MATERIALS LETTERS
·
2018
·
IF 2.687
Huan Zhou,Ying Yang,Mengmeng Yang,Wenjie Wang,Yaping Bi
Mesoporous hydroxyapatite is widely applied in biomedical and environmental fields due to its high surface area and adsorption capacity. In current work a one-step hydrothermal method to synthesize mesoporous HA was developed with the assistance of a cost-effective template vitamin C. It was observed the pore size and morphology of hydrothermally synthesized HA were correlated to applied solution composition. A combination of calcium hydroxide, orthophosphate, and vitamin C can finally result in mesoporous rod-like HA nanoparticles with surface area of 88 m 2 .g −1 and pore size of 15.7 nm on average. The mesoporous HA exhibited enhanced adsorption of model drug doxorubicin in comparison to conventionally synthesized HA as expected. Consequently, this work provides new pathway to prepare mesoporous HA with advantages of economy and convenience.
研究领域:
生物材料学
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纳米医学
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药剂学
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环境科学
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生物无机化学
✓ 已验证
DOI
高影响因子
Journal of Chemistry
·
2021
·Vol. 2021
·期 1
·5685596
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IF 2.506
Jia Ma,Jianer Wang,Yuping He,Yiwei Huang,Yejun Chen
Solvothermal reaction of 4,4’,4’-nitrilotribenzoic acid (H 3 TCA) with Ca(NO 3 ) 2 ·4H 2 O and Cd(NO 3 ) 2 ·4H 2 O successfully afforded a heterometallic compound, that is, [Cd 2 Ca(TCA) 2 (DMA) 2 (H 2 O) 3 ] n ·2n(DMA) ( 1 , DMA = N,N’-dimethylacetamide). The structure of 1 was further characterized through EA, diffraction of single crystal X-ray, and thermogravimetric analysis (TGA) together with powder X-ray diffraction (PXRD). Moreover, complex 1 ’s luminescent performance in solid state was also discussed at environmental temperature. The applications on the ischemic cerebral infarction therapy were evaluated, and the specific mechanism was investigated at the same time. Firstly, the hypersensitivity C-reactive protein (hs-CRP) content in human brain microvascular endothelial cell (HBMEC) was measured with real-time reverse transcription-polymerase chain reaction (RT-PCR). Then, interleukin-18 and interleukin-1 β content released through the HBMEC was detected with enzyme-linked immunosorbent assay (ELISA).
研究领域:
生物无机化学
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神经药理学
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炎症生物学
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转化医学
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分子影像学
✓ 已验证
DOI
高影响因子
CHEMICAL COMMUNICATIONS
·
2024
·Vol. 61
·期 8
·1701-1704
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IF 4.3
Hao-Xing Xu,Ze-Run Zhao,Xiao Wang
This study demonstrates that metal-doped-clay (MDC) can be a selective platform for ribose produced from formaldehyde under abiotic conditions. Ribose exhibits superior retention compared with other carbohydrates on naturally occurring minerals on the early Earth in the presence of divalent cations. This finding offers an insight into the necessity of the emergence of ribose as the backbone of extant RNA.
研究领域:
化学生物学
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分子进化
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前生命化学
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地球生物学
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生物无机化学
✓ 已验证
DOI
高影响因子
ORGANOMETALLICS
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2013
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IF 4.145
Huili Chen,Xiaokai Li,Ruichun Bai,Yanbo Wu,Yingfang Fan,Jianbin Chao
A phosphorescent probe, Ir(ppy)2Cl(DMF) (Ir2), for cysteine (Cys) is reported. The recognition is based on the time-dependent emission of Ir2-Cys. Importantly, this probe can discriminate Cys rapidly from homocysteine (Hcy). Probe Ir2 displays a highly selective 72 nm of luminescent red-shift toward Cys within 30 min with an obvious emissive color change from green to orange. After 30 min, the emission band blue shifts gradually with an emissive change from orange to green. TDDFT combined with CV studies indicates that the different emission profile is ascribed to the different binding modes of Ir2 to Cys with time. The probe can be used to determine Cys in semiaqueous solution.
研究领域:
无机化学
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分析化学
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生物无机化学
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发光传感器
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分子探针
✓ 已验证
DOI
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2019
·Vol. 33
·期 11
·e5196
·
IF 3.259
Hui-Min Lin,Jian-Rong Li,Chao Mu,Ao Li,Xu-Feng Liu,Pei-Hua Zhao,Yu-Long Li,Zhong-Qing Jiang,Hong-Ke Wu
Five monophosphine-substituted diiron propane-1,2-dithiolate complexes as the active site models of [FeFe]-hydrogenases have been synthesized and characterized. Reactions of complex [Fe 2 (CO) 6 {μ-SCH 2 CH(CH 3 )S}] ( 1 ) with a monophosphine ligand tris(4-methylphenyl)phosphine, diphenyl-2-pyridylphosphine, tris(4-chlorophenyl)phosphine, triphenylphosphine, or tris(4-fluorophenyl)phosphine in the presence of the oxidative agent Me 3 NO·2H 2 O gave the monophosphine-substituted diiron complexes [Fe 2 (CO) 5 (L){μ-SCH 2 CH(CH 3 )S}] [L = P(4-C 6 H 4 CH 3 ) 3 , 2 ; Ph 2 P(2-C 5 H 4 N), 3 ; P(4-C 6 H 4 Cl) 3 , 4 ; PPh 3 , 5 ; P(4-C 6 H 4 F) 3 , 6 ] in 81%–94% yields. Complexes 2 – 6 have been characterized by elemental analysis, spectroscopy, and X-ray crystallography. In addition, electrochemical studies revealed that these complexes can catalyze the reduction of protons to H 2 in the presence of HOAc.
研究领域:
无机化学
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生物无机化学
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电化学
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催化化学
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分子材料
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2016
·Vol. 34
·期 12
·1329-1334
·
IF 1.872
Keli Zhong,Jie Zhao,Xue Zhou,Shuhua Hou,Yanjiang Bian,Jianrong Li,Lijun Tang
A new (8-hydroxyquinolin-2-yl)methylene picolinohydrazide derivative ( L ) has been successfully synthesized and characterized. The probe L displays high selectivity to Co 2+ in CH 3 CN/HEPES (1:1, Ｖ / Ｖ , 10 mmol·L −1 , pH=7.4) with a fluorescence "ON-OFF" response. The Co 2+ ion recognition event possesses some distinct features including rapid response, high selectivity and sensitivity, good anti-interference ability and being applicable within a wide pH range. Based on job's plot and ESI-MS studies, the 1:1 binding mode was proposed. The binding constant of L and Co 2+ is 1.63×10 8 L·mol −1 and the detection limit is 1.15 µmol·L −1 . Natural water samples experiments revealed that probe L can be potentially applied to the detection of Co 2+ in real environment.
研究领域:
分析化学
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生物无机化学
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分子探针
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环境监测
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荧光传感
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Haibin Li,Fei Jiang,Song Ye,Yingying Wu,Kaiping Zhu,Deping Wang
The strontium-substituted hydroxyapatite microspheres (SrHA) incorporated alginate composite microspheres (SrHA/Alginate) were prepared via adding SrHA/alginate suspension dropwise into calcium chloride solution, in which the gel beads were formed by means of crosslinking reaction. The structure, morphology and in vitro bioactivity of the composite microspheres were studied by using XRD, SEM and EDS methods. The biological behaviors were characterized and analyzed through inductively coupled plasma optical emission spectroscopy (ICP-OES), CCK-8, confocal laser microscope and ALP activity evaluations. The experimental results indicated that the synthetic SrHA/Alginate showed similar morphology to the well-known alginate microspheres (Alginate) and both of them possessed a great in vitro bioactivity. Compared with the control Alginate, the SrHA/Alginate enhanced MC3T3-E1 cell proliferation and ALP activity by releasing osteoinductive and osteogenic Sr ions. Furthermore, vancomycin was used as a model drug to investigate the drug release behaviors of the SrHA/Alginate, Alginate and SrHA. The results suggested that the SrHA/Alginate had a highest drug-loading efficiency and best controlled drug release properties. Additionally, the SrHA/Alginate was demonstrated to be pH-sensitive as well. The increase of the pH value in phosphate buffer solution (PBS) accelerated the vancomycin release. Accordingly, the multifunctional SrHA/Alginate can be applied in the field of bioactive drug carriers and bone filling materials.
研究领域:
生物材料学
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骨组织工程
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药物递送系统
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生物医学工程
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再生医学
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生物无机化学
·
药剂学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）