JOURNAL OF RARE EARTHS
·
2014
·Vol. 32
·期 8
·686-690
·
IF 1.342
LIU Lisha,CHEN Haohong,LIU Biqiu,ZHANG Hui,TANG Bin,FENG Xianjuan,SUN Zhijia,ZHAO Jingtai
To explore novel nano-scintillator with a controllable architecture, pure and Eu 3+ doped lutetium oxyfluoride (Lu 7 O 6 F 9 ) powder were synthesized by combining mild hydrothermal method and solid state calcination approach. The products were all pure orthorhombic Vernier phase demonstrated by X-ray powder diffraction (XRD). The detailed crystal structure was also studied by Reitveld refinement. Lath-like microcrys tals composed of nanoparticles with unique hollow tube of the products were supported by the images of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Excited by X-ray with W as the target, the pure product showed intense broad emission with the peak at about 400 nm suitable for modern photoelectric multiplier tube (PMT), while the Eu 3+ doped sample transferred the incident energy to Eu 3+ ions and gave strong 5 D 0 → 7 F j ( j =0, 1, 2 and 4) emission, which fitted for imaging and labeling measurements. From the luminescent properties, both pure and Eu 3+ -doped products are potential excellent scintillator for X-ray imaging and other high energy detectors, and the pure product is also a good host candidate for rare earth doping.
研究领域:
材料科学
·
无机化学
·
发光材料
·
纳米医学
·
生物成像
·
辐射探测
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2014
·Vol. 44
·期 1
·237-246
·
IF 4.097
Ying Liu,Lining Sun,Jinliang Liu,Yu-Xin Peng,Xiaoqian Ge,Liyi Shi,Wei Huang
A novel mesoporous nanosphere functionalized with 3-(aminopropyl)triethoxysilane (APTES) and 2-(5-bromothiophen)imidazo[4,5-f][1,10]phenanthroline (5-Br-Tip) was synthesized (denoted as Tip-MSS). With the coordinating function of the 5-Br-Tip to lanthanide (Ln) ions, for the first time, LnL3(5-Br-Tip) complexes were linked to the mesoporous nanospheres. The derived materials, named Ln-Tip-MSS (Ln = Eu, Tb, Sm, Nd, Yb), were characterized by Fourier-transform infrared (FT-IR) spectroscopy, TEM, XRD (wide-angle and small-angle), N2 adsorption/desorption analysis, and fluorescence spectroscopy. Upon excitation in the ligand absorption, the Ln-Tip-MSS nanomaterials show characteristic visible (Eu, Tb, Sm) and NIR (Sm, Nd, Yb) luminescence (multicolor emission covered from 450 nm to 1400 nm spectral region). Of importance is that, with low cytotoxicity and good biocompatibility given by the methyl thiazolyl tetrazolium (MTT) assay, the Eu-Tip-MSS was successfully applied to cell imaging in vitro based on the Eu3+ luminescence (under 405 nm excitation).
研究领域:
纳米医学
·
生物成像
·
材料科学
·
分子探针
·
化学生物学
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 17
·8278-8283
·
IF 4.197
Zhiqiang Ye,Quankun Gao,Xin An,Bo Song,Jingli Yuan
A unique ruthenium(II) complex, [Ru(bpy)2(DNS-bpy)](PF6)2 [bpy: 2,2′-bipyridine, DNS-bpy: 4-(2,4-dinitrophenylthio)-2,2′-bipyridine], that can act as a probe for the recognition and luminescence sensing of biothiols has been designed and synthesized. Due to the presence of effective photo-induced electron transfer (PET) from the potent electron donor (Ru-bpy centre) to the strong electron acceptor (2,4-dinitrophenyl moiety), the Ru(II) complex itself is weakly luminescent. Reaction of [Ru(bpy)2(DNS-bpy)](PF6)2 with biothiols leads to the replacement of the 2,4-dinitrophenyl moiety by biothiols, which results in the loss of PET within the complex, to allow recovery of the MLCT-based emission of the Ru(II) complex with an 80-fold increase in luminescence intensity. Taking advantage of the high specificity and sensitivity, and the excellent photophysical properties of Ru(II) complexes, [Ru(bpy)2(DNS-bpy)](PF6)2 was successfully applied to the luminescence imaging of biothiols in living Daphnia magna. The results demonstrated the practical applicability of [Ru(bpy)2(DNS-bpy)](PF6)2 as a luminescent probe for the monitoring of biothiols in living bodies.
研究领域:
分析化学
·
分子生物学
·
化学生物学
·
生物成像
·
无机化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2015
·
IF 2.999
Chuanying Wang,Xianhua Cheng
β-NaYF 4 :Yb 3+ /Er 3+ microcrystals codoped with Cr 3+ ions were prepared for the first time via a facile hydrothermal method . The influence of doping concentration of Cr 3+ ions on growth and upconversion (UC) luminescence properties of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals were investigated in detail. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra and photoluminescence (PL) spectra were used for characterization. The results demonstrated that the morphology and size of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals were influenced by doping concentration of Cr 3+ ions, the possible mechanism was proposed. The UC intensity of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals was significantly enhanced by doping of Cr 3+ ions. In contrast to β-NaYF 4 :Yb 3+ /Er 3+ microcrystals without doping of Cr 3+ ions, the green and red emission intensities of the microcrystals codoped with 15 mol% Cr 3+ ions were enhanced by 16 and 7 times, respectively. The enhancement of the UC intensities should be ascribed to the distortion of local symmetry around Er 3+ ions, the UC mechanism was discussed. This work will be helpful for improving the UC intensity of other lanthanide-doped UC nano- and micro-crystals.
研究领域:
材料科学
·
无机化学
·
光功能材料
·
纳米医学
·
生物成像
·
分子影像学
·
光学材料
✓ 已验证
DOI
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
Ruming Jiang,Meiying Liu,Tingting Chen,Hongye Huang,Qiang Huang,Jianwen Tian,Yuanqing Wen,Qian-yong Cao,Xiaoyong Zhang,Yen Wei
The research in fluorescent organic nanoparticles (FONs) with aggregation-induced emission (AIE) feature shows an upward trend due to their outstanding optical properties and potential biomedical applications . In this work, a novel strategy has been developed for the first time through a catalyst-free azide-alkyne click reaction, which could directly conjugate azide containing polymers (PEGMA-AGE-N 3 ) and alkyne terminating AIE dye (named as PhE-OE) under mild experimental conditions. The final PEGMA-AGE-PhE copolymers containing AIE-active dye could self-assemble into FONs with intense fluorescence owing to their AIE feature. These PEGMA-AGE-PhE FONs were characterized by a series of characterization techniques in details. The cell viability as well as cell uptake behavior of PEGMA-AGE-PhE FONs was also examined to evaluate their potential for biomedical applications. We demonstrated that the catalyst-free azide-alkyne click reaction is effective for fabrication of AIE-active FONs and these AIE-active FONs showed high water dispersity and AIE feature. Moreover, the PEGMA-AGE-PhE FONs also exhibited low cytotoxicity and great potential for biological imaging. Taken together, a facile catalyst-free azide-alkyne click reaction with high efficiency has been developed for the preparation of AIE-active FONs, which showed excellent physicochemical properties for biological imaging applications.
研究领域:
材料科学
·
纳米技术
·
生物成像
·
聚合物化学
·
有机电子学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Yuan Jiao,Yifang Gao,Yating Meng,Wenjing Lu,Yang Liu,Hui Han,Shaomin Shuang,Lei Li,Chuan Dong
The construction of ratiometric fluorescence assay has displayed fantastic advantages in improving semi-quantitative visualization capability by presenting successive color changes. Herein, long-wavelength emission nitrogen-doped carbon dots (N-CDs) were developed for intrinsic ratiometric detection of silver ions (Ag+) and glutathione (GSH), accompanied by visualization fluorescence variation of orange and green. The label-free N-CDs were favorably obtained through one-step hydrothermal synthesis and displayed single long-wavelength emission at 618 nm under the excitation wavelength of 478 nm. Interestingly, a ratio rising peak emerges at 532 nm and the emission at 618 nm decreases with the introduction of Ag+, which exhibits ratiometric fluorescence emission characteristics (I618nm/I532nm) in the range of 0–140 μM with significant fluorescence varying from orange to green. Furthermore, the fluorescence of CDs@Ag(I) can be effectively ratiometric recovered by virtue of a specific reaction of GSH with Ag+, which is accompanied by the fluorescence of the solution returning from green to orange. In addition, the N-CDs hold excellent biocompatibility which can be implemented as the visualization biosensing platform for intracellular determination of Ag+ and GSH, demonstrating that proposed N-CDs have tremendous potential in biological systems.
研究领域:
分析化学
·
纳米材料
·
生物传感器
·
生物成像
·
环境监测
·
生物医学工程
✓ 已验证
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 44
·期 37
·16528-16533
·
IF 4.197
Z. C. Liu,W. P. Zhu,Y. H. Chen,Y. X. Li,Y. J. Ding,W. J. Yang,K. Li
In this paper, a simple small molecule (L) based on 4-(diethylamino)-2-hydroxy-benzaldehyde and carbohydrazide has been synthesized and characterized. Moreover, under ultrasonic conditions, a host–guest system with β-cyclodextrin and L was obtained. According to the hybridization process, the host–guest system showed excellent water solubility. The investigation of the fluorescence spectra revealed that the host–guest system exhibited a characteristic fluorescence behavior toward Al3+ in a pure water environment. Upon addition of Al3+, the host–guest system showed a strong blue fluorescence, which resulted from the fluorophore of L after the coordination of β-CD–L and Al3+ with a high binding constant (k = 3.1626 × 1011 M−1). In addition, SEM images demonstrated that the host–guest system expressed good crystallization behavior. Fluorescence microscope images of onion epidermal cells with β-CD–L–Al3+ proved that the water-soluble host–guest system possessed a high ability for cell permeability.
研究领域:
分析化学
·
超分子化学
·
荧光传感
·
环境监测
·
生物成像
✓ 已验证
DOI
高影响因子
Advanced Optical Materials
·
2024
·Vol. 12
·期 15
·2303018
·
IF 8
Xueqing Liu,Lu Chen,Xiaowen Huo,Feng Liu,Chuan Liao,Liangliang Zhang,Jiahua Zhang,Shaoan Zhang,Yang Li,Xiao-jun Wang,Yichun Liu
The ZnGa 2 O 4 :Cr 3+ phosphor has emerged as a significant luminescent material due to its long-lasting afterglow and near-infrared emission, making it suitable for applications in bioimaging and night-vision detection. However, the limited availability of excitation light sources poses a challenge for charging the phosphor. In this study, the charging capabilities of ZnGa 2 O 4 :Cr 3+ using visible lasers and a white flashlight as excitation sources are explored. By absorbing two excitation photons, the high-lying delocalized state of Cr 3+ can be excited through a two-step process, resulting in the filling of persistent luminescence traps and producing a long-lasting emission peaking at 696 nm. The application of the white flashlight revealed a nonlinear excitation threshold for charging at 1.5 mW cm −2 . The findings also uncovered that the excitation mechanism involves excited-state absorption and energy-transfer upconversion. Moreover, taking advantage of the unique excitability of the near-infrared persistent phosphor, the potential for charging persistent luminescent probes in vivo using chicken breast tissue as a representative model is showcased. The present upconversion charging approach may offer promising possibilities and introduce a novel excitation technique for ZnGa 2 O 4 :Cr 3+ persistent phosphor.
研究领域:
材料科学
·
光子学
·
发光材料
·
生物成像
·
光学传感
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Hongjun Song,Weijie Zhang,Ya Zhang,Caixia Yin,Fangjun Huo
Intracellular viscosity plays an important role for maintaining the diffusion, transportation, signal transmission and cell metabolism between biomolecules. And abnormal intracellular viscosity would cause various concurrent diseases such as fatty liver, hyperlipidemia and so on. However, as far as we know, there are quite few tools could be used for imaing of intracellular viscosity, much less in-depth investigation of the viscosity-related dysfunctional and disease. Herein, we have designed and developed a series of NIR fluorescent probes , in which the chemical bond between fluorophore and molecular rotor was designed with single bonds, double bonds, and extended double bonds, respectively. According to the theoretical calculations and experiments results, BP-III with was selected as the most sensitive fluorescence sensor for imaging viscosity change in vitro and in vivo. As the viscosity increasesd, the TICT (twisted intramolecular charge transfer) of BP- III was inhibited, accompanied with a strong red fluorescence enhancement at 740 nm. In addition, BP- III showed excellent mitochondrial target ability and can be used to imaging viscosity changes in mitochondrial of living cells. More importantly, the probe has been used for imaging the abnormal viscosity of fatty liver at the organ level. We expect this work would provide meaningful tool for promoting fundamental research in biological viscous environment and mitochondrial viscosity related diseases.
研究领域:
生物成像
·
分子探针
·
线粒体生物学
·
代谢性疾病
·
荧光光谱学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Wanyun Liu,Junchao Wei,Yiwang Chen,Ping Huo,Yen Wei
Photoluminescent fullerene nanoparticles/nanofibers have potential applications in bioimaging. A novel fluorescent nanofibrous material, consisting of fullerene nanoparticles and poly(L-lactide) (PLLA), was fabricated via a simple electrospinning method, and the composite nanofibers were characterized by various techniques such as scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM), and transmission electron microscopy (TEM). The nanofibers were uniform, and their surfaces were reasonably smooth, with the average diameters of fibers ranging from 300 to 600 nm. The fullerene nanoparticles were encapsulated within the composite nanofibers, forming a core–shell structure. The nanofiber scaffolds showed excellent hydrophilic surface due to the addition of water-soluble fullerene nanoparticles. The composite nanofibers used as substrates for bioimaging in vitro were evaluated with human liver carcinoma HepG2 cells, the fullerene nanoparticles signal almost displayed in every cell, implying the potential of fluorescent fullerene nanoparticles/PLLA nanofibers to be used as scaffolds for bioimaging application.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
生物成像
·
高分子科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）