Combined experimental/theoretical study of D-glucosamine promoted Ullmann-type C–N coupling catalyzed by copper(I): does amino really count?
Ullmann type C–N coupling reaction catalyzed by copper(I) with D-glucosamine derivatives as promoters was studied by means of combined experimental/theoretical investigation. The catalytic role of D-glucosamine was addressed. In contrast with previous speculations, the amino group may not count in the catalytic cycle in which the oxidative addition/reductive elimination mechanism works. Experimental results are in good agreement with theoretical findings. Extensive work indicates the wide applicability of the C–N coupling strategy exploited in this work.
研究领域:
有机化学
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催化化学
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药物化学
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计算化学
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合成方法学
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生物正交化学
·
金属有机化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）