng Weiying,Zhang Han,Duan Xiaoli,Qin Ning
Dietary exposure to heavy metals and metalloids [metal(loid)s] deserves increased attention; however, there is a lack of a comprehensive understanding of the risks of dietary exposure from multi-type food intake and multi-metal(loid) exposure using a bioaccessibility-corrected method. Here, we determined the concentration and bioaccessibility of six toxic metal(loid)s in six major food groups in an industrial city with intensive smelting activity. By incorporating children’s dietary patterns, the probability distribution of health risks from dietary metal(loid)s exposure was assessed. Marked differences were observed in the dietary exposure characteristics within metal(loid)s and major food groups. Cereal and vegetables were the major food groups local children intake. Cereals, meat, beans, and aquatic products had the highest concentrations of Cu and Cd, Pb and Cr, Ni, and As, respectively. Generally, meat, eggs, and aquatic products exhibited higher bioaccessibility than cereals, beans, and vegetables. The bioaccessibility of metal(loid)s decreased in the following order: Pb > Cr > Cu > Ni > As > Cd. For non-carcinogenic risks, the average hazard index was 7.3, with 99.6% exceeding acceptable levels. Arsenic was the dominant risk element and aquatic product was the main risk source. The aggregated carcinogenic risk was 3.4 × 10–3, with Cr the major risk contributor and cereals and meat the dominant food sources. The findings demonstrated that (1) the metal(loid) dietary exposure risk of children from areas with intensive smelting activities should be taken seriously, and (2) it is necessary to identify the specific food category and metal(loid) based on a comprehensive analysis of the metal(loid) concentration and bioaccessibility, and dietary habits of the population to effectively reduce risk.
研究领域:
环境科学
·
公共卫生
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Pengfei Wang,Naiyi Yin,Xiaolin Cai,Huili Du,Yaqi Fu,Ziqi Geng,Sharmin Sultana,Guoxin Sun,Yanshan Cui
Rice, a staple food for half the world’s population, easily accumulates arsenic (As). Research on As distribution in rice protein and starch and its relationship with rice As bioaccessibility remains limited. This study investigated As distribution, chemical composition, As bioaccessibility and speciation in rice by continuous extraction and in vitro digestion. Of the total As, 87.5–94.5% was in rice protein and 5.0–9.8% in rice starch. The As amount in different protein fractions decreased as follows: glutelin > globulin > albumin > prolamin. As(V), As(III) and DMA in rice were more bioaccessible in the small intestinal phase than the gastric phase, and almost all As(V) dissolved in the small intestinal phase. Bioaccessible As in gastrointestinal digestive solution and As mass in protein fractions (albumin, globulin, and glutelin) were significantly positively correlated ( p < 0.05). These results illuminate the bioaccessibility of As to humans consuming As-contaminated rice and avoid overassessment.
研究领域:
食品安全
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环境科学
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营养学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2017
·
IF 4.9
Shujun Zhang,Chao Li,Yunzi Li,Ruirui Zhang,Peng Gao,Xinyi Cui,Lena Q. Ma
For hydrophobic organic contaminants , physiologically based in vitro methods may need to include a sorption sink to simulate in vivo intestinal uptake. We compared PAH bioaccessibility in contaminated soils using five in vitro methods including physiologically based extraction test (PBET), in vitro digestion assay (IVD), method from Deutsches Institut für Normung (DIN), unified bioaccessibility method (UBM), and fed organic estimation human simulation test (FOREhST) in the absence and presence of Tenax as a sorption sink. The PAH bioaccessibility without Tenax were pretty low with values ranging from below detection limit to 13.4%, indicating the limited capacity of these in vitro models to accommodate PAHs. With addition of Tenax, bioaccessibility increased to 0.59–75.5% for all PAH congeners. Even with the dominant effect of sorption sink, bioaccessibility values significantly varied among all the five methods with DIN result being the highest at 7.0–34.8%. Based on multiple linear regression, Tenax, incubation time, and bile contents are identified to be the most important factors in controlling bioaccessibility. The understanding of these key factors for bioaccessibility is highly necessary to standardize in vitro methods, which helps to refine the assessment of health risk through exposure to ingested contaminants.
研究领域:
环境科学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2014
·
IF 3.902
Chao Li,Xin−Yi Cui,Ying−Ying Fan,Ying Teng,Zhong−Ren Nan,Lena Q. Ma
Physiologically based in vitro methods have been developed to measure bioaccessibility of organic contaminants in soils. However, bioaccessibility of hydrophobic organic contaminants (HOCs) can be underestimated by in vitro tests if gastrointestinal (GI) solution fails to provide sufficient sorption sink for HOCs. To circumvent this drawback, Tenax was included in GI solution as sorption sink to trap mobilized HOCs and maintain the desorption gradient between soil and GI solution. Polycyclic aromatic hydrocarbons (PAHs) were selected as target HOCs, and physiologically based extraction test (PBET) was selected as the in vitro method. Inclusion of Tenax in GI solution increased bioaccessibility of PAHs in five spiked soils from 8.25–20.8% to 55.7–65.9% and the bioaccessibility of PAHs in a field contaminated soil from 3.70–6.92% to 16.3–31.0%. Our results demonstrated the effectiveness of Tenax as sorption sink to enhance PAH mobilization in bioaccessibility measurement in soils.
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Qiang Lin,Yasir Hamid,Honhang Wang,Min Lu,Xuerui Cao,Tong Zou,Zhiqin Chen,Bilal Hussain,Ying Feng,Tingqiang Li,Zhenli He,Xiaoe Yang
Foliar application of zinc (Zn) or silicon nanoparticles (Si-NPs) may exert regulatory effects on cadmium (Cd) accumulation in rice grains, however, their impact on Cd bioavailability during human rice consumption remains elusive. This study comprehensively investigated the application of Zn with or without Si-NPs in reducing Cd accumulation in rice grains as well to exactly evaluate the potential risk of Cd exposure resulting from the rice consumption by employing field experiment as well laboratory bioaccessibility and bioavailability assay. Sole Zn (ZnSO 4 ) or in combination with Si (ZnSO 4 +Si and ZnO+Si) efficiently lowered the Cd concentration in rice grains. However, the impact of bioaccessible (0.1215–0.1623 mg kg −1 ) and bioavailable Cd (0.0245–0.0393 mg kg −1 ) during simulated human rice consumption depicted inconsistent trend. The straw HCl-extractable fraction of Cd (F HCl-Cd ) exhibited a significant correlation with total, bioaccessible, and bioavailable Cd in grains, indicating the critical role of F HCl-Cd in Cd accumulation and translocation from grains to human. Additionally, foliar spraying of Zn+Si raised the nutritional value of rice grains, leading to increased protein content and reduced phytic acid concentration. Overall, this study demonstrates the potential of foliar application of ZnSO 4 +Si in mitigating the Cd levels in rice grains and associated health risks upon consumption.
研究领域:
环境科学
·
食品科学
·
农业科学
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产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Erpeng Chao,Jieying Li,Liuping Fan
This study provides valuable insights into the structural and functional characteristics of bigels containing hydrophilic (catechin, CAT) and lipophilic (curcumin, CUR) compounds, emphasizing the relationship between their rheological properties and digestive behavior. By adjusting the oleogel-to-hydrogel (OG-to-HG) ratios, bigels were tailored to exhibit distinct mechanical properties and digestion behaviors. The bicontinuous structure formed at a 5:5 OG-to-HG ratio (sample O5H5) exhibited delayed lipolysis and enhanced bioaccessibility of CUR (68.16% ± 1.78%) and CAT (56.16% ± 1.78%). This was supported by its high thixotropic recovery rate (76.43% ± 0.10%), longest delay time ( =12.33 ± 0.44 s), and optimal stress-stiffness ratio (S value = 0.81 ± 0.02), outperforming other structural configurations (OG-in-HG and HG-in-OG). This structure hinders the accessibility of digestive enzymes and bile salts, thereby slowing the breakdown of the lipid phase. Correlation analysis indicated strong positive relationships between the creep recovery rate and both the free fatty acid (FFA) release rate (r = 0.98, p < 0.001) and the bioaccessibility of CUR (r = 0.92, p < 0.01) and CAT (r = 0.93, p < 0.01). These findings suggest that enhanced resistance to deformation in the bigel matrix contributes to improved network integrity and increased bioaccessibility of co-encapsulated nutraceuticals. This study underscores the potential of bigel-based co-delivery systems in personalized nutrition.
研究领域:
食品科学
·
营养学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2018
·
IF 4.946
Ruyu Gong,Chunyue Ai,Baojun Zhang,Xianglei Cheng
The accumulation of organic selenium (Se) in grains is helpful in understanding its bioaccessibility in various Se-enriched rice cultivars after soil selenite treatments. In the present study conducted with two rice cultivars, the organic Se as well as the glutelin-derived Se and the selenomethionine (SeMet) percentage in grains increased with soil Se levels. The available Se that was detected in the forms of SeMet (∼40%) and selenite (∼12%) accounted for more than 50% of the total Se in grains, and no significant differences were observed between the two rice cultivars ( P > 0.05). Simulated gastrointestinal digestion showed that the digested grain SeMet increased with the soil Se treatment levels, whereas there were minimal changes in the percentages of selenite in the grain. Furthermore, approximately half of the available SeMet was derived from the grain glutelin . These results suggest that the non-glutelin-derived Se in rice should be further studied.
研究领域:
植物学
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）