Coatings
·
2022
·Vol. 12
·期 9
·1351
·
IF 3.236
Hongqin Zhu,Ji Tan,Jiajun Qiu,Donghui Wang,Zhe Zhao,Zihan Lu,Gaoshan Huang,Xuanyong Liu,Yongfeng Mei
Titanium and its alloys have been widely used for orthopedic and dental implants. However, implant failures often occur due to the implant-related bacterial infections. Herein, titanium oxide nanotubes (TNTs) with an average diameter of 75 nm were formed by anodizing on the surface of titanium, and subsequently gold (Au) nanoparticles were deposited on TNTs by magnetron sputtering (Au@TNTs). The antibacterial study shows that TNTs surface decorated with Au nanoparticles exhibits the preferable effect in restricting the growth ofEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) even under dark conditions, and the antibacterial rates reached 84% and 75%, respectively. In addition, the constructed film showed no cytotoxicity. Such a selective bactericidal effect of Au@TNTs samples might be attributed to the photocatalytic memory effect, which provides a new insight in the designing of antibacterial surfaces for biomedical application.Keywords:biomaterials;nanoparticles;porous materials;sputtering
研究领域:
生物学
·
医学工程
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DOI
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2024
·Vol. 89
·期 10
·2812-2822
·
IF 2.5
Li Chen,Liu Jing,Lou Guanchen,Yu Chuning
View large Download slide View large Download slide Close modal The sequential extraction routes of biogenic materials from sewage sludge (SS) were investigated. Physical methods (ultrasound, heating) and chemical methods (sodium hydroxide, sodium carbonate) were used to extract extracellular polymeric substances (EPS) and alginate-like extracellular polymers (ALEs) from SS. The residues after extraction were further subjected to physical methods (heating) and chemical methods (sulfuric acid, sodium hydroxide) for protein extraction. A comparison was made between sequential extraction routes and direct extraction of biomaterials from sludge in terms of extraction quantity, material properties, and applicability. The results showed that sequential extraction of biomaterials is feasible. The highest extraction quantities were obtained when using sodium carbonate for EPS and ALE extraction and sodium hydroxide for protein, reaching 449.80 mg/gVSS, 109.78 mg/gVSS, and 5447.08 mg/L, respectively. Sequential extraction procedures facilitate the extraction of biomaterials. Finally, suitable extraction methods for different application scenarios were analyzed. Reported sequential extraction route of biomaterials from sludge. Sequential extraction enhanced the release of biomaterials. Appropriate extraction methods for different scenarios are clarified.
研究领域:
环境科学
·
生物技术
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DOI
PubMed
高影响因子
2D Materials
·
2020
·Vol. 7
·期 2
·022004
·
IF 7.14
Valentina Palmieri,Wanda Lattanzi,Giordano Perini,Alberto Augello,Massimiliano Papi,Marco De Spirito
Reconstruction of bone defects with the efficient restoration of tissue morphology and functionality is a critical medical challenge. Progress in 3D printing technologies offers new opportunities for precise bone architecture reproduction during scaffolds construction. At the same time, biomaterials are being designed and produced to achieve the desired functional, mechanical and supportive features and to guide cell behavior in vivo. Latest progress in biomaterials research makes the family of bidimensional carbon materials in the spotlight for their excellent bone regeneration and mechanical properties. Graphene, graphene oxide and reduced graphene oxide can also be 3D printed to obtain patient-tailored scaffolds with controlled feature sizes in the mesoscopic range. In this review, we describe technologies developed for graphene 3D printing focusing on the osteogenic properties of graphene scaffolds. The multiple benefits achievable by a proper design of the graphene surface as well as the concerns on their biocompatibility are also highlighted. We believe that this overview of the latest progress and trends will provide the basis for the future improvement of implantable graphene bone grafts.
研究领域:
生物医学工程
·
材料科学
·
再生医学
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DOI
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Zhang Liwen,Zhao Jinhong,Zhang Jie,Lou Bang,Li Huijie,Guo Fangyuan,Yang Gensheng,Hong Weiyong
The convergence of advanced materials science and additive manufacturing technologies has revolutionized medical applications ranging from orthodontic devices to patient-specific bone fixation systems. Despite these advancements, the clinical translation of 3D-printed orthopedic implants remains constrained by suboptimal biocompatibility of conventional manufacturing materials. This study systematically evaluates dental resin-based composites as alternative biomaterials for bone fixation devices, hypothesizing that their rapid photopolymerization kinetics, mechanical robustness, and inherent biocompatibility can address current limitations. Through stereolithography technology, ceftriaxone sodium-loaded bone fixation devices were developed with customized geometries tailored to diverse anatomical requirements. Material optimization revealed that a 7:3 ratio of ethoxylated bisphenol A dimethacrylate (BPA2EODMA) to triethylene glycol dimethacrylate (TEGDMA) achieved optimal mechanical performance. Cytocompatibility assessment using L929 fibroblasts demonstrated > 70% cell viability, confirming minimal cytotoxicity. The drug-eluting implants exhibited potent antimicrobial efficacy in 8-h elution assays, showing inhibition rates of 49.14 ± 4.89% ( Staphylococcus aureus ), 48.38 ± 5.88% ( Escherichia coli ), and 26.79 ± 2.69% ( Candida albicans ). These results validate the dual functionality of antibiotic-loaded dental resin constructs, positioning them as promising candidates for patient-specific orthopedic solutions that simultaneously address mechanical stability, osseointegration, and infection prevention.
研究领域:
生物医学工程
·
材料科学
·
药理学
·
骨科
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Xin Chen,Wenhao Liu,Chi Su,Jianyang Shan,Xiang Li,Yimin Chai,Yaling Yu,Gen Wen
Articular cartilage defects can lead to pain and even disability in patients and have significant socioeconomic loss. Repairing articular cartilage defects remains a long-term challenge in medicine owing to the limited ability of cartilage to regenerate. At present, the treatment methods adopted in clinical practice have many limitations, thereby necessitating the rapid development of biomaterials. Among them, decellularized biomaterials have been particularly prominent, with numerous breakthroughs in research progress and translational applications. Although many studies show that decellularized cartilage biomaterials promote tissue regeneration, any differences in cellular morphology, dynamics, and functionality among various biomaterials upon comparison have not been reported. In this study, we prepared cartilage-derived extracellular matrix (cdECM) biomaterials with different bioactive contents and various physical properties to compare their effects on the morphology, dynamics and functionality of chondrocytes. This cellular multimodal analysis of the characteristics of cdECM biomaterials provided a theoretical basis for understanding the interactions between biomaterials and cells, thus laying an experimental foundation for the translation and application of decellularized cartilage biomaterials in the treatment of cartilage defects.
研究领域:
组织工程
·
再生医学
·
生物材料科学
·
细胞生物学
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DOI
PubMed
高影响因子
Biomedical Materials
·
2011
·Vol. 6
·期 5
·055008
·
IF 2.467
Yan Wei,Xuehui Zhang,Yu Song,Bing Han,Xiaoyang Hu,Xinzhi Wang,Yuanhua Lin,Xuliang Deng
In recent years, interest in magnetic biomimetic scaffolds for tissue engineering has increased considerably. The aim of this study is to develop magnetic biodegradable fibrous materials with potential use in bone regeneration. Magnetic biodegradable Fe3O4/chitosan (CS)/poly vinyl alcohol (PVA) nanofibrous membranes were achieved by electrospinning with average fiber diameters ranging from 230 to 380 nm and porosity of 83.9–85.1%. The influences of polymer concentration, applied voltage and Fe3O4 nanoparticles loading on the fabrication of nanofibers were investigated. The polymer concentration of 4.5 wt%, applied voltage of 20 kV and Fe3O4 nanoparticles loading of lower than 5 wt% could produce homogeneous, smooth and continuous Fe3O4/CS/PVA nanofibrous membranes. X-ray diffraction (XRD) data confirmed that the crystalline structure of the Fe3O4, CS and PVA were maintained during electrospinning process. Fourier transform infrared spectroscopy (FT-IR) demonstrated that the Fe3O4 loading up to 5 wt% did not change the functional groups of CS/PVA greatly. Transmission electron microscopy (TEM) showed islets of Fe3O4 nanoparticles evenly distributed in the fibers. Weak ferrimagnetic behaviors of membranes were revealed by vibrating sample magnetometer (VSM) test. Tensile test exhibited Young's modulus of membranes that were gradually enhanced with the increase of Fe3O4 nanoparticles loading, while ultimate tensile stress and ultimate strain were slightly reduced by Fe3O4 nanoparticles loading of 5%. Additionally, MG63 human osteoblast-like cells were seeded on the magnetic nanofibrous membranes to evaluate their bone biocompatibility. Cell growth dynamics according to MTT assay and scanning electron microscopy (SEM) observation exhibited good cell adhesion and proliferation, suggesting that this magnetic biodegradable Fe3O4/CS/PVA nanofibrous membranes can be one of promising biomaterials for facilitation of osteogenesis.
研究领域:
生物医学工程
·
材料科学
·
组织工程
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Jiawei Wu,Run Hu,Shaoning Zeng,Wang Xi,Shiyao Huang,Junhui Deng,Guangming Tao
Integrating personal thermoregulation technologies into wearable textiles has enabled extensive and profound technological breakthroughs in energy savings, thermal comfort, wearable electronics, intelligent fabrics, and so forth. Nevertheless, previous studies have suffered from long-standing issues such as limited working temperature, poor comfort, and weak reliability of the textiles. Here, we demonstrate a skin-friendly personal insulation textile and a thermoregulation textile that can perform both passive heating and cooling using the same piece of textile with zero energy input. The insulation textile material is composed of biomaterial microstructured fibers that exhibit good thermal insulation, low thermal emissivity, and good dyeability. By filling these microstructure fibers with biocompatible phase-change materials and coating them with polydimethylsiloxane, the insulation textile becomes a thermoregulation textile that shows good water hydrophobicity, high mechanical robustness, and high working stability. The proposed thermoregulation textile exhibits slow heating/cooling rates with improved thermal comfort, offering feasible and adaptive options for personal cooling/heating scenarios and enabling scalable manufacturing for practical applications.
研究领域:
材料科学
·
纺织工程
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 4
·672
·
IF 5.719
Pengxiang Zhao,Yi Jin,Xiang Wu,Jin Huang,Lupeng Chen,Yanjie Tan,Hong Yuan,Jian Wu,Zhuqing Ren
Lipid droplets (LDs) play an important role in the regulation of cellular stress. This suggests LDs can be applied as safe and effective biomaterials to alleviate cellular stress and lipotoxicity. Here, we constructed a convenient method to generate stable and pure artificial lipid droplets (aLDs). aLDs can maintain their biological function by incubating LD-associated proteins or organelles in vitro. It was validated that perilipin-coated aLDs could be uptaken by cells, significantly reducing hydrogen peroxide-induced reactive oxidative species (ROS) and alleviating cellular lipotoxicity caused by excess fatty acid. Our work demonstrated a direct role of LDs in regulating cellular stress levels, providing methods and potential value for future research and medical applications of LDs.Keywords:artificial lipid droplets;biomaterials;lipotoxicity;ROS;Plin5;cell stress
研究领域:
细胞生物学
·
生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Xinghan Wu,Wenxin Xu,Xuantao Huang,Nianhua Dan,Yining Chen,Zhengjun Li,Yunbing Wang
Emergency repair of complicated full-thickness abdominal wall defects remains one of the most common and challenging surgical emergencies globally. Here, an integrated polydopamine permeating-cross-linking strategy was innovatively proposed to convert porcine acellular dermal matrix (pADM) into versatile, degradation-resistant biopatches (PDA-pADM) for efficiently repairing full-thickness abdominal wall defects. The strategy significantly addresses the challenge that natural-property improvement and biocompatibility of biomaterials are difficult to balance. Molecularly, dopamine (DA) molecules could fully permeate into the collagen fibers of the acellular dermal matrix and then automatically trigger the interfacial in situ polymerization of dopamine monomers among collagen fibers to achieve the efficient cross-linking of pADM. Surprisingly, the enzymatic durability of the biopatch shows significant improvements, extending the original duration from 3 to 20 d. Comprehensive in vivo experiments have shown that PDA-pADM can effectively promote angiogenesis and inhibit inflammatory response, so as to achieve regeneration and repair of abdominal wall damage.
研究领域:
生物医学工程
·
组织工程
·
外科手术
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产品关联
DOI
PubMed
高影响因子
Matter
·
2024
·
IF 17.3
Yi Zhang,Weiwei Shi,Chao Ma,Sikang Wan,Cong Li,Jianlei Shen,Jingjing Li,Xiaoguo Liu,Dong Chen,Fan Wang,Hongjie Zhang,Chunhai Fan,Kai Liu
The impressive mechanical properties of DNA molecules play important physiological and pathological roles, which arise from their
intrinsically ordered and periodic double-helix structures. Nevertheless, bulk fabrication of DNA-based materials that inherit their nanoscale mechanical strength remains a grand challenge. Here, we
developed a multiscale engineering approach to assemble with
highly ordered DNA bulk fibers. We found that the involvement of
metal ions enabled tunable assembly and orientation of DNA-metal
ensembles ranging from molecules to nanobundles and to macroscale filaments. This strategy remarkably enhanced the mechanical
performance of DNA fibers with the optimal tensile strength and
toughness reaching to 513 MPa and 130 MJ m3
, respectively,
which outperform even partially protein- and polymer-based fibers.
We further demonstrated the high scalability of this method by
continuous spinning of 1,000 m of robust fibers with 50 mg DNA,
which shows great promise in translations of DNA-based materials
in mechanobiology, bioelectronics, and beyond.
研究领域:
生物物理学
·
材料科学
·
分子生物学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Tao Wang,Xiqing Liu,Donglai Han,Yuxuan Sun,Changchang Ma,Yang Liu,Pengwei Huo,Yongsheng Yan
In this work, a biofiber was used as the natural polymer carrier to design a BiVO 4 QDs/cellulose fiber composite for photocatalytic application. The biofiber was obtained from bamboo, which was green, abundant and short growth cycle in Asia. Naturally rich groups of biofiber provided many sites to absorb the Bi 3+ to form the uniform distribution for BiVO 4 QDs . Moreover, a series of results indicated the strong connection was formed between biofiber and BiVO 4 QDs, which could increase the stability and electron transfer . Therefore, the new composite photocatalyst exhibited better stability and effectively photocatalytic activity . Moreover, the possible mechanism of synthesis and photocatalytic were discussed, which provided insight for synthesizing photocatalytic based on biomaterials.
研究领域:
材料科学
·
环境科学
·
生物学
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产品关联
DOI
高影响因子
Polymers
·
2022
·Vol. 14
·期 23
·5159
·
IF 4.967
Yiqi Chen,Yujie Duan,Han Zhao,Kelan Liu,Yiqing Liu,Min Wu,Peng Lu
Bio-based porous materials can reduce energy consumption and environmental impact, and they have a possible application as packaging materials. In this study, a bio-based porous foam was prepared by using a Pickering emulsion as a template. Nisin and waterborne polyurethane (WPU) were used for physical modification of 2,2,6,6-tetramethyl piperidine-1-oxyl-oxidized cellulose nanocrystals (TOCNC). The obtained composite particles were applied as stabilizers for acrylated epoxidized soybean oil (AESO) Pickering emulsion. The stability of the emulsion was characterized by determination of the rheological properties and microscopic morphology of the emulsion. The emulsion stabilized by composite particles showed better stability compared to case when TOCNC were used. The porous foam was obtained by heating a composite-particles-stabilized Pickering emulsion at 90 °C for 2 h. SEM (scanning electron microscopy) images showed that the prepared foam had uniformly distributed pores. In addition, the thermal conductivity of the foam was 0.33 W/m·k, which was a significant decrease compared to the 3.92 W/m·k of the TOCNC foam. The introduction of nisin and WPU can reduce the thermal conductivity of the foam, and the physically modified, TOCNC-stabilized Pickering emulsion provides an effective means to preparing bio-based porous materials.Keywords:TOCNC/Nisin/WPU;Pickering emulsion;biomaterials;porous foam;thermal insulation
研究领域:
材料科学
·
生物学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）