INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinding Yu,Jian Wang,Shenglai Zhou,Peng Pan,Tiantian Chen,Xi Wang,Wentao Liu
Due to the extreme difficulty of cartilage, we endeavored to fabricate a novel biodegradable scaffold using natural polysaccharide cellulose and poly(lactic- co -glycolic acid) (PLGA) microspheres incorporating controllably released the cartilage inducer kartogenin (KGN) for enhancing regenerative healing in cartilage tissue. Initially, to facilitate the loading of KGN, PLGA/KGN microspheres were fabricated using the solvent volatilization method. These microspheres exhibited high sphericity, with particle sizes diminishing from 12.11 to 3.27 μm as the emulsification rate increased. Demonstrating adequate encapsulation efficiency, the microspheres enabled controlled drug release, positively influencing cell migration and recruitment. Subsequently, a biodegradable cellulose composite scaffold loaded with PLGA/KGN microspheres was prepared using the freeze-drying method. Compared with pure MCC scaffolds, composite scaffolds had a lower degradation rate, and the incorporation of microspheres promoted cell proliferation and significantly elevated expression of cartilage-related specific genes. In a rat cartilage defect model, it was further demonstrated that the composite scaffold combined with stem cell implantation achieved an optimal repair effect, characterized by vigorous extracellular matrix secretion and increased maturity of the regenerated cartilage tissues, suggesting potential clinical application value as a novel articular cartilage repair product in the future.
研究领域:
组织工程学
·
再生医学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
·
2024
·
IF 9.7
Gang Wang,Quancheng Shu,Jinzhi Sun,Yucan Liu,Xiaoyong Yang,Hao Lin,Jing Ding,Yanxiang Zhang,Lijuan Lan,Hongwei Sun
To recycle the nutrients in spiramycin (SPM) fermentation residue (SFR) through biological methods, acid hydrothermal treatment (AHT) was employed as pretreatment to enhance SFR biodegradability. The results showed that the degradation rate of residual SPM in SFR reached 100% after 120 min at 100℃ and 0.30 M acid with a 30.5% and 89.7% increase in proteins and polysaccharides, respectively. The SPM degradation was faster at higher acidity and temperature. However, elevated SPM concentration and the presence of protein, humic acid, and polysaccharide inhibited SPM degradation. The disintegration of SFR was evidenced by changes in its microstructure and could be predicted through the release of dissolved organic matter. Eight major SPM intermediates were identified with lower mutagenicity and antibacterial activity testing against Staphylococcus aureus . These results demonstrate that AHT not only disintegrates SFR but also degrades the residual SPM antibiotics, which implies the possibility for practical applications.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Furong Li,Tao Zhu,Bo Yuan,Jun Yang,Qiuge Ju,Weifang Li,Zefu Ye,Xudong Xu,Zhujun Zhu
Formaldehyde, even at low concentrations, poses a significant indoor pollutant risk, underscoring the need for efficient and sustainable sorbents. This study introduces a novel, multifunctional, and fully biodegradable adsorbent derived from waste shrimp shells. The shells were converted into soluble chitosan, which was then physically crosslinked with branched amine-modified alginate, resulting in a porous biuret-modified alginate/chitosan (BCC) polymer. BCC, with a 6 wt% biuret content, demonstrated exceptional adsorption performance for low-concentration formaldehyde, achieving a capacity of 1.97 mg·g −1 —159% higher than alginate and 149 % greater than activated carbon. The adsorption kinetics followed the pseudo-second-order model, and the Sips isotherm model suggested a chemical adsorption-dominated mechanism, with physical adsorption acting as a supplementary process. Additionally, BCC exhibited excellent reusability, maintaining high adsorption efficiency after four regeneration cycles, and incorporated a colorimetric signaling function, with a detection threshold of 0.07 mg·m −3 and a sensitivity of 0.02 mg·m −3 . These findings provide valuable insights and a theoretical basis for developing effective, safe, and environmentally friendly formaldehyde adsorbents.
研究领域:
材料科学
·
环境科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Xiaoxue Shi,Yun Zhu,Guiyou Wang
An ideal tissue engineering scaffold should possess mechanical properties and biodegradability that are compatible with the host tissue. To address this issue, the ring-opening polymerization of ε-caprolactone (ε-CL) was conducted in conjunction with polyether polyols, poly(propylene glycol) (PPG) and poly(trimethylene ether) glycol (PO3G), to synthesize the triblock copolymers PCL-PPG-PCL and PCL-PO3G-PCL. Subsequently, biodegradable polyurethanes (PUs) were synthesized utilizing these triblock copolymers as the soft segments, while a PU incorporating poly(ε-caprolactone) (PCL) as the soft segment served as a control group. The influence of block polyols on the structural, morphological, mechanical, and degradation properties of the resulting materials was systematically investigated. The findings indicate that the PU from the triblock copolymers exhibited lower modulus, tensile strength, and hardness, a higher degradation rate compared to the PU from PCL. Additionally, these polyether-ester-based PUs demonstrated superior elastic recovery at strains exceeding 100% in comparison to the control PU sample. Biodegradable PUs were fabricated into porous scaffolds through electrospinning, and the mechanical properties of these scaffolds were tailored by adjusting the fiber diameters, achieving a modulus as low as 2 MPa. The biodegradable PUs developed in this study possess a low initial modulus and tunable mechanical properties, indicating their potential application in scaffolding.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
CORROSION SCIENCE
·
2024
·
IF 7.4
Fei Gao,En Su,Jiaming Hou,Jiale Wang,Yukun Zhou,Haotian Qin,Zhenhai Xie,Jinlong Mao,Huaiyu Li,Wenjie Tao,Yingqi Chen,Junyu Qian,Guojiang Wan
Long-term corrosion profile of molybdenum was studied in three different simulated body fluids up to 28 days, compared with magnesium, zinc, and iron from the perspective of biodegradable metals (bio-metals). Their corrosion rate, mode, products and surface characteristics were comprehensively fathomed. Strikingly, Mo showed progressively advantageous long-term corrosion behavior with the smallest corrosion rate, and most importantly, more uniform mode, as compared with the other three bio-metals. It also performed bilaterally under the simulated inflammatory and bovine serum protein added conditions, with different corrosion progressions. These findings provide an optimistic outlook in opting molybdenum as a new type of bio-metal.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Duan Man,Han Dongmei,Shen Wenbin,Chang Kun,Wang Xinyu,Gao Nan,Du Jianshi
The lymphatic system plays a crucial role in the immune system’s recognition and response to disease. Therefore, the imaging of the lymphatic system, especially lymphatic vessels, has emerged as a valuable tool for the diagnosis of metastasis. FDA-approved small-molecule dyes, namely, indocyanine green (ICG), have been widely applied to lymphatic vessels imaging. However, due to the small physical size, such molecule-based agents show no selectivity, and rapid clearance from lymph nodes. Herein, a biodegradable lymphatic targeting imaging agent based on the ICG-mesoporous silicon system (ICG@HMONs-HA) was obtained, which not only could target lymph vessels but also had a long residence time. The reported work provides a practical way for lymph vessel fluorescence imaging and paves the way for clinical translation of nanomaterial-based tracers.
研究领域:
医学影像学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2012
·
IF 5.479
Huihui Kuang,Suhong Wu,Zhigang Xie,Fanbo Meng,Xiabin Jing,Yubin Huang
Biodegradable nucleobase-grafted amphiphilic copolymer, the methoxyl poly (ethylene glycol)-b-poly (L-lactide-co-2-methyl-2(3-(2,3-dihydroxylpropylthio) propyloxycarbonyl)-propylene carbonate/1-carboxymethylthymine) (mPEG-b- P(LA-co-MPT)), was synthesized. 1H NMR titration and FT-IR spectroscopy indicated that the hydrogen-bonding could be formed between mPEG-b-P(LA-co-MPT) and 9-hexadecyladenine (A-C16). The hydrophobic microenvironment of the amphiphilic copolymer can protect the complementary multiple hydrogen bonds between mPEG-b-P(LA-co-MPT) and A-C16 from water effectively. The addition of A-C16 not only lowered the critical aggregation concentration (CAC) of mPEG-b-P(LA-co-MPT)/A-C16 nanoparticles (NPs) in aqueous solution but also induced different morphologies, which can be observed by transmission electron microscopy (TEM). Meanwhile, dynamic light scattering (DLS) and turbidometry was utilized to evaluate the effect of temperature and pH change on the stability of mPEG-b-P(LA-co-MPT)/A-C16 NPs. Cytotoxicity evaluation showed good biocompatibility of the mPEG-b-P(LA-co-MPT)/A-C16 NPs. The in vitro drug release profile showed that with the increase of A-C16 content, the doxorubiucin (DOX) release at pH 7.4 decreased, while the faster release rate was observed with the addition of A-C16 with a pH of 5.0. Importantly, DOX-loaded NPs exerted comparable cytotoxicity against MDA-MB-231 cells. This work provided a new method to stabilize NP structure using hydrogen-bonds and would have the potential to be applied in controlled drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Xiaotong Zhao,Jingyi Li,Jing Dai,Zhan Qu,Xiaoyun Li,Yong Wu,Shijun Hu,Jian Fang,Zhenya Shen,Miao Xiao,Mingliang Tang
Bioelectricity plays a pivotal role in human physiology and pathology, particularly within the cardiovascular system. Myocardial ischemia disrupts the normal transmission of electrical signals through the heart, leading to cardiomyocyte death, ventricular remodeling, and ultimately heart failure. Electrical stimulation (ES) has been proven to be an effective strategy for treating cardiac diseases. However, invasive electrode implantation and the unique anatomical position of the heart limit the clinical application of ES therapy. Developing wireless ES systems that effectively enhance bioelectric propagation and electrical activity in the heart can significantly advance therapeutic interventions. In this study, a lead-free, biodegradable and the Food and Drug Administration approved poly-L-lactic acid piezoelectric nanofiber is designed for wireless ES to the myocardium under ultrasonic stimulation, thus promoting structural and functional recovery of cardiac tissue in murine myocardial infarction model. Further study shows that the ultrasound-driven wireless ES system significantly enhanced mitochondria function and angiogenesis in vivo and in vitro experiments. Additionally, the ES system can regulate intracellular calcium ion concentration and cardia tissue contraction rhythm of isolated neonatal rat. Collectively, the findings offer a novel approach for the treatment of heart diseases and potential cardiac pacing applications under the ultrasound-driven wireless ES system.
研究领域:
生物医学工程
·
心血管疾病治疗
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Liyuan Rong,Xiaoyao Ji,Mingyue Shen,Xianxiang Chen,Xing Qi,Yulin Li,Jianhua Xie
The widely use of petroleum-based plastics causes serious environmental pollution and oil resource shortage. In this work, biodegradable films were prepared based on gallic acid (GA)-induced Chinese yam starch (YS) and chitosan (CS). The fresh-keeping effect of biodegradable films on the pork meat preservation were investigated. The prepared GA/YS/CS biodegradable films exhibited thinner thickness and better light transmittance, because CS effectively decreased the viscosity of film-forming solution and weaken its internal link structure. The SEM results and mechanical results revealed that the YS, GA, and CS had a good compatibility, GA modification and adding CS markedly improved the tensile strength of YS-based film, because the interaction between CS and starch molecular was facilitate owing to the NH 3 + of CS tended to form hydrogen bonds with the hydroxyl group of starch. Sensory analysis results suggested that GA/YS/CS films can effectively improve the quality of pork during storage compared to the package of polyethylene film. In summary, the prepared GA/YS/CS film in this work had practical application potential in pork preservation due to its excellent mechanical, antibacterial, oxidation resistance properties, and the development and application of biodegradable starch film can greatly reduce the increasingly serious environmental pollution pressure.
研究领域:
食品科学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2017
·Vol. 5
·期 4
·669-677
·
IF 4.21
Chao Wei,Yan Zhang,Zhongchen Song,Yiru Xia,Heng Xu,Meidong Lang
Stimuli-responsive nanocarriers have been limited for bench-to-bedside translation mainly because the stimuli sensitivity and responsive rate are not high enough to ensure sufficient drug concentration at the target sites for superior therapeutic benefits. Herein, we reported an enhanced bioreduction-responsive and biodegradable nanocarrier based on the amphiphilic poly(ester urethane) copolymers (PAUR-SeSe) bearing multiple diselenide groups on the backbone. The copolymer could spontaneously self-assemble into stable micelles in aqueous medium with an average diameter of 68 nm, which could be rapidly disassembled in a reductive environment as a result of the reduction-triggered cleavage of diselenide groups. Furthermore, the PAUR-SeSe micelles showed an enhanced drug release profile and cellular uptake compared with the disulfide-containing analogue (PAUR-SS). CCK8 assays revealed that the antitumor activity of DOX-loaded PAUR-SeSe micelles was much higher than that of DOX-loaded PAUR-SS micelles. Besides, the blank micelles and degradation products were nontoxic up to a tested concentration of 50 μg mL−1. Therefore, the enhanced therapeutic efficacy and good biocompatibility demonstrated that this drug nanocarrier had great potential for smart antitumor drug delivery applications.
研究领域:
药剂学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2013
·Vol. 214
·期 20
·2266-2275
·
IF 2.386
Jixian Liu,Zhen Liu,Xiong Luo,Xidan Zong,Jingquan Liu
The preparation of biodegradable and positively charged graphene–polymer nanocomposite for DNA uptake and release is presented. A pyrene-terminated poly(2-(dimethylamino) ethyl acrylate) is firstly synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization, followed by the attachment onto the graphene surface via the π–π stacking interaction. The positively charged polymer brushes benefit the uptake of the negatively charged DNA fragment via static interaction and the built-in disulfide linkage between the polymer chain and graphene surface allows the biodegradable release of DNA in the presence of reducing agents. X-ray photoelectron spectroscopy manifests the binding of DNA molecules to the polymer chains and agarose gel electrophoresis confirms the release of DNA.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 25
·2301398
·
IF 29.4
Guowen Zhou,Haishan Zhang,Zhiping Su,Xiaoqian Zhang,Haonan Zhou,Le Yu,Chaoji Chen,Xiaohui Wang
The growing environmental concern over petrochemical-based plastics continuously promotes the exploration of green and sustainable substitute materials. Compared with petrochemical products, cellulose has overwhelming superiority in terms of availability, cost, and biodegradability; however, cellulose's dense hydrogen-bonding network and highly ordered crystalline structure make it hard to be thermoformed. A strategy to realize the partial disassociation of hydrogen bonds in cellulose and the reassembly of cellulose chains via constructing a dynamic covalent network, thereby endowing cellulose with thermal processability as indicated by the observation of a moderate glass transition temperature ( T g = 240 °C), is proposed. Moreover, the cellulosic bioplastic delivers a high tensile strength of 67 MPa, as well as excellent moisture and solvent resistance, good recyclability, and biodegradability in nature. With these advantageous features, the developed cellulosic bioplastic represents a promising alternative to traditional plastics.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）