CHEMISTRY & BIODIVERSITY
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2019
·Vol. 16
·期 3
·e1800581
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IF 1.449
Jia Sun,Jin-Hai Yu,Jun-Sheng Zhang,Xiu-Qing Song,Jie Bao,Hua Zhang
Fourteen chromane derivatives of seven pairs of enantiomers ( 1 – 14 ) have been obtained from the ethanolic extract of the flower buds of Tussilago farfara L. Their structures with absolute configurations have been elucidated by detailed spectroscopic analyses, chemical methods, and particularly comparison of experimental ECD spectra with theoretically computed ones. Biological evaluations revealed that they did not show cytoprotective, antimicrobial, and α - glucosidase inhibitory activities. Graphical
研究领域:
植物化学
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药理学
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药物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
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IF 5.091
Xian-peng Zhang,Jian Luo,Da-xia Zhang,Tong-fang Jing,Bei-xing Li,Feng Liu
In this paper, porous microcapsules with tunable pore sizes were prepared using interfacial polymerization by employing a temperature-responsive cross-linking agent above its so-called cloud point temperature ( T scp ). The influences of porosity on the surface morphology , release profile and biological activity of the microcapsules were investigated. The results showed that both pore size and pore density could be controlled by regulating either the amount of cross-linking agent or the ratio of core material to shell material. Furthermore, the porosity of the microcapsules determined their release properties and further regulated the bioactivity of the microcapsules. In addition, the mechanism of pore formation was confirmed by investigating the morphology of microcapsules below the T scp . The microencapsulation methodology described here is convenient and versatile, which can be easily extended to encapsulate a broad range of lipophilic core materials.
研究领域:
药剂学
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生物材料
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纳米医学
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药物递送
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高分子科学
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DOI
高影响因子
Small
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2019
·Vol. 15
·期 52
·1905451
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IF 10.856
Lijun Ji,Mindong Gong,Tong Xu,Jun Gu,Xu Jiang,Taotao Liang,Yu Chen,Qingren Liu
The interactions of ions and molecules with material surface are highly dependent on the surface properties of the material. Therefore, the distribution of ions or molecules near the material surface may be affected by the surface properties. This phenomenon can be significant enough for controlling the structure of a material synthesized in the sub-micrometer scale confinement space of a template. This work confirms that inverse opals are perfect templates for offering confinement space, while their different surface properties can strongly affect ion and block copolymer distribution in the confinement space. This surface effect principle can be used for the controlled synthesis of colloids with complex composition. As an example, four kinds of mesoporous magnetic bioactive glass colloids with ordered mesopores, core–shell structure, open surface pores, or disordered mesopores are prepared by using polystyrene and carbon inverse opal templates. This work reveals that inverse opal templates possess great advantage in controlled synthesizing colloidal structures due to their surface effect on ions and molecules and confinement space.
研究领域:
生物材料学
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纳米医学
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组织工程
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药物递送
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生物矿化
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胶体化学
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DOI
高影响因子
MATERIALS LETTERS
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2017
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IF 2.572
Shu-Hui Xia,Shu-Hua Teng,Peng Wang
Polyvinyl alcohol/silica (PVA/SiO 2 ) hybrid fibers were prepared via a sol–gel combined electrospinning technique, and their potential application in bone tissue engineering was evaluated in terms of in vitro bioactivity. When the PVA concentration was 8%, the obtained PVA/SiO 2 hybrid fibers exhibited a uniform and continuous morphology, with an average fiber diameter of about 542.9 nm. The SiO 2 xerogel phase was uniformly distributed within the PVA matrix, and its actual content was very close to the theoretical value. After 3 days of immersion in simulated body fluid (SBF), the PVA/SiO 2 hybrid fibers displayed a vigorous precipitation of lamellar apatite crystals, reflecting their excellent in vitro bioactivity.
研究领域:
生物材料学
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组织工程
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纳米医学
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生物医学工程
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无机非金属材料
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再生医学
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2016
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IF 3.42
Haibin Li,Fei Jiang,Song Ye,Yingying Wu,Kaiping Zhu,Deping Wang
The strontium-substituted hydroxyapatite microspheres (SrHA) incorporated alginate composite microspheres (SrHA/Alginate) were prepared via adding SrHA/alginate suspension dropwise into calcium chloride solution, in which the gel beads were formed by means of crosslinking reaction. The structure, morphology and in vitro bioactivity of the composite microspheres were studied by using XRD, SEM and EDS methods. The biological behaviors were characterized and analyzed through inductively coupled plasma optical emission spectroscopy (ICP-OES), CCK-8, confocal laser microscope and ALP activity evaluations. The experimental results indicated that the synthetic SrHA/Alginate showed similar morphology to the well-known alginate microspheres (Alginate) and both of them possessed a great in vitro bioactivity. Compared with the control Alginate, the SrHA/Alginate enhanced MC3T3-E1 cell proliferation and ALP activity by releasing osteoinductive and osteogenic Sr ions. Furthermore, vancomycin was used as a model drug to investigate the drug release behaviors of the SrHA/Alginate, Alginate and SrHA. The results suggested that the SrHA/Alginate had a highest drug-loading efficiency and best controlled drug release properties. Additionally, the SrHA/Alginate was demonstrated to be pH-sensitive as well. The increase of the pH value in phosphate buffer solution (PBS) accelerated the vancomycin release. Accordingly, the multifunctional SrHA/Alginate can be applied in the field of bioactive drug carriers and bone filling materials.
研究领域:
生物材料学
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骨组织工程
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药物递送系统
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生物医学工程
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再生医学
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生物无机化学
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药剂学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2014
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IF 2.694
Guihua Ruan,Meiping Wei,Zhengyi Chen,Rihui Su,Fuyou Du,Yanjie Zheng
A novel large-volume immobilized enzyme reactor (IMER) on small column was prepared with organic–inorganic hybrid silica particles and applied for fast (10 min) and oriented digestion of protein. At first, a thin enzyme support layer was formed in the bottom of the small column by polymerization with α-methacrylic acid and dimethacrylate. After that, amino SiO 2 particles was prepared by the sol–gel method with tetraethoxysilane and 3-aminopropyltriethoxysilane. Subsequently, the amino SiO 2 particles were activated by glutaraldehyde for covalent immobilization of trypsin. Digestive capability of large-volume IMER for proteins was investigated by using bovine serum albumin (BSA), cytochrome c (Cyt- c ) as model proteins. Results showed that although the sequence coverage of the BSA (20%) and Cyt- c (19%) was low, the large-volume IMER could produce peptides with stable specific sequence at 101–105, 156–160, 205–209, 212–218, 229–232, 257–263 and 473–451 of the amino sequence of BSA when digesting 1 mg/mL BSA. Eight of common peptides were observed during each of the ten runs of large-volume IMER. Besides, the IMER could be easily regenerated by reactivating with GA and cross-linking with trypsin after breaking the –C N– bond by 0.01 M HCl. The sequence coverage of BSA from regenerated IMER increased to 25% comparing the non-regenerated IMER (17%). 14 common peptides. accounting for 87.5% of first use of IMER, were produced both with IMER and regenerated IMER. When the IMER was applied for ginkgo albumin digestion, the sequence coverage of two main proteins of ginkgo, ginnacin and legumin, was 56% and 55%, respectively. (Reviewer 2) Above all, the fast and selective digestion property of the large-volume IMER indicated that the regenerative IMER could be tentatively used for the production of potential bioactive peptides and the study of oriented protein digestion.
研究领域:
生物化学
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分子生物学
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蛋白质组学
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酶工程
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生物材料
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DOI
高影响因子
危险品化学品经营许可证（带存储）