JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
·
IF 5.895
Yuan Shi,Xiaokang An,Binbin Zhang,Xinglu Pan,Xiaohu Wu,Jun Xu,Wensheng Xiang,Fengshou Dong,Xiangjing Wang,Yongquan Zheng
Guvermectin is a biopesticide isolated from the secondary metabolites of Streptomyces sp. NEAU6, an endogenous actinomyces of a Chinese medicine named Paris polyphylla. However, the environmental degradation behavior and biotoxicity of guvermectin are still unclear, which may affect its rational application. Therefore, the degradation of guvermectin in water at different pH values (pH 4, pH 6, pH 7, and pH 9) and with or without light was investigated in the laboratory. The results showed that guvermectin could be degraded in pH 4 solution, and the presence of light irradiation enhanced the degradation process with a DT50 of 2.95 and 12 days for photolysis and hydrolysis, respectively. However, guvermectin was fairly stable in other conditions. Three products transformed from guvermectin degradation were identified by UPLC-QTOF/MS. Biotoxicity assessment was performed on Danio rerio and Daphnia magna Straus by ECOSAR prediction and in vivo biological tests. The test data showed that guvermectin and its transformation products exhibited low toxicities to D. rerio and D. magna Straus (LC50/EC50 > 100 mg a.i./L), and the transformation products had lower toxicity than their parent substance. The results provided a reference for elucidating the potential risk of guvermectin to nontarget organisms and promoting its rational use.
研究领域:
环境科学
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毒理学
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农药学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 18
·
IF 1.86
Shizhen Zhao,Xun Song,Xiuming Bu,Chong Zhu,Gang Wang,Fang Liao,Siwei Yang,Miao Wang
Because of the great demand for fluorescent materials, fluorescent dyes, semiconductor quantum dots, and carbon-based quantum dots have been studied extensively. However, the poor photostability and potential biological toxicity need to be resolved. In this study, we demonstrated the synthesis of a new biomass quantum dot, the polydopamine dot (PDADs), via a simple hydrothermal method under an acidic environment. This new biomass quantum dot showed not only remarkable photoluminescence properties (quantum yield = 0.93) but also a high stability and low toxicity. Moreover, these PDADs could be used as a fluorescent probe for the rapid detection of Cr(VI) (response time = 0.01 s). The detection limit (1 × 10 −11 M ) is the lowest detection limit reported for Cr(VI) fluorescent probes. The mechanism efficient quenching progress could have been due to the fast redox progress between the PDADs and Cr(VI). Moreover, we also showed a practical application of PDADs for Cr(VI) detection in vitro . © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44784.
研究领域:
材料科学
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环境科学
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分析化学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
JiaJia Xue,Dandan Lei,Xiumei Zhao,Yaru Hu,Shijie Yao,Kuangfei Lin,Zejian Wang,Changzheng Cui
Various pollutants are released during pharmaceutical production processes, which is of great concern. Most studies have focused on the terminal treatment results of mixed pharmaceutical wastewater, and further research on wastewater from the production processes is required. This study investigated the wastewater quality indicators, residual antibiotics, and biological toxicity of the wastewater during the production process in a large pharmaceutical producing factory in Northern China. The wastewater contained numerous organic pollutants, with the chemical oxygen demand (COD) values ranging from 2.0 × 10 3 to 2.6 × 10 5 mg L −1 and the total nitrogen (TN) values ranging from 1.3 × 10 3 to 2.0 × 10 4 mg L −1 . High concentrations of cephalexin and cefradine remained in the wastewater of the production workshop, with the highest concentration of cefradine reaching 1328 mg L −1 . The wastewater from the oxidation and solvent recovery workshops was more toxic to Vibrio fischeri and Daphnia magna than that of other workshops. Moreover, the biological acute toxicity of wastewater was significantly correlated with the concentration of COD and TN ( p < 0.01). This study provides new insights into the treatment of antibiotic production wastewater, illuminating the incomplete extraction of products and the significant risk posed by pharmaceutical wastewater to the environment.
研究领域:
环境科学
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药学
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毒理学
✓ 已验证
DOI
PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
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2019
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IF 3.775
Fengru Liu,Yiyin Zhang,Qiuyang Yu,Yizhong Shen,Zhi Zheng,Jieshun Cheng,Wencheng Zhang,Yingwang Ye
Ellagic acid (EA), a natural plant polyphenol, is usually used as a functional additive in variety of health foods . However, the potential toxicity of EA to human health should be paid enough attention. To clarify its biological toxicity in vivo , this study explored the binding mechanism of EA with bovine serum albumin (BSA) by means of spectroscopic approaches and molecular docking insimulative physiological conditions. The results showed that the mixture of BSA with EA could spontaneously cause the formation of BSA-EA complex through electrostatic interaction under simulative physiological conditions (0.01 mol·L −1 Tris-HCl, 0.015 mol L −1 NaCl, pH = 7.4). Molecular docking experiments revealed that EA was primarily bound to the hydrophobic pocket of the site I (subdomain IIA) of BSA. It has been reported that the binding of small functional molecules to serum albumins remarkably impacts their absorption, distribution, metabolism, and excretion features. Therefore, this study might be helpful for human to have an in-depth understanding of the biological effect of EA in vivo and guide human to take it safely and reasonably.
研究领域:
食品科学
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生物化学
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毒理学
✓ 已验证
DOI
高影响因子
Lubricants
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2025
·Vol. 13
·期 3
·103
·
IF 2.9
Wei Li,Huanyi Chen,Long Chen,Shanqin Ge,Qingzhao Cai,Genxiang Gong,Jinhong Yu,Kazuhito Nishimura,Nan Jiang,Tao Cai
Hydraulic technology has been instrumental in the extensive application of offshore mechanical equipment, particularly in drilling platforms and ships, where high-performance hydraulic fluids are essential for safe and efficient operations. Addressing the urgent need for water-based hydraulic fluids as an alternative to traditional oil-based fluids, this study introduces a novel water-based hydraulic fluid fortified with phytic acid, derived from plant seeds, to achieve low biotoxicity, low coefficient of friction, and reduced frictional heat generation. The integration of phytic acid has significantly enhanced the lubricating performance, reducing the average coefficient of friction to as low as 0.013, as tested by the four-ball tester, which is the lowest value reported to date. Real-time monitoring of the temperature rise of the friction testing apparatus using an infrared thermal imager revealed a 78.6% reduction in temperature increase. Acute toxicity assays using Brine Shrimp demonstrated that the 96 h LC50 value for the water–glycol flame-resistant hydraulic fluid with added phytic acid exceeded 26,304 mg/L, indicating low toxicity. Characterization analyses elucidated the mechanisms underlying the improved tribological properties, highlighting the potential of this eco-friendly fluid for safe and efficient offshore operations.
研究领域:
海洋工程
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生物技术
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材料科学
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产品关联
DOI
高影响因子
Chemical Engineering Journal Advances
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2023
·
IF 0
Juan Bao,Tingting Zhang,Shiying Wu,Chunhu Tan,Chang Liu,Lingling Wang,Weihua Li,Xianhuai Huang,Jiansheng Li,Rui Lu
Ag nanoparticles (AgNPs) are toxic and can accumulate in the human body or the environment, resulting in biotoxic effects. Ti 3 C 2 T x , a new class of graphene-like 2D nanomaterials, is used in numerous applications due to its special physicochemical properties. There is great concern about the potential damage that this material may cause to the environment and human health. In this study, the interaction mechanisms of Ti 3 C 2 T x , AgNPs and Ti 3 C 2 T x /AgNPs materials with human serum albumin (HSA) were characterized using multispectral analysis and zeta potential measurements, respectively. The results showed that the effects of the three materials on the conformational changes of HSA were AgNPs > Ti 3 C 2 T x /AgNPs > Ti 3 C 2 T x in order. Hydrogen bonding and electrostatic interaction forces played an important role in the binding process of Ti 3 C 2 T x and its complexes with HSA. Ag nanoparticles have a comparatively high level of biotoxicity and have a more significant effect on the conformational changes of proteins. Ti 3 C 2 T x itself has biocompatibility and a large specific surface area. The biotoxicity of Ti 3 C 2 T x /AgNPs complex is lower than that of AgNPs, indicating that the addition of Ti 3 C 2 T x can reduce the biotoxicity of Ag nanoparticles, and Ti 3 C 2 T x may be used as a carrier substance for Ag nanoparticles, which can reduce the toxicity of AgNPs while giving it unique properties similar to those of Ti 3 C 2 T x , thus improve the biosafety of Ag nanoparticles in the application process.
研究领域:
生物化学
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纳米医学
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环境科学
✓ 已验证
DOI
SCIENCE OF THE TOTAL ENVIRONMENT
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2022
·
IF 10.753
Zhiheng Li,Jiazheng Chen,Jie Chen,Jiaojun Jin,Hanmei Chen,Huijun Liu
Due to the persistence of ionic liquids (ILs) in aquatic environments, it is necessary to reveal their ecological risk to aquatic organisms. Herein, the biotoxicity of two alkyl-methylimidazolium nitrate ILs ([C 10 mim]NO 3 and [C 12 mim]NO 3 ) against Scenedesmus obliquus were studied. Results showed that the growth inhibition of S. obliquus increased with increasing concentrations of ILs, maximum values of 94.61% at 4 mg/L of [C 10 mim]NO 3 and 97.34% at 0.8 mg/L of [C 12 min]NO 3 were observed. The fluorescence parameters of photosystem II, such as light quantum yield and electron transfer rate, showed a negative relationship with the exposure dose. [C 12 mim]NO 3 had a more significant effect than [C 10 mim]NO 3 . Moreover, the redox homeostasis of algae was disrupted; the accumulation of reactive oxygen species , leading to obvious inhibition of superoxide dismutase and catalase activities was observed. A metabolomic analysis indicated that the contents of most metabolites were reduced significantly, and fructose and galactose decreased significantly by 42.3% and 88.6%, respectively, in the [C 10 mim]NO 3 treatment compared to those in the control. The inhibition of amino acid biosynthesis and glyoxylate and dicarboxylate metabolism explained the more serious biotoxicity of [C 12 mim]NO 3 than that of [C 10 mim]NO 3 . This study facilitates a better understanding of the environmental safety and ecological risks of ILs.
研究领域:
环境科学
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植物生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
·
IF 19.503
Runren Jiang,Guanghua Lu,Min Wang,Tianjian Dang,Jianchao Liu,Zhenhua Yan
Utilizing photocatalysis to degrade pollution is emerging as a promising way to treat wastewater, but is challenged by low efficiency and scanty toxicity cognition. In this work, Mn 3 O 4 /BiOCl based crystal plane engineering systems are applied for naproxen (NPX) degradation, and Mn 3 O 4 /BiOCl 010 displayed better degradation rate, which is 16 and 8 times than that of the Mn 3 O 4 /BiOCl 001 and BiOCl 010 . According to the degradation pathway analysis and biological toxicity experiments, the toxicity of the degradation solution increased first and then decreased, which may be caused by the mineralization of NPX and more toxic intermediates. Affected by the distinct internal charge transfer directions of the two crystal planes of BiOCl, Mn 3 O 4 /BiOCl 010 heterojunction system has a faster charge transform than that of Mn 3 O 4 /BiOCl 001 . Moreover, the valence cycle of Mn can further accelerate the charge transfer, which can also provide a powerful driving force for NPX elimination.
研究领域:
环境科学
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光催化
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毒理学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2023
·
IF 2.8
Zhenzhen Yao,Xiaoman He,Mengqiuzi Yin,Han Han,Qiwu Zhang
A mechanochemical (MC) method was employed for the remediation of soil contaminated with fluoranthene (C16H10, FL) a four-ringed polycyclic aromatic hydrocarbon (PAH) containing three benzene rings and a central five-membered heterocyclic ring, with the effects of soil inorganic components, milling conditions, and the degradation mechanism investigated. Results showed that the addition of SiO2 and kaolin to soil resulted in a greater increase in the effectiveness of FL removal than other inorganic additives. After 3 hours of milling at 500 rpm, the FL removal rate from SiO2 containing soil, reached 99.26%, with the removal efficiency increasing in accordance with an increase in milling duration and speed. The milled samples were characterized by FT-IR, Raman spectroscopy, and GC-MS analysis, revealing the mechanism of FL degradation, including destruction of the aromatic skeleton structure and the formation of amorphous carbon and graphite. The MC remediation method was applied to FL contaminated soil, showing that FL was efficiently degraded in soil without any soil additives, resulting in a significant reduction in the biotoxicity of the remediated soil. The organic matter, moisture content and pH of the actual soil changed slightly after mechanical ball milling. Thus, the MC method has high potential in the remediation of PAH-contaminated soils.HIGHLIGHTSA mechanochemical (MC) method for the degradation of fluoranthene was assessed.The use of silica and kaolin as soil additives enhances fluoranthene remediation.Fluoranthene can be efficiently removed from contaminated soil by milling alone.The degradation mechanism was skeleton structure destruction and carbonization.The biotoxicity of soil was significantly reduced by milling.
研究领域:
环境科学
·
土壤学
·
污染控制
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jing Yang,Shun-Feng Jiang,Wei-Fei Hu,Hong Jiang
The efficient elimination of biotoxicity of halogenated antibiotics by electrochemical dehalogenation pretreatment is required by a subsequent biochemical treatment process. Molybdenum disulfide (MoS 2 ) has been applied as an efficient catalyst for the hydrogen evolution and water splitting, without any investigation in electrochemical dehalogenation, particularly under complex environmental conditions. In this study, ultrathin MoS 2 nanosheets are fabricated via a simple one-step hydrothermal process, and proved as a promising catalyst for enhancing electrochemical dehalogenation of halogenated antibiotics of a chlorinated antibiotic florfenicol (FLO) under relevant environmental conditions. Results showed that the reaction rate constant of the ultrathin MoS 2 electrode (0.0135 min −1 ) was 4.1- and 28- fold higher than those of commercial MoS 2 and bare carbon paper, respectively, and the biotoxicity of treated effluent could almost be neglected. Free radical scavenging experiments and electrochemical performance test suggested that the dechlorination of FLO on ultrathin MoS 2 electrode was synergistically accomplished via the direct electron transfer and indirect reduction of active H*. Environmental conditions, namely, dissolved oxygen and humic acid had only a slight effect on the dechlorination efficiency. Electrochemical dechlorination of FLO was a gradual dechlorination process and FLO-2Cl (representing the removal of two chlorine atoms from FLO) was the final main product. Besides, the ultrathin MoS 2 electrode retained a good stability and the energy consumption of the ultrathin MoS 2 cathode at −1.2 V was 0.02643 kWh g −1 , more than those of commercial MoS 2 cathode and bare carbon paper. This study develops a new application of noble-metal-free electrode material for electrochemical dechlorination in wastewater.
研究领域:
环境科学
·
催化材料
✓ 已验证
DOI
高影响因子
ACS Nano
·
2017
·
IF 13.942
Fangfang Cao,Enguo Ju,Yan Zhang,Zhenzhen Wang,Chaoqun Liu,Wei Li,Yanyan Huang,Kai Dong,Jinsong Ren,Xiaogang Qu
Silver nanoparticles (AgNPs) have been used as a broad-spectrum antimicrobial agent, whose toxicity originates from the localized release of Ag+ ions. However, the residual AgNPs core could generate potential risk to humans and waste of noble metals. Herein, we infused the cysteine-modified molybdenum disulfide with minimum Ag+ ions and coated with a layer of cationic polyelectrolyte to construct an efficient and benign antimicrobial depot. The system exhibited much enhanced broad-spectrum antibacterial activity compared with an equivalent amount of silver nitrate, owing to its increasing accessibility of released Ag+ to the cell walls of microorganisms. More importantly, the antibacterial system could be successfully applied to treat wound infection, while retaining high antibacterial activities, exhibiting negligible biotoxicity and avoiding the waste of Ag.
研究领域:
材料科学
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生物学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2018
·Vol. 15
·期 7
·1520
·
IF 2.145
Zhuqiu Sun,In-Sun Kang,Qianyuan Wu,Jinying Xi,Hongying Hu
Ultraviolet (UV) photodegradation is increasingly applied to control volatile organic compounds (VOCs) due to its degradation capabilities for recalcitrant compounds. However, sometimes the UV photodegradation products are also toxic and can affect human health. Here, 10 VOCs at 150~200 ppm in air were treated using a laboratory-scale UV reactor with 185/254 nm irradiation, and the biotoxicity of their off-gas was studied by investigating their off-gas absorption solutions. The CO2increase and VOC decrease were 39~128 ppm and 0~42 ppm, respectively, indicating that the VOCs and their products were mineralized in off-gas absorption solutions. The total organic carbon (TOC) of the absorption solutions are 4~20 mg∙L−1. Luminescent bacteria andDaphnia magnawere used to detect the acute toxicity, and anumuassay was used to determine the genotoxic potential. Trichloroethylene showed a highest toxicity to luminescent bacteria, while chlorobenzene had the lowest toxicity. Water-soluble UV photodegradation products for styrene are very toxic toDaphnia magna. In theumuassay, the genotoxicities of off-gas absorption solutions of trichloroethylene, methylbenzene, ethyl acetate, butyl alcohol, and styrene were 51.26, 77.80, 86.89, 97.20, and 273.62 mg (4-NQO)·L−1respectively. In addition, the analysis of the genotoxicity/TOC and intermediates products indicated that the off-gas absorption solutions of styrene, trichloroethylene, and butyl alcohol contain many highly toxic substances.Keywords:VOCs;UV photodegradation;biotoxicity;luminescent bacteria;Daphnia magna
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）